Patrice Mawa Akusa
ID:
|
Exploring immune responses in primary and more advanced Schistosoma mansoni infection and treatment of preschool-age children using Aurora spectral flow cytometry
REFNo: HS1223ES
Objective 1: To characterize immune responses of PSAC in primary and more advanced S. mansoni infection
Objective 2: To determine the effect of PZQ treatment of S. mansoni on immune responses in PSAC.
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Uganda |
2021-03-03 |
2024-03-03 |
Medical and Health Sciences |
|
Non-degree Award |
|
LYDIA NAKIGANDA JACENTA
ID:
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Demographic characteristics, attitudes, behaviours and sexually transmitted infections among female sex workers using HIV Pre- Exposure Prophylaxis living in the fishing communities around Lake Victoria Basin, Uganda.
REFNo: HS813ES
i.To define demographic characteristics
ii.To explore sexual behaviours, in association with PrEP prescription,
iii. To explore self-reported adherence rates and correlates of adherence
iv. To examine the STI disease burden, use of condoms and explore associations between condom use and STIs.
v. To explore factors that might facilitate or challenge PrEP use, such as side effects and stigma, and
vi. To understand FSWs’ experiences, perceptions of & attitudes towards PrEP
|
Uganda |
2021-03-01 |
2024-03-01 |
Medical and Health Sciences |
|
Degree Award |
|
Jaffer Okiring
ID:
|
Increasing malaria trends amidst routine core interventions among residents of varying transmission settings of Uganda
REFNo: HS1033ES
1) To compare the malaria trends measured using Test Positivity Rate and Total laboratory confirmed cases of malaria relative to incidence in high malaria settings in Uganda
2) To determine household level factors associated with malaria incidence at 68 sites with varying malaria transmission intensity.
3) To investigate the environmental factors associated with malaria incidence and how these factors modify the impact of core vector control interventions in Uganda
4) To develop a model that can predict malaria incidence in different epidemiological settings and how the incidence will vary with the roll out of different core interventions in Uganda.
|
Uganda |
2021-03-01 |
2024-03-01 |
Medical and Health Sciences |
|
Degree Award |
|
Elizeus Rutebemberwa
ID: UNCST-2022-R009070
|
Evaluation and Scale-up Strategy for the Doctor@Distance Programme in Uganda
REFNo: HS955ES
4.3 General objective
To evaluate the Doctor@Distance programme by identifying current benefits and gaps and exploring the path for further development of the programme and potential embedment of the programme in the larger health system.
4.4 Specific objectives
1.To explore what the multi-stakeholder perceptions are on the design and daily practice of the Doctor@Distance programme
2.To analyse the design and current utilisation of the Doctor@Distance programme and identify potential gaps in its coverage (how often is it used, by whom, for which diseases, etc.)
3.To evaluate the current healthcare gaps in the communities in which the community health entrepreneurs of the Doctor@Distance programme are active
4.To explore how the Doctor@Distance programme can be scaled-up to other districts within Uganda
5.To investigate multi-stakeholder perceptions on the possibility of integration of the Doctor@Distance programme in the larger health system in Uganda
|
Uganda |
2021-03-01 |
2024-03-01 |
Medical and Health Sciences |
|
Non-degree Award |
|
Richard Nyeko
ID: UNCST-2021-R012815
|
Pre-hospital exposure to, and antimicrobial drug resistance patterns among febrile children presenting to St. Mary’s Hospital Lacor, northern Uganda
REFNo: HS1091ES
General objective
To determine the prevalence of pre-hospital exposures to antibiotics, common bacteria and their susceptibility to microbial drugs among febrile children presenting to a tertiary health facility in northern Uganda.
Specific objectives
1. To determine the prevalence of pre-hospital exposures to antibiotics among febrile children presenting at St Mary’s Hospital Lacor
2. To establish the common bacterial isolates among febrile children presenting at St Mary’s Hospital Lacor
3. To determine the microbial resistance patterns among febrile children presenting at St Mary’s Hospital Lacor
|
Uganda |
2021-03-01 |
2024-03-01 |
Medical and Health Sciences |
|
Non-degree Award |
|
Aidah Nanvuma
ID: UNCST-2024-R015734
|
EVALUATING THE CAPACITY BUILDING MODEL USED TO NURTURE INDEPENDENT RESEARCH INVESTIGATORS AT THE INFECTIOUS DISEASES INSTITUTE, UGANDA
REFNo: HS1100ES
Objective 1: To describe Capacity Building Unit support activities and scholarly outputs and outcomes since inception.
Objective 2: To determine how particular components of the unit scientific and non-scientific support(Inputs) contribute to scholar (past and present) outputs and outcomes since inception.
Objective 3: To identify and address areas of improvement in unit support activities through the engagement of current and former stakeholders (beneficiaries and benefactors).
|
Uganda |
2021-03-01 |
2024-03-01 |
Medical and Health Sciences |
|
Non-degree Award |
|
Moses Joloba Lutaakome
ID: UNCST-2022-R011558
|
A Study to Validate and Improve an Automated Image Analysis Algorithm to Detect Tuberculosis in Sputum Smear Slides: Version 1.0 dated Nov 2020
REFNo: HS1144ES
1. Validate the platform, and assess efficiency improvements from computerized detection approaches.
a. Perform a slide specimen digitization (400 slides, 98 images/slide, 39,200 images).
b. Classify all images as dark/medium/light based on color histogram data.
c. Assess accuracy vs. manual microscopy, and sensitivity/specificity vs. bacterial culture.
d. Develop a new image analysis algorithm by integrating software applications that include Artificial Intelligence (AI) approaches via Convolutional Neural Networks (CNN).
2. Quantify slide staining quality and variability through the use of novel methods which exploit the color spectra of stained slides.
a. Determine factors which led to poor slide preparation.
b. Test a new quality control method (HistoQC) to standardize clinical slide preparations
|
Uganda |
2021-03-01 |
2024-03-01 |
Medical and Health Sciences |
|
Non-degree Award |
|
THOMSON LAKWO LURONI
ID: UNCST-2023-R007843
|
Evaluation of the Diagnostic Tests in Areas Hypoendemic for Onchocerciasis –Uganda: a follow-up study.
REFNo: HS1220ES
Objective 1: Evaluate the distribution of anti-OV-16 antibody and other markers of O. volvulus infection in multiple age groups over time in an area of active intervention for onchocerciasis
Objective 2: To determine whether a serologic threshold of 2% that modeling suggested is consistent with interruption of transmission.
Objective 3: Monitor for sero-reversion of OV-16 antibody positivity in a nested cohort of individuals who participated in the previous study.
|
Uganda |
2021-03-01 |
2024-03-01 |
Medical and Health Sciences |
|
Non-degree Award |
|
Moses Joloba Lutaakome
ID: UNCST-2022-R011558
|
Predicting the Future: Incipient Tuberculosis (PreFIT)
REFNo: HS1242ES
1.1 Aim:
To validate the clinical performance, cost, and feasibility of a package of ready-to-use new and existing candidate diagnostic assays for the prediction of the development of active TB.
1.2 Objectives:
1. Establish a multi-country diagnostic evaluation cohort of highly exposed TB contacts free of co-prevalent active TB, followed prospectively for active TB development over a 12-months period, and collect and store biological specimens from these contacts at pre-set time-points for laboratory testing; and
2. Validate a package of candidate assays for their predictive accuracy (sensitivity, specificity, positive and negative predictive values) for incident TB, feasibility, and cost. Based on combining results for the different tests, cost-optimised predictive algorithms will be derived.
|
Uganda |
2021-03-01 |
2024-03-01 |
Medical and Health Sciences |
|
Non-degree Award |
|
Miriam Nansunga
ID:
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ASSESSMENT OF THE SAFETY AND EFFICACY OF COMMON MEDICINAL PLANTS OF CENTRAL UGANDA ON IMPAIRED LEARNING AND MEMORY IN RATS
REFNo: HS648ES
1. To identify medicinal plants of Central Uganda used in the management of memory impairment.
2. To determine the effect of the aqueous extracts of the 5 most commonly mentioned plants on escape latency in the Morris Water Maze and step down latency in Passive Avoidance test.
3. To determine the effect of the total crude extracts of the two most effective plants on: acetylcholine, glutamate; muscarinic receptor M1, M3 and M5; glutamate receptors AMPA and NMDA in the hippocampus and orbital frontal cortex
4. To establish the safety and toxicity profile of the two most active plants extracts on memory and learning enhancement.
|
Uganda |
2021-02-26 |
2024-02-26 |
Medical and Health Sciences |
|
Degree Award |
|
Leevan Tibaijuka
ID: UNCST-2021-R012986
|
Predictors for preterm neonatal mortality at Mbarara Regional Referral Hospital
REFNo: HS469ES
General objective
To Describe the Predictors for Preterm Neonatal Mortality among preterm babies delivered at Mbarara Regional Referral Hospital (MRRH).
Specific objectives
1. To describe the neonatal mortality of preterm babies at Mbarara Regional Referral Hospital
2. To describe the association of antenatal care attendance, antenatal corticosteroid use and mode of delivery with preterm neonatal death at Mbarara Regional Referral Hospital
|
Uganda |
2021-02-25 |
2024-02-25 |
Medical and Health Sciences |
|
Degree Award |
|
Francis Ekadu
ID:
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Uganda Bribery Index
REFNo: SS392ES
To increase citizens awareness on the prevalence, gravity and impact of corruption in uganda
|
Uganda |
2021-02-25 |
2024-02-25 |
Social Science and Humanities |
|
Non-degree Award |
|
Lucrèce Ahovègbé Yémalin Judith
ID:
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Evaluation of two medicinal plants on key factors causing treatment failure in Hepatitis C infection
REFNo: HS1004ES
1. Evaluate the antiviral and anti-mutagenic effect of A. nilotica and T. ciliata on HCV in presence and absence of DAA
2. Evaluate the effect of A. nilotica and T. ciliata on induced mutation in HCV infection in presence and absence of DAA
3. Determine effect of A. nilotica and T. ciliata on immunologic parameters involved in body response to HCV in presence and absence of DAA
4. Investigate the genotypes of HCV circulating in African region (Uganda, Benin) and their response in vitro to DAAs
|
Benin |
2021-02-25 |
2024-02-25 |
Medical and Health Sciences |
|
Degree Award |
|
PAUL KATO KALYEBARA KALYEBARA
ID:
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INCIDENCES OF RE-MARRIAGE, LIVE CHILDBIRTH AND RECURRENCE OF INCONTINENCE AMONG WOMEN THAT UNDERWENT OBSTETRIC FISTULA REPAIR AT MBARARA REGIONAL REFERRAL HOSPITAL FROM 2010 TO 2019
REFNo: HS1060ES
General objective
To determine the incidences of re-marriage, live childbirth and recurrence of incontinence among women who had successful obstetric fistula repair at Mbarara Regional Referral Hospital from 2009 to 2019.
Specific objectives
1. To determine the incidence of re-marriage among women who had successful fistula repair at Mbarara Regional Referral Hospital from 2010 to 2019.
2. To determine the incidence of live childbirth among women who had successful obstetric fistula repair at Mbarara Regional Referral Hospital from 2010 to 2019.
3. To compare recurrence rates of incontinence after childbirth occurring among women who had successful genitourinary and rectovaginal fistula repair at MRRH from 2010 to 2019.
|
Uganda |
2021-02-25 |
2024-02-25 |
Medical and Health Sciences |
|
Degree Award |
|
FREDDIE SSENGOOBA Peter
ID: UNCST-2021-R011834
|
Political Economy Analysis of sub-national health management in Eastern and Southern Africa
REFNo: SS664ES
This study will explore the dynamics taking place at sub-national level (e.g. within counties or districts) as well as between national and sub-national levels along the following objectives:
1. Analyze the environment for decision-making and implementation of health plans at sub-national level, including existing formal and informal processes for decision-making; political, financial, social, and other influences on sub-national prioritization, decision-making and resource allocation, including relevant changes over time (e.g. post-devolution), and how data and evidence play a role.
2. Identify and characterize key stakeholders with a role in sub-national health management and systems—key characteristics will include technical capacity, their use of data and evidence, the relationships and power dynamics between them, and the existing structures for engagements with non-health sector authorities, both formal and informal.
3. Assess existing formal and informal accountability mechanisms for sub-national decision-making for health (both within the health system and for external stakeholders like beneficiary communities, sub-national decision-makers (county/district), and development partners) with a view to identify ways to improve the relative effectiveness of accountability mechanisms in decision processes.
4. Analyze social sector spending trends and beneficiaries, their relation to health sector policies, and how local governance structures influence them, where available.
5. Develop draft plan for piloting strategies to address challenges identified by the PEA, including proposed implementation and monitoring and evaluation approaches, as appropriate.
6. Analyze the policy environment on community health, including key stakeholders, to identify potential approaches for integrating a new community health extension worker program into existing systems, especially at district level
7. Analyze the current digital health innovations governance and accountability structures, (including key stakeholders across sectors and how their responsibilities and priorities overlap,) to identify strategies for strengthening existing structures, enhancing accountability and minimizing duplication
|
Uganda |
2021-02-25 |
2024-02-25 |
Social Science and Humanities |
|
Non-degree Award |
|
Silvia Kahihu Wairimu
ID:
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Improving the Impact of VSLAs on Refugees’ and Host Communities’ Self- reliance, Resilience and Economic Capacity
REFNo: SS658ES
Our main objective is to investigate different facets of the VSLA (structure, benefits, and barriers as well as future opportunities) with the aim of optimizing its design. This is because we hypothesize that optimizing the structure of the VSLA will lead to increased financial inclusion of the group members as well as social capital.
|
Kenya |
2021-02-25 |
2024-02-25 |
Social Science and Humanities |
|
Non-degree Award |
|
Dianah Ahumuza Ateenyi
ID:
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The impact of tax incentives on the realisation of economic and social rights: A focus on tax holidays and the right to basic education in Uganda
REFNo: SS666ES
1. To examine the historical background and justification of tax incentives generally and tax holidays specifically especially in Uganda.
2. To explore the adequacy of the legal and policy framework on tax incentives, especially tax holidays in Uganda and how it impacts revenue for the realisation of ESRs, specifically the right to basic education;
3. To analyse the relationship between government revenue and basic education financing and how it the realisation of the right to basic education.
4. To recommend appropriate legal, policy and administrative reforms for the better management of tax incentives generally and tax holidays specifically for the realisation of Uganda’s international and domestic ESRs obligations, with specific emphasis on the right to basic education.
|
Uganda |
2021-02-25 |
2024-02-25 |
Social Science and Humanities |
|
Degree Award |
|
Joseph Lutaakome
ID: UNCST-2020-R008323
|
An International Observational Study to Characterize Adults
Who Are Hospitalized with Influenza or Other Targeted Respiratory Viruses
(INSIGHT Protocol No. 003 version 3.0, dated 27 August 2013); Flu003 PLUS
AND
Genomic Study: INSIGHT Protocol No. 004 version 2.0, dated 27 August 2013 -A substudy of qualifying INSIGHT studies
REFNo: HS1108ES
The objectives of this study for participants with confirmed influenza are to:
1. Characterize individuals who are hospitalized with influenza in terms of demographics, co-morbid conditions, prior influenza vaccination (seasonal, including 2009 H1N1) and pneumococcal vaccination, and use of antivirals, overall and according to influenza type, A or B, and influenza A subtype.
2. Estimate the percent who die and who develop a composite outcome, overall and according to the identified influenza type or subtype: death, a requirement for mechanical ventilation or admission to the intensive care unit (ICU), or prolonged hospitalization following enrollment (duration of hospitalization >28 days) at 60 days after enrollment.
3. Study risk factors, (e.g., patient and viral characteristics, geographic location, influenza type and subtype) for mortality and the composite outcome of death, a requirement for mechanical ventilation or admission to the ICU, or prolonged hospitalization following enrollment (duration of hospitalization >28 days).
4. Establish a repository of oropharyngeal, nasal and lower airway samples to determine a laboratory diagnosis; to molecularly characterize the virus, including subtype, antigenic and genetic analyses; to identify known signature mutations for antiviral drug resistance, mutational evolution, and additional re-assortment; and assess possible co-pathogens.
5. In a subset of patients requiring mechanical ventilation, to collect paired upper and lower airway samples to molecularly characterize the virus according to anatomic location, assess the potential emergence of antiviral resistance and assess possible co-pathogens.
6. Establish a repository of serum and plasma for future studies, including measurement of biomarkers that predict disease severity and measures of host response to infection with influenza virus.
7. Compare the characteristics and outcomes of patients infected with different influenza virus types and subtypes, including 2009 H1N1 virus, over time and by geographic region.
8. Identify and characterize other viral and bacterial pathogens, including coinfections.
The objectives of this study for participants with targeted non-influenza viral respiratory infections are to:
1. At enrollment, characterize individuals who are hospitalized with a targeted viral respiratory disease in terms of possible source of infection and mode of transmission, demographics and co-morbid conditions.
2. At 28 and 60 days of follow-up, estimate the percent who die, require admission to the ICU, have prolonged hospitalization, or recover.
3. Establish a repository of prospectively collected serum, plasma and respiratory tract specimens for future studies, including measurement of biomarkers that predict disease severity and measures of host immune response to infection.
|
Uganda |
2021-02-25 |
2024-02-25 |
Medical and Health Sciences |
|
Non-degree Award |
|
Jane Frances Namatovu
ID:
|
CONTINUING PROFESSIONAL DEVELOPMENT FOR PRIMARY CARE DOCTORS IN LOW RESOURCE SETTINGS: DEVELOPING A COMPETENCY-BASED FRAMEWORK
REFNo: HS1170ES
1.To determine the CPD training needs of primary care doctors working in public general hospitals (GHs) and health center IVs (HC IVs) of central Uganda
2.To explore the perceived barriers to and facilitators of CPD among primary care doctors working in public GHs and HC IVs of central Uganda
3.To explore the views of key stakeholders on CPD for doctors working in public GHs and HC IVs of central Uganda
4.To develop a competency-based CPD framework for primary care doctors working in public GHs and HC IVs of central Uganda
|
Uganda |
2021-02-25 |
2024-02-25 |
Medical and Health Sciences |
|
Degree Award |
|
Dennis Muhanguzi
ID: UNCST-2019-R001101
|
Targeting Domestic Animals and Tsetse Fly Vectors to Control Nagana and Accelerate Elimination of Acute Sleeping Sickness from Hot Spot Villages of Eastern Uganda
REFNo: A107ES
The main objective of this study will be to determine whether targeting hotspot villages would accelerate elimination of rHAT
The specific objectives of this project will be to determine;
i. If rHAT hotspot village-based interventions [two doses of diminazene aceturate 40 days apart at the beginning of the intervention and monthly RAP] will progressively reduce T. brucei s.l. reservoir in cattle and hence insidious rHAT transmission.
ii. The drivers of insidious rHAT transmission in hotspot rHAT hotspot villages in Dokolo and Kaberamaido districts.
|
Uganda |
2021-02-25 |
2024-02-25 |
Agricultural Sciences |
|
Non-degree Award |
|
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