Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Jane Namagga Kasozi
ID:
HIV-Associated Neurocognitive Burden: Feasibility of Implementing International HIV Dementia Scale into a Nurse-led HIV Model at TASO centres in southwestern Uganda
REFNo: HS814ES

1.To determine the prevalence of HIV- associated neurocognitive disorders using IHDS among PLWH attending TASO centres in rural Southwestern Uganda.

2.To identify the risk factors associated with HIV- associated neurocognitive disorders among PLWH attending TASO centres in rural Southwestern Uganda.

3.To assess the impact of an education intervention on nurses’ knowledge and skills regarding the use of IHDS in screening and managing HIV- associated neurocognitive disorders

4.To explore nurses' perceptions towards screening and managing HIV- associated neurocognitive disorders using IHDS among HIV positive clients attending TASO centres in rural Southwestern Uganda.

5.To determine the feasibility of implementing IHDS into a nurse-led model of HIV care.

Uganda 2021-02-15 2024-02-15 Medical and Health Sciences Degree Award
Andrew Ssemata
ID: UNCST-2023-R008259
 Exploring and understanding the life skills, sexual, reproductive and mental health needs among adolescents and young people with Spina bifida and Hydrocephalus disability in Sub Saharan Africa; a mixed methods study. (REMHAND)
REFNo: SS703ES

To explore and understand the life skills, sexual, reproductive and mental health needs among adolescents and young people with Spina bifida and Hydrocephalus disability and their significant others (siblings and parents) in Uganda.

Specific objectives
1. Explore and understand the life skills, sexual, reproductive and mental health needs among children and adolescents with disability.
2. Explore the SRH vulnerabilities, and experience (barriers and facilitators) to accessing SRH and mental health services.
3. Explore caregiver (parents and siblings) experiences and perspectives of the health implications of long‐term informal caregiving for children with SBH and disability.
4. Investigate the health, wellbeing and factors affecting the mental health of parents and siblings caring for children with disabilities.

 Uganda 2021-02-15 2024-02-15 Social Science and Humanities Non-degree Award
Bas van Boekholt
ID:
Turn-taking interactions in chimpanzees (Pan troglodytes schweinfurthii) in the wild
REFNo: NS153ES

To shed light on the evolution of language by providing the first systematic insights into the development of turn-taking in chimpanzees
 Netherlands 2021-02-15 2024-02-15 Natural Sciences Non-degree Award
Geoffrey Babughirana Babughirana
ID:
Effect of implementing the timed and targeted counselling (ttC) model on pregnancy outcome and Newborn survival in rural Uganda. A Quaisi experimental study in Hoima and Mansidi district
REFNo: HS574ES

To determine the effect of ttC on pregnancy outcomes and Newborn survival in Rural Uganda

1. To ascertain the extent to which ttC improves uptake of timely Goal Oriented ANC with a focus on the recommended 4 visits
2. To determine whether ttC contributes to the recommended hygienic birthing practices
3. To establish the extent to which ttC improves essential new-born care practices (ENC) during the new born period
4. To ascertain the extent to which ttC fosters positive male involvement in Pregnancy and New Born care
5. To ascertain the relationship between ttC implementation and appropriate pregnancy weight gain by end of Pregnancy.
6. To ascertain the relationship between ttC implementation and appropriate birth weight

Uganda 2021-02-12 2024-02-12 Medical and Health Sciences Non-degree Award
Francis Ssali
ID: UNCST-2021-R012134
 A5379: B-ENHANCEMENT OF HBV VACCINATION IN PERSONS LIVING WITH HIV (BEe-HIVe): Evaluation of HEPLISAV-B
REFNo: HS622ES

• To compare the week 12 seroprotection response (SPR) of a two-dose regimen of HEPLISAV-B (Group A, Arm 1) versus the week 28 SPR of a standard three-dose regimen of ENGERIX-B (Group A, Arm 3) in Hepatitis B virus (HBV) vaccine-experienced participants living with HIV (Group A).

• To compare the week 28 SPR of a three-dose regimen of HEPLISAV-B (Group A, Arm 2) versus a standard three-dose regimen of ENGERIX-B (Group A, Arm 3) in HBV vaccine-experienced participants living with HIV (Group A).

• To determine the week 28 SPR of a three-dose regimen of HEPLISAV-B in HBV vaccine-naïve participants living with HIV (Group B).

• To describe adverse events (AEs) reported in each study arm (Groups A and B, separately) over the duration of the study.


Uganda 2021-02-12 2024-02-12 Medical and Health Sciences Non-degree Award
Clare Cheromoi -
ID:
Interrogating Political Corruption in Post-Independent Uganda: A Historical Perspective, 1962-2017.
REFNo: SS488ES

(1) To describe the transhistorical patterns and evolution of political corruption in Uganda between 1962 and 2017.
(2) To examine the political actors involved in the political corruption scandals experienced in post-independent Uganda.
(3) To explore the proximate and underlying causes of political corruption that are transhistorical in post-independent Uganda.
(4) To assess the transhistorical interrelationships between political corruption and anticorruption responses in post-independent Uganda.

Uganda 2021-02-12 2024-02-12 Social Science and Humanities Degree Award
Leonard Omadang
ID:
PREVALENCE, RISK FACTORS AND ECONOMIC IMPACT OF CYSTIC ECHINOCOCCOSIS IN LIVESTOCK HERDS AMONG THE PASTORAL AND AGRO-PASTORAL COMMUNITIES IN UGANDA
REFNo: A87ES

i. To determine the prevalence of Echinococcosis in livestock slaughtered in selected abattoirs in Uganda.

ii. To determine risk factors associated with cystic echinococcosis in livestock in selected pastoral and agro-pastoral communities in Uganda.

iii. To determine the economic losses of CE in livestock kept by the pastoral and agro-pastoral communities in Uganda.

 Uganda 2021-02-12 2024-02-12 Agricultural Sciences Degree Award
Nathan Kenya-Mugisha
ID: UNCST-2021-R013752
 Implementation of a Quality Improvement Intervention to Improve Discharge Practices for Children recovering from Severe Infection Using a District model in Gulu and Rukungiri Districts
REFNo: HS926ES

The main objective in implementing this program is to improve patient outcomes for children recovering from Severe Infection though implementation of a multi-faceted quality improvement intervention targeting health workers, care givers and the community health workers.
Specifically we intend to :
1. Evaluate how a targeted behavior change intervention can affect health worker behaviors and facility readiness to assess and manage children during the discharge process.
2. To evaluate the effectiveness of a facility-based linkage to a community based follow-up system to improve post-discharge care for children recovering from severe infections

 Uganda 2021-02-12 2024-02-12 Medical and Health Sciences Non-degree Award
Fred  Bulamba
ID: UNCST-2020-R014888
 The three delays model and Postpartum haemorrhage: a mixed-methods study at a teaching hospital in eastern Uganda
REFNo: HS932ES

Overall aim
The overall aims of this study are to understand how delays impact development of primary PPH (using the three-delays model) and how available preventive and therapeutic interventions are administered.

 Uganda 2021-02-12 2024-02-12 Medical and Health Sciences Non-degree Award
Janet Lewis I
ID:
Reducing Prejudice Against Refugees Pilot
REFNo: SS662ES

The vast majority (85%) of the world’s political refugees live in developing countries, according to UNHCR. As of early 2019, Uganda was home to over one million refugees from South Sudan, and had the largest refugee/asylum-seeker population in Africa (ACCORD 2019). Uganda has a strong national commitment to hosting refugees that is reflected in its immigration policies, leading some to call it a “melting pot” of regional nationalities. Still, its population faces challenges absorbing these refugees that are common to host countries. Relations are often strained between the refugee population and Ugandans, some of who perceive refugees as unwelcome competition for local resources and services (World Vision 2018; UNHCR 2018; ACCORD 2019).
This study will allow us to better understand the perceptions of Ugandans towards South Sudanese refugees, and measure both the extent of anti-refugee prejudice there and whether a perspective-taking intervention is effective at reducing prejudice. This knowledge will be crucial for understanding how best to design a later, larger study, which could substantially advance knowledge about prejudice reduction towards refugees in Uganda.
Furthermore, this study will provide a useful indication about whether our full version of this study will be able to measure spillover of the treatment through social networks; we will ask respondents in our endline survey about whether and with whom respondents discussed the intervention. Prejudicial attitudes are socially reinforced; changing one person’s mind may be difficult if that person’s peers still hold prejudicial beliefs. Likewise, if many of one’s peers have begun to reconsider their own prejudices, one may be encouraged to do so as well. Our prior work leads us to expect the information to spread widely, and some change in attitudes and behavior, but only for those connected to a treatment recipient via certain kinds of social ties (Larson and Lewis 2017, 2018). Practitioners often assume that interventions spread from a subset of individuals to their broader community through felicitous spillovers. If this pilot is successful, our full study will be among the first to measure whether and how this occurs for prejudice reduction through networks. This knowledge could, among other things, lead to more efficient designs of community prejudice-reduction projects. Moreover, even if spillover effects are not present, the full study will be able to detect how news of the intervention spreads through local networks. Doing so will provide rare, direct evidence of information dissemination through word-of-mouth networks, which is useful for the design of programs aimed at seeding any type of public service message – from news intended to diffuse conflicts, to information about a new technology that promises to better hold politicians accountable or improve public health.

Our pilot study therefore addresses four questions:
(1) What is the extent of anti-refugee prejudice among Ugandans living in villages in West Nile?
(2) Do positions towards refugees correlate with their positions in village social networks?
(3) Can a brief conversation oriented towards taking the perspective of South Sudanese refugees reduce Ugandans’ prejudice toward them? If so, does the effect persist after 2-3 weeks?
(4) To what extent does news spread about this perspective-taking exercise, and through which types of contacts?
 USA 2021-02-12 2024-02-12 Social Science and Humanities Non-degree Award
AGGREY DHABANGI
ID:
Hemolytic Disease of the Newborn in Uganda: Burden and Clinical Characteristics (Short title: HDN in Uganda)
REFNo: HS1089ES

To determine the prevalence of HDN due to RhD among newborn infants with jaundice admitted to Kawempe National Referral hospital in Uganda.
 Uganda 2021-02-12 2024-02-12 Medical and Health Sciences Non-degree Award
Peter Elyanu James
ID: UNCST-2021-R013210
 PREVALENCE AND RISKS ASSOCIATED WITH METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS LIVING WITH HIV IN UGANDA. A PILOT STUDY
REFNo: HS1128ES

i To determine the prevalence of MetS among children and adolescents living with HIV in Uganda.
ii To identify risks factors for the development of MetS in children and adolescents living with HIV.

Uganda 2021-02-12 2024-02-12 Medical and Health Sciences Non-degree Award
Abner Tagoola
ID:
A phase 2b study to Evaluate the safety and efficacy of IMR-687 in subjects with sickle cell disease.
REFNo: HS1092ES

1. To evaluate the fetal Hb (Hbf) response to IMR-687 versus placable.

2. To evaluate of IMR-687 versus placable
 Uganda 2021-02-11 2024-02-11 Medical and Health Sciences Non-degree Award
Afiz Kibuuka Kibuuka
ID: UNCST-2021-R012755
 A Phase 2b Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease
REFNo: HS1150ES

Objectives:
Primary Objectives
• To evaluate the fetal hemoglobin (HbF) response to IMR-687 versus placebo
• To evaluate the safety of IMR-687 versus placebo Seconduy Efficacy Objectives
• To evaluate the effect of IMR-687 versus placebo on HbF-associated biomarkers
• To evaluate the effect ofIMR-687 versus placebo on indices of red cell hemolysis
• To evaluate the effect ofIMR-687 versus placebo on indices of white blood cell (WBC) adhesion
To evaluate the effect of IMR-687 versus placebo on the incidence of vaso-occlusive crises (vocs)
• To evaluate the effect of IMR-687 versus placebo on quality of life measures Pharmacokinetic•Óbjectives
• To evaluate the PK ofIMR-687 and any major circulating metabolites
Exploratory Efficacy Objectives
To evaluate the effect of IMR-687 versus placebo on changes in red blood cell (RBC) characteristics and total Hb e To evaluate the effect of IMR-687 versus placebo on renal function
• To evaluate the effect of IMR-687 versus placebo on indices associated with cardiovascular pathophysiology and ischemic stroke risk

 Uganda 2021-02-11 2024-02-11 Medical and Health Sciences Non-degree Award
Casim Tolo Umba
ID: UNCST-2021-R012658
 Action Towards Reducing Aquatic snail-borne Parasitic diseases (ATRAP)
REFNo: NS128ES

The main objective of the project is to improve Health through the prevention and mitigation of risks that originate at the interface between humans, animals and the environment. In this project we want to increase the capacity to prevent infections by snail-borne diseases in western Uganda. The strategic objectives are as follows:
1. To strengthen scientific research capacity.
2. To strengthen physical and virtual diffusion of scientific research
results to the larger scientific community
3. To raise awareness about snail borne diseases to the general public.
4. To support good governance, based on the scientific results.
5. To develop synergies and complementary activities among partners through multi-partner governance and coordination


 Uganda 2021-02-10 2024-02-10 Natural Sciences Degree Award
MIRIAM NAKALEMBE
ID: UNCST-2019-R000824
 Designing and Piloting of a Mobile-based Transport Technology linking Mothers to Health Facilities to Reduce Maternal and New-born Deaths in Uganda during the COVID-19 Pandemic.
REFNo: HS1148ES

1. To identify the existing automated maternal services apps and assess the extent to which they provide near real-time information and communication between mothers and the transporters at community level.
2. To develop a mobile-based transport technology that improves two-way communication between mothers and the transporters at community levels
3. To pilot the mobile-based transport technology for its usability and acceptability

 Uganda 2021-02-10 2024-02-10 Medical and Health Sciences Non-degree Award
Anthony Nuwa
ID:
Evaluating the feasibility, acceptability and protective efficacy of seasonal malaria chemoprevention in two districts in Karamoja, Uganda
REFNo: HS1182ES

Objective 1: To document the adaptation of SMC in Karamoja region in Uganda
Objective 2: To Assess the process of implementing SMC in Uganda, with regards to coverage and quality of implementation
Objective 3: To assess the acceptability of SMC among policy makers, implementers, and beneficiaries.
Objective 4: To determine the impact of SMC on malaria incidence and prevalence among children under 5 years in the Karamoja region and assess the protective efficacy of SPAQ
Objective 5: To analyse cost of SMC delivery to children 3-59 months in Karamoja region
Objective 6: Monitor the safety of sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) when used in SMC among children 3-59 months in Karamoja region.

 Uganda 2021-02-10 2024-02-10 Medical and Health Sciences Non-degree Award
Noah Kiwanuka
ID: UNCST-2021-R010125
 Capturing spatial patterns of new M. tuberculosis infection in Kampala, Uganda
REFNo: HS1230ES

To map the geo-spatial incidence of Mtb infections in a prospective community cohort study of HIV+ and HIV- adults in Kampala Uganda. GPS tracking technology will be used to trace and map subjects to locate areas of high Mtb transmission, or hotspots. Study participants without tuberculous infection will be followed for IGRA/TST conversion for up to 2 years with serial plasma samples taken quarterly.
To determine and validate whether a defined plasma signature found in other studies can identify recent Mtb infection in persons who developed LTBI. Using a paired analysis, we will evaluate baseline and follow-up samples within individuals to determine whether changes associated with new Mtb infection in the community can be detected in plasma with published and newly developed biomarkers. Using a nested case control design, we will compare incident infections with randomly selected controls from the cohort who did not convert

 Uganda 2021-02-10 2024-02-10 Medical and Health Sciences Non-degree Award
Daphine Namara Arinaitwe Namara
ID:
The Risk of Diabetes and pre-Diabetes associated with use of Dolutegravir based Antiretroviral Therapy among adult persons living with HIV: A Case-control study at Mulago ISS clinic, Kampala, Uganda
REFNo: HS1077ES

Primary objective: To determine the risk of DM and pre-DM associated with the use of DTG-based ART among adult PLHIV at Mulago ISS Clinic.
Secondary objective; To determine other risk factors for DM and pre-DM among PLHIV adult PLHIV at Mulago ISS Clinic.

 Uganda 2021-02-09 2024-02-09 Medical and Health Sciences Non-degree Award
Christine Nalwadda Kayemba
ID: UNCST-2020-R014220
 A BASELINE ASSESMENT FOR THE ADVANCING SEXUAL REPRODUCTIVE HEALTH AND RIGHTS (ANSWER) PROGRAM IN THE WEST NILE AND ACHOLI SUBREGIONS IN UGANDA
REFNo: HS1079ES

General objective

To analyse the situation of sexual and reproductive health and rights (SRHR) aspects as well as GBV in the intervention districts of UNFPA’s programme targeting to advance SRHR in the Acholi and West Nile sub regions in Uganda, in order to generate scientific evidence that will inform evidence based planning, implementation and form a basis for monitoring and evaluation of the program interventions.

Specific objectives

1.To conduct Health facility assessment at targeted health facilities in West-Nile and Acholi sub regions in regards to offering quality equitable SRHR services (FP/Maternal health/Post abortion Care, HIV testing and Post GBV) that is responsive to the needs of women, girls, boys and men, refugees, and people with disabilities

2.To undertake an assessment of SRHR Knowledge, Attitudes and Practices (KAP) of adolescents and youth in school including refugees and people with disabilities from a sample of 1,800 targeted schools (primary & secondary) in the study districts on GBV and SRHR.

3.To conduct an assessment of SRHR Knowledge, Attitudes and Practices (KAP) of adolescents and youth out of school including refugees and people with disabilities in the study districts on GBV and SRHR.

4.To conduct a budget and expenditure analysis of key sectors at national level and the district local governments focusing on implementation of and accountability towards the demographic dividend priorities.
 Uganda 2021-02-09 2024-02-09 Medical and Health Sciences Non-degree Award
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