Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Yang Jae Lee
ID: UNCST-2021-R012449
 Destigmatization of Mental Illness Through Theater
REFNo: HS1764ES

1. Primary Objective
Effectiveness of a community theater-based destigmatization program to combat stigma and increase care-seeking habits as measured by KAP (knowledges, attitudes, and practices) survey and focus groups at the beginning and the end of the intervention

2. Secondary Objective
1) Assess the general prevalence of mental health conditions for patients attending outpatient visits for general medical conditions
2) Assess KAP towards mental health of healthcare providers to shape future interventions in mental health destigmatization

 USA 2021-12-10 2024-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Simon Kasasa
ID:
Evaluating the effectiveness of grouped intensive adherence counselling sessions in improving viral load re-suppression in Uganda
REFNo: HS1850ES

The main goal of this study is to evaluate the effectiveness of grouped intensive adherence counselling sessions in improving viral load re-suppression in Uganda.
The specific primary objectives of our study are as follows:
1. To compare the proportion of patients who have suppressed HIV viral load between those who have undergone grouped IAC relative to individualized IAC.
2a. To establish the PLHIV’s beliefs, and perceptions about receiving IAC using small patients groups relative to individual level.
2b. To establish the perceptions and experiences of HIV counselors about using grouped intensive adherence counseling scheme relative to the individualised scheme to deliver IAC messages.

Uganda 2021-12-10 2024-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Loduk Michael
ID:
Assessing the effect of patients’ health literacy levels on post-operative early surgical care outcomes at four rural-based hospitals in Western Uganda
REFNo: HS1907ES

MAIN OBJECTIVE:
to assess the effect of patients’ level of health literacy on early post-operative surgical care outcomes in (KIU-TH, Ishaka Adventist hospital, Comboni hospital Kyamuhunga, and Kitagata general hospital) the four rural-based hospitals in western Uganda.

SPECIFIC OBJECTIVES:
1. To assess the health literacy levels among patients receiving surgical care at the rural-based hospitals of KIU-TH, Ishaka Adventist hospital, Comboni hospital Kyamuhunga, and Kitagata general hospital.
2. To determine the early post-operative surgical outcomes of pain, wound infection at the surgical site, and patient’s well-being among the study population.
3. To establish the relationship between health literacy levels and early post-operative surgical outcomes among the study population.


Uganda 2021-12-10 2024-12-10 Medical and Health Sciences Non-Clinical Trial Degree Award
Akatukwasa  Cecilia
ID: UNCST-2021-R013537
 PrEP preferences around the time of pregnancy among mobile women.
REFNo: SS1105ES

The objective of this study is to elucidate the role of mobility in attitudes and preferences regarding PrEP initiation and engagement during the perinatal period.
 Uganda 2021-12-09 2024-12-09 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jane  Kabami
ID: UNCST-2021-R012588
 Effects of the COVID-19 pandemic on the HIV Care Continuum in South Western Uganda
REFNo: HS1855ES

1.To evaluate the effect of the COVID-19 pandemic across the HIV Care Cascade including: ART initiation, retention in care, and viral suppression among PLWH in South Western Uganda
To explore the changing practices, barriers and facilitators to the delivery of HIV services during the COVID-19 pandemic from the perspective of PLWH, health workers and community members
 Uganda 2021-12-08 2024-12-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Deborah Ekusai-Sebatta
ID: UNCST-2021-R003878
 Willingness and Feasibility of Using Injectable Antiretroviral Therapy Among Women From Prevention- of- Mother- to- Child- HIV- Transmission- Programs In Uganda
REFNo: SS1095ES

Aim 1: To explore participant perceptions about willingness to use and roll out of LART in PMTCT programs.
Aim 2: To explore the fears, concerns, potential barriers and hindrances in delivering LART to women in PMTCT programs.
Aim 3: To establish the health facility readiness of PMTCT programs to support LART

 Uganda 2021-12-08 2024-12-08 Social Science and Humanities Non-Clinical Trial Non-degree Award
Shillah  Kwikiiriza
ID: UNCST-2021-R012682
 Improving the production and marketing of squash by smallholder youth farmers in Kamuli, Uganda
REFNo: A76ES

1.evaluate the effect(s) of soil mulching and cultivar for improved squash production and yield. 2.determine market vendor requirements for buying and selling of squash. 3.determine the partial cost budgets and the gross margin of cultivars of squash produced with or without soil mulch and in experimental plots. 4.investigate the potential of farmer cooperatives for in- and out of school youth farmers (15 – 35 years) participating in schools’ home gardening projects.
Uganda 2021-12-07 2024-12-07 Agricultural Sciences Non-Clinical Trial Degree Award
JULIET MWANGA-AMUMPAIRE
ID: UNCST-2022-R009420
 An open-label, multicentre, randomized, adaptive platform trial of the safety and efficacy of several therapies, including antiviral therapies, versus control in mild/moderate cases of COVID-19
REFNo: HS1789ES

Primary objective: to compare the efficacy of alternative treatment strategies versus control on the risk of progression to severe respiratory disease
The secondary objectives are:
 To compare the safety of each study arm to control, up to Day 21 of follow-up
 To compare the rate of hospitalizations due to COVID-19 in each study arm versus control
 To compare the time to hospitalization due to COVID-19 in each study arm versus control
 To compare the rate of hospitalizations for other reason than Covid-19 in each study arm versus control
 To compare the disease-free rate in each study arm versus control
 To compare the death rate in each study arm versus control
 To compare time to worsening of SpO2 < 93in each study arm versus control
 To compare the capacity to prevent severe progression between study arms
 To identify risk factors for severe progression
 To assess efficacy in sub-groups of patients e.g. with pre-existing conditions/co-morbidities, by age group, sex, BMI, timeframe between onset of symptoms and randomization.

 Uganda 2021-12-07 2024-12-07 Medical and Health Sciences Clinical Trial Non-degree Award
Herbert Muyinda
ID: UNCST-2019-R000373
 Cango Lyec Study (Healing the Elephant): Developing and Testing Interventions to Reduce HIV Risk, Increase Access to Treatment and Promote Resilience in War Affected Populations in Northern Uganda (Follow-up Study)
REFNo: HS1816ES

To pilot the feasibility and acceptability of Wayo/Nero and mHealth intervention packages to support both prevention and care for HIV/AIDS, Hepatitis B, and war related trauma.,Investigate associations between posttraumatic stress, resilience, and depression, with HIV/Hepatitis B incidence among conflict-affected populations in Northern Uganda,Estimate prevalence and incidence of HIV, syphilis, Hepatitis B, and identify associated risk factors among conflict-affected populations in Northern Uganda ,Our overarching goal is to develop, test and scale up culturally-safe, strengths-based, trauma-informed, technology-enhanced (CSTT) interventions among war affected populations. ,
 Uganda 2021-12-07 2024-12-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Edith Wakida K
ID: UNCST-2019-R001225
 Enhancing the Capacity for Providers in Mental Health Integration (ECaP-MHI): A pilot intervention study in Lira district, Northern Uganda
REFNo: HS1847ES

1.4.1 To gather baseline data on the mental disorder diagnoses recorded by PHCPs at a selected HC IV in Lira district before the pilot intervention (in objective four)
1.4.2 To explore contextual barriers and/or challenges likely to affect the ability of Lira DHMT to support PHCPs using the adapted ECaP-MHI intervention
1.4.3 To adapt the training component of the ECaP-MHI intervention
1.4.4 To assess implementation of the DHMTs supporting PHCPs to integrate mental health
services into using the adapted ECaP-MHI intervention
Uganda 2021-12-07 2024-12-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Tana Chongsuwat
ID:
Evaluation of Understanding, Perceptions, and Attitudes Toward Cervical Cancer Screening, Prevention, and Treatment Services Available to Women in Gulu City, Uganda
REFNo: HS1862ES

Understand attitudes and perceptions regarding seeking cervical cancer screening, treatment, or prevention services.,Assess the level of knowledge of men and women on cervical cancer etiology, risk factors, screening, and prevention services available to them.,
 USA 2021-12-07 2024-12-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ezekiel Mupere
ID: UNCST-2021-R011972
 Adaptive immunity to Mtb-infection and TB disease among young Ugandan children”
REFNo: HS1870ES

1.To recruit Ugandan children 5 years and younger (< 60 months), with and without perinatal HIV-exposure and/or infection, who are household contacts of an adult with confirmed TB disease
2.To identify immunologic phenotypes that correlate with TB disease, versus remaining asymptomatic following TB household contact, in young children with and without perinatal HIV-exposure and/or infection
3.To determine if MTB-specific T cell and/or antibody profiles can be used to distinguish TB disease from asymptomatic MTB infection, in young children with and without perinatal HIV-exposure and/or infection
4.To determine how perinatal HIV exposure/infection alters MTB-specific adaptive immune profiles

 Uganda 2021-12-07 2024-12-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Richard Muhindo
ID:
Tackling coronavirus disease-2019 Vaccine Hesitancy among People Living with HIV in Kampala, Uganda
REFNo: HS1902ES

To describe the prevalence and factors associated with COVID-19 vaccine hesitancy among adult PLHIV in Kampala, Uganda.
2. To explore the drivers of COVID-19 vaccine hesitancy among adult PLHIV in Kampala, Uganda.
3. To develop and pilot educational materials to promote COVID-19 vaccine uptake among adult PLHIV in Kampala, Uganda

 Uganda 2021-12-07 2024-12-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Alison Elliott
ID: UNCST-2023-R006524
 Voluntary stool collection for optimizing laboratory techniques at the MRC/UVRI and LSHTM Uganda Research Unit
REFNo: HS1910ES

Objectives of the research project:
• To obtain Schistosoma mansoni ova for training and optimisation of the process of miracidia hatching and snail infection
• To obtain S. mansoni ova for training and optimisation of the process of sex determination of cercariae
• To develop materials such as S. mansoni DNA that can be used as reagents and/or positive controls.
• To make available S. mansoni materials for use in the routine evaluation of proficiency of assays and for the testing of reagents and new assay kits

 UK 2021-12-07 2024-12-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
CHRISTINE MBABAZI -MPYANGU
ID:
Thriving Together: Creating Social Support Groups for the Reintegration and Empowerment of Formerly Abducted Women in Northern Uganda
REFNo: SS965ES

1) Assess the current social, economic and psychological status of formerly abducted women in Northern Uganda as compared to never abducted comparable women
2) Scientifically test the effectiveness of women’s support groups in facilitating the reintegration of formerly abducted women, raising their aspirations, creating economic opportunities and increasing their overall well-being.
Uganda 2021-12-06 2024-12-06 Social Science and Humanities Non-Clinical Trial Non-degree Award
MISAKI WAYENGERA
ID:
DEVELOPMENT OF AFFORDABLE, EASY TO USE, AND RAPID POINT OF CARE DIAGNOSTIC TESTING PLATFORMS FOR COVID-19 SUITING REMOTE SETTINGS OF SUB-SAHARAN AFRICA.
REFNo: HS1648ES

1.To optimize and validate reagents (recombinant peptides, monoclonal and polyclonal antibodies)’s performance towards capture of SARS- CoV 2 virus antigen and host specific antibodies
2.To develop prototypes of lateral flow immunochromatography test (LFT) and tube-agglutination test platforms for COVID19 testing
3.To perform In-dependent validation of the developed test platforms.


Uganda 2021-12-03 2024-12-03 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ayebazibwe Kakoba Gloria
ID:
Determinants of uptake of Mass Drug Administration for schistosomiasis control in Butiaba, Uganda
REFNo: SS1083ES

1. To determine the uptake of Praziquantel during Mass Drug Administration for schistosomiasis control among adults in Butiaba, Uganda 2. To examine socio demographic characteristics associated with uptake of Praziquantel during Mass Drug Administration for schistosomiasis control among adults in Butiaba, Uganda. 3. To assess barriers related to knowledge that are associated with uptake of Praziquantel during Mass Drug Administration for schistosomiasis control among adults in Butiaba, Uganda. 4. To assess barriers related to attitudes that are associated with uptake of Praziquantel during Mass Drug Administration for schistosomiasis control among adults in Butiaba, Uganda
 Uganda 2021-12-03 2024-12-03 Social Science and Humanities Non-Clinical Trial Degree Award
Catherine Birabwa
ID: UNCST-2021-R012851
 INCREASING COVERAGE AND UPTAKE OF VOLUNTARY FAMILY PLANNING IN EMERGENT TOWNS AND CITIES IN UGANDA – THE CASE OF JINJA AND IGANGA
REFNo: HS1826ES

General objective To contribute to the reduction of unmet of unmet need and increased use of VFP in urban settings by adapting high-impact practices in FP and developing and testing a tailored package of interventions to increase coverage and uptake of VFP services in emerging urban areas. The project also aims to contribute to improved performance of urban health systems in the study sites with regard to VFP. Specific objectives Implementation objectives i. To develop and implement a tailored package of high-impact interventions fit for emerging urban settings in Uganda using participatory approaches ii. To improve understanding of FP and decision-making capacity for healthy reproductive or contraceptive behaviors; strengthen effective delivery and management of FP services. Research objectives i. To explore the current coverage of VFP and barriers and facilitators of contraception use in emergent urban settings in eastern Uganda ii. To assess the effectiveness, facilitators and barriers of the proposed intervention package in improving VFP service provision, accessibility and utilization iii. To explore how unintended pregnancies/birth could be associated with child survival and childhood health care in urban settings
 Uganda 2021-12-03 2024-12-03 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Andrew Arinaitwe
ID:
News Media Presentation Of Basic Education Teachers during the COVID-19 Pandemic: A Content Analysis of the Daily Monitor and the New Vision in Uganda.
REFNo: SS1068ES

1. To examine how teacher story coverage in the The Daily Monitor and The New Vision relates to the frames and themes of the research in the space of May 2020 to August 2020 during the COVID-19 pandemic.
2. To identify the frames of teacher stories in the The Daily Monitor and The New Vision in Uganda between May 2020 to August 2020 during the COVID-19 pandemic.
3. To examine the major themes of teacher stories that were published in the The Daily Monitor and The New Vision in Uganda newsrooms between May 2020 to August 2020 during the COVID-19 pandemic.
Uganda 2021-12-03 2024-12-03 Social Science and Humanities Non-Clinical Trial Degree Award
Henry Kajumbula Mawerere
ID: UNCST-2019-R001531
 Low-interventional, multi-centre study of the burden of nosocomial infections among hospitalised patients in sub-Saharan Africa
REFNo: HS1880ES

Aim:
To assess antimicrobial resistance rates, as well as clinical outcomes (including treatment outcomes, mortality rate, hospital length of stay), healthcare resource utilisation (HCRU) and associated costs among hospitalised patients with nosocomial infections at Mulago Specialised Referral Hospital.

Study Objectives:
1. To estimate the prevalence of resistance in nosocomial infections(NI) amongst patients hospitalized at Mulago Specialized Referral Hospital
2. To describe treatment outcomes amongst hospitalized patients with NI, at the end of therapy and at hospital discharge
3. To assess mortality rates (all-cause & infection-related) of hospitalized patients with NI, at the end of therapy & at hospital discharge
4. To assess hospital length of stay amongst hospitalized patients with NI.

Secondary Study Objectives
1. To describe treatment outcomes amongst hospitalized patients with NI at Day 14/30 post-treatment initiation
2. To assess mortality rates (all-cause and infection-related) of hospitalized patients with NI, at Day 14/30 post-treatment initiation
3. To assess ICU length of stay amongst hospitalized patients with NI.
4. To describe the characteristics of hospitals participating in the study
5. To assess HCRU and associated costs post-hospitalization amongst hospitalized patients with NI
6. To assess the nursing care demand amongst hospitalized patients with NI

 Uganda 2021-12-03 2024-12-03 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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