Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Kellen Tumutegyereize Busingye
ID: UNCST-2025-R017809
Faculty Pedagogical Practices in Leveraging Digital Technologies to Enhance Inclusive Learning in Public Universities; Uganda.
REFNo: SS4455ES

1.To explore faculty perceptions towards leveraging digital technologies in fostering inclusive learning environments. 2.To analyse how faculty use digital technologies to prepare for delivery of instruction that presents content in multiple formats. 3.To examine how faculty utilize digital technologies to facilitate multiple means of student engagement during the teaching-learning process. 4.To assess how faculty use digital technologies to provide students with multiple options for demonstrating their learning progress.
Uganda 2025-10-14 10:20:25 2028-10-14 Social Science and Humanities Non-Clinical Trial Degree Award
Grace Ndeezi
ID: UNCST-2019-R001802
Understanding and managing fevers from infections spread by animals Multi-centre study Protocol version 2.0, 17 July 2025
REFNo: HS6492ES

Our overarching goal is to improve the diagnosis and management of zoonotic causes of acute febrile illness (ZAFI) in paediatric populations in sub-Saharan Africa.
The specific aims and objectives are to:
1. Determine the common causes of ZAFI and associated factors in paediatric patients living in urban and rural areas of Uganda, Kenya and Ethiopia
1.1. Quantify the burden of non-malarial fever and identify the major zoonotic aetiologies
1.2. Identify risk factors for and clinical indicators of infection with specific zoonotic pathogens
2. Develop and test novel technologies and approaches for diagnosing ZAFI that are suitable for use in LMIC and field settings
2.1. Evaluate point-of-care (PoC) tests and pilot prototype molecular diagnostic platforms for key zoonotic pathogens
2.2. Determine the best sequence of tests to optimise diagnosis of fever
3. Involve communities and the health sector in Uganda, Kenya and Ethiopia in defining improved approaches to diagnosis and management of ZAFI
3.1. Identify community perceptions on the causes of AFI and care seeking behaviours for fever
3.2. Develop and validate a decision support tool for diagnosis and management of ZAFI in clinical settings
4. Strengthen capacity and capability for research on diagnosis and management of zoonotic diseases in Uganda, Kenya and Ethiopia
4.1. Develop and implement evidence-based capacity strengthening plans to ensure that all partner affiliated laboratories have the capability to perform quality-assured molecular diagnostics research for zoonotic infections
4.2. Develop a cohort of clinical and laboratory scientists with expertise in ZAFI

Uganda 2025-10-10 13:30:11 2028-10-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
DORCAS LAMUNUOWOT
ID: UNCST-2025-R018451
Effectiveness of health education intervention on malaria control during pregnancy in rural communities: A case of Lamwo district in Northern Uganda.
REFNo: HS6569ES

1. Assess the current knowledge and awareness, attitude, and practices regarding malaria control among pregnant women in Lamwo District, Northern Uganda.
2. To adapt and implement the culturally tailored health education intervention targeting malaria control and prevention among pregnant women in Lamwo district, Northern Uganda
3. Assess the effectiveness of health education intervention on improving knowledge, attitudes, and practices regarding malaria control among pregnant women in Lamwo district, Uganda.
4. To explore the perceptions and experiences of midwives and pregnant women regarding the implementation and impact of the health education intervention for malaria control and prevention in pregnancy in Lamwo district, Northern Uganda.

Uganda 2025-10-08 9:57:08 2028-10-08 Medical and Health Sciences Non-Clinical Trial Degree Award
Sarah Kristiansen
ID: UNCST-2023-R007322
Supporting Ugandan Caregivers in Teaching Menstrual Care Skills to Individuals with Developmental Disabilities
REFNo: SS4157ES

To understand the effects of a program designed to teach parents and educators of individuals with developmental disabilities instructional procedures for teaching menstrual care skills to the young women they care for. Additionally, to understand the effects of a training program to teach an educator from the sponsor organization, Home of Hope, to continue with training procedures to promote sustainability.
USA 2025-10-08 8:29:05 2028-10-08 Social Science and Humanities Non-Clinical Trial Degree Award
Ahna Ballonoff Suleiman
ID: UNCST-2025-R019613
Thrive Together: Strengthening Contraception through Lived Experience of Flourishing
REFNo: SS4403ES

1. Bring existing, validated VFP and human flourishing frameworks and evidence into rigorous dialogue; 2. ground understanding of common VFP and human flourishing domains in lived experience expertise of culturally diverse young people, women and couples; 3. Engender first-ever expert consensus on the common domains of human flourishing and VFP; 4. Deliver evidence-based, consolidated guidance to programmers and decision-makers to advance VFP as part of human flourishing, and human flourishing as part of VFP.
USA 2025-10-08 19:23:37 2028-10-08 Social Science and Humanities Non-Clinical Trial Non-degree Award
Moffat  Nyirenda Joha
ID: UNCST-2020-R019333
Understanding the Effects of Behavioural Risk Factors and Lifestyle Changes Among Non-overweight and Obese Type 2 Diabetes Mellitus Patients in Malawi and Uganda.
REFNo: HS6497ES

Main Objective:
• To determine whether behavioural risk factors (diet and physical activity) contribute to NOW T2DM and to assess whether current national lifestyle change guidelines have similar effects on glucose control and other outcomes among NOW and obese T2DM patients in Malawi and Uganda.

Specific Objectives:

i. To establish a cohort of newly diagnosed NOW and obese T2DM patients and matched non-diabetic controls in Malawi and Uganda.
ii. To compare baseline dietary and physical activity patterns among NOW and obese T2DM participants and their matched controls.
iii. To administer health education based on national guidelines and compare 6-month outcomes (weight loss and glucose control) in NOW versus obese participants.

Malawi 2025-10-08 19:03:35 2028-10-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
ANN AKITENG ROSE
ID: UNCST-2025-R019916
Assessing Healthcare Barriers and Identifying Implementation Strategies to Mitigate Cardiovascular Risks Among Market Vendors in Urban Markets in Kampala and Mbarara, Uganda
REFNo: HS6472ES

The aim of this study is to generate formative quantitative data on the health status, cardiovascular disease (CVD) risk factors, daily routines, and healthcare access and barriers of market vendors in Uganda in order to identify opportunities for culturally appropriate and feasible lifestyle modification interventions and potential implementation strategies to reduce CVD risk.
Uganda 2025-10-08 18:59:30 2028-10-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
PATIENCE AYESIGA
ID: UNCST-2023-R003499
The implications of wetland dynamics on water qiuality for conservation of Rwizi macro catchment south western Uganda
REFNo: SS4498ES

To characterize the spatial-temporal dynamics and explore drivers of wetland degradation for middle Rwizi catchment. 2.To assess the implications of wetland degradation on sediment for middle Rwizi catchment. 3.To analyze the influence of nutrients on water quality for middle Rwizi catchment. 4.To evaluate the effectiveness of existing conservation develop suitable restoration and conservation mechanisms for improved catchment health of middle Rwizi system.
Uganda 2025-10-08 18:58:01 2028-10-08 Social Science and Humanities Degree Award
Obondo Sande James
ID: UNCST-2019-R000241
Effect of Mycobacterium tuberculosis and its cell wall glycolipids on the HIV Reservoir in CD4+ T cells
REFNo: HS5439ES

1. To determine if MTB molecules (e.g. PIM6, LAM, MTB lysate) induce HIV expression in memory CD4+ T cells from ART-suppressed HIV infected persons.

2. To determine the size of peripheral HIV reservoir in memory CD4+ T cells in HIV infected individuals with active TB compared to HIV infected individuals with history of documented treated TB, LTBI, and no LTBI (HIV-monoinfected).

3. To assess longitudinal changes in the size of peripheral HIV reservoir in memory CD4+ T cells in HIV infected individuals with active TB before initiation of TB treatment and at the end of treatment

Uganda 2025-10-08 18:16:22 2028-10-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kansiime Cecilia
ID: UNCST-2025-R017890
OPTIMIZATION OF THE REARING SUBSTRATES FOR BLACK SOLDIER FLY LARVAE AND ITS ACCEPTABILITY AS AN ALTERNATIVE PROTEIN SOURCE AMONG POULTRY FARMERS IN THE RWENZORI REGION
REFNo: A647ES

(i) To determine the appropriate growing substrates for black soldier fly larvae as a source of protein for poultry. (ii) To assess farmers perceptions and acceptance of black soldier fly larvae as a source of protein for poultry. (iii) To determine the economic feasibility of using black soldier fly larvae as a source of protein for poultry.
Uganda 2025-10-08 13:11:23 2028-10-08 Agricultural Sciences Non-Clinical Trial Degree Award
Richard Selwanga
ID: UNCST-2025-R018576
THE EVOLUTION OF THE LINGUISTIC LANDSCAPE OF KAMPALA: LANGUAGE POLICY, MULTILINGUALISM, AND PUBLIC PERCEPTIONS
REFNo: SS4333ES

(i) To examine the language of public signs in the LL Kampala District from the colonial to post-colonial period. (ii) To analyse the impact of language policies on language visibility in the LL of Kampala District from the colonial to post-colonial period. (iii) To investigate the role that multilingualism has played in shaping the LL of Kampala District from the colonial to post-colonial period. (iv) To explore the perceptions of the target readership towards language use in the contemporary LL of Kampala District.
Uganda 2025-10-08 13:06:29 2028-10-08 Social Science and Humanities Non-Clinical Trial Degree Award
Mulebeke Ronald
ID: UNCST-2025-R017304
IMPLEMENTATION AND ASSESSMENT OF THE THRIVE PROJECT; STRENGTHENING MENTAL HEALTH AND SOCIOECONOMIC RESILIENCE AMONG YOUTH LIVING WITH HIV IN WAKISO DISTRICT, UGANDA
REFNo: HS6493ES

1. To conduct a gap assessment of the current mental health services for youth living with HIV in Wakiso District.

2. To explore the structural, social and policy related barriers to effective integration of mental health services into HIV care for YLWH in Wakiso District.

3. To explore the structural, social and policy related facilitators to effective integration of mental health services into HIV care for YLWH in Wakiso District.
4. To assess the feasibility of integrating Group Support Psychotherapy training in improving mental health outcomes among YLWH at Mildmay Uganda Hospital in Wakiso District.
5. To assess the feasibility of economic empowerment in improving mental health outcomes among YLWH seeking care at Mildmay Uganda Hospital in Wakiso District.
6. To conduct a process evaluation of the THRIVE project among YLWH at Mildmay Uganda Hospital in Wakiso District.

Uganda 2025-10-08 11:21:31 2028-10-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Robert MPIIRA
ID: UNCST-2022-R005391
Community Engagement and Access to Services Related to Gender-Based Violence and Sexual Reproductive Health and Rights in Uganda: A Qualitative Study
REFNo: SS4367ES

● Do male influencers view themselves as agents of change (or potential agents of chance) for AGYW? Can they be adequately motivated to serve as champions or advocates for AGYW rights, and if so, what would incentivize them to play that role most effectively?,● What role do YDCs or other community-based support groups/networks play in supporting AGYW\'s social and economic empowerment, as well as the long-term sustainability of interventions?,● What are the current service gaps in SRHR and GBV within the targeted communities? What institutional or system-strengthening support is needed to address these gaps and improve the effectiveness of referrals?,● What are the main barriers associated with discussing SRHR and GBV topics with family members and men toward shifting social norms and what strategies can help effectively mitigate these barriers?,● What are the key barriers and enablers faced by the AIM 2.0 programme in influencing existing community structures, particularly informal structures, to improve the socio-economic conditions and empowerment for AGYWs?,To ensure the implementers fully understand the contexts where they are working and if necessary adapt the implementation activities through more enhanced community engagement in order to improve access to services for AGYW, particularly SRHR and GBV protection. ,
Uganda 2025-10-07 10:35:55 2028-10-07 Social Science and Humanities Non-degree Award
Musa Sekikubo
ID: UNCST-2021-R014010
Congenital and Maternal Point of care Rapid Testing for Syphilis Study, Uganda (COMPARTS)
REFNo: HS6397ES

Main Objective: Conduct a pilot study of the reformulated Dual Path Platform (DPP) Syphilis Test and Treat (TnT) and Congenital Syphilis (CS) test, manufactured by Chembio, for a cohort of mother-baby pairs from Uganda.


Specific Objectives
a) Assess treponemal and non-treponemal antibody levels in perinatal blood from mothers and compare these findings with IgM and IgG results from the DPP Syphilis TnT assay.

b) Assess treponemal and non-treponemal antibody levels in newborn and cord blood from paired babies and compare these findings with IgM and IgA results from the DPP Syphilis CS assay.

c) Determine the performance characteristics of the POC device by calculating the sensitivity, specificity, positive and negative predictive values, and the proportion of tests that return invalid results or errors.
Uganda 2025-10-07 10:25:59 2028-10-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Patience Atukunda
ID: UNCST-2023-R005832
BUILDING ARTIFICIAL INTELLIGENCE MODELS FOR BREAST CANCER DIAGNOSIS USING CLINICAL, ULTRASOUND AND CYTOLOGY DATA
REFNo: SIR559ES

i To build and evaluate an Artificial Intelligence Model for prediction of breast cancer using clinical features ii To build and evaluate an Artificial Intelligence model for breast cancer diagnosis using ultrasound data iii To build and evaluate an Artificial Intelligence model for breast cancer diagnosis using cytology data iv To build and evaluate an Artificial Intelligence model to integrate clinical, radiology and pathology findings into one report
Uganda 2025-10-01 12:21:26 2028-10-01 Engineering and Technology Non-Clinical Trial Degree Award
Anne Akello Ruth
ID: UNCST-2022-R009131
ASSESSMENT OF OCCUPATIONAL HAZARDS AND HEALTH EFFECTS AMONG WORKERS OF GRAIN MILLS IN SOROTI CITY, UGANDA
REFNo: HS6278ES

1. To identify occupational hazards in work places within grain mills in Soroti city.
2. To establish knowledge, attitudes and practices (KAP)on occupational hazards among workers of grain mills in Soroti city.
3. To examine the status of implementation of OSH policies by owners and workers of the grain mills in Soroti city.
4. To determine the health effects of exposure to occupational hazards among workers of grain mills in Soroti city
5. To establish the factors that influence occurrence of occupational hazards and health effects among workers of grain mills in Soroti city.

Uganda 2025-10-01 12:20:18 2028-10-01 Medical and Health Sciences Non-Clinical Trial Degree Award
Marvious Kiwanuka
ID: UNCST-2023-R006348
Surveillance of human and vector behaviors to understand malaria transmission at sentinel sites in Uganda
REFNo: HS6483ES

To monitor geographic and temporal trends in malaria burden and assess the impact of population level control interventions across a range of epidemiological settings in Uganda in relation to human behaviors and vector bionomics.
Uganda 2025-09-30 14:43:46 2028-09-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Judith Nanyondo Semanda
ID: UNCST-2025-R019750
Design and Evaluation of Human-Centred, Data-Driven Bundles for Improving Hand and Surface Hygiene Practices in Ugandan Health Facilities
REFNo: HS6507ES

1. To explore the barriers and facilitators to hand and surface hygiene compliance among clinical staff and cleaners in the health facilities of Masaka region.
2. To design data-driven hand and surface hygiene care bundles using a human centered design approach.
3. To assess the effectiveness of hand and surface hygiene care bundles in improving compliance with hand and surface hygiene practices among clinical staff and cleaners.

Uganda 2025-09-30 14:41:24 2028-09-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JAMES KAWUKI STEPHEN
ID: UNCST-2025-R019616
ENERGY POVERTY, HOUSEHOLD HEALTH STATUS AND HEALTH EXPENDITURE: A STRATEGIC MANAGEMENT AND POLICY IMPLICATION IN UGANDA’S ENERGY AND HEALTH SECTORS
REFNo: SS4396ES

i. To examine the relationship between energy poverty and Household health expenditure. ii. To evaluate the relationship between energy poverty and Household health status, with specific attention the role of gender and energy usage behaviour. iii. To establish the relationship between Household health expenditure and Household health status. iv. To develop a strategic management model that incorporates affordability sensitivity and gender- responsive interventions to mitigate energy poverty and improve health outcomes.
Uganda 2025-09-30 14:40:12 2028-09-30 Social Science and Humanities Non-Clinical Trial Degree Award
Apolo Balyegisawa P
ID: UNCST-2025-R017645
Evaluation of the XF 300 Flow Cytometer, CD4 easy count kit, CD4% easy count kit and CD4/CD8 easy count kit in Tests 1112 - Explorative External Method Comparison Study and 1149.2 - Clinical Performance Study
REFNo: HS6435ES

Test 1112 - Compare the results from the XF-300 Flow Cytometer and its reagent kits with the comparator device (FACSLyric) and reagent kits Test 1149.2 - Investigate the clinical performance of the XF-300 Flow Cytometer in combination with the three kits CD4, CD4% and CD4/CD8 easy count kit.
Uganda 2025-09-30 14:39:06 2028-09-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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