Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
DENISH  ONGOL OGWANG
ID: UNCST-2025-R022077
THE IMPLEMENTATION OF THE PRISONERS’ RIGHT TO VOTE IN UGANDA. A CASE STUDY OF LUZIRA PRISONS, 1995-2021
REFNo: SS4502ES

1. To assess the adequacy of the legal framework for the implementation of prisoners’ right to vote in Uganda.
2. To identify the challenges that Luzira Prisons face in the implementation of the prisoners’ right to vote
3. To develop a framework for the implementation of the prisoners’ right to vote in Uganda.

Uganda 2025-10-24 17:35:10 2028-10-24 Social Science and Humanities Non-Clinical Trial Degree Award
Mudarshiru Bbuye
ID: UNCST-2025-R019080
EXPLORING THE ASSOCIATION BETWEEN AIR QUALITY AND THE BURDEN OF RESPIRATORY TRACT INFECTIONS IN KAMPALA, UGANDA
REFNo: HS6603ES

General objective To explore the impact of ambient air pollution on the incidence, prevalence, and severity of respiratory tract infections, and the extent of enforcement of air quality control policies and regulations in Kampala, Uganda, a low-resourced urban setting Specific Objectives 1.To conduct a systematic review and meta-analysis to quantify the association between ambient air pollution and respiratory tract infections in low- and middle-income countries (LMICs). 2. To characterise the spatial variation in ambient PM2.5 exposure and its correlation with respiratory tract infection health effect among sub-populations in Kampala, Uganda 3.To determine the effect of air quality policies and regulations on the long-term ambient PM2.5 levels and the respiratory tract infections health effects in Kampala, Uganda. 4. To explore the limitations of adaptation and enforcement of air pollution control policies and regulations to reduce the ambient air pollution health effects in Kampala, Uganda.
Uganda 2025-10-24 17:34:12 2028-10-24 Medical and Health Sciences Non-Clinical Trial Degree Award
Dr. James Wasike Mangeni Byanasaye
ID: UNCST-2020-R008019
DENTAL ANTIMICROBIAL STEWARDSHIP IN UGANDA - DEVELOPING AN EVIDENCE BASED INTERVENTION
REFNo: HS6561ES

Aim: To develop evidence-based, behaviour science informed antimicrobial stewardship intervention aimed at reducing antibiotic prescribing to adult patients for dental issues.
Objectives:
1. To understand the factors that influence antibiotic prescribing by health care practitioners to adult patients for dental issues.
2. To explore the perspectives of patients seeking dental care on the use of antibiotics for dental issues.
3. To explore community stakeholders' perspectives on the use of antibiotics for dental issues
4. To co-produce an evidence-based, behaviour science informed dental antibiotic stewardship intervention for Uganda.


Uganda 2025-10-24 17:32:56 2028-10-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Deogratius Ssemwanga
ID: UNCST-2025-R021563
Performance Evaluation for Diagnostic Tests
REFNo: HS6649ES

Primary Objective

The overall objectives of this performance evaluation are:

• To verify the performance characteristics of new on-the-market NAATs and antigen RDTs.
• To establish well-characterized viral pathogen sera/plasma reference panels to support evaluation efforts and quality assurance.

• To evaluate the performance characteristics of new, on-the-market, EIAs and RDTs (IgA, IgG and IgM).
• To train laboratory and POC staff in biosecurity and the required technical skills to perform diagnostic testing.

Specific Objectives:

• To confirm whether or not a new NAAT complies with the manufacturer’s specifications,
• To determine the performance equivalence of new on-the-market NAATs, including POC devices, using available gold standards (or any other comparatively/equally as good WHO/FDA approved NAAT),
• To determine the performance equivalence of new on-the-market antigen tests against the gold-standard NAAT,
• To determine the sensitivity and specificity of new on-the-market diagnostic EIAs and RDTs against a gold-standard method,
• To evaluate the operational characteristics of new on-the-market immunoassays. Operational utility characteristics that may be considered include;
o ease of performance
o specimen type utility
o inter-reader variability
o reaction endpoint stability
o suitability for use in facilities with limited infrastructure (no/limited electricity, no/limited clean water)
• To document SOPs and train laboratory staff in performing testing using recommended diagnostic tests,
• To establish a repository of well-characterized natural infection and vaccination sera/plasma as well as swabs/extracted RNA to support future evaluation and verification of immunoassays.
• To establish a cohort of natural infection and vaccinated cases in the country whose samples and demographic characteristics will be used to help understand the dynamics of human immunity development to viral infection in order to inform the clinical interpretation of the various diagnostic assays.

Uganda 2025-10-24 17:31:36 2028-10-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Grace Muzanyi
ID: UNCST-2021-R013731
Exploration Of the Correlation Between Active TB Immunological Markers and Sputum Culture: A Cytokine TB (CYTO-TB) Study
REFNo: HS6426ES

Main Objective
1. To explore the correlation of TB immunological markers (IL-2, IL-2Ra, I-P10, MIP-?, MCP-1) and TB sputum cultures at five-time points: before the start of treatment (Month 0), then Months 1, 2, 5, and 6.
Specific Objectives
1. 1. To assess the level of each or a combination of cytokines at the time points of active TB diagnosis, months 1, 2, 5, and 6, and how they relate to sputum culture on liquid (days to positivity) and solid (quantitative colony counts) media
2. 2. 2. To assess the baseline level of each cytokine or a combination and how it correlates with (a) the clinical response to TB treatment at months 1, 2, 5, and 6; (b) the clinical severity, and radiographic extent (severity) of TB disease at diagnosis and end of treatment.
3. 3. To evaluate the differences in the TB cytokine levels between active and latent TB during treatment with ERHZ (for active TB), and 6H (for latent TB), stratified by HIV status
4. 4. To evaluate the TB cytokine levels across three populations of active TB, Latent TB, and TB-exposed healthy volunteers who are TST/IGRA negative
5. 5. To compare the cost-effectiveness of TB immunological markers against sputum culture (standard of care).
Uganda 2025-10-24 17:30:54 2028-10-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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