Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Dorothy Stamps Sarah
ID: UNCST-2019-R001036
 Dry Rifting in the Albertine-Rhino graben, Uganda (DRIAR)
REFNo: NS294ES

Investigating the physics of strain accommodation in the magma-poor Albertine- Rhino Graben of the East African Rift System using geodynamic modeling and GNSS geodesy
 USA 2021-10-08 2024-10-08 Natural Sciences Non-Clinical Trial Non-degree Award
Marsiale Kamugisha
ID:
'Analysing the Impact of Transformative Governance and Agroforestry on Household Food Security in Southwestern Uganda'
REFNo: A130ES

1)To assess contributory factors responsible for determining household transition to food security.
2)To evaluate the household governance system that enhances agroforestry-based food security.
3)To assess households’ potential benefits of agroforestry beyond food security.

Uganda 2021-10-06 2024-10-06 Agricultural Sciences Non-Clinical Trial Degree Award
Nadine Schubert
ID:
Genetically-based social communication in an inbred group-living wild mammal
REFNo: NS273ES

The aim is to investigate the role of immune genes of the major histocompatibility complex (MHC) in affecting odour cues used for social communication in banded mongooses. Furthermore, we want to investigate the link between MHC composition of an individual and fitness parameters as well as the impact of the MHC on microbiota communities. Last, it is crucial to test the ability of banded mongooses to discriminate MHC-based differences in odour cues in a natural setting.
 Germany 2021-10-05 2024-10-05 Natural Sciences Non-Clinical Trial Degree Award
Christine  Wiltshire Sekaggya
ID: UNCST-2019-R000578
 Clinical Predictors of 3-Months Isoniazid Rifapentine (3HP)- Related Adverse Drug Reactions (ADR) During Tuberculosis Preventive Therapy (PAnDoRA-3HP study)
REFNo: HS1582ES

Primary Objectives
1.To describe the safety profile of 3HP among people receiving tuberculosis preventive therapy.
2.To describe the effect of adverse drug reactions on tuberculosis preventive therapy completion rates
Secondary Objective
1.To describe the pharmacokinetic and pharmacogenomic determinants of ADRs among people receiving tuberculosis preventive therapy in Uganda
2.To determine the efficacy of 3HP when used for tuberculosis preventive therapy.

 Uganda 2021-10-04 2024-10-04 Medical and Health Sciences Clinical Trial Non-degree Award
Joseph Lutaakome
ID: UNCST-2020-R008323
 An International Multicenter, Randomized, Double-Blind, PlaceboControlled Trial of the Safety and Efficacy of Anti-Coronavirus Hyperimmune Intravenous Immunoglobulin for the Treatment of Adult Outpatients in Early Stages of COVID-19
REFNo: HS1715ES

Primary Objective
Primary objective: Among outpatients with recently diagnosed SARS-CoV-2 infection to compare the safety and efficacy of a single infusion of hIVIG (pooled for the 2 hIVIG

products) versus placebo, each given with SOC, on clinical status after seven days. Two hypotheses will be tested to address this primary objective, which compares the primary endpoint among two study populations: 1) participants where neutralizing MAb was not specified as part of SOC treatment (stratum 1, see Section 6.1 Overall Study Design); and 2) all randomized participants (stratum 1 and stratum 2 combined). hIVIG will be considered superior to placebo if either of the two hypotheses are rejected.
Secondary Objectives and Endpoints
Secondary objectives, including subgroup analyses and safety outcomes, will be addressed for all randomized participants and for those in stratum 1 and 2 separately.
Secondary Endpoints
The clinical status as classified on the ordinal outcome scale will be assessed with a number of additional analyses comparing hIVIG (pooled for the 2 hIVIG products) with placebo, among the overall study population as well as for the key subgroup of those not receiving anti-SARS-CoV-2 monoclonal antibodies as part of SOC (stratum 1), including:
1. All-cause hospitalization or death through 28 days.
2. All-cause mortality through 28 days.
3. Significant disease progression through 28 days, using a time to event analysis with outcome defined by fulfilling criteria for category 4 or 5 on the ordinal scale.
4. Distribution of ordinal scale outcome at Day 4, 14, and 28.
5. The proportion of participants with any disease progression at Day 7, using a sliding dichotomous scale progression defined by a categorization on the ordinal scale that is worse than the status at entry

 Uganda 2021-10-04 2024-10-04 Medical and Health Sciences Clinical Trial Non-degree Award
Joyce  Nankumbi
ID:
The status of OFSP production, utilization and the nutritional status and welfare of sweet potato growing households in northern and eastern Uganda
REFNo: A152ES

1. To characterise the consumption of vitamin A rich foods among households in the selected northern and eastern districts of Uganda 2. What is the food security status in the households in the selected northern and eastern districts in Uganda? 3. To document the production and consumption of orange-fleshed sweet potato among households in the selected northern and eastern districts in Uganda? 4. To identify infant feeding practices of women in the selected districts of northern and eastern regions in Uganda? 5. To identify water, hygiene and sanitation practices of households in the selected northern and eastern districts in Uganda 6. To establish the knowledge, attitudes and perception on the consumption of beta carotene-rich orange-fleshed sweet potatoes/ vitamin A-rich foods among households in the northern and eastern regions in Uganda,To determine status of orange-fleshed sweet potato production, utilization and the nutritional status and welfare of sweet potato growing households. in northern and eastern Uganda ,
 Uganda 2021-10-01 2024-10-01 Agricultural Sciences Non-Clinical Trial Non-degree Award
Arthur Nuwagaba
ID:
TOP MANAGEMENT TEAM CHARACTERISTICS AND PERFORMANCE OF UGANDAN STATE AGENCIES
REFNo: SS999ES

iv. Establish the joint effect of top management team characteristics, strategy implementation and external environment on the performance of Ugandan state agencies.,iii. Determine the moderating effect of the external environment on the relationship between top management team characteristics and the performance of Ugandan state agencies.,ii. Establish the mediating effect of strategy implementation on the relationship between top management team characteristics and performance of Ugandan state agencies.,i. Determine the influence of top management team characteristics on the performance of Ugandan state agencies.,The main objective of the study is to determine the influence of strategy implementation and external environment on the relationship between the TMT characteristics and the performance of state agencies in Uganda.,
 Uganda 2021-10-01 2024-10-01 Social Science and Humanities Non-Clinical Trial Degree Award
Wang Vibeke
ID:
Supporting Parenting Care Corners in Markets to Reduce Unpaid Care Work for the Vulnerable Business Women in Uganda
REFNo: SS944ES

1. To deepen the evidence base on whether and how reducing women’s unpaid childcare burden increases their productivity and income.
2. To examine the factors that impede access to parenting care facilities among vulnerable women engaged in business markets in Uganda and how these could be mitigated.
3. Evaluate the effects of parenting care facilities, financial subsidy and parents’ training on the productivity of mothers and profitability of their businesses.
4. To inform government action through tested and proven models for scaling up parenting care corners to both structured and unstructured markets
5. To provide proof of concept on how governments can introduce affordable, effective, and sustainable childcare models that work for vulnerable mothers who work in informal markets in Uganda.

Norway 2021-10-01 2024-10-01 Social Science and Humanities Non-Clinical Trial Non-degree Award
Aida Cuni Sanchez
ID:
Monitoring forest dynamics in Bwindi National Park
REFNo: NS282ES

• Does tree growth change with increasing altitude?
• How do taxonomic, forest structural and environmental attributes affect tree growth?
• How do carbon stocks change over time at different altitudes?

 Spain 2021-10-01 2024-10-01 Natural Sciences Non-Clinical Trial Non-degree Award
Radhika Sundararajan Lu
ID:
A pilot study of adherence support delivered by informal health providers to improve entry to and retention in HIV care in rural Uganda
REFNo: HS1747ES

: Pilot test the adapted intervention to evaluate implementation and impact on linkage/retention in HIV and ART adherence among individual PLWH,Adapt an evidence-based layperson adherence support curriculum for delivery by TH.,
 USA 2021-10-01 2024-10-01 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Hannah Kibuuka
ID: UNCST-2020-R014355
 Evaluation of Clinical Chemistries from Biospecimens Collected with a Painless Capillary Blood Collection TASSO SST Among a Subset of Patients Enrolled in an Observational Study of Sepsis in Uganda
REFNo: HS1751ES

We plan to compare capillary chemistry values collected via the painless Tasso collection device to standard serum chemistry values collected via venipuncture at a single study visit (Day 28 of the main study(HS 2292)) for each consenting participant. We plan to evaluate the correlation between chemistry values from capillary versus venous blood collection and identify any scenarios where the values diverge such as for high or low values or for specific analytes collected in a remote field location. We plan to review the failure rate and causes for failure for the Tasso device
 Uganda 2021-10-01 2024-10-01 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Moses Ntaro
ID: UNCST-2020-R014133
 Effect of student community engagement on sanitation behavior: a case of Community Led Total Sanitation in Kabale District
REFNo: HS1135ES

To evaluate the effect of students community engagement on household level ODF status in Kabale District, Uganda so as to demonstrate the contribution of students in improving CLTS implementation and outcomes
 Uganda 2021-09-29 2024-09-29 Medical and Health Sciences Degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
 Infant extended safety follow-up study – an observational study of brain imaging and child development in infants (DolPHIN-2 PLUS)
REFNo: HS1639ES

1. To determine if there are developmental differences following exposure to DTG or EFV. 2. To examine brain structure and microstructure of HEU children. 3. To determine developmental outcomes. 4. To validate the Hyperfine, low-field MRI system 5. To explore the impact of environmental factors such as antenatal iron-deficient anaemia on brain development in a high-risk birth cohort
Nigeria 2021-09-29 2024-09-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Tom  Ngabirano Denis
ID: UNCST-2020-R014491
 Effect of Enhanced Neonatal Jaundice Education on Knowledge, Early Detection and Care Seeking by Postnatal Mothers at Jinja Regional Referral Hospital
REFNo: HS1479ES

Objectives General objective To improve mothers’ knowledge of neonatal jaundice for early detection, proper care and prevention of severe neonatal jaundice. Specific objectives 1. To assess the level of mothers’ knowledge about neonatal jaundice at JRRH. 2. To implement an enhanced neonatal jaundice education package for postnatal mothers at JRRH. 3. To assess the effect of an enhanced neonatal jaundice education package on the level of knowledge, early detection and care seeking by postnatal mothers at JRRH.
 Uganda 2021-09-29 2024-09-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Lukia Namaganda Hamid
ID:
Malnutrition as a probable predictor of mortality in cerebral palsy (CP), and the effect of positive deviance and parent facilitator training strategies to malnutrition and caregiving among children and adolescents with CP in the Iganga, Mayuge and Bugweri rural districts of eastern Uganda
REFNo: HS1427ES

Specific Objectives:
1. To assess mortality and whether malnutrition is one of the predictors among a population based sample of children and adolescents with cerebral palsy the Iganga Mayuge-Health and Demographic Surveillance Site (IM-HDSS), Uganda
2. To assess the difference in the change in nutritional status in 2015 and 2019 among children with CP compared to their age and sex matched controls without CP at the IM-HDSS, Uganda.
3. To explore positive and negative nutrition practices among caregivers of well-nourished and under-nourished children with cerebral palsy respectively at the IM-HDSS, Uganda.
4. To determine the difference in the effectiveness of the positive deviance strategy and parent facilitator trainings on CP child and adolescent malnutrition and caregiving within the Iganga, Mayuge and Bugweri districts, Uganda.

 Uganda 2021-09-29 2024-09-29 Medical and Health Sciences Clinical Trial Degree Award
Scholastic Ashaba
ID: UNCST-2023-R007613
 Self-management among adolescents living with HIV in Uganda
REFNo: HS1697ES

Aim 3: Assess feasibility, acceptability, and preliminary effects of the self-management intervention on HIV outcomes for ALHIV transitioning to adult HIV care,Aim 2: Develop a self-management intervention that will enable ALHIV to successfully transition to adult HIV care,Aim 1: Use qualitative research to elaborate a conceptual model of the barriers faced by ALHIV transitioning to adult HIV care in Uganda,
 Uganda 2021-09-29 2024-09-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Willy Ssengooba
ID: UNCST-2022-R001801
 Evaluation of a new stool-based qPCR for TB diagnosis in children and people living with HIV: a multicentre study in Eswatini, Mozambique and Uganda
REFNo: HS1615ES

To create a biorepository of well characterized pediatric samples at each of the study sites to support the future development and evaluation of novel biomarker research. ,To evaluate the quantitative stool qPCR platform as a tool to monitor treatment response in children and PLHIV,To compare the diagnostic performance of the stool qPCR platform to individual sputum and stool Xpert Ultra, urine LAM, sputum smear, sputum (MGIT) culture results against a clinical diagnosis and bacteriological reference standard,To evaluate the diagnostic accuracy of the stool Mtb qPCR tool compared to a composite reference standard (sputum and stool Xpert Ultra, sputum culture and urine TB-LAM) and clinical diagnosis. ,
 Uganda 2021-09-29 2024-09-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Lillian Wambuzi Ogwang
ID: UNCST-2021-R013189
 Seroprevalence of SARS-CoV-2 based on antibody testing among HIV infected mothers and their children in the PROMOTE Cohort at the MU-JHU Research Collaboration: July 2020 through June 2021 SUBSTUDY Version 2.0 Dated 16 Jun 2021
REFNo: HS1658ES

1. To determine the seroprevalence of COVID-19 IgG antibody among PROMOTE women living with HIV on antiretroviral therapy, and their HIV exposed children enrolled in PROMOTE; based on Roche ELISA antibody testing of plasma samples collected July 2020 to Jun 2021• To determine the association of COVID-19 exposure and PROMOTE participant characteristics such as age, CD4 count, BMI, maternal ARV therapy, pregnancy, Breast feeding, maternal Viral load, hospitalization in the past year with SARS-CoV-2 antibody positivity, comorbidity diagnosis (e.g. hypertension, obesity, asthma, TB, pulmonary, cardiac, renal disease, sickle cell disease).

3• To use PROMOTE data to determine maternal and pregnancy outcomes among PROMOTE women who were found to have had COVID-19 infection during pregnancy based on antibody testing during the period July 2020 - June 2021.

Uganda 2021-09-29 2024-09-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
 Evaluation of the performance of the Salmonella Bioline™ typhi IgG/IgM Fast test in a near-patient testing environment, including evaluation of usability
REFNo: HS1700ES

To evaluate the usability of the Bioline™ Salmonella typhi IgG/IgM Fast test in the near-patient environment using a questionnaire based survey. ,To establish the performance of the Bioline™ Salmonella typhi IgG/IgM Fast test in a near-patient setting compared to the performance in a professional lab (i.e. Central Public Health Laboratory) using venous whole blood samples. ,
 Uganda 2021-09-29 2024-09-29 Medical and Health Sciences Clinical Trial Non-degree Award
Martin Ariapa
ID: UNCST-2021-R013296
 Play and Learning in Children’s Eyes
REFNo: SS1022ES

To develop the Children’s Experiences of LtP Protocol (CELP) with its corresponding modules and items, intended for use by a coach or instructional support staff, by soliciting direct insights from children about their LtP experiences. To develop the Formative Observation and Reflection Assessment (FORA) with its corresponding modules and items, intended for use by ECD and primary education teachers as they implement a LtP practice in the classroom. To develop and validate a set of formative tools designed to help teachers in low-and middle-income countries assess and improve their practice in Learning through Play (LtP), through a deeper understanding of how children experience LtP in their classrooms,
 Uganda 2021-09-29 2024-09-29 Social Science and Humanities Non-Clinical Trial Non-degree Award
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