Harriet Mayanja-Kizza
ID: UNCST-2021-R013074
|
A Survey Assessing Male Reproduction During or After Treatment Containing Pretomanid
REFNo: HS1340ES
To evaluate the paternity status in male participants who have received a pretomanid containing regimen in one of the following TB Alliance clinical trials: STAND, Nix-TB, SimpliciTB or ZeNix.
|
Uganda |
2021-04-21 |
2024-04-21 |
Medical and Health Sciences |
|
Non-degree Award |
|
Freddy Kitutu Eric
ID: UNCST-2020-R014751
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Using community influencer groups to address COVID-19 misinformation and vaccine hesitancy in Buikwe, Uganda
REFNo: HS1140ES
The evaluate the effect of community influencer groups on COVID-19 misinformation and potential COVID-19 vaccine hesitancy.,To form and empower community influencer groups against COVID-19 misinformation and potential COVID-19 vaccine hesitancy ,To explore the effect of COVID-19 misinformation on potential hesitancy towards a future COVID-19 vaccine,To determine the prevalence of potential hesitancy to a future COVID-19 vaccine in Buikwe,To determine the prevalence of COVID-19 misinformation in Buikwe,
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Uganda |
2021-04-15 |
2024-04-15 |
Medical and Health Sciences |
|
Non-degree Award |
|
Noleb Mugisha Mugume
ID:
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Integrating cervical cancer screening in HIV clinics and assessing the effect of using a modified referral protocol on access to cancer services among HIV-positive women in Uganda
REFNo: HS1219ES
Major objective: To assess the effect of a modified referral protocol on access to cancer services among HIV-positive women with positive cervical cancer screening findings and describe acceptability of integrating cervical cancer screening services in HIV clinics and referring women with positive screening results using the modified referral protocol.
Specific objectives
1. To assess the effect of using a modified referral protocol on access to cancer services among HIV-positive women with positive cervical cancer screening findings.
2. To describe experiences of HIV-positive women and health care providers with implementation of integrated cervical cancer screening services in HIV clinics and referral using a modified referral protocol
3. To describe acceptability of a program that provides integrated cervical cancer screening services in HIV clinics to women presenting for routine HIV care and links those with positive screening findings to cancer care services using a modified referral protocol among health care providers and mangers in the clinics.
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Uganda |
2021-04-15 |
2024-04-15 |
Medical and Health Sciences |
|
Degree Award |
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victoria nakibuuka
ID: UNCST-2020-R014741
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Developmental care packages to improve neonatal outcomes – a multidisciplinary approach
REFNo: HS1254ES
To survey current knowledge, practices and attitudes towards developmental care to assess potential barriers and facilitators to implementing and integrating developmental To observe current practice in NICU’s care packages in NICU’s in LMIC
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Uganda |
2021-04-15 |
2024-04-15 |
Medical and Health Sciences |
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Non-degree Award |
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Cissy Kityo
ID: UNCST-2021-R013663
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D3 (PENTA 21)
A randomised non-inferiority trial with nested PK to assess DTG/3TC fixed dose formulations for the maintenance of virological suppression in children with HIV infection aged 2 to <15 years old
REFNo: HS1288ES
The overall aim is to evaluate two-drug therapy with DTG/3TC FDC given once daily in comparison with triple-drug ART in HIV-1 infected children and adolescents who are virologically-suppressed on their ART regimen.
PRIMARY OBJECTIVE
To assess whether DTG/3TC is non-inferior to SOC, consisting of an anchor drug (NNRTI, PI or INSTI) and 2 NRTIs, in terms of virological suppression
HYPOTHESIS
Switching to DTG/3TC will provide non-inferior virological suppression to remaining on SOC over 96 weeks.
SECONDARY OBJECTIVES
 To evaluate clinical and laboratory adverse events associated with the trial antiretrovirals
 To evaluate new resistance mutations in participants with virological rebound (confirmed VL≥50 copies/mL)
 To assess low level viraemia and virological reservoirs
 To evaluate adherence, tolerability, acceptability, sleep and health-related quality of life
 To evaluate and model the pharmacokinetics and pharmacodynamics of dispersible and film-coated fixed-dose DTG/3TC formulations in children weighing 6-<40kg using WHO weight band-aligned dosing
 To evaluate cost-effectiveness of treatment maintenance with DTG/3TC FDC if DTG/3TC is shown to be non-inferior to SOC
|
Uganda |
2021-04-15 |
2024-04-15 |
Medical and Health Sciences |
|
Non-degree Award |
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Godfrey Siu
ID: UNCST-2021-R005439
|
The impact of COVID-19 on domestic care work in Uganda
REFNo: SS770ES
1. To determine the burden and patterns of domestic care work during the COVID-19 response phase.
2. To determine the barriers and facilitators of domestic work during the lockdown.
3. To examine the effects of COVID-19 on the social, economic and family relations.
|
Uganda |
2021-04-15 |
2024-04-15 |
Social Science and Humanities |
|
Non-degree Award |
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James Katungyi
ID:
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The effect of daytime circadian thermal variability on the well-being of building occupants. A case study of office type building occupants in Kampala.
REFNo: SIR41ES
The research objective is to compare short and long-term impacts, of variable indoor thermal conditions (which mimic the outdoor variability) versus static thermal conditions, on the wellbeing of building occupants.
|
Uganda |
2021-04-13 |
2024-04-13 |
Engineering and Technology |
|
Degree Award |
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Susannah Mayhew Harding
ID:
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Rapid Qualitative Research to support integrated environment, livelihoods and health programming in Uganda (“Supporting Integrated Programmingâ€)
REFNo: HS1137ES
The research objectives are to:
1) Determine the environmental, livelihood and health challenges facing communities living in/near Rushebeya wetland;
2) Identify how, and through what structures and processes, people in these communities make decisions about and respond to identified challenges; and identify whether these responses have changed over time;
3) Examine whether there are differences in responses by age, sex or socio-economic background.
4) Identify messages and intervention activities to address the challenges felt by different groups in these communities.
|
UK |
2021-04-13 |
2024-04-13 |
Medical and Health Sciences |
|
Non-degree Award |
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Joseph Nkamwesiga
ID:
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Epidemiology of Peste des Petits Ruminants (PPR) in Uganda
REFNo: A103ES
General Objective:
To determine national PPR risk profiles [low, medium and high], seroprevalence and incidence of different PPRV lineages, factors that influence PPRV transmission and hence develop a dynamic PPRV transmission model and the best control intervention(s) to limit PPRV transmission in selected livestock production systems in Uganda
The specific objectives of this study are to:
i. stratify Uganda districts into different PPR risk profiles [low, medium and high] by undertaking presence only ecological niche (MaxEnt) modeling of the past PPR outbreaks, small ruminant movements and vaccination coverage data sets
ii. estimate seroprevalence of PPRV and epidemiological factors that influence PPRV transmission within and between different PPR risk profiles and small ruminant production systems
iii. estimate PPR incidence and PPRV lineages involved in different PPR outbreaks across different small ruminant production systems [or agro-ecological zones] in Uganda
iv. develop a PPRV transmission dynamic and eradication model for PPR in selected small ruminant production systems [agro-ecological zones] in Uganda using compartmentalized SEIR mathematical modeling approach
|
Uganda |
2021-04-13 |
2024-04-13 |
Agricultural Sciences |
|
Degree Award |
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Freddy Kitutu Eric
ID: UNCST-2020-R014751
|
Strengthening Antimicrobial Stewardship, Consumption and Use in Uganda (SAMSU)
REFNo: HS1155ES
To conduct Antimicrobial Consumption and Use by ATC/DDD Methodology and the WHO AWaRE classification Antimicrobials intended for use in Humans for the Years 2017, 2018, 2019 and 2020 using Medicine Imports and Local Manufacture Data in Uganda (SCACUS)To examine health facility bottlenecks and determinants of antimicrobial use that affect antibiotic stewardship practices at outpatient departments with the aim of strengthening healthcare professionals’ AMS capability in Eastern Uganda (SAMSEU)
|
Uganda |
2021-04-13 |
2024-04-13 |
Medical and Health Sciences |
|
Non-degree Award |
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Stavia Turyahabwe Stavia
ID: UNCST-2022-R011373
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From Directly-Observed Therapy (DOT) to Video Observed Therapy (VOT): A study on the use of evidence based Digital Adherence Technologies (DAT) for improving TB Treatment outcomes
REFNo: HS1183ES
a. Active Case Finding Strategy: To study the impact of increase in case finding of drugs susceptible case in the selected 2 TB units of Kabarole and Mbarara, where the component will be tested.
b. Active Patient Compliance Toolkits: To test the efficacy of patient led adherence using mobile based Video Observed Therapy approach in improving the TB adherence rate and overall improvement in TB treatment outcomes;
c. Active Community-Led Supervision: To test the improvement in TB treatment outcomes like TB Success Rates, Cure rates and Adherence rates in the community let supervision model;
d. Active Ground Building Activities; To assess the change in knowledge, attitude and practice (KAP) level of TB patients; their family members and the community around TB and related issues.
|
Uganda |
2021-04-13 |
2024-04-13 |
Medical and Health Sciences |
|
Non-degree Award |
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Bruce Kirenga J
ID: UNCST-2019-R001460
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SITUATIONAL ANALYSIS OF EXISTING CAPACITY AND RESOURCES AT MEAKERERE UNIVERSITY TO SUPPORT A RESEARCH TRAINING PROGRAM FOCUSING ON NON-COMMUNICABLE DIEASES AND AGEING AMONG PEOPLE LIVING WITH HIV/AIDS
REFNo: HS1252ES
General Objective
To describe existing research capacity, training and resources within the MakCHS that can be leveraged to design a successful NCD-HIV-Ageing training program at MakCHS
Specific Objectives
To describe existing NCD, HIV and ageing research at Makerere University and collaborating institutions within MakCHS and Mulago Hospital complex.
To define the existing NCD, HIV and ageing training activities at Makerere University and collaborating institutions within MakCHS and Mulago Hospital complex.
To outline the existing resources to support research and training on NCDs, HIV and ageing at Makerere University and other collaborating institutions within MakCHS and Mulago Hospital complex.
To define a pool of potential trainees that could be recruited for research training on NCDs, HIV and ageing at Makerere University and collaborating institutions within MakCHS and Mulago Hospital complex
|
Uganda |
2021-04-13 |
2024-04-13 |
Medical and Health Sciences |
|
Non-degree Award |
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Barbara Balikuddembe Ndagire Balikuddembe
ID:
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Dental Practitioners’ Knowledge, Attitudes, and Practices Regarding Caries Risk Assessment in the Management of Dental Caries in Uganda: A Cross Sectional Study
REFNo: HS1275ES
i. To determine the knowledge of dental practitioners regarding caries risk assessment in the management of dental caries in Kampala metropolitan.
ii. To determine the attitudes of dental practitioners regarding caries risk assessment in the management of dental caries in Kampala metropolitan.
iii. To determine the practices of dental practitioners regarding caries risk assessment in the management of dental caries in Kampala metropolitan.
iv. To explore the training needs of CRA among trainers of dental practitioners in Kampala metropolitan.
|
Uganda |
2021-04-13 |
2024-04-13 |
Medical and Health Sciences |
|
Degree Award |
|
Victor Musiime
ID: UNCST-2021-R013794
|
A randomized Trial to investigate strategies to reduce mortality among HIV-infected and HIV-exposed children admitted with severe acute malnutrition in Mulago Hospital, Kampala, Uganda
REFNo: HS1277ES
Primary objective
1. To investigate whether empirical use of an antibiotic with greater antimicrobial sensitivity (ceftriaxone) than standard of care (ampicillin plus gentamicin) will reduce mortality among 300 HIV-infected and HEU children admitted with severe acute malnutrition at Mwanamugimu Nutrition Unit, Mulago Hospital in a randomised controlled trial.
Secondary objectives
2. To compare the length of hospitalization, weight-for-height, weight-for-age and height-for-age z-scores between ceftriaxone versus standard of care (ampicillin and gentamicin) treatment arms.
3. To ascertain the frequency of different bloodstream bacterial pathogens and their antimicrobial sensitivities among HIV-infected and HEU children admitted with severe acute malnutrition at Mwanamugimu Nutrition Unit, Mulago Hospital participating in the randomised trial.
4. To ascertain the prevalence of, and factors associated with, HIV-infection among children admitted with severe acute malnutrition at Mwanamugimu Nutrition Unit, Mulago Hospital in light of improved PMTCT approaches in a cross-sectional evaluation at admission, among 280 children.
5. To evaluate the pharmacokinetic (PK) parameters of LPV/r among severely malnourished HIV infected children using sparse PK samples. The PK parameter values obtained will then be used in pharmacokinetic-pharmacodynamic (PK-PD) models to determine a possible optimal dose of LPV/r among severely malnourished children, which could then subsequently be evaluated in a clinical trial.
|
Uganda |
2021-04-13 |
2024-04-13 |
Medical and Health Sciences |
|
Non-degree Award |
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Freddy Kitutu Eric
ID: UNCST-2020-R014751
|
Exploring access to health care and medicines during COVID-19 in Mukono and Luwero districts: critical challenges and feasible policy options for the medicines retail sector
REFNo: HS1302ES
To describe the practical, policy and political barriers to including pharmacies, drug shops and private clinics in the response to COVID-19 and the means to overcome them.,. To describe how national actors and district officials would like to involve the medicines retail sector in their pandemic planning and action for COVID-19. ,To explore how the medicines retail sector in Uganda could be involved in response to COVID-19 and future outbreaks,To document the impact of the COVID-19 pandemic and public health response on the ability of women and the parents of young children in Uganda to access medicines,To document the effect of the government response to COVID-19 on supply of healthcare services/ care provision by drug shops, pharmacies and private clinics in Uganda,To describe how policy can be adapted to ensure continuity of access to essential medicines and support the involvement of the retail sector in COVID-19 activities during this and future outbreaks,To understand how the public health response to COVID-19 is shaping the supply of and access to treatment in the medicines retail sector in Uganda;,
|
Uganda |
2021-04-13 |
2024-04-13 |
Medical and Health Sciences |
|
Non-degree Award |
|
Irene Mutuku M.
ID:
|
KNOWLEDGE, ATTITUDES AND PRACTICES TOWARDS COVID-19
PREVENTION MEASURES AMONG COMMUNITIES AT
SELECTED GAZETTED INTERNATIONAL
ENTRY-POINTS OF KIGEZI
SUB-REGION,
UGANDA
REFNo: SS660ES
General objective
To assess the knowledge, attitudes and practices towards COVID-19 prevention measures in communities living at gazetted international entry points of the Kigezi sub-region in Uganda.
Specific objectives
i. To establish the knowledge of the community members in selected gazette international entry points in the Kigezi region regarding measures instituted to stop the spread of COVID-19 in Uganda.
ii. To assess the attitudes of the community members in selected gazetted international entry points in the Kigezi region towards measures instituted to stop the spread of COVID- 19 in Uganda.
iii. To investigate the practices of community members in selected gazetted international entry points in the Kigezi region on measures instituted to stop the spread of COVID- 19 in Uganda.
|
Kenya |
2021-04-09 |
2024-04-09 |
Social Science and Humanities |
|
Non-degree Award |
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NEEMA NAKYANJO -
ID:
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Fishing and inland communities – understanding transmission linkages and networks
REFNo: SS698ES
a) To understand the socio-structural context of migration of high risk persons/key populations to and from high HIV prevalence Lake Victoria fishing communities and other geographic areas with high HIV-prevalence
b) To use molecular, social and epidemiological data to identify and elucidate the factors/associations of transmission linkages/networks within key and general population cohorts/groups.
c) To increase our understanding of HIV prevention and care utilization of high risk persons/key populations moving to and from places with high rates of HIV infection
|
Uganda |
2021-04-09 |
2024-04-09 |
Social Science and Humanities |
|
Non-degree Award |
|
JULIET MWANGA-AMUMPAIRE
ID: UNCST-2022-R009420
|
Impact of malnutrition on pharmacokinetic of rifampicin, isoniazid, pyrazinamide and ethambutol in TB-HIV co-infected children
REFNo: HS1217ES
Primary Objective
To assess the effect of Severe Acute Malnutrition (SAM) on plasma concentration of rifampicin, isoniazid, pyrazinamide, and ethambutol in children with TB.
Secondary Objectives
1. To assess the effect of HIV-infection and antiretroviral treatment on plasma concentration of rifampicin, isoniazid, pyrazinamide, and ethambutol in children with TB and Severe Acute Malnutrition (SAM)
2. To assess whether new WHO-based dosages will achieve rifampicin, isoniazid, pyrazinamide, and ethambutol drug concentrations above the target therapeutic concentrations in HIV-TB co-infected children with and without SAM
3. To assess the effect of nutritional parameters, HIV-infection, antiretroviral treatment, and other factors (age, liver enzymes, NAT2 status) on PK parameters of rifampicin, isoniazid, pyrazinamide, and ethambutol in HIV-infected children with TB
4. To build a PK/PD relationship between drug concentrations and TB treatment outcomes
5. To assess rifampicin protein binding in relation with malnutrition and albuminemia
6. To derive an optimal dosing algorithm for rifampicin, isoniazid, pyrazinamide, and ethambutol that will adequately provide optimal exposures to malnourished and HIV infected children
|
Uganda |
2021-04-09 |
2024-04-09 |
Medical and Health Sciences |
|
Non-degree Award |
|
Eva Laker Odongpiny Agnes
ID: UNCST-2024-R004807
|
A Toll-Free Call Intervention to Improve Adverse Events Reporting in Patients On Dolutegravir in Three Health Centers in Kampala, Uganda and a Prospective Cohort Study to Describe Adverse Events to Dolutegravir at the Infectious Diseases Institute (DOLUPHARM)
REFNo: HS1263ES
A) Primary objective (Objective 1)
To determine whether a toll-free phone system for reporting of adverse events by clinicians and patients improves adverse event reporting compared to standard reporting methods using paper based or online forms by clinicians in three health centers initiating/switching patients to DTG between November 2020 and October 2021.
B) Secondary objective (Objective 2)
To determine level of uptake and the experiences of clinicians and patients with using a toll-free phone system for reporting adverse events compared to standard reporting methods using paper based or online forms in three health centers initiating/switching patients to DTG between November 2020 and October 2021
Prospective Cohort Study
A) Primary objective (Objective 3)
To describe the incidence and factors associated with occurrence of different adverse events among patients being switched/initiated on a DTG-based regimen at the IDI.
B) Secondary objective (Objective 4)
To determine whether occurrence of adverse events affects adherence to medications among patients being switched/initiated on a DTG-based regimen at the
|
Uganda |
2021-04-09 |
2024-04-09 |
Medical and Health Sciences |
|
Non-degree Award |
|
Miriam Nakalembe
ID: UNCST-2021-R014040
|
NEW APPROACHES FOR THE EARLY DETECTION OF CERVICAL NEOPLASIA
REFNo: HS1161ES
1. Determine acceptability and accuracy of a low-cost smartphone confocal micro-endoscope imaging technique for the diagnosis of CIN 2+. Confocal images will be compared against gold-standard histopathology to obtain preliminary diagnostic performance characteristics.
2. Compare various cervico-vaginal fluid (CVF) biomarkers to gold-standard histopathology for the diagnosis of CIN 2+. Qualitative and quantitative levels of biomarkers will be compared against gold-standard histopathology to obtain diagnostic performance characteristics.
|
Uganda |
2021-04-08 |
2024-04-08 |
Medical and Health Sciences |
|
Non-degree Award |
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