Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Noeline Nakasujja
ID: UNCST-2019-R001428
The impact of the COVID-19 pandemic and its response on the mental health of people with pre-existing mental conditions in Uganda.
REFNo: HS1781ES

5. To explore the experiences and views of people with SMI, their families/caretakers and mental health clinicians regarding the MMHC,4. To assess the effectiveness of an outreach mobile mental health clinic (MMHC)7 initiative to mitigate the care and messaging gap for people with SMI during the Covid-19 pandemic and its response.,3. To explore the experiences and viewsof people with SMI and their families/caretakers regarding COVID -19 and its response ,2. To assess the effect of COVID -19 and its response on access to care for people with SMI ,1. To assess the effect of COVID -19 and its response on the mental health of people with SMI ,
Uganda 2021-11-18 2024-11-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jack Rugasira
ID:
GREEN SUPPLY CHAIN PRACTICES AND ENVIRONMENTAL SUSTAINABILITY: A CASE OF SELECTED UGANDA MANUFACTURERS ASSOCIATION ENTITIES IN KAMPALA
REFNo: NS308ES

i. To determine the relationship between green sourcing and resource use efficiency in Kampala district.
ii. To determine the impact of green manufacturing on ecological balance in Kampala district.
iii. To assess the relationship between green transportation and availability of clean air and water in Kampala district.
iv. To determine the relationship between reverse logistics and wetland management in Kampala district

Uganda 2021-11-18 2024-11-18 Natural Sciences Non-Clinical Trial Degree Award
Thereza Piloya Were
ID: UNCST-2019-R000491
The Relation Between Mean Glucose and HbA1c in Ugandan Children and Youth with T1D: An Observational Study
REFNo: HS606ES

PRIMARY OBJECTIVES
1. To determine the relation between laboratory-measured HbA1c and mean glucose as measured by continuous glucose monitoring (assessed over 10-14 days per sensor period).
2. To determine the consistency of the relationship between laboratory- measured HBA1C and the mean glucose using multiple measurements in Ugandan Children and youth.
3. To determine the relation between laboratory-measured HbA1c and factors known to impact red blood cell survival.
SECONDARY OBJECTIVE
To determine the relation between point-of-care HbA1c and mean glucose in this population.

Uganda 2021-11-17 2024-11-17 Medical and Health Sciences Non-degree Award
Catherine Atuhaire
ID: UNCST-2021-R013090
A multi-morbidity study of diabetes mellitus, hypertension and Postpartum depression among postnatal mothers (MMDHAPPD) in Mbarara city, Uganda
REFNo: HS1836ES

To explore the challenges and coping strategies of mothers suffering from these multiple morbidities in Mbarara city, Uganda,To compare the serum cortisol levels of mothers diagnosed with and without postpartum depression,To determine the prevalence of hypertension among mothers diagnosed with postpartum depression in Mbarara city, Uganda ,To determine the prevalence of diabetes among mothers diagnosed with postpartum depression in Mbarara city, Uganda ,To assess the association between postpartum depression and either diabetes, hypertension or both among mothers in Mbarara city, Uganda,To determine the prevalence of postpartum depression based on the DSM-5 among mothers in Mbarara city, Uganda,To investigate the association between PPD and diabetes / hypertension or both and to explore the challenges and coping mechanisms experienced by these mothers suffering from these multiple morbidities in Mbarara city, Uganda,
Uganda 2021-11-17 2024-11-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Leevan Tibaijuka
ID: UNCST-2021-R012986
Maternal comorbidities in pregnancy and post-delivery at Mbarara Regional Referral Hospital
REFNo: HS1734ES

3) To adapt a mobile application and assess the feasibility and acceptability of a pilot implementation of an intervention of sending appointments reminders and health education tips inform of SMS and pre-recorded voice messages to post-delivery women with co-morbidities to improve their compliance to follow-up appointments at MRRH. ,2) To compare the incidence of adverse maternal-fetal outcomes in women with and without medical co-morbidities and determine the predictors of adverse maternal-fetal outcomes among women admitted for delivery at MRRH. ,1) To determine the prevalence of and modifiable risk factors associated with medical comorbidities among pregnant and post-delivery women at MRRH.,To explore medical co-morbidities among pregnant and post-delivery women at Mbarara Regional Referral Hospital (MRRH),
Uganda 2021-11-17 2024-11-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Janet SEELEY
ID:
African Prostate Cancer - Disparities in Outcomes in Uganda (APC-DOUG)
REFNo: HS1790ES

Aim/goal of study (General Objective)
The African Prostate Cancer - Disparities in Outcomes in Uganda (APC-DOUG) study aims to evaluate the health system, socioeconomic and clinical factors that impact public hospitals across Uganda to deliver affordable interventions that improve and reduce inequalities in prostate cancer outcomes.

1.6 Specific objectives
1. To evaluate the current structure and organisation of clinical care for prostate cancer
2. To understand the socio-economic, cultural and geographic barriers to accessing care

UK 2021-11-17 2024-11-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
ALLAN BAGUMA
ID: UNCST-2021-R012022
Effect of Covid-19 pandemic and national lockdown on utilization of childhood immunization services at Kisenyi health centre IV KCCA health facility in Kampala.
REFNo: HS1879ES

General Objective
To determine the effect of Covid-19 pandemic and national lockdown on utilization of childhood immunization services at Kisenyi health centre IV health facility in Kampala.
Specific Objectives
1. To determine the pre-lockdown childhood immunization coverage at Kisenyi health facility in Kampala.
2. To determine the coverage of child hood immunization at Kisenyi health facility in Kampala during the national lockdown.
3. To assess the barriers and facilitators of childhood immunization at Kisenyi health centre IV facility in Kampala during the covid 19 pandemic.
4. To determine the coverage of child hood immunization at Kisenyi health facility in Kampala post the national lockdown

Uganda 2021-11-17 2024-11-17 Medical and Health Sciences Non-Clinical Trial Degree Award
Ritah Kigonya
ID:
Enhancing Livelihood Outcomes in Biodiversity offset Schemes in Uganda’s Oil and Gas Industry’s CSR Strategies
REFNo: SS332ES

The overall objective of the study is to enhance incorporation of people’s use and cultural values of biodiversity during the design and implementation of biodiversity offsets. The specific objects include; Objective 1: Mapping the extent of biodiversity offset projects and their effects on community livelihoods. Objective 2; Analyze the extent to which biodiversity-based livelihood compensation schemes (social offset schemes) attain their desire objectives. Objective 3; Use lessons from biodiversity-based compensation schemes to ascertain who to compensate, what to compensate and how to compensate them during implementation of biodiversity-based livelihoods
Uganda 2021-11-16 2024-11-16 Social Science and Humanities Non-Clinical Trial Degree Award
JOSAPHAT KAYOGOZA BYAMUGISHA
ID: UNCST-2019-R001680
REPRODUCTIVE TRACT INFECTIONS AMONGST STUDENTS: ADDRESSING THE CHALLENGE AT MAKERERE UNIVERSITY
REFNo: HS1810ES

To determine the prevalence of RTIs among Makerere University students,To assess the Reproductive Tract Infections (RTIs) related knowledge, attitude and practices (KAP) of the Makerere University population.,To address the challenge of Reproductive Tract Infections amongst students by establishing the prevalence, knowledge of students towards RTIs and reducing the gap through use of youth friendly approaches.,
Uganda 2021-11-15 2024-11-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
RACHAEL KULWENZA
ID:
EXPLORING THE TEACHING OF READING IN LOWER PRIMARY CLASSES IN KOCHEKA SUBCOUNTY, UGANDA. A CASE OF ONE GOVERNMENT PRIMARY SCHOOL.
REFNo: SS987ES

•To find out what teaching and learning approaches do teachers use to teach reading in the lower primary level. •To investigate how do the approaches that teachers use in teaching reading in lower primary levels impact the development of the reading competences of the children?
•To find out what opportunities and challenges exist when teaching reading to learners in the lower primary level?

Uganda 2021-11-15 2024-11-15 Social Science and Humanities Non-Clinical Trial Degree Award
RICHARD EDEMA BAZIL
ID:
Investigating how teachers use mother tongue as a medium of instruction for lower primary mathematics
REFNo: SS1013ES

The objectives of the study are to establish: -
1. How the teachers are providing for the use of mother tongue as a medium of instruction during preparation for teaching and learning lower primary mathematics?
2. How the teachers are using mother tongue as a medium of instruction during teaching and learning processes of mathematics in P1 to P3?
3. The opportunities presented by the use of mother tongue in the teaching and learning of mathematics in P1 to P3?
4. The challenges the teachers face in the use of Mother tongue as a medium of instruction for mathematics in lower primary classless?

Uganda 2021-11-15 2024-11-15 Social Science and Humanities Non-Clinical Trial Degree Award
Arthur Bagonza
ID:
EFFECT OF COVID-19 ON PAEDIATRIC FEVER TREATMENT AMONG REGISTERED PRIVATE DRUG SELLERS IN EAST-CENTRAL UGANDA
REFNo: HS1729ES

1. To determine the effect of lock-down due to COVID-19 on treatment of children less than five years presenting with malaria,diarrhoea and pneumonia symptoms at registered private drug shops in Luuka district, East Central Uganda.

2. To explore perceptions of drug sellers and key stakeholders regarding treatment of children less than five years presenting with malaria,diarrhoea and pneumonia symptoms at registered private drug shops in Luuka district,East Central Uganda.

Uganda 2021-11-15 2024-11-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Fatumo  Segun Adeyemi
ID:
Causal Relationship between Cardiometabolic traits and Chronic Kidney Disease in African Population.
REFNo: HS1730ES

1. To Identify genetic determinants of kidney function in continental Africa"
2. To investigate the predictive utility of Polygenic Risk Scores for Chronic Kidney disease in Africans.
3. To assess the causal effect of kidney function on cardiometabolic diseases using Mendelian Randomisation Approach.

UK 2021-11-15 2024-11-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Geoffrey Beyihayo Akiiki
ID:
Native Chicken Project
REFNo: A154ES

To establish genetic markers associated with economic traits among indigenous chicken eco-types,To establish genetic and phenotypic parameter estimates for economic traits among indigenous chicken eco-types,To assess the genetic diversity of indigenous chickens eco-types based on mitochondrial DNA (mtDNA),To characterize indigenous chicken based on qualitative and quantitative phenotypic traits ,To characterize and identify genetic markers of egg and growth traits for selection of highly productive indigenous multipurpose chickens ,
Uganda 2021-11-15 2024-11-15 Agricultural Sciences Non-Clinical Trial Degree Award
David Guwatudde
ID: UNCST-2021-R008522
The Uganda Non-Communicable Diseases (NCD) Risk Factor Mobile Phone Survey - 2021
REFNo: HS1738ES

1.Evaluate the efficacy (as measured by the response rate), of conducting a mobile phone survey to collect data on the common NCD risk factors

2.Collect data on specific NCD disease conditions, and the self-reported NCD risk factors to support monitoring and evaluation of programs and policies in Uganda.

3.Generate comparable data from mobile phone surveys within Uganda over time.

4.Provide data to the Ministry of Health and other relevant ministries, and make recommendations on developing, improving, and enhancing prevention and response strategies to address NCDs and NCD associated disabilities in Uganda.
Uganda 2021-11-15 2024-11-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Allan Kalyesubula Edward
ID: UNCST-2021-R012991
The prevalence of oral diseases and their associated factors in children and adolescents attending the diabetes clinic at Mulago
REFNo: HS1799ES

1. To determine the prevalence of dental caries among children and adolescents attending the diabetes clinic at Mulago.
2. To determine the prevalence of periodontal diseases among children and adolescents attending the diabetes clinic at Mulago.
3. To determine the associated risk factors for dental caries among children and adolescents attending the diabetes clinic at Mulago.
4. To determine the associated risk factors for periodontal diseases among children and adolescents attending the diabetes clinic at Mulago
Uganda 2021-11-15 2024-11-15 Medical and Health Sciences Non-Clinical Trial Degree Award
Adeodata Rukyalekere Kekitiinwa
ID: UNCST-2019-R000799
BREATHER Plus: A randomized open-label 2-arm, 96-week trial evaluating the efficacy, safety and acceptability of short cycle (five days on, two days off) dolutegravir/tenofovir-based triple antiretroviral therapy (ART) compared to daily dolutegravir/tenofovir- based triple ART in virologically suppressed HIV-infected adolescents aged 12 to 19 years of age in sub-Saharan Africa, Version 2.0, Dated 18-Mar-2020; ISRCTN #: 85058577
REFNo: HS1822ES

Major Objective: A randomized open-label 2-arm, 96-week trial evaluating the efficacy, safety and acceptability of short cycle (five days on, two days off) dolutegravir/tenofovir-based triple antiretroviral therapy (ART) compared to daily dolutegravir/tenofovir-based triple ART in virologically suppressed HIV-infected adolescents aged 12 to 19 years of age in sub- Saharan Africa
Specific Objectives
To evaluate an innovative and contemporary ART strategy in HIV-infected adolescents to provide choice for young people facing life-long treatment. Output from this RCT will provide evidence on efficacy, safety and acceptability of a novel treatment approach in HIV-infected adolescents in sub-Saharan Africa
To evaluate the virological efficacy, safety, acceptability and Quality of Life of DTG-based Short-cycle Therapy with weekends off compared with Continuous Therapy with a DTG- based ART regimen
To optimize treatment for HIV-infected adolescents in sub-Saharan Africa

Uganda 2021-11-15 2024-11-15 Medical and Health Sciences Clinical Trial Non-degree Award
Mvuyo Sikhondze Maqhawe
ID:
DIABETIC FOOT ULCERS: SURGICAL CHARACTERISTICS, TREATMENT MODALITIES AND SHORT-TERM TREATMENT OUTCOMES AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS1857ES

General Objective
To describe the surgical characteristics, treatment modalities and short-term treatment outcomes of diabetic foot ulcers at Mbarara Regional Referral Hospital.

Specific Objectives
1. To describe the surgical characteristics of diabetic foot ulcers observed at Mbarara Regional Referral Hospital.
2. To describe the treatment modalities of diabetic foot ulcers at Mbarara Regional Referral Hospital.
3. To document the short-term treatment outcomes of patients with diabetic foot ulcers at Mbarara Regional Referral Hospital.
Eswatini 2021-11-15 2024-11-15 Medical and Health Sciences Non-Clinical Trial Degree Award
Sabine, Willemina, Johanna Luning
ID:
Gold Matters: Transformations to Sustainability in Artisanal and Small Scale Gold Mining in Uganda
REFNo: SS716ES

1. To consider whether a transformative approach toward sustainability can arise in Artisanal and Small Scale Gold Mining (ASGM).
2. To explore new notions of sustainability and transformations.
3. To contribute to a better understanding of the dynamic, heterogeneous reality of ASGM.
Netherlands 2021-11-11 2024-11-11 Social Science and Humanities Degree Award
Jessica Perkins M
ID: UNCST-2021-R013564
Perceptions of Social Norms and Personal Propensity to Engage in HIV Testing: A Mixed Methods Study and Intervention in Rural Uganda
REFNo: SS812ES

We propose a study to assess norms and perceptions about HIV prevention and related topics. This includes assessing village norms (i.e., the behaviours or attitudes of more than 50% of the adult population), perceived norms, how people form their perceptions, which social reference groups are the most meaningful, and the difference between actual norms and individuals’ perceptions of what most others do or believe. We will also examine whether perceptions are associated with personal behaviours and attitudes. Project 1 Aim: To engage in secondary analysis of quantitative data about perceived social norms and actual population norms around HIV prevention behaviours and related topics across different social reference groups. Aim 1: We will assess the prevalence of perceived and actual behavioural norms. We will do this both at the village-level and across various sociodemographic and health indicators. We will consider a behaviour the village norm if it is reported by more than 50% of adults. Aim 2: Because the parent study includes nearly all adults living in Nyakabare Parish, we can compare the actual village norm (assessed in Aim 1) to perceptions of the village norm. The parent study asked participants about their perceptions of what most other adults in the village do or think. Aim 3: Using the self-reported behaviours, attitudes, and norm perceptions, we will test whether individuals’ perceptions of what is normative is related to their personal attitudes and behaviours. Project 2 Aim: To use qualitative research methods to understand the nuances of HopeNet participants’ perceptions about local norms and design valid survey questions that elicit perceived social norms about HIV testing within different reference groups. Aim 1: Through in-depth interviews, scenarios related to HIV prevention attitudes and behaviours and perceived norms about salient social reference groups will be discussed. Aim 2: Based on results from Aim 1, survey questions using different ways of assessing norms will be developed to assess perceived social norms around HIV-related prevention behaviours and attitudes among different reference groups. Aim 3: Through cognitive interviews, the content validity of these survey questions to elicit perceptions of social norms about HIV-related attitudes and behaviours among specific social reference groups will improve.
USA 2021-11-11 2024-11-11 Social Science and Humanities Non-Clinical Trial Non-degree Award
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