Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Moses Joloba Lutaakome
ID: UNCST-2022-R011558
Predicting the Future: Incipient Tuberculosis (PreFIT)
REFNo: HS1242ES

1.1 Aim:
To validate the clinical performance, cost, and feasibility of a package of ready-to-use new and existing candidate diagnostic assays for the prediction of the development of active TB.
1.2 Objectives:
1. Establish a multi-country diagnostic evaluation cohort of highly exposed TB contacts free of co-prevalent active TB, followed prospectively for active TB development over a 12-months period, and collect and store biological specimens from these contacts at pre-set time-points for laboratory testing; and
2. Validate a package of candidate assays for their predictive accuracy (sensitivity, specificity, positive and negative predictive values) for incident TB, feasibility, and cost. Based on combining results for the different tests, cost-optimised predictive algorithms will be derived.

Uganda 2021-03-01 2024-03-01 Medical and Health Sciences Non-degree Award
Miriam Nansunga
ID:
ASSESSMENT OF THE SAFETY AND EFFICACY OF COMMON MEDICINAL PLANTS OF CENTRAL UGANDA ON IMPAIRED LEARNING AND MEMORY IN RATS
REFNo: HS648ES

1. To identify medicinal plants of Central Uganda used in the management of memory impairment.
2. To determine the effect of the aqueous extracts of the 5 most commonly mentioned plants on escape latency in the Morris Water Maze and step down latency in Passive Avoidance test.
3. To determine the effect of the total crude extracts of the two most effective plants on: acetylcholine, glutamate; muscarinic receptor M1, M3 and M5; glutamate receptors AMPA and NMDA in the hippocampus and orbital frontal cortex

4. To establish the safety and toxicity profile of the two most active plants extracts on memory and learning enhancement.

Uganda 2021-02-26 2024-02-26 Medical and Health Sciences Degree Award
Leevan Tibaijuka
ID: UNCST-2021-R012986
Predictors for preterm neonatal mortality at Mbarara Regional Referral Hospital
REFNo: HS469ES

General objective
To Describe the Predictors for Preterm Neonatal Mortality among preterm babies delivered at Mbarara Regional Referral Hospital (MRRH).
Specific objectives
1. To describe the neonatal mortality of preterm babies at Mbarara Regional Referral Hospital
2. To describe the association of antenatal care attendance, antenatal corticosteroid use and mode of delivery with preterm neonatal death at Mbarara Regional Referral Hospital

Uganda 2021-02-25 2024-02-25 Medical and Health Sciences Degree Award
Francis Ekadu
ID:
Uganda Bribery Index
REFNo: SS392ES

To increase citizens awareness on the prevalence, gravity and impact of corruption in uganda
Uganda 2021-02-25 2024-02-25 Social Science and Humanities Non-degree Award
Lucrèce Ahovègbé Yémalin Judith
ID:
Evaluation of two medicinal plants on key factors causing treatment failure in Hepatitis C infection
REFNo: HS1004ES

1. Evaluate the antiviral and anti-mutagenic effect of A. nilotica and T. ciliata on HCV in presence and absence of DAA
2. Evaluate the effect of A. nilotica and T. ciliata on induced mutation in HCV infection in presence and absence of DAA
3. Determine effect of A. nilotica and T. ciliata on immunologic parameters involved in body response to HCV in presence and absence of DAA
4. Investigate the genotypes of HCV circulating in African region (Uganda, Benin) and their response in vitro to DAAs

Benin 2021-02-25 2024-02-25 Medical and Health Sciences Degree Award
PAUL KATO KALYEBARA KALYEBARA
ID:
INCIDENCES OF RE-MARRIAGE, LIVE CHILDBIRTH AND RECURRENCE OF INCONTINENCE AMONG WOMEN THAT UNDERWENT OBSTETRIC FISTULA REPAIR AT MBARARA REGIONAL REFERRAL HOSPITAL FROM 2010 TO 2019
REFNo: HS1060ES

General objective
To determine the incidences of re-marriage, live childbirth and recurrence of incontinence among women who had successful obstetric fistula repair at Mbarara Regional Referral Hospital from 2009 to 2019.
Specific objectives
1. To determine the incidence of re-marriage among women who had successful fistula repair at Mbarara Regional Referral Hospital from 2010 to 2019.
2. To determine the incidence of live childbirth among women who had successful obstetric fistula repair at Mbarara Regional Referral Hospital from 2010 to 2019.
3. To compare recurrence rates of incontinence after childbirth occurring among women who had successful genitourinary and rectovaginal fistula repair at MRRH from 2010 to 2019.

Uganda 2021-02-25 2024-02-25 Medical and Health Sciences Degree Award
FREDDIE SSENGOOBA Peter
ID: UNCST-2021-R011834
Political Economy Analysis of sub-national health management in Eastern and Southern Africa
REFNo: SS664ES

This study will explore the dynamics taking place at sub-national level (e.g. within counties or districts) as well as between national and sub-national levels along the following objectives:
1. Analyze the environment for decision-making and implementation of health plans at sub-national level, including existing formal and informal processes for decision-making; political, financial, social, and other influences on sub-national prioritization, decision-making and resource allocation, including relevant changes over time (e.g. post-devolution), and how data and evidence play a role.
2. Identify and characterize key stakeholders with a role in sub-national health management and systems—key characteristics will include technical capacity, their use of data and evidence, the relationships and power dynamics between them, and the existing structures for engagements with non-health sector authorities, both formal and informal.
3. Assess existing formal and informal accountability mechanisms for sub-national decision-making for health (both within the health system and for external stakeholders like beneficiary communities, sub-national decision-makers (county/district), and development partners) with a view to identify ways to improve the relative effectiveness of accountability mechanisms in decision processes.
4. Analyze social sector spending trends and beneficiaries, their relation to health sector policies, and how local governance structures influence them, where available.
5. Develop draft plan for piloting strategies to address challenges identified by the PEA, including proposed implementation and monitoring and evaluation approaches, as appropriate.
6. Analyze the policy environment on community health, including key stakeholders, to identify potential approaches for integrating a new community health extension worker program into existing systems, especially at district level
7. Analyze the current digital health innovations governance and accountability structures, (including key stakeholders across sectors and how their responsibilities and priorities overlap,) to identify strategies for strengthening existing structures, enhancing accountability and minimizing duplication

Uganda 2021-02-25 2024-02-25 Social Science and Humanities Non-degree Award
Silvia Kahihu Wairimu
ID:
Improving the Impact of VSLAs on Refugees’ and Host Communities’ Self- reliance, Resilience and Economic Capacity
REFNo: SS658ES

Our main objective is to investigate different facets of the VSLA (structure, benefits, and barriers as well as future opportunities) with the aim of optimizing its design. This is because we hypothesize that optimizing the structure of the VSLA will lead to increased financial inclusion of the group members as well as social capital.
Kenya 2021-02-25 2024-02-25 Social Science and Humanities Non-degree Award
Dianah Ahumuza Ateenyi
ID:
The impact of tax incentives on the realisation of economic and social rights: A focus on tax holidays and the right to basic education in Uganda
REFNo: SS666ES

1. To examine the historical background and justification of tax incentives generally and tax holidays specifically especially in Uganda.
2. To explore the adequacy of the legal and policy framework on tax incentives, especially tax holidays in Uganda and how it impacts revenue for the realisation of ESRs, specifically the right to basic education;
3. To analyse the relationship between government revenue and basic education financing and how it the realisation of the right to basic education.
4. To recommend appropriate legal, policy and administrative reforms for the better management of tax incentives generally and tax holidays specifically for the realisation of Uganda’s international and domestic ESRs obligations, with specific emphasis on the right to basic education.

Uganda 2021-02-25 2024-02-25 Social Science and Humanities Degree Award
Joseph Lutaakome
ID: UNCST-2020-R008323
An International Observational Study to Characterize Adults Who Are Hospitalized with Influenza or Other Targeted Respiratory Viruses (INSIGHT Protocol No. 003 version 3.0, dated 27 August 2013); Flu003 PLUS AND Genomic Study: INSIGHT Protocol No. 004 version 2.0, dated 27 August 2013 -A substudy of qualifying INSIGHT studies
REFNo: HS1108ES

The objectives of this study for participants with confirmed influenza are to:

1. Characterize individuals who are hospitalized with influenza in terms of demographics, co-morbid conditions, prior influenza vaccination (seasonal, including 2009 H1N1) and pneumococcal vaccination, and use of antivirals, overall and according to influenza type, A or B, and influenza A subtype.

2. Estimate the percent who die and who develop a composite outcome, overall and according to the identified influenza type or subtype: death, a requirement for mechanical ventilation or admission to the intensive care unit (ICU), or prolonged hospitalization following enrollment (duration of hospitalization >28 days) at 60 days after enrollment.

3. Study risk factors, (e.g., patient and viral characteristics, geographic location, influenza type and subtype) for mortality and the composite outcome of death, a requirement for mechanical ventilation or admission to the ICU, or prolonged hospitalization following enrollment (duration of hospitalization >28 days).

4. Establish a repository of oropharyngeal, nasal and lower airway samples to determine a laboratory diagnosis; to molecularly characterize the virus, including subtype, antigenic and genetic analyses; to identify known signature mutations for antiviral drug resistance, mutational evolution, and additional re-assortment; and assess possible co-pathogens.

5. In a subset of patients requiring mechanical ventilation, to collect paired upper and lower airway samples to molecularly characterize the virus according to anatomic location, assess the potential emergence of antiviral resistance and assess possible co-pathogens.

6. Establish a repository of serum and plasma for future studies, including measurement of biomarkers that predict disease severity and measures of host response to infection with influenza virus.

7. Compare the characteristics and outcomes of patients infected with different influenza virus types and subtypes, including 2009 H1N1 virus, over time and by geographic region.

8. Identify and characterize other viral and bacterial pathogens, including coinfections.

The objectives of this study for participants with targeted non-influenza viral respiratory infections are to:

1. At enrollment, characterize individuals who are hospitalized with a targeted viral respiratory disease in terms of possible source of infection and mode of transmission, demographics and co-morbid conditions.

2. At 28 and 60 days of follow-up, estimate the percent who die, require admission to the ICU, have prolonged hospitalization, or recover.

3. Establish a repository of prospectively collected serum, plasma and respiratory tract specimens for future studies, including measurement of biomarkers that predict disease severity and measures of host immune response to infection.

Uganda 2021-02-25 2024-02-25 Medical and Health Sciences Non-degree Award
Jane Frances Namatovu
ID: UNCST-2020-R014353
CONTINUING PROFESSIONAL DEVELOPMENT FOR PRIMARY CARE DOCTORS IN LOW RESOURCE SETTINGS: DEVELOPING A COMPETENCY-BASED FRAMEWORK
REFNo: HS1170ES

1.To determine the CPD training needs of primary care doctors working in public general hospitals (GHs) and health center IVs (HC IVs) of central Uganda
2.To explore the perceived barriers to and facilitators of CPD among primary care doctors working in public GHs and HC IVs of central Uganda
3.To explore the views of key stakeholders on CPD for doctors working in public GHs and HC IVs of central Uganda
4.To develop a competency-based CPD framework for primary care doctors working in public GHs and HC IVs of central Uganda
Uganda 2021-02-25 2024-02-25 Medical and Health Sciences Degree Award
Dennis Muhanguzi
ID: UNCST-2019-R001101
Targeting Domestic Animals and Tsetse Fly Vectors to Control Nagana and Accelerate Elimination of Acute Sleeping Sickness from Hot Spot Villages of Eastern Uganda
REFNo: A107ES

The main objective of this study will be to determine whether targeting hotspot villages would accelerate elimination of rHAT The specific objectives of this project will be to determine; i. If rHAT hotspot village-based interventions [two doses of diminazene aceturate 40 days apart at the beginning of the intervention and monthly RAP] will progressively reduce T. brucei s.l. reservoir in cattle and hence insidious rHAT transmission. ii. The drivers of insidious rHAT transmission in hotspot rHAT hotspot villages in Dokolo and Kaberamaido districts.
Uganda 2021-02-25 2024-02-25 Agricultural Sciences Non-degree Award
NOLBERT GUMISIRIZA KAGAMBIRWE
ID:
Investigating how the specialized and decentralized treatment healthcare models for all forms of epilepsy in Uganda fared in the covid-19 pandemic
REFNo: HS1156ES

1. To assess the government strategy of decentralized care and treatment for persons with all forms of epilepsy in Uganda, before COVID-19.

2. To assess the effects of the COVID-19 pandemic on access to epilepsy care in Uganda

3. To assess the socio-economic and mental health effects of the COVID-19 pandemic on persons with epilepsy in Uganda.

4. To generate ideas and strategies to improve the existing models for epilepsy care in Uganda∙

Uganda 2021-02-25 2024-02-25 Medical and Health Sciences Degree Award
Bjorn Van Campenhout -
ID: UNCST-2020-R014080
Impact of Covid-19 on maize and dairy value chains in Uganda
REFNo: SS699ES

Specific objective: To assess the impact of Covid-19 on the maize and dairy value chain in Uganda. Specific objective: to determine how the COVID-19 pandemic affected production, marketing/sales and welfare of actors/households along the two value chains.
Belgium 2021-02-25 2024-02-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Godfrey Ejuu
ID: UNCST-2021-R013978
Effectiveness of Inclusive Home-based Early Learning Model in Increasing Access to Early Child Education (ECE) for Children in Marginalised Communities
REFNo: SS740ES

1. To describe contextually relevant pedagogical practices that result into better child school readiness outcomes in home based ECCE centres
2. To compare the impact of the play- based ECCE curriculum model program on children’s school readiness relative to the control group
3. To determine the impact of pedagogical mentorship program on teacher professional well-being, classroom quality, and children’s school readiness relative to a control group

Uganda 2021-02-25 2024-02-25 Social Science and Humanities Non-degree Award
Eddy Walakira Joshua
ID: UNCST-2022-R009077
SITUATION ANALYSIS OF THE IMPACT OF COVID - 19 ON GLOBAL FUND TO END MODERN SLAVERY’S SUPPORTED PROGRAMMES TO END COMMERCIAL SEX EXPLOITATION OF CHILDREN AND ENDING LABOUR EXPLOITATION
REFNo: SS757ES

This is a program evaluation study focusing on CSEC and OLR programs. As a result, the primary questions are divided into two corresponding to the two study sub-components.

Broadly, this study seeks to establish the likely impact of COVID 19 on the implementation of the Commercial and Sex Exploitation programmes supported by the Global Fund to End Modern Slavery, in Kampala and Karamoja areas.
Uganda 2021-02-25 2024-02-25 Social Science and Humanities Non-degree Award
Samwel Wangombe
ID:
INTERNAL CONTROLS, REGULATORY MECHANISMS AND FINANCIAL ACCOUNTABILITY IN INDIGENOUS NON-PROFIT ORGANISATIONS IN UGANDA
REFNo: SS734ES

1. Describe the accounting internal controls applicable to indigenous non-profit organisations.
2. Determine the significance of accounting internal controls on the level of compliance with legal and/or regulatory requirements.
3. Determine the significance of accounting internal controls on the choice of self-regulatory mechanism.
4. Evaluate the extent to which resource dependence theory determines the quality and consistency of financial reporting.
5. Explain the relationship between internal controls, regulatory mechanisms and financial accountability.
Kenya 2021-02-24 2024-02-24 Social Science and Humanities Degree Award
Murungi Elizabeth Mwebesa
ID:
Creating an Ecosystem exemplifying Cross Sector Cooperation Approach towards road safety of motorcycles in Kampala, Uganda
REFNo: SIR43ES

Each safe riding behavior belongs to either Priority (P), Speed (S) or Comprehension (C). So it is imperative to understand which factors affect which behavior and the extent of this effect.Therefore the objectives of this study are;
a)To identify the PPM (Push, Pull, Mooring) factors that promote each of the safe riding behaviors (PSC component).

b)To understand the extent to which push, pull and mooring factors influence the behavior of riders that have had contact with these parameters and those that haven’t.

c)To create a Theory of Change (ToC) model to propose the possible road map to changing the behaviors of riders. Leveraging on these two results above, a proposal of the possible road map to changing the behavior of riders will be made by creating a Theory of Change (ToC) table

Uganda 2021-02-24 2024-02-24 Engineering and Technology Degree Award
Goretty Nagawa Mary
ID:
Implications of Land Use and Land Cover Changes towards Household Food Security in the Forested and Grassland areas of Mount Elgon Slopes
REFNo: NS122ES

Overall aim of the study
The study seeks to analyze land use and cover changes; and to establish the contribution of this towards carbon emission levels, and climate variations; and to assess the implication towards household food security by looking at the quality, diversity and quantity acquisition procedures within the households of Mount Elgon slopes.
1.3.2 Specific objectives
1. To analyse land use and cover changes on Mt Elgon slopes and assess their impact on CO2 effluxes from the soil in forest and grass land cover/use types.
2. To assess climate variability in relation to land use and land cover changes; and CO2 effluxes in the forested and grassland areas of Mt Elgon Slopes.

3. To assess the impact of land use and cover changes on household food security on Mount Elgon slopes.

Uganda 2021-02-24 2024-02-24 Natural Sciences Degree Award
Emanuele Colonnelli
ID:
Do Corruption Perceptions Kill Competition?
REFNo: SS654ES

Increasing competition in public procurement is a key priority in many developing countries. High and widespread participation in the public procurement market is crucial to ensure the proper functioning of the procurement system, and ultimately high quality public investment. Public procurement of goods and services represents the primary area of government investment, accounting for 14.5% of GDP in low-income countries.
In this study, which takes place in Uganda, we aim to study the role played by a key potential barrier to competition in the public procurement market: firms' perception of public procurement as a rigged system, driven by bureaucratic corruption and personal connections. If these perceptions are widespread among market participants, governments may find it challenging to increase competition for public procurement. Furthermore, if perceptions spillover across public bodies, perceptions of systemic corruption may negatively affect competition even in those public bodies which manage to achieve high performance standards. This may in turn hinder bureaucrats' incentive to increase the performance of their organization, since efforts to reform a public body may not directly map into better perceptions of it among the public.
Italy 2021-02-24 2024-02-24 Social Science and Humanities Non-degree Award
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