Carolyne Onyango
ID:
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Re-Calibration of Quantitative and Contextual Factors to Predict Child Cognitive Deficits in HIV-Exposed Children in the PROMISE/PROMOTE Study Cohorts (CD PROMOTE Study) Version 2.0, dated 08 March 2020
REFNo: HS795ES
1. To identify clinical, maternal, home-environment factors that are associated with the risk of CD among HIV exposed but uninfected children.
2. To develop a CD risk prediction tool for HIV exposed uninfected children informed by identified risk factors observed in Aim 1 and existing literature
|
Uganda |
2020-12-18 |
2023-12-18 |
Medical and Health Sciences |
|
Non-degree Award |
|
Bruce Twinamasiko
ID:
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FEASIBILITY OF A COMMUNITY HEALTH WORKER-LED INTERVENTION TO CONTROL HIGH BLOOD PRESSURE IN SOUTHWESTERN UGANDA: A PILOT PRAGMATIC CLUSTER RANDOMIZED TRIAL (CHIP TRIAL)
REFNo: HS881ES
1.To test whether a multifaceted intervention program will lead to blood pressure control among patients with uncontrolled blood pressure over a 12-month period compared to usual care.
2.To evaluate whether a multifaceted intervention program will improve hypertension control among hypertensive patients over a 12-month period, compared to usual care.
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Uganda |
2020-12-18 |
2023-12-18 |
Medical and Health Sciences |
|
Non-degree Award |
|
Grace Ndeezi
ID: UNCST-2019-R001802
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Effect of Vitamin D supplementation on Sickle cell disease hospitalisation and related complications among Children in Mulago Hospital: A randomised clinical trial
REFNo: HS985ES
Objectives
The overarching goal for this study is to evaluate whether vitamin D supplementation can decrease the need for hospitalisations in Ugandan children with SCD
Primary objectives:
1. To determine the frequency of hospitalisation among children with SCD supplemented with vitamin D versus placebo.
2. To determine the effect of vitamin supplementation on serum levels of 25 Hydroxyvitamin D levels in children with SCD
Secondary objectives:
To determine the:
1. Incidence of vaso-occlusive crises (VOC)
2. Incidence of acute severe respiratory illnesses
3. Severe adverse events
4. Requirements for blood transfusion among children supplemented with vitamin D versus Placebo in children with sickle cell anaemia
|
Uganda |
2020-12-18 |
2023-12-18 |
Medical and Health Sciences |
|
Non-degree Award |
|
Tumuhairwe Juliet
ID:
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The Challenge Initiatives Approach to City engagement – Coaching case study
REFNo: SS645ES
This study is meant to explore the successes, challenges and innovations of The Challenge Initiative’s (TCI) coaching model
Specific objectives
1. Document the intensity and focus of TCI coaching to-date, including which high-impact approaches governments most commonly request coaching for, how often, and what their impact has been.
2. Explore how local governments and service providers perceive the TCI coaching model, including, whether they believe it has been beneficial, and if so, how.
3. Understand if TCI’s coaching has led to system strengthening and improvements in the healthcare system both related to family planning and AYSRH service delivery, but also beyond. Additionally, document which system strengthening elements of coaching are most notable to TCI beneficiaries.
4. Document the ways in which TCI’s coaching has worked well and, perhaps, not worked as planned. Use this information to develop recommendations for how TCI can strengthen its coaching model.
5. Understand how the TCI coaching model can be sustained by TCI supported geographies even after a city ‘graduates’ from TCI (i.e., achieves program success and certain milestones, indicating the city no longer needs TCI’s support)
|
Uganda |
2020-12-18 |
2023-12-18 |
Social Science and Humanities |
|
Non-degree Award |
|
Diana Ntamu Nandagire
ID:
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Small and Growing Businesses: A Segmentation Study in Uganda and Nigeria
REFNo: SS647ES
The purpose of the study is to test Dalberg’s segmentation framework of small and growing businesses (SGBs) by determining the effectiveness of that framework. By testing the framework, “maps†shall be created, funding gaps shall be established and recommendations made for the two African countries (Uganda and Nigeria).
The study will be guided by the following objectives;
a) To determine the extent to which the Dalberg framework defines SGBs in Uganda and Nigeria.
b) To establish the reasons why SGBs seek financing in their operations and the challenges in accessing funding.
c) To identify organisations that invest in SGBs and establish the proportion of their portfolio dedicated to SGBs.
d) To establish the total capital available in funding organisations to SGBs.
e) To establish the challenges of investing in SGBs.
|
Uganda |
2020-12-18 |
2023-12-18 |
Social Science and Humanities |
|
Non-degree Award |
|
Florence Nassiwa
ID:
|
Effect of climate variability adaptation strategies on livelihood of smallholder vegetable farmers in Kampala District Uganda
REFNo: SS649ES
i. To establish the effect of technological development adaptation strategies on livelihood of smallholder vegetable farmers.
ii. To determine the effect of government programs and insurance adaptation strategies on livelihood of smallholder vegetable farmers.
iii. To assess the effect of farm production adaptation strategies on livelihood of smallholder vegetable farmers
iv. To establish the effect of farm financial management adaptation strategies on livelihood of smallholder vegetable farmers.
v. To evaluate constraints smallholder vegetable farmers encounter in adapting to climate variability.
|
Uganda |
2020-12-18 |
2023-12-18 |
Social Science and Humanities |
|
Degree Award |
|
Kamya Moses
ID: UNCST-2020-R014203
|
Impact of housing modifications combined with piperonyl butoxide (PBO) long-lasting insecticidal nets (LLINs) on the malaria burden in Uganda: a cluster-randomised trial
REFNo: HS1072ES
Primary Objective;
To evaluate the effect of housing modifications plus PBO LLINs, compared to PBO LLINs alone, on the incidence of clinical malaria in Ugandan children aged < 60 months
Secondary Objectives;
1) Epidemiology: To assess the impact of housing modifications + PBO LLINs, compared to PBO LLINs alone, on (1) parasite prevalence, and (2) prevalence of anaemia in children 6m-14y
2) Entomology: To assess the impact of housing modifications + PBO LLINs, compared to PBO LLINs alone, on (1) indoor and outdoor densities of malaria vectors; (2) entomological inoculation rate (EIR); (3) human biting rates (indoor and outdoor); and (4) To evaluate the patterns of insecticide resistance through the phenotypic and molecular detection methods, in mosquito vectors from clusters with housing modification + PBO LLINs, compared to PBO LLINs alone
3) Housing modifications: (1) To understand the local context regarding housing; (2) To assess acceptability of the housing modification interventions quantitatively, among the cohort members and the community, over time; (3) To assess acceptability of the housing modification interventions through qualitative research among the community opinion leaders and members, in both intervention and control clusters, over time; (4) To assess durability of housing modification interventions; (5) To assess environmental measures in houses with modifications + PBO LLINs; (6) To assess feasibility of housing modification including labour and materials, maintenance requirements, time required; (7) To conduct a process evaluation of the interventions, by developing a logic model, assessing the implementation of the housing modifications, and examining the mechanisms of effect
4) Economics: (1) To measure cost-effectiveness of housing modifications + PBO LLINs, compared to PBO LLINs alone, under research conditions; (2) To cost the different components of the interventions and identify factors contributing to major costs; (3) To estimate potential cost of providing housing interventions at scale over longer periods of time.
|
Uganda |
2020-12-18 |
2023-12-18 |
Medical and Health Sciences |
|
Non-degree Award |
|
Elly Katabira
ID:
|
REDUCING STROKE BURDEN IN UGANDA USING TARGETED MANAGEMENT INTERVENTION (TEAM). A RANDOMISED, PROSPECTIVE 6 – MONTH CONTROLLED TRIAL.
REFNo: HS1094ES
Objective 1: To refine the TEAM curriculum for optimal acceptability and integration in the Ugandan setting guided by input from stakeholders (patients/family, clinicians, administrators).
Objective 2: To conduct an RCT comparing efficacy of TEAM vs. enhanced treatment as usual (ETAU) in 246 Ugandans (TEAM, N= 123; ETAU, N= 123) at high risk for stroke.
Objective 3: Identify barriers and facilitators to TEAM implementation.
|
Uganda |
2020-12-18 |
2023-12-18 |
Medical and Health Sciences |
|
Non-degree Award |
|
Joseph Lutaakome
ID: UNCST-2020-R008323
|
A Multicenter, Adaptive, Randomized, Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for Hospitalized Patients with COVID-19
REFNo: HS1099ES
SARS-CoV-2 is a novel coronavirus causing COVID-19 and has spread very rapidly. Safe and effective treatments are urgently needed. One antiviral treatment, remdesivir, and an anti-inflammatory drug, dexamethasone, have shown benefit; these are now the COVID-19 standard-of-care treatment for in patients in many parts of the world. The structure of the natural antibodies that hasten recovery from COVID-19 are now known; this means synthetic forms have been manufactured. These synthetic neutralising monoclonal antibodies (nMAb) ‘neutralise’ the virus by binding to it and prevent it from entering cells in the body, including the lungs. By giving an infusion of these nMAb(s) in addition to COVID-19 standard-of-care treatment, we hope hospitalised patients will recover more quickly.
The primary endpoint of TICO is to test whether in hospitalized adults with confirmed COVID-19 infection, the nMAb(s) result in more people with ‘sustained’ recovery i.e. discharged from hospital, alive, and home for 14 consecutive days by Day 90.
1) For everyone enrolled during stage 1 and 2 of the trial the secondary research questions are to define, the numbers of deaths through 90 days of follow-up; the number of people who experience sustained recovery over 90 days, the time to discharge from the initial hospital, and the number of days alive up to day 90.
2) Changes in the scores to assess people’s lung and respiratory function on Days 1-7, and Days 14 and 28.
3) Changes between Day 0 and Day 5 in the National Early Warning (NEW) score, this is a scoring system validated in the UK, which is able to score how sick people are, and their risk of dying, based on things like their blood pressure, pulse rate and body temperature.
4) Clinical organ failure defined by development of any one or more of the following through Day 28
a. Respiratory system dysfunction including the need for oxygen therapy or ventilation
b. Cardiac problems include heart attacks and heart failure
c. Low blood pressure requiring drug support to maintain it
d. kidney dysfunction including needing dialysis
e. liver dysfunction including liver failure and abnormal liver tests
f. Brain and nerve problems including acute confusion, strokes, brain swelling, meningitis, and weakness of the legs
g. Blood problems including major bleeding
h. thrombotic events in the veins or arteries
i. Serious infections including sepsis.
5) Safety and tolerability as measured by: grade 3 and 4 clinical adverse events, serious adverse events, or death through Day 5 and through Day 28; Infusion-related reactions of any severity and the percentage of participants for whom the infusion was interrupted or stopped prior to completion.
6) Change in the levels and types of antibodies against COVID-19, from baseline to Days 1, 3, 5 and 28 and 90.
|
Uganda |
2020-12-18 |
2023-12-18 |
Medical and Health Sciences |
|
Non-degree Award |
|
Patrick Wakida
ID:
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MARKET RESEARCH STUDY TO UNDERSTAND THE MARKET POTENTIAL FOR CANCER TESTING EQUIPMENT IN UGANDA
REFNo: SS679ES
i. To understand current diagnostic and treatment pathways in breast cancer.
ii. To gain an understanding of breast cancer management including mapping diagnostic and treatment pathways
iii. To understand the processes and challenges of penetrating the invitro diagnostics products market the Uganda.
iv. To determine the need for molecular invitro diagnostics product In Uganda
|
Uganda |
2020-12-18 |
2023-12-18 |
Social Science and Humanities |
|
Non-degree Award |
|
Nelson Sewankambo K
ID: UNCST-2020-R014578
|
Feasibility and acceptability of Dialog+ in Primary care-Uganda
REFNo: HS1116ES
i. test the feasibility and acceptability of DIALOG+ for patients with non-communicable physical health conditions in primary care
ii. explore the adaption of Dialog+ intervention through a process of stakeholder consultation and refine the training materials to promote wider implementation and upscale
iii. explore the effect of using the adapted Dialog+ intervention on patient outcomes
|
Uganda |
2020-12-18 |
2023-12-18 |
Medical and Health Sciences |
|
Non-degree Award |
|
Catherine Mwesigwa
ID: UNCST-2019-R000988
|
FEASIBILITY OF INTEGRATING ORAL HEALTH IN THE PRIMARY CARE OF HIV PEDIATRIC PATIENTS IN KAMPALA, UGANDA
REFNo: HS1055ES
1. To determine the factors that influence integrating oral health at pediatric HIV care facilities.
2. To assess the effectiveness of an oral health education intervention in pediatric HIV care.
3. To explore the feasibility of integrating oral health within primary HIV-care in a low-resource setting
|
Uganda |
2020-12-17 |
2023-12-17 |
Medical and Health Sciences |
|
Non-degree Award |
|
Nazarius Tumwesigye Mbona
ID: UNCST-2019-R000664
|
Research Protocol for the Impact and Economic Evaluation of Health Systems Strengthening Interventions in the West Nile region of Uganda
REFNo: HS1110ES
To determine the status and associated factors (i. DHSS intervention, ii. Quality of Care, iii. SBCC) of coverage of maternal and child health and nutrition services in intervention and counterfactual districts during 2019
2: To determine the status and associated factors (i. DHSS intervention, ii. Quality of Care, iii. SBCC) of use of maternal and child health and nutrition services in intervention and counterfactual districts during 2019
3: To determine the differences and the associated factors (i. DHSS intervention, ii. Quality of Care, iii. SBCC) of the change in coverage of maternal and child health and nutrition services from 2019 to 2024 between intervention and counterfactual districts
4: To determine the differences and the associated factors (i. DHSS intervention, ii. Quality of Care, iii. SBCC) of the change in use of maternal and child health and nutrition services from 2019 to 2024 between intervention and counterfactual districts
5: To establish the cost and effectiveness of DHSS, quality improvement and SBCC in the use and coverage of maternal and child health and nutrition services from 2019-2024
|
Uganda |
2020-12-17 |
2023-12-17 |
Medical and Health Sciences |
|
Non-degree Award |
|
Grace Kaisa Tibagwa
ID:
|
Analysing routine patient data collected through the LifeHealth Network for trends of clinical and public health importance
REFNo: HS1007ES
To analyse data of patients with infectious diseases (such as malaria, HIV, TB), non-communicable diseases (such as cancer, diabetes) and serious health conditions (such as sickle cell anaemia) subscribing to the LifeHealth model for any trends of clinical and public health importance.
|
Uganda |
2020-12-16 |
2023-12-16 |
Medical and Health Sciences |
|
Non-degree Award |
|
Viola Nyakato Nilah
ID: UNCST-2021-R013698
|
Sexual and reproductive health and wellbeing during COVID-19: A study protocol for online national surveys and global comparative analyses
REFNo: SS560ES
The overall goal of this global study is to better understand sexual and reproductive health among adults during COVID-19 using an online convenience sample from 23 countries. The primary study aims are listed below:
1) To determine the impact of COVID-19 social restriction measures on sexual health, with a focus on safe sex practices
2) To determine the impact of COVID-19 social restriction measures on domestic violence, with a focus on gender-based violence
3) To determine the impact of COVID-19 social restriction measures on access to essential reproductive health commodities and services, including contraceptives, abortion, maternal health services
Secondary study aims including the following:
1) To determine the impact of COVID-19 social restriction measures on mental health
2) To determine the impact of COVID-19 social restriction measures on harmful cultural practices
3) To determine the impact of COVID-19 social restriction measures on STI and HIV/AIDS testing and treatment
4) To determine the impact of COVID-19 social restriction measures on nutrition
|
Uganda |
2020-12-16 |
2023-12-16 |
Social Science and Humanities |
|
Non-degree Award |
|
Musa Sekikubo
ID: UNCST-2020-R014404
|
Understanding COVID-19 in pregnant women and their babies in Uganda
REFNo: HS913ES
Primary objectives
• To describe the seroepidemiology of COVID-19 among pregnant women in Uganda
• To assess the risk of COVID-19 in newborn infants born to pregnant women with confirmed or probable COVID-19 and determine possible routes of mother-to-child transmission
• Secondary objectives
• To determine the clinical course and pregnancy outcomes in women infected with SARS-CoV-2 during pregnancy
• To determine the presence of SARS-CoV-2 in various mother and baby samples (serum, throat and nasal swabs, vaginal swab, placenta swabs and biopsies, and breast milk) and estimate the duration of viral excretion
• To assess the immune responses to SARS-CoV-2 in pregnant women and their babies
• To work with communities to understand perceptions surrounding infection prevention and control techniques to reduce the spread of COVID-19 amongst the pregnant population
|
Uganda |
2020-12-16 |
2023-12-16 |
Medical and Health Sciences |
|
Non-degree Award |
|
Mark Jordans
ID: UNCST-2020-R014861
|
Quasi-experimental study of a group-based psychosocial support intervention (movement-based activities “TeamUpâ€) for children affected by conflict and adversity in Uganda
REFNo: HS941ES
The aim of this quasi-experimental study is to evaluate the outcomes of the TeamUp intervention for children aged 10-14 years attending community primary schools, compared to a standard of care.
|
Netherlands |
2020-12-16 |
2023-12-16 |
Medical and Health Sciences |
|
Degree Award |
|
Jolly Beyeza-Kashesya
ID:
|
mHealth for Improvement of Access to Maternal Health Services in the Era of Covid-19 Pandemic (SMS Maama Project)
REFNo: HS1076ES
Primary objective:
Assess whether a mHealth platform increases maternal health knowledge in the areas of birth preparedness, pregnancy and birth complications as measured by the pre- and post- survey.
Secondary objectives:
1. To provide knowledge of COVID-19 symptoms, transmission, diagnosis, and treatment, in a time of social distancing and learn
2. To improve access and linkages to maternal health services and information as well as provide appropriate referrals for pregnant women.
3. To inform the adoption of mHealth into future health delivery plans.
|
Uganda |
2020-12-16 |
2023-12-16 |
Medical and Health Sciences |
|
Non-degree Award |
|
Rawlance Ndejjo
ID: UNCST-2022-R010993
|
Sustainable health and multisectoral collaborations in Uganda in the COVID-19 response and post-recovery period
REFNo: HS1107ES
• To explore perspectives of key stakeholders around sustainable health and multisectoral collaborations in Uganda in the context of COVID-19 and post-COVID-19 recovery period.
• To establish the gaps around sustainable health and multisectoral collaborations in Uganda in the context of COVID-19 and post-COVID-19 recovery period.
• To explore the opportunities around sustainable health and multisectoral collaborations in Uganda in the context of COVID-19 and post-COVID-19 recovery period.
• To identify the needs around sustainable health and multisectoral collaborations in Uganda in the context of COVID-19 and post-COVID-19 recovery period.
|
Uganda |
2020-12-16 |
2023-12-16 |
Medical and Health Sciences |
|
Non-degree Award |
|
Fred Kyeyune
ID:
|
Development of Assays for Mass screening of Sars Cov-2 infections in communities
REFNo: HS1114ES
1:To develop and optimize highly sensitive assays (index assays) for mass screening of Sars Cov-2: two types of assays will be developed: 1) assays that improve the limit of detection (LOD) of Sars Cov-2 by LAMP, q PCR and Next Generation sequencing assays 2) Low cost sequence specific assay for testing of Sars Cov-2 vrius
2: To perform a comparative analysis of the above assays to the Gold standard
assay for detection of Sars Cov-2.
Aim 3: To assess the index assays and gold standard assays for mass screening of Sars Cov-2 infections.
|
Uganda |
2020-12-16 |
2023-12-16 |
Medical and Health Sciences |
|
Non-degree Award |
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