Phillip Ssekamatte
ID:
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IMMUNOLOGICAL, METABOLIC AND GENETIC CHANGES AMONG PATIENTS WITH TUBERCULOSIS AND TYPE 2 DIABETES MELLITUS IN UGANDA
REFNo: HS1696ES
Study objectives
General objective
To assess the effect of type 2 DM on Mtb-specific T-cell subset functional phenotypes during metformin and isoniazid therapy, and type 2 DM on the immunological, metabolic and genetic TB responses.
Specific objectives
(i) To determine the effect of type 2 DM on frequency, function (activation and cytokine secretion), and survival of Mtb-specific T-cell subsets (CD4+ and CD8+) in patients having both type 2 DM and LTBI during metformin and isoniazid therapy.
(ii) To assess baseline differences in Mtb-specific T-cell subset functional phenotypes to LTBI between people with and without type 2 DM.
(iii) To profile baseline immune-metabolic changes among type 2 DM and LTBI patients.
(iv) To investigate baseline differences in gene expression signatures (TB Risk-11) to LTBI between people with and without type 2 DM.
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Uganda |
2022-04-21 |
2025-04-21 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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Barnabas Bakamutumaho
ID: UNCST-2021-R012636
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Maintenance and transmission of Rift Valley Fever Virus and other emerging infectious diseases in East and Central Africa: Version number: 1.0
REFNo: HS1713ES
(i) Determine whether low-level RVF virus transmission and disease among or between animals and humans occurs during the inter-epidemic periods (IEPs)
(a). To describe host immune responses to RVF infections in humans and livestock during inter-epidemic periods.
(ii) Conduct detailed niche modelling of RVF high risk and low risk ecologies to determine the important ecological risk factors associated with persistence of RVF virus and recurrence of outbreaks in animals and humans.
(iii) Investigate impact of climate change on the RVF permissive ecologies and its effect on RVF virus transmission
2.2.2 Secondary objective
(iv) Conduct pathogen discovery on human, livestock, and wildlife samples collected from ECA countries to identify other circulating emerging infectious pathogens which are of epidemic or pandemic potential.
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Uganda |
2022-04-21 |
2025-04-21 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Etheldreda Nakimuli-Mpungu
ID: UNCST-2020-R014808
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Tele-Psychotherapy for Youth using Mobile Phones during Covid-19 Pandemic
REFNo: HS2106ES
1. We aim to conduct online and community-based participatory qualitative research to obtain information on the potential usefulness of individual tele-support psychotherapy in addressing depression during the Covid-19 pandemic.
2. We will compare the effectiveness of individual tele-support psychotherapy (TSP) delivered by trained lay counsellors in combination with standard mental health services (SMHS) for depression with use of SMHS alone.
3. We aim to compare the effects of TSP combined with SMHS and SMHS alone on other psychosocial variables including self-esteem, anxiety, alcohol and substance use, social support, stigma, number of disability days, asset possession, poverty indices, and cost-effectiveness measures.
4. To conduct a process evaluation of trial activities informed by Linnan and Steckler’s process evaluation frameworks to specifically determine indicators of feasibility, acceptability, fidelity, and to explore causal mediating processes and contextual influences
5. We will also explore whether or not the effects of TSP and SMHS are moderated by alcohol and drug use.
6. We shall explore whether the strength of a therapeutic relationship will mediate the effects of TSP and SMHS on depression
|
Uganda |
2022-04-21 |
2025-04-21 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Joseph Erume
ID:
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Profiling virulence markers and drivers enabling Escherichia coli to cause neo-natal and post-weaning piglet diarrhea in major pig producing districts of Uganda
REFNo: A190ES
1. To determine the adhesins in the 157 E. coli previously isolated from Kayunga and Mityana districts, Central Uganda
2. To determine the significance of E. coli species in the etiology of piglet diarrhea in the major pig producing districts of Uganda.
3. To determine drivers which underlie the dynamics and perpetuation of E. coli infections of pigs in the major pig producing districts of Uganda.
4. To molecularly characterize virulence markers of E. coli species involved in diarrheal outbreaks in piglets in the small holder pig production systems in major pig producing districts of Uganda.
5. To determine the antimicrobial susceptibility of E. coli isolates isolated from diarrheic piglets in the small holder pig production systems in selected major pig producing districts of Uganda.
|
Uganda |
2022-04-21 |
2025-04-21 |
Agricultural Sciences |
Non-Clinical Trial |
Non-degree Award |
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Paula Rabaey Ann
ID:
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A seat for every child: Ensuring safe and dignified mealtimes for children with disabilities
REFNo: SS1247ES
Determine in country stakeholder interest in promoting and using the chair,Determine percent change in caregiver stress level while feeding child in the chair versus current position (without adaptive equipment),Determine ability and level of ease/difficulty with which caregivers can independently position their child correctly in the chair ,Determine change in feeding position and tolerance for using the chair (from child’s current feeding position to being fed in the chair),To pilot test SPOON Foundation’s low-cost feeding chair for acceptability, usability, and feasibility for families with a child with a disability (CWD) in Uganda. ,
|
USA |
2022-04-20 |
2025-04-20 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
|
Ali Ssetaala
ID: UNCST-2021-R011817
|
CHILI- Analysis of Cervical cancer burden and screening practices in Uganda
REFNo: HS2167ES
1. To understand the current cervical cancer burden, screening, and management practices in Uganda.
2. To obtain relevant stakeholders’ input before starting the development of the cervical cancer screening intervention with a self-sampling device.
|
Uganda |
2022-04-20 |
2025-04-20 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Dinah Amongin
ID: UNCST-2020-R014663
|
An exploratory, mixed-method study of family planning self-care in Nepal, Niger, and Uganda
REFNo: HS2117ES
1. To explore perceptions of FP self-care among women of reproductive age (15-49 years) and men age 18 years and above.
2. To describe FP self-care behaviors and preferences among women of reproductive age (15-49 years) and men age 18 years and above.
3. To examine provider perspectives on FP self-care
|
Uganda |
2022-04-20 |
2025-04-20 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Dinah Amongin
ID: UNCST-2020-R014663
|
Effect of maternal exposure to air pollution on birth weight outcomes: A cohort Study among Urban Communities in Wakiso District, Uganda
REFNo: HS2141ES
To describe the association between maternal exposure to air pollution and pregnancy complications of antepartum haemorrhage and pre-eclampsia.,To describe the factors associated with the levels of PM 2.5 personal exposure among pregnant women in Urban Communities in Wakiso District, Uganda,To describe the association between maternal air pollution exposure (PM 2.5 and birth weight of their babies.,To assess the effect of maternal exposure to particulate matter on birth outcomes in Urban Communities in Wakiso District, Uganda,
|
Uganda |
2022-04-20 |
2025-04-20 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Janepher Nyakake
ID:
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Supporting young and female entrepreneurs for SME growth in Uganda and Somalia
REFNo: SS1256ES
To analyze the “potential impacts” of the interventions of these two innovation agencies on their supported SME clients to develop a package for rigorous evaluation.
|
Uganda |
2022-04-20 |
2025-04-20 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
|
Rebecca PAHULJE Rose
ID:
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Examining the northward shift in the distribution of African fishes in association with climate change
REFNo: NS345ES
To understand how climate is affecting the physiology and distribution of tropical fishes.
Specifically;
- To quantify the thermal limits and hypoxia tolerance of tropical fishes and the degree to which these limits are plastic
- To understand and predict how tropical fishes will respond to climate change – either via persistence in situ or changing their distribution by moving to more favourable thermal/oxygen regimes.
|
Canada |
2022-04-20 |
2025-04-20 |
Natural Sciences |
Non-Clinical Trial |
Degree Award |
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ALBERT KABANDA
ID:
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Dry Rifting In the Albertine-Rhino Graben, Uganda (DRIAR)
REFNo: NS342ES
Objectives: A geophysical, geochemical, geological, and geodynamic investigation of the Albertine-Rhino Graben in western and northwestern Uganda to improve our understanding of continental rifting in areas where volcanic activity is minimal.
|
Uganda |
2022-04-19 |
2025-04-19 |
Natural Sciences |
Non-Clinical Trial |
Degree Award |
|
Susan Nakireka Tumwesigye
ID:
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DETERMINANTS OF COVID-19 OUTCOMES IN UGANDA: A MULTICENTRE, MIXED-METHODS STUDY
REFNo: HS2090ES
Broad Objective
To describe the determinants of COVID-19 outcomes in Uganda
Specific Objectives
1.To describe the clinical characteristics and co-morbidities among patients hospitalized with COVID-19.
2.To determine the clinical outcomes (mortality, ICU admissions, length of stay) following hospitalization for COVID-19
3.To describe radiological patterns of COVID-19
4.To describe outcome of COVID-19 patients managed at home.
5.To explore the experience of patients managed with COVID-19 at home.
?
|
Uganda |
2022-04-19 |
2025-04-19 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Gerald Mboowa
ID:
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PATHOGEN DETECTION IN CHILDREN LIVING WITH HIV PRESENTING WITH NON-MALARIAL FEBRILE ILLNESS USING METAGENOMIC SEQUENCING
AT BAYLOR-UGANDA
REFNo: HS2140ES
Primary objective: This project aims to utilise Shotgun metagenomic sequencing (sMGS) to comprehensively characterize microbial pathogens in Children Living with HIV Presenting with Non-Malarial Febrile Illness attending Baylor College of Medicine Children's Foundation –HIV treatment clinic
Secondary objectives:
1. To identify and characterize microbial pathogens in Ugandan children and adolescents living with HIV attending Mulago National Referral Hospital, Baylor-Uganda clinic with non-malarial febrile illness (NMFI)
2. To identify and describe the frequency of comorbidities in children with perinatally acquired HIV-infection with NMFI in Uganda
|
Uganda |
2022-04-19 |
2025-04-19 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
|
Nahwera Loyce
ID:
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EFFECTS OF 12-WEEKS AEROBIC DANCE ON BLOOD PRESSURE, PERCENT BODY FAT AND hs-CRP IN HYPERTENSIVE PATIENTS ATTENDING KYAMBOGO MEDICAL CENTRE, UGANDA
REFNo: HS2202ES
1. To establish the baseline systolic and diastolic blood pressure, percent body fat and hs-CRP levels in stage 1 hypertensive patients attending Kyambogo University Medical Centre in Kampala, Uganda.
2. To determine the effect of a 12-week aerobics dance programme on Systolic Blood Pressure (SBP) levels in stage 1 hypertensive patients attending Kyambogo University Medical Centre in Kampala, Uganda.
3. To determine the effect of a 12-week aerobics dance programme on Diastolic Blood Pressure (DBP) levels in stage 1 hypertensive patients attending Kyambogo University Medical Centre in Kampala, Uganda.
4. To establish the effect of a 12-week aerobics dance programme on percent body fat in stage 1 hypertensive patients attending Kyambogo University Medical Centre in Kampala, Uganda.
5. To determine the effect of a 12-week aerobics dance programme on hs-CRP levels in stage 1 hypertensive patients attending Kyambogo University Medical Centre in Kampala, Uganda.
|
Uganda |
2022-04-19 |
2025-04-19 |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
|
Frederick GOGARTEN Jan
ID:
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Comparing traditional monitoring of Kibale wildlife population abundance and health with molecular based environmental DNA based approaches
REFNo: NS343ES
To test the use of air DNA and fly-derived DNA for describing mammal and parasite communities by using the long-term monitoring efforts across transects in Kibale National Park.
Specifically aim to explore the role of flies in disease ecology in and around groups of primates in Kibale National Park, and their potential role as vectors at the human-wildlife interface, including the exploration of changes in fly density and disease prevalence.
|
Germany |
2022-04-19 |
2025-04-19 |
Natural Sciences |
Non-Clinical Trial |
Non-degree Award |
|
HAMEL Fortin Liana
ID:
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Interaction between hypoxia and thermal tolerance in the cyprinid fish (Enteromius neumayeri)
REFNo: NS346ES
To look at the interaction between hypoxia (low oxygen) adaptation and thermal tolerance in tropical African fishes, of particular interest in Kibale National Park.
The project will specifically investigate how local adaptation to hypoxia affects the thermal and hypoxia tolerance of Enteromius neumeyari before and after acclimating fish to elevated water temperature
|
Canada |
2022-04-19 |
2025-04-19 |
Natural Sciences |
Non-Clinical Trial |
Degree Award |
|
Matthieu Chemin
ID:
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Lawyers for Consumer Protection: Evidence from a Field Experiment in Uganda
REFNo: SS1255ES
3.The UCC would be especially important in this context, as they serve as the telecom regulator for mobile money transactions. Furthermore, the UCC is currently developing plans for the creation of a “communications tribunal”, which is the ideal endpoint for those in the treatment group to have their disputes resolved.,2.This intervention would also be informative to consumer protection agencies simply so that they are made aware of both how prevalent the problem of mobile money fraud is, and how they can most effectively address it.,1.Findings of this intervention would be relevant to policymakers on several levels. First, conclusions from CTDR-U’s platform would be of utmost interest to regulators who are involved with fraud, especially when it relates to mobile money agent fraud such as in Buku and Mazer (2017).,
|
Canada |
2022-04-14 |
2025-04-14 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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Elisam Magara
ID:
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PRESERVATION OF ORAL HISTORY IN THE MINISTRY OF THE WORD: BRIDGING EVANGELICAL GAP IN THE MARKETPLACE AMONG THE BANYANKOLE IN UGANDA
REFNo: SS1248ES
Purpose of the Study
Preserving of oral history restores the identity as one way to claim back the lost identity. As Marcus Garvey asserts, “a people without knowledge of the past history, origin and culture is like a tree without toots”. Therefore, careful effort is needed in assessment of oral history genres that best suits the ministration of the Word in the market place. This study aims at establishing strategies for applying Oral History in the Ministry of the Word in the Marketplace in Uganda.
Specific Objectives
This study shall be able to:
1. Establish the kind of oral history practices among the Banyankole available for the ministry of the Word.
2. Analyze the techniques in the ministration of the Word in the marketplace in Uganda.
3. Develop strategies for applying oral history in the Ministry of the Word for the Kingdom of God.
|
Uganda |
2022-04-14 |
2025-04-14 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
|
Sebastian Linnemayr
ID: UNCST-2021-R012696
|
Goals for Adherence with Low-cost Incentives (GOALS)
REFNo: HS2207ES
The objective in year 1 is to identify the incentive design most effective for improving adherence.
The objective in year 2 is to maintain adherence improvements at the clinically optimal level of 90 percent and achieve viral suppression.
The objective in year 3 is to measure adherence for 12 months after the intervention ends to assess the impact of the different treatment arms on behavior change once incentives are withdrawn (persistence).
|
USA |
2022-04-14 |
2025-04-14 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Benon Zebosi
ID:
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Factors associated with functional capacity and nutritional status among community dwelling elderly aged 65 to 85 in Lugazi municipality, Buikwe district
REFNo: SS1031ES
1. To assess the nutritional status of the elderly persons aged 65 to 85 in Lugazi municipality, Buikwe district.
2. To assess the functional capacity of the elderly persons aged 65 to 85 in Lugazi municipality, Buikwe district.
3. To investigate the association between functional capacity and nutritional status of the elderly persons aged 65 to 85 in Lugazi municipality, Buikwe district.
|
Uganda |
2022-04-13 |
2025-04-13 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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