Nixon Niyonzima
ID: UNCST-2020-R014577
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MUTATIONAL PROFILE OF TRIPLE NEGATIVE BREAST CANCER IN WOMEN SEEKING CARE AT THE UGANDA CANCER INSTITUTE
REFNo: HS1264ES
1. To describe the mutational profile of triple negative breast cancer in women seeking care at the Uganda Cancer Institute
2. To describe the relationship between the mutational load and the primary tumor size of triple negative breast cancer in women seeking care at the Uganda Cancer Institute
3. To describe the differences in mutational profile by histological type in patients with triple negative breast cancer in women seeking care at the Uganda Cancer Institute
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Uganda |
2021-03-12 |
2024-03-12 |
Medical and Health Sciences |
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Degree Award |
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Nathan Kenya-Mugisha
ID: UNCST-2021-R013752
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An Evaluation of the Pediatric Care Process in Uganda for Improvement of Quality of Care
REFNo: HS1227ES
The primary objective of this study is to evaluate the typical pediatric care process at a representative sample of hospitals in Uganda
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Uganda |
2021-03-11 |
2024-03-11 |
Medical and Health Sciences |
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Non-degree Award |
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Peter Olupot-Olupot
ID:
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Severe MAlaria A Research and Trials consortium: A protocol for a prospective case control observational study
REFNo: HS1231ES
To characterise the contemporary epidemiology (including features at presentation and the diagnostic and treatment pathway) of severe malaria presenting to hospital for admission in children in Africa, through conducting a prospective multicentre observational study across 7 sites in 6 countries, enrolling two cohorts of hospitalised children (i.e. stratified) with severe and non-severe malaria.
For this study, severe malaria will be defined as children with a positive POC pHRPT2 test (Paracheck) meeting WHO criteria or Teule criteri. For severe malaria, we will characterise the proportions presenting with different severe complications, or combination of any of or all of these, and compare these proportions across sites.
Secondary Objectives
i. To compare baseline characteristics of admitted children with severe and non-severe malaria.
ii. To document time from presentation to the hospital ‘gateway’ (e.g. outpatients or emergency/triage centre) to ward admission and time to first dose of parenteral artesunate to assess whether delays in initiating definitive antimalarial treatment could contribute to malaria severity.
iii. To estimate the incidence of significant post-discharge events to day-180 including readmission (all-cause and for malaria (i.e. relapse)) and all-cause mortality in severe and non-severe malaria.
iv. To develop (year 1) and evaluate (years 2 and 3) a point-of-care quantitative plasma Plasmodium falciparum histidine-rich protein2 (pfHRP2) test for estimating total body parasite burden, which could be used to swiftly identify those at greatest risk of poor outcomes.
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Uganda |
2021-03-11 |
2024-03-11 |
Medical and Health Sciences |
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Non-degree Award |
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Tom Lutalo
ID:
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Measuring adult health and mortality in Low- and Middle-Income Countries
REFNo: HS640ES
1. To evaluate the accuracy of survey data on adolescent and adult mortality collected retrospectively through siblings’ survival histories (SSH), compared to the reference mortality data collected prospectively.
2. To test whether the siblings of respondents can be reached and interviewed via mobile phone, in order to collect data on the risk factor of adult mortality
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Uganda |
2021-03-10 |
2024-03-10 |
Medical and Health Sciences |
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Non-degree Award |
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Levicatus Mugenyi
ID: UNCST-2020-R014759
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Understanding Factors Associated with IPT Completion among Recipients of Care on ART/IPT Aligned Multi-month Refills across the Differentiated Service Delivery Models
REFNo: HS1228ES
The primary objective is to understand factors associated with completion of IPT among clients in MoH’s integrated IPT/ART models.
Specific objectives:
1.To compare IPT completion rates amongst clients across the five DSD models: Facility-Based Individual Management (FBIM), Facility-Based Group (FBG), Fast Track Drug Refill (FTDR), Community Client Led ART Delivery (CDDP), and Community Drug Distribution Points (CCLAD).
2.To understand individual and facility level factors associated with IPT completion across the different DSD models
3.To compare IPT uptake across the different DSD models
4.To compare the frequency of adverse events (AEs) reported by clients on IPT across the different DSD models
5.To document patient and service provider KAP towards the IPT/ART integrated model
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Uganda |
2021-03-10 |
2024-03-10 |
Medical and Health Sciences |
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Non-degree Award |
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Pontiano Kaleebu
ID: UNCST-2021-R013577
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A Phase 1 Trial of ChAdOx1- and MVA-vectored Conserved Mosaic HIV-1 Vaccines in Healthy, Adult HIV-1-negative Volunteers in Eastern and Southern Africa
REFNo: HS844ES
Safety
ï‚· To evaluate the safety and tolerability of a prime boost vaccine regimen utilizing non-replicating simian adenovirus (ChAdOx1) followed by non-replicating poxvirus modified vaccinia virus Ankara (MVA) in adults in Eastern and Southern Africa
Immunogenicity
ï‚· To evaluate the specific T-cell immune responses induced by the ChAdOx1.tHIVconsv1 followed by MVA.tHIVconsv3&4 vaccines in vaccine recipients.
SECONDARY
ï‚· To assess tHIVconsvX-specific T-cell responses of for their frequency, breadth and duration in vaccine recipients.
ï‚· To assess functional T-cell responses in vaccine recipients that inhibit replication in vitro of viruses of major HIV-1 clades A, B, C and D.
EXPLORATORY
ï‚· To assess induction of plurifunctional tHIVconsvX-specific memory T cells in the vaccine recipients.
ï‚· Characterization of the gut microbiome composition and richness.
|
Uganda |
2021-03-05 |
2024-03-05 |
Medical and Health Sciences |
|
Non-degree Award |
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Esther Buregyeya
ID: UNCST-2020-R014116
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USING SHORT MESSAGE SERVICE REMINDERS AND MOBILE MONEY INCENTIVES TO ENHANCE LINKAGE TO CARE OF PRESUMPTIVE TUBERCULOSIS PATIENTS IN UGANDA: A RANDOMISED CONTROLLED TRIAL
REFNo: HS993ES
To evaluate the TB diagnostic process and linkage to care by doing cohort analysis.
2. Develop and adapt an SMS reminders and MM incentives to improve linkage to care among TB patients.
3. Conduct a randomized controlled trial of SMS reminders and MM incentives sent to presumptive and confirmed TB patients to improve linkage to care and treatment.
4. To build sustainable capacity in TB research clinical trials in Uganda.
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Uganda |
2021-03-05 |
2024-03-05 |
Medical and Health Sciences |
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Non-degree Award |
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Jude Onyango Tadeo
ID:
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FAMILY SUPPORT, DIABETES SELF-MANAGEMENT, AND GLYCEMIC CONTROL AMONG PATIENTS ATTENDING DIABETIC CLINICS OF REGIONAL REFERRAL HOSPITALS IN EASTERN UGANDA (FS-DSM-GC STUDY)
REFNo: HS1040ES
Research Study objectives:
General objective:
To examine the association between perceived family support, diabetes self-management behavior and glycemic control among patients attending Regional Referral hospitals in the eastern region of Uganda.
Specific objectives:
1. To determine the association between perceived family support and diabetes self-management behavior among patients attending outpatient clinics of Regional Referral Hospitals in the eastern region of Uganda.
2. To determine association between perceived family support and glycemic control among patients attending outpatient clinics of Regional Referral Hospitals in the eastern region of Uganda.
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Uganda |
2021-03-05 |
2024-03-05 |
Medical and Health Sciences |
|
Non-degree Award |
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Jonathan Mayito
ID:
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Utility of the monocyte to lymphocyte ratio in diagnosing latent tuberculosis among HIV-infected individuals with a negative tuberculosis symptom screen.
REFNo: HS1066ES
1. To determine the diagnostic performance of the monocyte to lymphocyte ratio against IGRA in diagnosing latent TB among HIV-infected individuals with a negative tuberculosis symptom screen.
2. To determine the change in the monocytes to lymphocytes ratio measured at baseline, and three months among HIV-infected individuals during tuberculosis preventive therapy.
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Uganda |
2021-03-05 |
2024-03-05 |
Medical and Health Sciences |
|
Non-degree Award |
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Namulema Edith
ID:
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Evaluation of the Safety and Tolerability of the ‘LeVe CPAP Flow Generator’ in Healthy Volunteers at Mengo Hospital in Kampala Uganda
REFNo: HS1250ES
To determine the safety, tolerability and acceptability of the LeVe CPAP Flow Generator’ among healthy volunteers at Mengo Hospital and to ensure they do not cause harm.
|
Uganda |
2021-03-05 |
2024-03-05 |
Medical and Health Sciences |
|
Non-degree Award |
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Patrice Mawa Akusa
ID:
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Establishing a pool of school-going adolescent girls and boys as immunisation ambassadors in Entebbe, Uganda
REFNo: HS1215ES
Overall rationale
One way of engaging and empowering mothers and communities and linking them to immunisation services is by use of their own daughters and sons. The relationship between mother and her daughter is full of learning experiences and one of the strongest bonds.
Mothers also have emotional relationship with their sons and will likely listen to them.
Objectives
The objective of the project is to establish a pool of school-going adolescent girls and boys as‘immunisation ambassadors’ and change agents able to engage and empower mothers and community members and link them to maternal and neonatal immunisation services by training them on vaccines and leadership skills.
|
Uganda |
2021-03-03 |
2024-03-03 |
Medical and Health Sciences |
|
Non-degree Award |
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Sylvia Nabukenya
ID: UNCST-2019-R000906
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UNDERSTANDING STAKEHOLDER PERSPECTIVES, PREFERENCES AND EXPERIENCES FOR THE RETURN OF PHARMACOGENOMICS RESEARCH RESULTS AMONG PEOPLE LIVING WITH HIV AIDS.
REFNo: SS735ES
GENERAL OBJECTIVE
To explore stakeholder perspectives, preferences and experiences in contribution to development of locally contextualized institutional guidelines for returning individual pharmacogenomics research results to people living with HIV.
SPECIFIC OBJECTIVES
1. To explore stakeholders’ attitudes, perspectives and experiences towards the return of individual pharmacogenomics research results among people living with HIV.
2. To determine factors that influence decisional preferences for receiving individual pharmacogenomics research results among people living with HIV
3. To develop institutional guidelines for the return of individual pharmacogenomics research results to research participants.
|
Uganda |
2021-03-03 |
2024-03-03 |
Social Science and Humanities |
|
Degree Award |
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Patrice Mawa Akusa
ID:
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Exploring immune responses in primary and more advanced Schistosoma mansoni infection and treatment of preschool-age children using Aurora spectral flow cytometry
REFNo: HS1223ES
Objective 1: To characterize immune responses of PSAC in primary and more advanced S. mansoni infection
Objective 2: To determine the effect of PZQ treatment of S. mansoni on immune responses in PSAC.
|
Uganda |
2021-03-03 |
2024-03-03 |
Medical and Health Sciences |
|
Non-degree Award |
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LYDIA NAKIGANDA JACENTA
ID:
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Demographic characteristics, attitudes, behaviours and sexually transmitted infections among female sex workers using HIV Pre- Exposure Prophylaxis living in the fishing communities around Lake Victoria Basin, Uganda.
REFNo: HS813ES
i.To define demographic characteristics
ii.To explore sexual behaviours, in association with PrEP prescription,
iii. To explore self-reported adherence rates and correlates of adherence
iv. To examine the STI disease burden, use of condoms and explore associations between condom use and STIs.
v. To explore factors that might facilitate or challenge PrEP use, such as side effects and stigma, and
vi. To understand FSWs’ experiences, perceptions of & attitudes towards PrEP
|
Uganda |
2021-03-01 |
2024-03-01 |
Medical and Health Sciences |
|
Degree Award |
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Jaffer Okiring
ID:
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Increasing malaria trends amidst routine core interventions among residents of varying transmission settings of Uganda
REFNo: HS1033ES
1) To compare the malaria trends measured using Test Positivity Rate and Total laboratory confirmed cases of malaria relative to incidence in high malaria settings in Uganda
2) To determine household level factors associated with malaria incidence at 68 sites with varying malaria transmission intensity.
3) To investigate the environmental factors associated with malaria incidence and how these factors modify the impact of core vector control interventions in Uganda
4) To develop a model that can predict malaria incidence in different epidemiological settings and how the incidence will vary with the roll out of different core interventions in Uganda.
|
Uganda |
2021-03-01 |
2024-03-01 |
Medical and Health Sciences |
|
Degree Award |
|
Elizeus Rutebemberwa
ID: UNCST-2022-R009070
|
Evaluation and Scale-up Strategy for the Doctor@Distance Programme in Uganda
REFNo: HS955ES
4.3 General objective
To evaluate the Doctor@Distance programme by identifying current benefits and gaps and exploring the path for further development of the programme and potential embedment of the programme in the larger health system.
4.4 Specific objectives
1.To explore what the multi-stakeholder perceptions are on the design and daily practice of the Doctor@Distance programme
2.To analyse the design and current utilisation of the Doctor@Distance programme and identify potential gaps in its coverage (how often is it used, by whom, for which diseases, etc.)
3.To evaluate the current healthcare gaps in the communities in which the community health entrepreneurs of the Doctor@Distance programme are active
4.To explore how the Doctor@Distance programme can be scaled-up to other districts within Uganda
5.To investigate multi-stakeholder perceptions on the possibility of integration of the Doctor@Distance programme in the larger health system in Uganda
|
Uganda |
2021-03-01 |
2024-03-01 |
Medical and Health Sciences |
|
Non-degree Award |
|
Richard Nyeko
ID: UNCST-2021-R012815
|
Pre-hospital exposure to, and antimicrobial drug resistance patterns among febrile children presenting to St. Mary’s Hospital Lacor, northern Uganda
REFNo: HS1091ES
General objective
To determine the prevalence of pre-hospital exposures to antibiotics, common bacteria and their susceptibility to microbial drugs among febrile children presenting to a tertiary health facility in northern Uganda.
Specific objectives
1. To determine the prevalence of pre-hospital exposures to antibiotics among febrile children presenting at St Mary’s Hospital Lacor
2. To establish the common bacterial isolates among febrile children presenting at St Mary’s Hospital Lacor
3. To determine the microbial resistance patterns among febrile children presenting at St Mary’s Hospital Lacor
|
Uganda |
2021-03-01 |
2024-03-01 |
Medical and Health Sciences |
|
Non-degree Award |
|
Aidah Nanvuma
ID: UNCST-2024-R015734
|
EVALUATING THE CAPACITY BUILDING MODEL USED TO NURTURE INDEPENDENT RESEARCH INVESTIGATORS AT THE INFECTIOUS DISEASES INSTITUTE, UGANDA
REFNo: HS1100ES
Objective 1: To describe Capacity Building Unit support activities and scholarly outputs and outcomes since inception.
Objective 2: To determine how particular components of the unit scientific and non-scientific support(Inputs) contribute to scholar (past and present) outputs and outcomes since inception.
Objective 3: To identify and address areas of improvement in unit support activities through the engagement of current and former stakeholders (beneficiaries and benefactors).
|
Uganda |
2021-03-01 |
2024-03-01 |
Medical and Health Sciences |
|
Non-degree Award |
|
Moses Joloba Lutaakome
ID: UNCST-2022-R011558
|
A Study to Validate and Improve an Automated Image Analysis Algorithm to Detect Tuberculosis in Sputum Smear Slides: Version 1.0 dated Nov 2020
REFNo: HS1144ES
1. Validate the platform, and assess efficiency improvements from computerized detection approaches.
a. Perform a slide specimen digitization (400 slides, 98 images/slide, 39,200 images).
b. Classify all images as dark/medium/light based on color histogram data.
c. Assess accuracy vs. manual microscopy, and sensitivity/specificity vs. bacterial culture.
d. Develop a new image analysis algorithm by integrating software applications that include Artificial Intelligence (AI) approaches via Convolutional Neural Networks (CNN).
2. Quantify slide staining quality and variability through the use of novel methods which exploit the color spectra of stained slides.
a. Determine factors which led to poor slide preparation.
b. Test a new quality control method (HistoQC) to standardize clinical slide preparations
|
Uganda |
2021-03-01 |
2024-03-01 |
Medical and Health Sciences |
|
Non-degree Award |
|
THOMSON LAKWO LURONI
ID: UNCST-2023-R007843
|
Evaluation of the Diagnostic Tests in Areas Hypoendemic for Onchocerciasis –Uganda: a follow-up study.
REFNo: HS1220ES
Objective 1: Evaluate the distribution of anti-OV-16 antibody and other markers of O. volvulus infection in multiple age groups over time in an area of active intervention for onchocerciasis
Objective 2: To determine whether a serologic threshold of 2% that modeling suggested is consistent with interruption of transmission.
Objective 3: Monitor for sero-reversion of OV-16 antibody positivity in a nested cohort of individuals who participated in the previous study.
|
Uganda |
2021-03-01 |
2024-03-01 |
Medical and Health Sciences |
|
Non-degree Award |
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