Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Kamya Moses
ID: UNCST-2020-R014203
 A case-control study to assess the effectiveness and safety of the R21/matrix-M malaria vaccine
REFNo: HS6009ES

To assess the Vaccine Effectiveness (VE) of R21/Matrix-M vaccine against severe malaria caused by Plasmodium falciparum.

To assess the Vaccine Effectiveness (VE) of the R21/Matrix-M vaccine against clinical malaria in high-transmission perennial areas caused by Plasmodium falciparum.

To assess if the R21/Matrix-M vaccine recipients are at an increased risk of death (all-cause).
 Uganda 2025-06-02 17:04:40 2028-06-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
 PROTOCOL FOR THE PERFORMANCE EVALUATION OF ALINITY M HIV-1 ASSAY USING DRIED BLOOD SPOT SPECIMENS HIV VIRAL LOAD ASSAY FOR WHO PREQUALIFICATION ASSESSMENT
REFNo: HS6061ES

• To assess the Alinity m HIV-1 DBS assay’s agreement with a cobas HIV-1 Quantitative nucleic acid test for use on the cobas 6800/8800 Systems (Roche Diagnostics GmbH) on clinical specimens, including:
o Quantitative assessment of bias, limits of agreement and correlation
o Misclassification above or below the clinical threshold (1000 copies/mL)
• To assess the analytical performance of the Alinity m HIV-1 assay using DBS:
o Precision (repeatability and within-laboratory reproducibility)
o Linear range on the main subtypes
o Limit of detection
o Cross-contamination
• To describe the operational characteristics and ease of use of the Alinity m HIV-1 assay using DBS and its suitability for use in countries with limited infrastructure.

 Uganda 2025-05-29 17:20:17 2028-05-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
 STANDARDTM M10 HR-HPV: Evaluation of Clinical Performance and Usability in the hands of untrained users.
REFNo: HS6022ES

Demonstration of usability of the STANDARDTM M10 Hr-HPV assay. ,Demonstration of sample type equivalence for the STANDARDTM M10 Hr-HPV assay: ThinPrep® PreservCyt® Solution (Hologic) vs. BD SurePathTM Collection Vial (Becton, Dickinson and Company),Determination of the relative diagnostic sensitivity and specificity i.e. compared with the Roche Cobas HPV assay (used according to the current standard of care at the study site).,Determination of clinical accuracy i.e. absolute diagnostic sensitivity for CIN2+ and CIN3+ and absolute diagnostic specificity for ≤ CIN1.,To demonstrate the clinical performance of the STANDARDTM M10 Hr-HPV assay when used by healthcare professionals in a laboratory setting or health institution (i.e. intended use setting), the following objectives have been defined.,
 Uganda 2025-05-29 17:19:03 2028-05-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Anatoli Mawanda
ID: UNCST-2024-R015927
 GENETIC AND MOLECULAR DETERMINANTS OF BREAST CANCER DISPARITY AMONG AFRICAN, AFRICAN AMERICAN AND WHITE POPULATIONS
REFNo: HS6015ES

To study the genetic, molecular, and biological regulators of breast cancer in Ugandan
women and compare them with African American and white women.
 Uganda 2025-05-29 17:17:31 2028-05-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Christabel Gero Anyango
ID: UNCST-2025-R017108
 Perspectives of Child Domestic Workers and Their Employers: A Qualitative Study in Kampala, Uganda
REFNo: SS3860ES

• To establish patterns of entry into, exit out of and conditions of child domestic work in the Ugandan setting, including patterns that constitute human trafficking. Entry patterns will include decision making and influences to enter domestic work, while exit will encompass strategies used to transition to other work roles and the types of work roles entered following domestic work. • To understand employers’ perceptions of and views on child domestic workers, including reasons for recruiting younger workers, strategies to recruit CDWs, views on the benefits, drawbacks and development needs of younger workers, treatment and remuneration of CDWs, and awareness of laws and policies related to young workers, among others.
Kenya 2025-05-29 17:15:05 2028-05-29 Social Science and Humanities Non-Clinical Trial Non-degree Award
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