Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Adam Hewitt Smith
ID: UNCST-2019-R001658
Family SuppleMented pAtient monitoRing afTEr suRgery (SMARTER) pilot trial
REFNo: HS944ES

To develop a training and support intervention, in accordance with the MRC complex intervention framework, to train family carers to perform and document basic vital signs, to supplement routine monitoring of patients by nursing staff, whilst they provide personal care to their relatives after surgery and to evaluate the effect of this intervention on frequency of documented vital signs for patients in the first three days after surgery in a stepped-wedge cluster trial.
To evaluate compliance with the trial intervention, and how this changes over the duration of the trial.
To evaluate the effect of the intervention on in-patient mortality, to inform the design of a subsequent international clinical trial across Africa
UK 2021-03-23 2024-03-23 Medical and Health Sciences Degree Award
Robin NESBITT Clark
ID:
Impact of COVID-19 on HIV and TB patient care in Malawi and Uganda
REFNo: HS1218ES

To describe the impact of COVID-19 and the public health measures to control the spread of COVID-19, on HIV and TB patients and their care in the MSF projects in Chiradzulu, Malawi and Arua, Uganda, including patient perspectives and perceptions.
Canada 2021-03-23 2024-03-23 Medical and Health Sciences Non-degree Award
Victoria Nankabirwa
ID: UNCST-2021-R011871
Pilot Randomized Controlled trial: Preventing infant Malnutrition (PrIM)
REFNo: HS1226ES

Primary Objective
To determine the effect of early small volume supplementation (ESVS) on weight-for-age Z-scores (WAZ) at 30 days of age.
Secondary Objectives
1. To determine the effect of ESVS on WLZ at 30 days of age.
2. To determine the effect of ESVS on WAZ, WLZ, and LAZ through 6 months
of age.
3. To measure the effect of ESVS on breastfeeding duration through 6 months of
age.
4. To determine the effect of ESVS on intestinal microbiota at 30 days of age.
Uganda 2021-03-23 2024-03-23 Medical and Health Sciences Non-degree Award
Catherine Barasa Asekenye
ID:
Development of community-led approaches to support sexual and reproductive health among survivors of trafficking in Uganda
REFNo: SS746ES

1. Define survivor-led SRH priorities
2. Identify gaps in addressing priorities as identified by survivors and local healthcare providers
3. Test the methodological suitability of two participatory approaches (Photovoice and participatory action research) as transformative methods
4. Bring together stakeholders working with communities of survivors, and based on objectives 1–3, develop a Phase II intervention that supports transformative participatory research approaches among communities of survivors and works with local healthcare providers to provide integrated SRH, as per the needs and expectations of survivors
Uganda 2021-03-23 2024-03-23 Social Science and Humanities Non-degree Award
Dennis Muhanguzi
ID: UNCST-2019-R001101
Prevalence and Economic Importance of Key Endemic Livestock Diseases in Kaabong and Amudat Districts, Karamoja Region
REFNo: NS163ES

The specific objectives of this project will be to determine: -
i.Sero-prevalence of FMD, CBPP and CCPP in Amudat and Kaabong districts, Karamoja region
ii.Prevalence of Tick-borne hemoparasites [TBHs] in cattle populations from Amudat and Kaabong districts, Karamoja region
iii.Prevalence of helminths Species of Veterinary importance in Amudat and Kaabong districts, Karamoja region
iv.Estimates of the socioeconomic impact of FMD, CBPP and CCPP in Amudat and Kaabong districts, Karamoja region
v.Estimates of the socioeconomic impact of TBHs in Amudat and Kaabong districts, Karamoja region
vi.Estimates of the socioeconomic impact of different helminths Species of Veterinary importance in Amudat and Kaabong districts, Karamoja region
Uganda 2021-03-23 2024-03-23 Natural Sciences Non-degree Award
Andrew Mujugira
ID: UNCST-2019-R000871
PrEP Persistence and Risk of HIV and Sexually Transmitted Infections among Transgender Men in Uganda
REFNo: HS990ES

Aim 1: Characterize HIV and STI prevalence and risk among trans men Aim 2: Evaluate PrEP uptake and persistence among HIV-negative trans men Aim 3: Explore sexual health experiences and risk behaviours of trans men in Uganda
Uganda 2021-03-22 2024-03-22 Medical and Health Sciences Non-degree Award
Justin Willis
ID:
Uganda’s past, Uganda futures: debates over government, equality and justice, 1979-80
REFNo: SS473ES

· The building of an interdisciplinary research team that demonstrates the relevance of study of the past through a co-produced programme of research and capacity-building;
· Providing a cohort of early-career Ugandan scholars with mentored experience in the techniques of researching the past through interdisciplinary methods, academic writing, and writing for non-academic audiences;
· Producing a published volume showcasing the work of the team;
· Publishing a project blog presenting key findings of the research to non-academic audienc-es
· Creating media outputs that widen the audience and impact of the research
· Presenting the research to civil society organizations, policy makers and a wider audience through a final mini-conference
· The development of one or more applications for further external funding that will enable the career progression of these researchers and the sustainability of the network

UK 2021-03-19 2024-03-19 Social Science and Humanities Non-degree Award
Ponsiano Ocama
ID: UNCST-2019-R000440
Obesogenic Impact of Dolutegravir-based Antiretroviral Therapy among HIV-Infected Ugandans
REFNo: HS1029ES

The primary aim is to rigorously investigate the obesogenic effects of DTG switches including: 1. Body composition changes, using body mass index (BMI) and anthropometrics and whole body DXA to measure lean and fat mass (including whole body, trunk, and limb). 2. Ectopic fat changes, emphasizing hepatic fat as measured noninvasively using the continuous attenuation parameter (CAP) measured in dB/m by FibroScan. 3. Cardiometabolic changes, through measurement of HOMA-IR, hemoglobin (Hb)A1c, and fasting lipid panel. We will also explore a major potential mechanism of INSTIrelated weight gain by measuring orexigenic (ghrelin, adiponectin) and anorexigenic (leptin, PYY) hormones, which have been implicated in the pathogenesis of antipsychotic related weight gain, as well as weight loss related to bariatric surgery
Uganda 2021-03-18 2024-03-18 Medical and Health Sciences Non-degree Award
Aisa Muhamad
ID:
Rewards Management and Performance of Selected Secondary Schools in the Central Region of Uganda
REFNo: SS713ES

i) To establishthe rewards provided in theselected secondary schools in central region of Uganda.
ii) To examine the relationship between monetary rewards andthe performance of secondary schools in central region of Uganda.
iii) To examine therelationships ofnon-monetary tangible rewardsand the performance of secondary schools in central region of Uganda.
iv) To establish the relationships ofnon-monetary intangible rewards and the performance of secondary schools in central region of Uganda.
v) To examine the level of school performance in the selected secondary schools in central region of Uganda.

Uganda 2021-03-18 2024-03-18 Social Science and Humanities Degree Award
Andrew Mujugira
ID: UNCST-2019-R000871
Formative research to guide PrEP delivery within harm reduction services for people who use drugs in Uganda
REFNo: HS1202ES

Aim 1. To explore experiences with and willingness for PrEP for PWUD:
a.among PWUD in Kampala, Uganda, explore willingness to use PrEP.
b.among providers of oral PrEP and services for PWUD in Kampala, Uganda, explore willingness to prescribe PrEP

Aim 2. To explore experiences during the COVID-19 pandemic with regards to:
a.accessing services by PWUD
b.providing services for mental health, substance use, HIV prevention, and social services by harm reduction providers
Uganda 2021-03-18 2024-03-18 Medical and Health Sciences Non-degree Award
ABDUL WALUSANSA
ID:
Drug Resistant Bacterial Contamination and Efficacy of Selected Herbal Medicines Sold in Kampala, Uganda
REFNo: HS1278ES

The broader aim of this study is examining the prevalence, antibiotic susceptibility, resistance genes in bacterial contaminants, and the antibacterial efficacy of selected herbal medicines sold in Kampala, in order to contribute to the mitigation of AMR.,To determine the antibacterial efficacy of some herbal medicines against selected drug-resistant bacterial isolates in Kampala. ,To examine the risk factors for bacterial contamination of herbal medicines sold in Kampala, Uganda ,To determine antibiotic resistance genes in multi-drug resistant bacteria isolated from herbal medicines sold in Kampala.,To determine the prevalence and antibiotic susceptibility of pathogenic bacterial contaminants such as, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Salmonella spp, Shigella spp, and Clostridium perfringens in herbal medicines sold in Kampala.,
Uganda 2021-03-18 2024-03-18 Medical and Health Sciences Degree Award
Francis Kombe Kazungu
ID:
Implications of fieldworkers’ institutional support systems for research integrity practices in Africa
REFNo: SS760ES

i) Describe and analyse the existing literature, including concepts and theories related to fieldworkers’ institutional support systems and policies
ii) Identify and describe existing fieldworkers' institutional support systems at the participating research institutions.
iii) Critically evaluate how existing fieldworkers' institutional support systems and policies shape fieldworkers ethical and research integrity practices.
iv) Develop a best practice model and make recommendations to the participating institutions on fieldworkers’ institutional support systems

Kenya 2021-03-18 2024-03-18 Social Science and Humanities Degree Award
John Rek
ID: UNCST-2024-R004373
Bednet use across a spectrum of malaria transmission risk in Tororo and Busia Uganda
REFNo: SS769ES

1. Determine household- and individual-level characteristics that correlate with poor bednet use using novel metrics from an electronic adherence monitor.
2. Relate bednet use to malaria-related outcomes such as mosquito density, malaria infection and clinical malaria episodes.
3. Develop a theoretical behavioral model of bednet adherence using qualitative interviews.
4. Compare methods for objective bednet adherence monitoring using the SmartNet platform.

Uganda 2021-03-18 2024-03-18 Social Science and Humanities Non-degree Award
Aubryn Sidle Allyn
ID:
Barriers to Returning Girls to School After COVID-19 Related School Closures in East Africa
REFNo: SS750ES

1. Identify and disseminate information about the barriers that adolescent girls in Uganda are facing that may prevent school resumption once directives to resume are given.

2. Identify and disseminate information about promising best practice programming in distance education and returning formerly school-going adolescent girls to school, once schools

USA 2021-03-18 2024-03-18 Social Science and Humanities Non-degree Award
Agnes Kiragga
ID:
Piloting a HIV Risk assessment application to increase awareness and uptake of HIV prevention services among young adults in Uganda. (SIDARISK)
REFNo: HS1293ES

• To assess the extent of high-risk sexual behavior and related practices among young adults using a web-based individualized HIV risk platform (SIDARISK)
• To establish the feasibility of using an existing telehealth platform for the referral and linkage to HIV/STI testing and prevention services following risk assessment by the SIDARISK application.
• To understand acceptability of the SIDARISK application for HIV risk assessment among young adults in Uganda
• To establish the feasibility of using a telehealth platform for provision of information on HIV risk reduction and linkage to HIV and PrEP services following using of the SIDARISK application

Uganda 2021-03-18 2024-03-18 Medical and Health Sciences Non-degree Award
Catriona  Waitt John
ID: UNCST-2019-R001068
Pilot feasibility study for uptake and implementation of a clinical algorithm for warfarin dosing in sub-Saharan African patients in the War-PATH Ugandan and South African clinical study sites.
REFNo: HS721ES

To evaluate whether the clinical algorithm improves anticoagulation control compared with local standards of care.
To determine the feasibility and acceptability of implementation of a clinical algorithm developed from the observational phase (phase 2) of the War-PATH study
UK 2021-03-17 2024-03-17 Medical and Health Sciences Non-degree Award
Ben Jones
ID:
Challenging categories: educated unemployed youth as institutional innovators in rural Uganda
REFNo: SS599ES

The objective of the study is to examine participation in local institutions to challenge understandings of youth, education and
unemployment. The outputs involve academic publications and advocacy work. The target population are educated unemployed youth and actors working with local institutions, including churches and courts. By “educated unemployed youth” we mean youth who are educated up to a minimum of S4.
UK 2021-03-17 2024-03-17 Social Science and Humanities Non-degree Award
Cissy  Kityo
ID: UNCST-2021-R013663
Gut Integrity and Metabolic Complications in Youth Living with HIV in Uganda.
REFNo: HS1036ES

The overall objective is to use surrogate markers to investigate the interplay between intestinal integrity, microbial translocation, immune activation, systemic inflammation and metabolic comorbidities in YLPHIV residing in urban and rural settings in Uganda.
Specific Aim 1: Assess differences in gut integrity, microbial and fungal translocation markers, as well as inflammation in YLPHIV compared to HIV-uninfected controls in Kampala (urban), and Gulu (rural), Uganda.
Specific Aim 2: Assess whether markers of gut integrity, translocation and inflammation are associated with adiposity, measured by dual-energy X-ray absorptiometry (DXA) and levels of the homeostatic assessment of insulin resistance (HOMA) in YLPHIV and HIV-uninfected participants in Kampala and Gulu.
Specific Aim 3: Assess the relationship between gut and inflammatory biomarkers and diet, physical activity, socioeconomic status and air pollution.
Uganda 2021-03-17 2024-03-17 Medical and Health Sciences Non-degree Award
Christine Kiconco
ID:
Management of Agricultural Indigenous Knowledge in Agricultural Research Organizations in Uganda.
REFNo: SS739ES

1. To establish the efforts of AR4D organizations towards AIK management
2. To examine how AR4D researchers’ perceptions of AIK influence their attitudes towards AIK management
3. To assess how facilitating conditions influence AIK management efforts in AR4Ds
4. To explore strategies that can enhance AIK management in AR4Ds to prevent continued AIK loss and increase possibilities for its access and utilization in agricultural development.
Uganda 2021-03-17 2024-03-17 Social Science and Humanities Degree Award
Shevin  Jacob Thomas
ID:
Understanding Drivers of Antimicrobial Resistance Among Mothers and Children in Uganda (DRUM+)
REFNo: HS1185ES

Understanding Drivers of Antimicrobial Resistance Among Mothers and Children in Uganda (DRUM+)
Specific Objectives:
Determine the prevalence of ESBL-E and ESBL-K bloodstream infections (BSI) and colonization among peripartum women and neonates/children < 5yo hospitalized with suspected sepsis.
2. Among peripartum women and neonates/children < 5yo hospitalized for suspected sepsis, determine the clinical outcomes, including morbidity (e.g., incidence of chronic kidney disease), mortality percentage (in-hospital and up to 4 months after the date of hospitalization) and frequency of readmission up to 4 months after the date of hospitalization.
3. Determine whether there is a molecular epidemiologic linkage between household carriage (including humans, associated domestic animals, and environment) of ESBL-E and ESBL-K AND patients (peripartum women or neonates/children < 5yo) hospitalized with sepsis who have ESBL-E and ESBL-K BSI or colonization.
4. Among patients (peripartum women or neonates/children < 5yo) hospitalized with sepsis who have ESBL-E and ESBL-K BSI or colonization, evaluate drivers of AMR transmission in Uganda (e.g., directionality of transmission and independent risk factors for transmission) using a dynamic agent-based model incorporating their microbiologic resistance data AND the data from linked households describing microbiological resistance and WASH observations.
USA 2021-03-17 2024-03-17 Medical and Health Sciences Non-degree Award
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