Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Henry Mugerwa
ID: UNCST-2019-R000420
 A5402 An Open-Label, Randomized Controlled Trial of Pramipexole versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD with Mild Neurocognitive Disorder (MND) in Persons with HIV
REFNo: HS6604ES

1.2 Primary Objectives

1.2.1 To compare pramipexole to escitalopram in the treatment of MDD (and comorbid MDD with MND) based on the Beck Depression Inventory-II (BDI-II/BDI-2) total score [Beck 1996] from baseline to week 24.

1.2.2 To evaluate the safety of pramipexole and escitalopram in PWH having MDD (and comorbid MDD with MND) from baseline to week 24.

1.3 Secondary Objectives

1.3.1 To compare pramipexole to escitalopram in the treatment of MDD using MDD caseness, neurocognitive outcomes, and functional status from baseline to week 24.

1.3.2 To compare the depression, neurocognitive, and functional status outcomes in PWH with MDD alone and with comorbid MDD with MND treated with pramipexole versus escitalopram from baseline to week 24.

1.3.3 To compare the impact of pramipexole and escitalopram on all outcomes above by female versus male sex (assigned at birth) from baseline to week 24.

1.3.4 To determine the impact of pramipexole compared to escitalopram on the measure of HIV-1 RNA viral load in the peripheral blood.

1.4 Exploratory Objectives

1.4.1 To characterize associations between escitalopram trough concentrations and treatment efficacy (BDI-II/BDI-2 total score) as well as participant adverse events (adverse event frequency, severity, and discontinuation rates).

1.4.2 To characterize associations between escitalopram trough concentrations and genetic polymorphisms that affect metabolizing enzymes of escitalopram (known metabolizing enzymes include CYP2C19, CYP2D6, and CYP3A4).

1.4.3 To explore associations between cerebrospinal fluid (CSF) concentrations of escitalopram and BDI-II/BDI-2 total score.

1.4.4 To evaluate adverse events potentially related to drug interactions between antiretroviral therapy (ART) and escitalopram and pramipexole, respectively.

1.5 Substudy Objective

1.5.1 CSF Substudy

To compare the impact of pramipexole and escitalopram on biomarker outcomes in a CSF substudy of participants with MDD alone.

 Uganda 2025-10-29 16:04:25 2028-10-29 Medical and Health Sciences Clinical Trial Non-degree Award
Abel  Kakuru
ID: UNCST-2022-R009193
 Dihydroartemisinin-piperaquine plus sulfadoxine-pyrimethamine versus sulfadoxine-pyrimethamine alone for the prevention of febrile illnesses in children with sickle cell anemia: a double-blind randomized controlled trial
REFNo: HS6294ES

1.
To compare the incidence of all-cause febrile illness among children with sickle cell anemia randomized to receive monthly SP vs. monthly DP+SP.
2.
To compare the incidence of adverse events among children with sickle cell anemia randomised to receive monthly SP vs. monthly DP+SP.
3.
To compare the prevalence of markers of antimalarial resistance, including those associated with SP and DP resistance, among parasitemic children with sickle cell anemia randomized to receive monthly SP vs. monthly DP+SP.
 Uganda 2025-10-29 15:55:44 2028-10-29 Medical and Health Sciences Clinical Trial Non-degree Award
Jane  Kabami
ID: UNCST-2021-R012588
 Peerled Dynamic Choice HIV Prevention for Women. The Peer-led DCP Study
REFNo: HS6556ES

To refine and pilot test a Peer-led Dynamic Choice HIV Prevention intervention for women at elevated HIV risk in southwestern Uganda
 Uganda 2025-10-29 12:53:43 2028-10-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Hannah Tusabe Not Applicable
ID: UNCST-2025-R022045
 EXPLORING THE IMPLEMENTATION OF EARLY GRADE READING METHODOLOGY IN UGANDA PRIMARY SCHOOLS
REFNo: SS4540ES

1.3.1 Main Objective

To explore the implementation of Early-Grade Reading Methodology in primary schools in Uganda.

1.3.2 Specific Objectives

To establish the current practices of Early-Grade Reading methodologies by teachers in primary schools in Uganda.

To identify the challenges teachers face in implementing Early-Grade Reading methodologies in their classrooms.

To determine strategies that can be adopted to improve the implementation of Early-Grade Reading methodologies in Ugandan primary schools.
 Uganda 2025-10-29 12:51:10 2028-10-29 Social Science and Humanities Non-Clinical Trial Degree Award
richard kasirye
ID: UNCST-2025-R018157
 Instructional Technologies for Teacher Education at Busitema University: Application of Skills to Practice
REFNo: SS4450ES

The study aims to answer: How do Busitema University’s teacher education alumni apply ICT knowledge and skills in the secondary schools where they teach? What are their experiences in using ICT in their classrooms? How can the university improve the teacher education program to better prepare graduates for technology-enhanced teaching?
 Uganda 2025-10-29 12:48:06 2028-10-29 Social Science and Humanities Non-Clinical Trial Degree Award
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