Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Alex Saturday
ID: UNCST-2023-R007459
 INVESTIGATION OF SPATIO-TEMPORAL VARIATION IN BIOLOGICAL AND PHYSICO-CHEMICAL WATER QUALITY PARAMETERS IN LAKE BUNYONYI, SOUTH-WESTERN UGANDA
REFNo: NS149ES

i. To determine the Spatio-temporal variations of bacterial fecal indicators of water in Lake Bunyonyi.
ii. To assess the Spatio-temporal variations in phytoplankton composition and biomass in the water of Lake Bunyonyi.
iii. To determine the Spatio-temporal variations of physicochemical quality of water in Lake Bunyonyi.
iv. To examine the seasonal variations of the trophic state conditions of Lake Bunyonyi ecosystem
v. To investigate the processes that governs nutrient dynamics in Lake Bunyonyi ecosystem.

Uganda 2021-01-28 2024-01-28 Natural Sciences Degree Award
Emily Otali
ID:
A study of health and forage patterns of wild African honeybees (Apis mellifera scutellata) and their impact on the survival of Kibale National Park, its threatened chimpanzees and elephants.
REFNo: A82ES

The general objective for this study is to engage farmers and students living around Kibale National Park, Uganda, in an accessible and culturally relevant participatory science project that collects and analyzes data measuring colony health and foraging plants of wild African honeybees for a period of two years. This will be achieved through:
• Developing participatory science project appropriate for rural Ugandan farmers and partnering students.
• Establishing baseline colony health and forage patterns for the wild African honey bee in the Kibale National Park ecosystem.
• Determining if colony health and forage patterns for the wild African honey bee knowledge will help achieve maximum honey yields and increased forage diversity.

 Uganda 2021-01-28 2024-01-28 Agricultural Sciences Non-degree Award
Jackson Mukonzo
ID: UNCST-2021-R013916
 IDENTIFICATION, VALIDATION AND OPTIMIZATION OF AVAILABLE DRUG MOLECULES FOR CLINICAL TREATMENT OF COVID-19.-IVCOM
REFNo: HS1065ES

1. Explore the clinical use of combination anticoagulant: lower dose aspirin and ivermectin, an FDA-approved anti-parasitic drug therapy in treatment of COVID-19 patients in an exploratory randomized trial.
2. To identify target molecules through testing and screening for SARS-CoV-2 activity of existing substances, molecules or formulations on basis of registered activity claims or scientific evidence for anti- SARS-CoV-2 activity including herbal preparations, quinolone derivatives (chloroquine and hydroxyquinoline) in combination with zinc, HIV entry and protease inhibitors, HCV protease inhibitors and entry inhibitors as well as agents with inhibitory and down regulatory effect on ACE2 and those that might be identified thorough literature search.
3. Use bioinformatics tools to perform structural optimization of molecules identified in objective 2 above for efficacy and safety of COVID-19 patents and conduct early phase clinical trials on the resulting molecules.
Uganda 2021-01-28 2024-01-28 Medical and Health Sciences Non-degree Award
Alex Mabirizi
ID:
ASSESING THE EFFECT OF CONCURRENT VACCINE ADMINISTRATION FOR PESTE DES PETITS RUMINANTS, CAPRIPOX AND CONTAGIOUS CAPRINE PLEUROPNEUMONIA ON IMMUNITY OF SHEEP AND GOATS IN UGANDA
REFNo: A106ES

1. To determine antibody titres against PPR, CCPP and Capripox Virus following single and concurrent administration of two or three vaccines.
2. To determine cytokine responses to PPR, CCPP and Capripox Virus following single and concurrent administration of two or three vaccines.

Uganda 2021-01-28 2024-01-28 Agricultural Sciences Degree Award
faith mbabazi musinguzi
ID:
Role conflict and Burnout among university administrators in selected universities in Uganda
REFNo: SS552ES

4. To assess the influence of role conflict on burnout for administrators across universities.,3. To establish the administrators’ experience with role conflict and burnout among administrators.,2. 2. To examine the degree to which role conflict constructs predict burnout among non-academic administrators.,1.To establish the extent to which role conflict constructs predict burnout among academic administrators.,
 Uganda 2021-01-27 2024-01-27 Social Science and Humanities Degree Award
Ponsiano Ocama
ID: UNCST-2019-R000440
 Clinical and immunological impact of Schistosoma mansoni infection and treatment on the course of chronic hepatitis B virus (HBV) infection in HIVuninfected patients in Uganda
REFNo: HS1002ES

To determine Clinical and immunological impact of Schistosoma mansoni (Sm) infection and treatment on the course of chronic hepatitis B virus (HBV) infection in Uganda. This will be done through the following aims: Aim 1: To define and quantify Sm infection, treatment response, and reinfection rates within a cohort of chronic HBV patients Aim 2: To determine the impact of Sm infection and treatment on HBV virological markers, disease stage, and longer-term progression among urban Ugandans Aim3: To determine if HBV-specific immunological responses in the periphery and within the liver are altered in response to Sm infection and treatment

Uganda 2021-01-27 2024-01-27 Medical and Health Sciences Non-degree Award
Miriam Nakalembe
ID: UNCST-2021-R014040
 Understanding CIN2+ among HIV infected women after LEEP: An epidemiological and immunohistochemical study
REFNo: HS1154ES

1. To assess the incidence and risk factors for “recurrent” CIN2/3 after LEEP among HIV- infected women.
2. To determine baseline HR-HPV types (in tissue) among HIV-infected women with CIN2/3 undergoing LEEP compared to the HR-HPV types with “recurrent” cervical lesions after a second LEEP.
3. To determine the immunohistochemical differences between the initial and repeat LEEP specimens among HIV-infected women with “recurrent” CIN2/3

 Uganda 2021-01-27 2024-01-27 Medical and Health Sciences Non-degree Award
Edward Nsubuga
ID:
Work place violence and interventions used at mental health units in uganda
REFNo: HS435ES

Identifying the patterns of workplace violence,contributing factors ,and remedial interventions available in place for such victims.
 Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
Joseph Kagaayi
ID: UNCST-2024-R015946
 Hard to reach populations in Uganda; An observational cohort study
REFNo: HS607ES

Aim 1-We will first determine CHP coverage and HIV incidence among hard-to-reach persons using enhanced surveillance techniques.

Aim 2-We will then characterize ongoing sources of incident HIV infection through partner tracing of newly HIV-infected participants and matched HIV-negative controls, viral phylogenetics, and sexual network analyses.

Aim 3-Finally, we will determine if state-of-the-art CHP can engage hard-to-reach populations and reduce population-level HIV incidence to a level sufficient for HIV elimination by 2030.



Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
 Evaluation of impact of National Research Information Management System on the research regulatory process in Uganda
REFNo: HS906ES

The general objective of this proposal is to determine the usage of NRIMS as well as evaluate the experiences and attitudes of users of the systems at Makerere University, Mulago Hospital and UCI RECs.
2.1.1 Primary Objective
1. To determine the turnaround time between submission of protocols to review and approval, and time to receipt of feedback from REC for one year before and one year after roll out of NRIMS for RECs in Makerere Hospital Complex and UCI
2.1.2 Secondary Objectives
1. To qualitatively document and compare stakeholders’ experiences regarding use of the paper based and the NRIMS for research protocol review and approval in Makerere University, Mulago Hospital complex and UCI at start of roll out and one year after of roll out.
Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
RACHEAL ALINAITWE
ID: UNCST-2020-R014509
 The feasibility of involving Village Health Team Members in identifying and referring older persons with cognitive impairment in Wakiso District, Uganda.
REFNo: HS988ES

1. To assess the feasibility of involving Village Health Team Members in identifying older persons with cognitive impairment in Wakiso district, Uganda.
2. To assess the feasibility of involving Village Health Team members in referring older persons with cognitive impairment to health centre III for care in Wakiso district, Uganda.

 Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
Juliana Namutundu
ID:
DEVELOPMENT AND VALIDATION OF A CERVICAL CANCER RISK SCORING SYSTEM FOR PREDICTING CERVICAL CANCER AMONG UGANDAN WOMEN AGED 25-49 YEARS
REFNo: HS1043ES

1) To develop a cervical cancer risk scoring system for Ugandan women based on major sexual, behavioral, and reproductive risk factors.
2) To validate a cervical cancer risk scoring system for Ugandan women based on major sexual, behavioral, and reproductive risk factors.

 Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
Patrick Tumusiime Kagurusi
ID:
Documenting lived experiences of youth in Sub Saharan Africa during the covid-19 pandemic: implications for policy and program considerations
REFNo: SS650ES

General Objective
To document the lived experiences of youth in Sub Saharan Africa and programmatic considerations for their health and well-being in the wake of the COVID-19 pandemic.
Specific Objectives:
1. To document the lived experiences of the youth in Sub Saharan Africa across health and socio-economic tiers during the COVID-19 pandemic
2. To document coping strategies by the youth on health and socio-economic effects during the COVID-19 pandemic
3. To assess how the coping strategies employed help youth navigate the health and socio-economic effects of the pandemic.
4. To document recommendations that can mitigate health and socio-economic effects of the pandemic for future policies and programmes targeting the youth
 Uganda 2021-01-25 2024-01-25 Social Science and Humanities Non-degree Award
GRACE NAMBATYA KYEYUNE
ID:
A Phase IIa randomized double-blind, placebo-controlled clinical trial to determine the preliminary safety and efficacy of UBV-01N in adult patients infected with SARS-COV-2 (COVID-19) in Kampala, Uganda.
REFNo: HS1207ES

a) To evaluate the preliminary safety and of UBV-01N, in adult patients diagnosed with COVID-19 and treated with UBV-01N
b) To assess the preliminary efficacy of UBV-01N + standard of care, compared to UBV-01N placebo + standard of care, in adult patients diagnosed with COVID-19, in Kampala, Uganda.

 Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
Ruth Namazzi
ID: UNCST-2020-R014305
 Health-related Quality of Life (HRQoL) of Ugandan children with Sickle Cell Disease (SCD): A comparative study of HRQoL outcomes in the Zinc for Infection Prevention (ZIPS) trial and at the Nalufenya Sickle Cell Clinic (NSCC)
REFNo: HS1069ES

This proposal is designed as a sub-study nested within the ‘Zinc for Infection Prevention in Sickle cell anemia (ZIPS) trial, and has 3 specific aims –

Aim 1: To determine, using a SCD-specific testing instrument, if HRQoL outcomes of children with SCD enrolled in a clinical trial (ZIPS) differ from children with SCD who receive standard of care at the Nalufenya Sickle Cell Clinic (NSCC) in Jinja, Uganda

Aim 2: To determine, using an SCD-specific testing instrument, if HRQoL of children with SCD in the ZIPS study differs between those on zinc supplementation vs. those on placebo

Aim 3: To document caregiver perceptions regarding factors influencing HRQoL of children with SCD in the ZIPS study (those on zinc supplementation vs. those on placebo) and those receiving standard of care at the Nalufenya Sickle Cell Clinic (NSCC) in Jinja, Uganda

 Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
Christine  Wiltshire Sekaggya
ID: UNCST-2019-R000578
 Evaluating the effect of private provider engagement on access to TB screening and diagnostic services in two large urban districts in Uganda: an observational study.
REFNo: HS1106ES

The overall aim of this study is to determine the effect of private health providers on access to TB diagnostic services in two large urban cities in Uganda.

The primary objective will be to:
1. To examine the effect of community pharmacies’ engagement on a) time to TB treatment and b) costs incurred while seeking care for TB by patients with bacteriologically confirmed TB in the PRES project in Kampala and Wakiso

The secondary objectives will be to
2. To understand community pharmacies’ perspectives towards provision of TB screening services and linkage to treatment.
3. To identity other infectious causes of cough among patients who are screened for TB at community pharmacies

 Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
JUSTINE NAMWAGALA MUKOSE
ID:
Explorative investigation of the burden and risk factors of uvula infections and associated traditional uvulectomy practices in Luwero district and surrounding areas
REFNo: HS1167ES

OBJECTIVES


The overarching objective of this explorative research study is to investigate and document, in a scientifically sound manner, the condition called “akamiro”; determine the case definition, describe its general epidemiology including the beliefs and perceptions around it and the traditional surgical procedure, and commence etiological investigations.


Our proposed specific objectives are;

1. To determine the clinical case definition of the uvula infections called “akamiro” – general and age-specific case definitions for infants, children, adolescents and adults.
2. To investigate major risk factors of uvula infections /“akamiro”.
3. To determine the magnitude and associated factors of uvula infections /“akamiro”, and geo-map its spread.
4. To determine the prevalence of traditional uvulectomy and its outcomes and sequelae.

5. To establish the community beliefs, perceptions and practices associated with “akamiro”.

 Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
Munshi Sulaiman
ID:
Women’s Leadership in Village Savings and Loan Associations (VSLAs) in Uganda
REFNo: SS685ES

The research has two key objectives. The first is to understand the current starus and barriers of women to take leadership roles in VSLA committees. The second objective is to identify possible interventions that can strengthen their leadership roles.
Bangladesh 2021-01-25 2024-01-25 Social Science and Humanities Non-degree Award
Janet SEELEY
ID:
The direct and indirect effects of HIV/AIDS on the Health and wellbeing of older people. Wave 5 Study protocol
REFNo: SS696ES

The aim of the study is to describe longitudinally the survival, health and wellbeing of older people who are directly and indirectly affected by HIV and AIDS, with special attention to the effects of the introduction of ART. In addition, we aim to investigate the impact of the COVID-19 pandemic on health and wellbeing of WOPS participants

Specific objectives

1. To describe the effects of HIV and HIV treatment on the (physical and mental) health and wellbeing of older people
2. To determine the effects of HIV in older people especially older women on their social situation, with special focus on care giving.
3. Document some of the biomarkers associated with chronic inflammation and immune function in the ageing process
4. To document the causes and risk factors for mortality among older people with and without HIV in Uganda.
5. To document the patterns of multimorbidity in older people with and without HIV in Uganda
6. Investigate the impact of the COVID-19 pandemic and the lockdown on the WOPS participants


 UK 2021-01-25 2024-01-25 Social Science and Humanities Non-degree Award
Gloria Nakato Valentine
ID:
Developing and deploying aflatoxin biological control products for integrated aflatoxin management in Uganda and making it accessible through private sector engagement
REFNo: A114ES

Obj. 1: Develop, validate, and register at least one biocontrol product (Aflasafe) for aflatoxin management in maize, sorghum and groundnut.
Obj. 2: Create awareness among stakeholders (e.g., farmers, traders, consumers) along the maize, sorghum, and groundnut value chains of the health and trade impacts of aflatoxins, and to improve knowledge and use of strategies for mitigating aflatoxin that are centered on pre-harvest use of biocontrol products, best agricultural and post-harvest management practices.
Obj. 3: Develop and implement a strategy for commercializing Aflasafe to ensure wide distribution and availability to stakeholders through private sector engagement.

 2021-01-25 2024-01-25 Agricultural Sciences Non-degree Award
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