Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Jenna Grzeslo
ID:
Exploring the Feasibility of Empowerment and Livelihood for Adolescents (ELA) in an Afterschool Setting: Formative Research to Inform Programming and Policy in Uganda
REFNo: SS693ES

1. BRAC would like to explore the feasibility of school and government uptake of the programming.

2. Finally, to inform future experimental evaluations, we seek to understand the role of dosage (e.g., the number and frequency of meetings) in designing the updated ELA curriculum.
USA 2021-04-27 2024-04-27 Social Science and Humanities Non-degree Award
Pakoyo Kamba Fadhiru
ID:
A prospective cohort study of oral morphine self-medication by caregivers of paediatric patients at Mulago National Referral Hospital, Kampala
REFNo: HS1331ES

To determine the effect of diversion of patients’ oral morphine by caregivers on their health related quality of life and that of patients in paediatric clinics at Mulago National Referral Hospital,To determine the prevalence and compliance with necessary written internal controls for prescribing, dispensing and administration of oral morphine by paediatrics clinics at Mulago National Referral Hospital,To determine the effect of home-based oral morphine use in palliative care on drug use disorders among caregivers of paediatric patients at Mulago National Referral Hospital. This will be achieved by comparing the prevalence and incidence of self-medication with oral morphine and other controlled drugs between caregivers of paediatric patients with and without prescribed oral morphine.,To determine the factors associated with self-medication with oral morphine among caregivers of paediatric patients on prescribed oral morphine in paediatrics clinics at Mulago National Referral Hospital,To determine the prevalence and incidence of self-medication with oral morphine among caregivers of paediatric patients on prescribed oral morphine in paediatrics clinics at Mulago National Referral Hospital. This will be achieved through a baseline survey of prevalence followed by longitudinal evaluation of incidence of self-medication at endline.,To understand the compliance of paediatric clinics with oral morphine controls and the effect of diversion of patients’ oral morphine by caregivers on the quality of life of paediatric patients and caregivers,4. To determine the effect of diversion of patients’ oral morphine by caregivers on their health related quality of life and that of patients in paediatric clinics at Mulago National Referral Hospital.,3. To determine the prevalence and compliance with necessary written internal controls for prescribing, dispensing and administration of oral morphine by paediatrics clinics at Mulago National Referral Hospital.,2. To determine the effect of home-based oral morphine use in palliative care on drug use disorders among caregivers of paediatric patients at Mulago National Referral Hospital. This will be achieved by comparing the prevalence and incidence of self-medication with oral morphine and other controlled drugs between caregivers of paediatric patients with and without prescribed oral morphine.,1. To determine the prevalence and incidence of self-medication with oral morphine among caregivers of paediatric patients on prescribed oral morphine in paediatrics clinics at Mulago National Referral Hospital. This will be achieved through a baseline survey of prevalence followed by bimonthly longitudinal monitoring of incidence of self-medication.,
 Uganda 2021-04-27 2024-04-27 Medical and Health Sciences Non-degree Award
Sophie Mylan Katherine Hardman
ID:
Epidemics in Refugee Settlements: An ethnographic exploration of ‘Preparedness’ in Palabek Refugee Settlement, Northern Uganda, during times of COVID-19
REFNo: SS745ES

The objective of this study is to understand how epidemic ‘preparedness’ in refugee settlements can pay greater attention to histories, ideas and practices from refugees themselves. Through ethnographic research, including, but not restricted to, fieldwork in Palabek Refugee Settlement, northern Uganda, during times of COVID-19, the connections and disconnections between global policy, biomedical approaches, and ‘preparedness from below’ will be explored as equal objects of study.
 UK 2021-04-27 2024-04-27 Social Science and Humanities Degree Award
Eugene Ruzagira
ID: UNCST-2023-R008282
 PRELIMINARY INVESTIGATIONS TO SUPPORT COVID-19 VACCINE ROLL-OUT IN UGANDA [CO-ROLL]
REFNo: SS767ES

The study objectives are
1. To assess uptake of COVID-19 vaccination and associated factors among HCWs and older (>50 years) persons in Uganda
2. To describe the knowledge and attitudes towards COVID-19 vaccines among HCWs and older (>50 years) persons in Uganda
3. To describe the profile of anti-SARS-CoV-2 IgG antibodies before and after vaccination in HCWs and older (>50 years) persons in Uganda.
4. To describe cellular immune responses to SARS-CoV-2 antigens before and after vaccination in HCWs and older (>50 years) persons in Uganda.
5. To describe pre-COVID-19 immunisation innate response profiles, and relate these to the antigen specific vaccine responses in HCWs and older (>50 years) persons in Uganda
6. To determine the social and structural factors that influence uptake of COVID-19 vaccines in HCWs and older (>50 years) persons in Uganda

 Uganda 2021-04-27 2024-04-27 Social Science and Humanities Non-Clinical Trial Non-degree Award
Ronald Mangeni
ID:
Utility of pooled sputum samples for Tuberculosis screening in a high TB burden setting.
REFNo: HS1329ES

- The overall aim of this study is to determine sensitivity and specificity of pooled sputum samples in the diagnosis of TB in a healthcare setting in Uganda

Secondary objectives
- To determine the effect of varying bacterial loads on the sensitivity and specificity of sputum pooling
- To determine the effect of different pooling ratios on the sensitivity and specificity of sputum pooling
 Uganda 2021-04-27 2024-04-27 Medical and Health Sciences Non-degree Award
FREDRICK MAKUMBI
ID:
Understanding how information on abortion is shared in social networks: a mixed-methods follow up study to refine two social network-based methods for measuring abortion incidence
REFNo: SS814ES

This study aims to understand how information on pregnancy termination is shared within social networks and use this information to assess and improve the use of two social-network based methods for estimating abortion incidence.

Specific objectives
(1) Improve the robustness and accuracy of the estimate of abortion incidence in Uganda
(2) Assess how diffusely information about pregnancy termination is shared within women’s social networks in Uganda
(3) Provide detailed information on the timing and purpose of pregnancy termination disclosure

Uganda 2021-04-27 2024-04-27 Social Science and Humanities Non-degree Award
Martha Mulerwa
ID:
Inter-rater reliability and comparison of the repeatability of four different approaches to setting up goniometers and torsiometers to measure forearm and wrist kinematics.
REFNo: SIR60ES

General objective: Compare the four different approaches to setting up an electro-goniometer and torsiometer listed above in order to determine the most appropriate procedure for wrist kinematics measurements.

Specific Objectives:
To evaluate the repeatability of the four setup procedures
To evaluate inter-rater reliability when setting up the electro-goniometer and torsiometer using the four setup procedures during wrist kinematics
To evaluate intra-rater reliability when setting up the electro-goniometer and torsiometer using the four setup procedures during wrist kinematics

 Uganda 2021-04-27 2024-04-27 Engineering and Technology Non-Clinical Trial Degree Award
Chaning Jang Ahn Wong
ID:
Contextualizing Moral Foundations Theory for Better Messaging in Uganda
REFNo: SS797ES

General Objective:
This study seeks to contextualize the Moral Foundation Theory to the Ugandan context through various instruments to have a better understanding of the social, and personal values of its population.
Specific and Achievable Objectives:
The breakdown of the general objective of this project is as follows:
Adapt the moral foundation research process, as laid out by Knutson and Haidt, to the Ugandan context through exploratory and confirmatory analysis
Diagnose the distribution of moral decision-making across five themes by examining respondents’ classifications of moral violations.
Seeking to understand how the foundations are distributed across the general population.
Use the validated set of moral foundations to inform behavioral change communication/messaging campaigns.

USA 2021-04-27 2024-04-27 Social Science and Humanities Non-Clinical Trial Non-degree Award
Enock Matovu
ID:
Development of Indirect Enzyme Linked Immunosorbent Assay [ELISA] for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) Surveillance in Uganda
REFNo: HS1382ES

i. To evaluate commercially available formulations of the spike and nucleocapsid antigens derived from E. coli, insect and human cell expression systems to determine the best performer
ii. To determine the diagnostic sensitivity and specificity of the spike and nucleocapsid antigens-based indirect ELISA for diagnosis and community sero-surveillance of SARS-COV2

 Uganda 2021-04-27 2024-04-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Roy Mayega William
ID: UNCST-2022-R010983
 Differences in the formation and development of informal settlements and their effects on residents’ health and safety.
REFNo: SS715ES

General objective
The objective of the proposed research is to conduct formative research in Kampala, Uganda as part of a larger research agenda to compare informal settlements in four countries in East Africa, Uganda, Rwanda, Tanzania and Kenya to determine how history of formation, government strategies to improve settlements and the kinds of improvements that have been made affect the health and well-being of residents.
Specific objectives
Specific objectives of the proposed research include the following.
1. To explore how informal settlements in Kampala, Uganda are formed and how this may cause differences in the settlement’s health hazards.
2. formal To explore strategies that Uganda has taken to improve informal settlements and the health effects of these efforts for the families and children who live in informal settlements.
3. To qualitatively identify the most pressing health needs of families and children in the selected informal settlements within Kampala.

Uganda 2021-04-26 2024-04-26 Social Science and Humanities Non-degree Award
John Storey Douglas
ID:
Understanding factors that influence people's health-seeking behavior to inform a social and behavior change communications campaigns in Uganda
REFNo: SS761ES

The overall objective of this research is to suggest ways of improving the OBULAMU brand and to develop a set of recommendations
to inform a national-level social and behavior change communication strategy for the Ministry of Health in Uganda. In order to achieve this objective, the following smaller objectives will be met:
a)To identify the characteristics and behaviors of different brand users.
b)To understand the barriers and levers to improve past communication efforts.
c)To understand baseline attitudes, perceptions and the socio-ecological context which influences users' health-related decisions.
d)To identify the critical moments in people’s lives across which different health needs become salient
e)To design and test solutions to address the barriers faced by end-users and provide holistic recommendations that can inform the redesigning efforts of the OBULAMU campaign and provide inputs into the national SBC strategy.

 USA 2021-04-26 2024-04-26 Social Science and Humanities Non-degree Award
Gerald Mboowa
ID:
Assessing knowledge, attitudes, perceptions, and skills towards the use of face masks: A community-level perspective
REFNo: SS489ES

i. To assess knowledge, attitudes, and perceptions towards the use of face masks by high- risk groups in Kampala district, Uganda.
ii. To assess skills towards the use of face masks, evaluate the face masks for safety and fitness-for-use, and provide a classification for those commonly circulating on the Ugandan market.
iii. To educate and skill high- risk groups in Kampala district on the rational use and disposal of face masks.

 Uganda 2021-04-22 2024-04-22 Social Science and Humanities Non-degree Award
Lillian Tindyebwa --
ID:
Gender Dynamics - Analysis of Convicts in selected Prisons in Kigezi Region
REFNo: SS521ES

1. To explore gender dynamics of crimes for convicts in major prisons at selected districts in the Kigezi region
2.To identify types of crimes committed by men and women convicts in major prisons in the Kigezi region
3. To establish the gendered patterns formed in committing crimes by convicts in major prisons in the Kigezi region.
4.To explore the underlying motives to commit various crimes by the convicts in major prisons at districts in the Kigezi region.
5.To establish the influence of community that could cause the person to commit a crime.
 Uganda 2021-04-22 2024-04-22 Social Science and Humanities Non-degree Award
Anthony Kadoma
ID:
Understanding stakeholder perceptions on wetland ecosystem services to support conservation and restoration activities
REFNo: SS705ES

To establish past, present, and future wetland conservation and restoration activities in Wakiso district

Identify the stakeholders involved and their roles and motivations

Document and analyze the perceptions stakeholders have on wetland ecosystem services and

To synthesize stakeholders' perceptions and their integration into wetland conservation and restoration activities.
Uganda 2021-04-22 2024-04-22 Social Science and Humanities Degree Award
Moffat  Nyirenda Joha
ID: UNCST-2020-R019333
 Understanding differential effects of lipid lowering agents on lipid isoforms: a multi-center retrospective study in Uganda
REFNo: HS1292ES

a. To determine the patterns of dyslipidaemia among patients who present with dyslipidaemia at primary care and specialist hospitals in Uganda
b. To describe the patient characteristics that are associated with different patterns of dyslipidaemia
c. To determine the commonly used lipid lowering agents
d. To examine the differences in response to lipid lowering therapy
e. To determine the proportion of optimal control among individuals taking lipid-lowering agents
f. To examine the times to optimal LDL-C control among individuals taking lipid-lowering agents

 Malawi 2021-04-22 2024-04-22 Medical and Health Sciences Non-degree Award
Elizabeth Brannon Lynn
ID:
The Role of Former Female Fighters in the National Resistance Movement
REFNo: SS791ES

During conflict, women step into a number of roles that were traditionally reserved for men--with some women joining rebel forces to fight, others taking up peace activism to combat such fighting, and many stepping into roles that were traditionally held by men. A strong literature has emerged detailing women's violent participation in conflict, as well as the motivations, dynamics, and implications of their action. Through their participation, women are able to experience greater equality with men, in addition to building critical skills and networks. However, little is known about how former rebel women build on these experiences post-conflict. Instead, much of the literature suggests that former rebel women experience significant marginalization after conflict, minimizing their future opportunities. Such patterns seem further at odds with patterns of rebel-group-to-political-party transformations. In this project, I have two main objectives. I seek to understand the post-conflict fate of former female fighters and how it relates to former rebel party politics. I ask if and how former female fighters are able to build on their conflict experiences and networks to access positions of political power in the post-conflict environment. Further, I seek to understand broader patterns in which women are elected after conflict. To understand these dynamics, I intend to collect systematic candidate data in Uganda and will complement this will a qualitative analysis based on interviews with former female combatants for the National Resistance Army.
 USA 2021-04-22 2024-04-22 Social Science and Humanities Non-Clinical Trial Degree Award
Anthony Mugeere Buyinza
ID:
PEAK YOUTH, CLIMATE CHANGE AND THE ROLE OF YOUNG PEOPLE IN SEIZING THEIR FUTURE
REFNo: SS670ES

General Objective:

To explore how climate change in Uganda is affecting young lives and youth livelihoods in the regions of Karamoja and Jinja.

Specific objectives:
(i) To document the diverse lives and livelihood strategies of young people
in rural and urban settings;
(ii) To find out how climate change impacts upon young people's lives and livelihoods;

(iii) To identify youth solutions to the challenges they face.
 Uganda 2021-04-21 2024-04-21 Social Science and Humanities Non-degree Award
Elizabeth Ayebare Ombeva
ID: UNCST-2020-R003666
 An education package to improve health worker communication with women and families after stillbirth or neonatal death: A feasibility study
REFNo: HS1102ES

1. To pilot an education package and associated resources, including train the trainer/training manuals and audio-visual aids to improve health worker communication in Malawi, Uganda, Zambia and Zimbabwe.
2. For feasibility
a. Explore the acceptability and implementation of the package with facility staff receiving training, trainers and service managers across settings.
b. Explore the acceptability and implementation of the package with undergraduate midwifery students receiving training.
c. Assess uptake and attendance/completion of the package.
d. Explore impacts of the research and education package on practice and clinical services.
3. To prepare for a full-scale evaluation:
a. Define the most appropriate primary and secondary outcomes to assess the effect of the educational package on health workers’ communication and parents’ experiences.
b. Assess the acceptability and burden of data collection for participants.
c. Use data to optimise the design and estimate the sample size for a full-scale trial.
d. Exploration of key resources associated with implementing the educational package will be completed to provide an economic understanding of the intervention and its potential impact.
e. To utilise existing and develop additional networks to identify potential sites for a full-scale trial.
4. To combine the feasibility, acceptability and uptake data to develop a full trial protocol by the end of the study.

 Uganda 2021-04-21 2024-04-21 Medical and Health Sciences Non-degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
 SARS-CoV-2 seroconversion: a sero prevalence study among cancer patients and health workers at the Uganda Cancer Institute
REFNo: HS1240ES

3. To describe the temporal trends in the anti- SARS-CoV-2 antibody sero-prevalence among cancer patients at the Uganda Cancer Institute,2. To describe the clinical and demographic characteristics associated with history of exposure to SARS-CoV-2 and severity of COVID-19 disease in cancer patients. ,1. To determine SARS-CoV-2 antibody sero-prevalence in cancer patients attending care at the Uganda Cancer Institute,
 Uganda 2021-04-21 2024-04-21 Medical and Health Sciences Non-degree Award
Conrad Muzoora Kihembe
ID: UNCST-2019-R001432
 A randomized clinical TriaL of early empiric Anti-Mycobacterium tuberculosis therapy for Sepsis in sub-Saharan Africa (ATLAS trial)
REFNo: HS1272ES

The primary hypothesis of this clinical trial protocol is that immediate and sepsis specific dose of anti-TB therapy will result in improved 28-day mortality for study participants admitted to hospital with HIV and sepsis in Tanzania and Uganda compared to standard care alone.

The primary objective is:
1) To conduct a randomized 2x2 factorial clinical trial of 1) immediate initiation of empiric anti-TB therapy plus standard care vs diagnosis dependent anti-TB therapy plus standard care alone and 2) sepsis-specific anti-TB therapy plus standard care vs conventional WHO weight-based anti-TB therapy plus standard care for patients presenting with sepsis to two hospitals in Uganda and Tanzania.
1a) To determine if empiric immediate initiation of anti-TB therapy plus standard care improves 28 day mortality compared to diagnosis dependent anti-TB therapy plus standard care.
1b) To determine if sepsis-specific dose anti-TB therapy plus standard care improves 28 day mortality compared to conventional WHO weight-based anti-TB therapy plus standard care.

The secondary objectives include:
1) To determine if empiric immediate initiation of anti-TB therapy plus standard care improves in-hospital mortality compared to diagnosis dependent anti-TB therapy plus standard care
2) To determine if sepsis-specific dose anti-TB therapy plus standard care improves in hospital mortality compared to conventional WHO weight-based anti-TB therapy plus standard care.
3) To determine if empiric immediate initiation of anti-TB therapy plus standard care improves 6 month mortality compared to diagnosis dependent anti-TB therapy plus standard care
4) To determine if sepsis-specific dose anti-TB therapy plus standard care improves 6 month mortality compared to conventional WHO weight-based anti-TB therapy plus standard care.
5) To determine the safety of increased dose anti-TB therapy for patients with sepsis
6) To determine if early achievement of target serum drug concentrations of isoniazid and rifampin, measured at day-2 of TB treatment, associates with more rapid clinical improvement among patients with confirmed TB.

 Uganda 2021-04-21 2024-04-21 Medical and Health Sciences Non-degree Award
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