Isaac Ssinabulya
ID: UNCST-2021-R004352
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ImpleMEntation of a Digital-first care deLiverY model for heart failure in Uganda (MEDLY Uganda)
REFNo: HS4581ES
In this study, we will implement a digital-first, multi-component strategy for HF (Medly Uganda) and evaluate both implementation and clinical outcomes. The primary objective is to assess the implementation and clinical effectiveness of a digital-first implementation strategy to improve HF self-care in Uganda. We will conduct a stepped-wedge, cluster randomized trial in outpatient departments at 6 Ugandan RRH. The co-primary outcomes will be the Self-Care of HF Index (implementation) and the composite of mortality and HF hospitalization (clinical effectiveness). The secondary objectives will include the following.
Conduct a mixed method process evaluation to inform iterative adjustments to the implementation process. We will use a community-engaged approach to systematically collect qualitative and quantitative process data at pre-determined time points based on the Learn-As-You-Go design and make contextually appropriate implementation adaptations. Prior to recruitment, we will also explore patients’ journeys to heart failure diagnosis in Uganda through a qualitative component by conducting in-depth interviews. The aims of this work will be to explore factors associated with patient’s journeys to heart failure diagnosis, including descriptions of initial symptoms, progression, health care referral journey, barriers and facilitators to care, and role of health education and self-care awareness.
We will assess the implementation fidelity and sustainability of Medly Uganda with a focus on reach, adoption, and maintenance. Using Medly Uganda meta data from patients (app) and providers (dashboard), we will identify patterns and predictors of usage. We will interview patients and providers to explore these findings, and ensure implementation fidelity. We will also explore patient and provider perspectives on the sustainability of Medly Uganda, using semi-structured interviews to explore patient and provider barriers and facilitators of long-term use, to surface strategies that would optimize Medly Uganda implementation over time.
We shall explore cost, cost effectiveness, and sustainability factors for Medly Uganda. We will collect and examine cost data from patients and facilities examining the unit cost (cost per HF patient treated and per HF patient controlled) of control and Medly Uganda scenarios both from a financial and societal perspective. Primary outcomes for cost effectiveness analysis will be the Incremental Cost-Effectiveness Ratio per patient treated and per death averted.
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Uganda |
2024-11-18 22:56:37 |
2027-11-18 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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MUTEEBWA LABAN
ID: UNCST-2022-R010550
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Barriers and facilitators of the intention to use, and the preferred model for HIV Self-Testing among young women in the Kampala Metropolitan Area
REFNo: HS5167ES
4. To assess factors associated with the intention to use HIVST services among AGYW in KMA.,3. To determine the preferred model for delivering HIVST services among AGYW in KMA.,2. To explore the barriers and facilitators influencing the use of HIVST services among AGYW in KMA,1. To determine the level of intention to use HIVST services among AGYW in KMA ,To determine the level of intention to use HIVST services, the influencing barriers and facilitators, associated factors and the preferred model for delivering HIVST services among AGYW in the KMA, Uganda.,
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Uganda |
2024-11-18 22:50:43 |
2027-11-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Hannah Kibuuka
ID: UNCST-2020-R014355
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Secondary Analysis Protocol entitled “Biomarker-guided patient stratification for diagnosis, prognosis, and monitoring of severe infectious disease at the point of need"
REFNo: HS5187ES
Transition existing host-based biomarker classifiers to protein and nucleic acid based fieldable detection devices to validate and optimize performance
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Uganda |
2024-11-18 22:47:28 |
2027-11-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Edgar Mulogo Mugema
ID: UNCST-2023-R008170
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Getting Malaria “off the backs” of women and children in western Uganda
REFNo: HS4758ES
The scientific objective is to demonstrate the protective effect of permethrin-treated lesus against P. falciparum malaria in infants and young children.,
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Uganda |
2024-11-18 13:40:11 |
2027-11-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Catherine Nabbumba
ID: UNCST-2024-R002912
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Genome wide association studies and polygenic prediction of major depressive disorder in samples of African ancestry from Uganda
REFNo: HS5159ES
1) investigate the prevalence and sociodemographic and clinical correlates of MDD among general outpatients attending care at 5 hospitals in Uganda
2) undertake a systematic review on common genetic variants associated with MDD among respondents of non-European ancestry using different datasets from PGC
3) explore common genetic variants associated with MDD in 2 African samples (ED6 study (n=150 cases, 150 controls) (A) and NeuroGAP study (n=324 cases, 876 controls) (B))
4) optimise a PRS for MDD initially developed from MDD-PGC datasets for use in the African setting of Uganda
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Uganda |
2024-11-18 13:36:01 |
2027-11-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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THOMSON LAKWO LURONI
ID: UNCST-2023-R007843
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Evaluating the specificity and cross-reactivity of Mansonella perstans sera against biomarkers for Onchocerca volvulus and Wuchereria bancrofti
REFNo: HS4889ES
To evaluate the specificity and cross-reactivity of M. perstans sera against biomarkers of O. volvulus and W. bancrofti.
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Uganda |
2024-11-18 13:34:32 |
2027-11-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Rogers Kalyetsi
ID: UNCST-2024-R004177
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GENETIC DIVERSITY OF PLASMODIUM FALCIPARUM AND VECTOR SPOROZOITE INFECTIVITY RATES IN SELECTED FLOOD PRONE VILLAGES IN KASESE DISTRICT, WESTERN UGANDA
REFNo: HS4978ES
d. Generate maps for the spatial distribution of infected Anopheles mosquitoes and identify the hot spots in the flood-prone selected villages in Kasese district.,C. To determine vector species composition and sporozoite effectivity rates in selected flood-prone villages in Kasese district,b. Describe the genetic diversity of P. falciparum species responsible for malaria epidemics in selected flood-prone villages in Kasese district.,a. To establish the positivity rates of P. falciparum among children ? 12 years in selected flood-prone villages in Kasese district ,To determine the genetic diversity of Human Plasmodium falciparum species and vector sporozoite effectivity in selected flood-prone villages in Kasese district, western Uganda,
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Uganda |
2024-11-18 13:24:42 |
2027-11-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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Noah Nyende Robert
ID: UNCST-2024-R003575
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Health-Seeking Behaviour and Utilization of Sexual and Reproductive Health Services by Adolescents in Uganda: An Analysis of Attitudes, Perceptions and Preferences in The Busoga Region.
REFNo: SS3374ES
4. To assess how personal factors moderate the effect of health-seeking behaviours and the utilization of SRH services by adolescents in the Busoga region of Uganda,3. To examine the relationship between health-seeking preferences and the utilization of sexual and reproductive health (SRH) services by adolescents in the Busoga region of Uganda.,2. To explore the influence of health-seeking perceptions on the utilization of sexual and reproductive health (SRH) services by adolescents in the Busoga region of Uganda.,1. To investigate the effect of health-seeking attitudes on the utilization of sexual and reproductive health (SRH) services by adolescents in the Busoga region of Uganda.,This study aims to investigate the influence of health-seeking behaviours on the utilization of sexual and reproductive health (SRH) services by adolescents in the Busoga region of Uganda. The ultimate objective is to contribute to the creation of an evidence-based model that improves the delivery and acceptance of SRH services among adolescents in Uganda.,
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Uganda |
2024-11-18 13:22:16 |
2027-11-18 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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LADY MARY KABAPAGASA
ID: UNCST-2024-R002479
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DIGITAL LITERACY COMPETENCIES AND SKILLS AMONG INFORMAL SMALL-SCALE WOMEN TRADERS IN THE RWENZORI REGION, UGANDA
REFNo: SS3371ES
5. To develop a policy brief to empower informal women traders with digital literacy skills and competencies in the country.,4. To examine the support systems available to informal small-scale women traders to optimally use digital devices and platforms to enhance their businesses in Rwenzori region,3. To examine the factors that influence the use of digital devices and platforms by informal small-scale women traders to boost trade in Rwenzori region,2. To establish digital literacy competencies and skills among informal small-scale women traders that enhance their use of digital devices and platforms for trade in Rwenzori region,1. To establish the types and application of digital devices and platforms that informal small-scale women traders use to enhance performance of their trade in Rwenzori region.,To examine the digital literacy competencies and skills among informal small-scale women traders in Rwenzori region, Uganda aiming to develop a national policy brief for empowering them with relevant digital literacy competencies and skills.,
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Uganda |
2024-11-14 9:11:43 |
2027-11-14 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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Deo Wabwire Ogema
ID: UNCST-2021-R013932
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A Phase 2 Randomized, Adaptive, Dose-Ranging, Open-Label Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis (RAD-TB) Version 2.0, Dated 21 Mar 2024
REFNo: HS5088ES
Primary objectives
(i)To compare Mycobacterial Growth in Tube (MGIT) liquid culture Time to Positivity (TTP) slope over the first 6 weeks of treatment for each experimental treatment arm to the standard of care (SOC) arm.
(ii)To compare new Grade 3 or higher adverse events (AEs) (safety) over the first 8weeks of treatment for each experimental treatment arm to the SOC arm.
Secondary Objectives
i)To compare time to stable culture conversion by MGIT liquid culture by week 8
for each experimental treatment arm to the SOC arm.
ii)To compare MGIT liquid culture TTP slope over the first 8 weeks of treatment for
each experimental treatment arm to the SOC arm.
iii) To compare new Grade 3 or higher AEs (safety) over 26 weeks of treatment for
each experimental treatment arm to the SOC arm.
iv) To compare discontinuations of anti-TB drugs for any reason prior to 8 and 26
weeks of treatment for each experimental treatment arm to the SOC arm.
v) To determine the dose- and exposure-response relationships between experimental drug estimated pharmacokinetic (PK) parameters with safety and efficacy.
vi) To compare a composite of efficacy and safety outcomes using a risk-benefit
approach for each experimental treatment arm to the SOC arm.
vii) To compare MGIT liquid culture TTP slope over the first 6 weeks of treatment for Arms 3A-3B and Arms 4A-4B compared to Arm 2.
viii) To compare durable cure by 52 weeks after treatment initiation in each
experimental treatment arm to the SOC arm.
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Uganda |
2024-11-13 18:02:04 |
2027-11-13 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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