Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Stevens Bechange
ID: UNCST-2022-R009190
Eye Health Systems Assessment – Uganda
REFNo: HS4368ES

Examine how the above components of the eye health system recognise and address the needs of groups identified as vulnerable to exclusion from services,Assess the available eye care infrastructure,Assess the information system for eye health,Determine available medical products, vaccines and technologies for eye care,Determine available human resources for eye health,Describe eye care service delivery ,Assess the health financing mechanisms in operation,Describe the governance and leadership function ,The overall objective of this study is to examine and document the strengths and weaknesses of all components of the eye health care delivery system and health system linkages – thus providing a basis for targeted programmatic work to strengthen the eye health systems infrastructure and improving outcomes for eye conditions in Uganda.,
Uganda 2024-06-21 17:51:54 2027-06-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
George Kasule William
ID: UNCST-2023-R006891
EVALUATION OF NON-SPUTUM-BASED DIAGNOSTICS AND BIOMARKERS FOR DETECTION OF M. TUBERCULOSIS AMONG CHILDREN AND PEOPLE LIVING WITH HIV
REFNo: HS4344ES

To assess literature review of Mycobacterium tuberculosis biomarkers in non-invasively collected non-sputum samples of the Oral-Gut and Nasal pharynx parts of humans. To determine the diagnostic performance of novel stool-based biomarkers for detecting tuberculosis in children and among PLHIV using stool samples.To determine the diagnostic performance of breath-based biomarkers for detecting tuberculosis in children and among PLHIV.To determine the diagnostic performance of novel urine-based biomarkers for detecting tuberculosis in children and among PLHIV.To explore health workers’ and policymakers’ perceptions on the use of non-sputum-based assays for detecting tuberculosis in children and among PLHIV in Uganda.
Uganda 2024-06-21 17:50:21 2027-06-21 Medical and Health Sciences Non-Clinical Trial Degree Award
Rose Nabirye Chalo
ID: UNCST-2020-R014645
DEVELOPMENT OF AN INTER-PROFESSIONAL EDUCATIONAL PROGRAMME FOR THE ASSESSMENT OF MENTAL HEALTH OF PREGNANT TEENAGERS
REFNo: SS2691ES

The proposed project seeks to promote inter-professional education by developing an educational programme that will be used for inter-professional training of students in the health professions on the mental health assessment of pregnant teenagers.,
Uganda 2024-06-21 17:48:53 2027-06-21 Social Science and Humanities Non-Clinical Trial Non-degree Award
Daniel Iraguha Ndungutse
ID: UNCST-2024-R003686
DETECTION OF PAROXYSMAL ATRIAL FIBRILLATION AMONG RHEUMATIC HEART DISEASE REGISTRY PATIENTS AT THE UGANDA HEART INSTITUTE, A PREVENTIVE STRATEGY AGAINST STROKE
REFNo: HS4389ES

• To determine the prevalence of paroxysmal
atrial fibrillation using ambulatory ECG
monitoring among participants with severe
RHD in the Uganda Heart registry
• To determine factors associated with
paroxysmal atrial fibrillation among
participants with severe RHD in the Uganda
RHD registry

Uganda 2024-06-21 17:47:52 2027-06-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jonathan Izudi
ID: UNCST-2019-R000469
Integrating Tuberculosis Treatment into Community Pharmacies to improve TB/HIV outcomes in Uganda: the Community Pharmacy Tuberculosis Treatment (COPHAT) study
REFNo: HS4397ES

To evaluate the implementation and preliminary effectiveness of integrating TB treatment into community pharmacies among people with TB/HIV.,To adapt a person-centered strategy for integrating TB treatment into community pharmacies using a human-centered design methodology.,To explore the barriers and facilitators to integrating TB treatment into community pharmacies among people with TB/HIV.,The main objective of this Community Pharmacy Tuberculosis Treatment (COPHAT) study is to develop and pilot an implementation strategy focused on integrating TB treatment into community pharmacies among people with TB/HIV in Kampala, Uganda. ,
Uganda 2024-06-21 17:46:35 2027-06-21 Medical and Health Sciences Clinical Trial Non-degree Award
JUSTINE MUKALERE
ID:
CONNECTING COMMUNITIES TO HEALTH SYSTEMS THROUGH VILLAGE HEALTH TEAMS: A TECHNOLOGY-ENABLED FRAMEWORK. A CASE OF BUGWERI, BULAMBULI, KIBUKU DISTRICTS
REFNo: SIR284ES

iii. To evaluate the designed framework to establish its applicability in connecting communities to health systems.,ii. To design a technology-enabled framework that will connect villages to health systems through Village Health Teams,i. To study the challenges faced by Village Health Teams in Kibuku, Bulambuli and Bugweri districts based on the existing framework and generate requirements,To enhance the connectivity between communities and the health systems through Village Health Teams based on a technology-enabled framework.,
Uganda 2024-06-21 17:45:14 2027-06-21 Engineering and Technology Non-Clinical Trial Degree Award
Leticia Kyohangirwe
ID: UNCST-2024-R004144
Determining the effect of psychiatric disorders on clinical outcomes among adolescents with HIV in Uganda over a one-year period.
REFNo: HS4120ES

The overall objective is to determine effect of psychiatric disorders on clinical outcomes among adolescents with HIV in Uganda using a longitudinal analysis approach.
Uganda 2024-06-19 15:57:59 2027-06-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kearsley Stewart
ID: UNCST-2021-R011830
Addressing Sickle Cell Disease in Uganda: A Multi-Sectoral Approach
REFNo: HS4276ES

Aim 3: We aim to assess the current digital capacity (smart mobile phone access, internet access, data security, access to data) of KHCIV sickle cell patients, their caregivers, and KHCIV clinic staff in order to understand their preparedness for using mobile applications to improve sickle cell disease care. We seek to identify facilitators and barriers to uptake of mHealth tools and interventions, including Nanbar Health for patients and SCD Toolbox for KHCIV providers. In addition, we aim to determine the feasibility of using the Nanbar Health and SCD Toolbox mobile applications in Kalangala District and propose solutions for adaptation to enhance sickle cell care and improve outcomes beyond Kalangala District for others in Uganda. ,Aim 2: We aim to improve clinical monitoring of home-based adherence to hydroxyurea by exploring the feasibility and acceptability of using a rapid point-of-care electrophoresis sickle cell test (Gazelle) to monitor fetal hemoglobin for sickle cell patients taking hydroxyurea at their quarterly clinic visits to KHCIV. In addition, we aim to understand the facilitators and barriers to successful home-based adherence to hydroxyurea through a home visit to interview patient and caregivers about their adherence-related behaviors and observe conditions in the home that directly influence adherence to hydroxyurea, such as pill storage. ,Aim 1: We aim to explore the facilitators and barriers to uptake of newborn screening at KHCIV at a time when the Government of Uganda is scaling up newborn sickle cell testing across the country. We will describe the challenges for staff at a remote government health care facility to scale up newborn sickle cell testing. We will study parental perspectives on newborn sickle cell testing and their experiences with the current standard-of-care (dried blood spots) sent by KHCIV to the Central Public Health Laboratory in Kampala.,This study aims to reduce the burden of SCD in Uganda through a multi-sectoral study of the facilitators and barriers to: scale-up of universal newborn screening, adherence to treatments such as hydroxyurea, and improved access to sickle cell health education through mHealth digital apps. ,
USA 2024-06-18 11:20:00 2027-06-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Fred Nalugoda
ID: UNCST-2021-R013343
The Rakai Orphans in Communities (ROC)
REFNo: SS2744ES

The specific aims are to:
1. Define, over time, the potentially changing impact of orphanhood on HIV risk factors and HIV infection among AYA from RCCS Rounds 6-23 (1999-2027).
2. Explore issues related to mechanism and measurement to better understand the population burden of orphanhood among AYA. Key issues include 1-timing of orphaning (i.e., age they became an orphan), 2-influence of orphanhood vs. parental absence from the household, 3-the burden of orphanhood over time among children 0-14 years, and 4-validating the route of transmission (behavioral vs. perinatal) among adolescents first entering the RCCS.
3. Through life history interviews, explore the mechanisms by which orphanhood and age at orphaning may influence HIV risk among AYA and adolescent social outcomes and to assess how programs can be tailored to meet the needs of this vulnerable population. Interviews will be conducted with youth and their adult caretakers; each should be able to differentially report on events and circumstances of the orphaning period.
4. Estimate the economic impact of declining HIV-related orphanhood on youth, families, and communities. In a cost-benefit analysis, we will examine benefits of declining orphanhood (decreased adult mortality, decreased orphanhood, increased educational status, decreased HIV infection among youth) and costs (costs for ART, MMC).
Uganda 2024-06-17 11:41:08 2027-06-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
John Ekure
ID:
LONG-TERM OUTCOMES OF THE MANAGEMENT OF OPEN FRACTURES AT KUMI ORTHOPAEDIC CENTER: A RETROSPECTIVE AND PROSPECTIVE LONGITUDINAL STUDY
REFNo: HS3238ES

To prospectively determine the long-term outcomes of management of open fractures of long bones at KOC from Sept 2023 to Sept 2033.,To retrospectively determine the long-term outcomes of the management of open fractures of long bones at Kumi Orthopaedic Center from 2010 to 2022.,to retrospectively and prospectively determine the long-term outcomes of the management of open fractures of long bones using surgical techniques at Kumi Orthopaedic Center.,
Uganda 2024-06-12 15:43:48 2027-06-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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