Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Maxine Atuheirwe
ID:
COVID-19 vaccine hesitancy: misinformation and perceptions of COVID-19 vaccine safety/uptake among health care workers versus general public in Uganda
REFNo: HS2013ES

d. To understand the impact of misinformation on COVID-19 vaccine up take,c. To compare vaccine acceptance among health care workers versus general public in Uganda ,b. To compare the attitudes and beliefs towards COVID-19 vaccine among health care workers versus general public in Uganda.,a. To assess knowledge of COVID-19 vaccine among health care workers versus general public in Uganda, and its correlation with intent to get vaccinated,The overall goal of the project is to understand the impact of misinformation on COVID-19 vaccine up take which will be addressed by three objectives; ,
 Uganda 2022-01-28 2025-01-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joseph  Matovu KB
ID: UNCST-2020-R014654
 Peer-led HIV self-testing to improve HIV testing and linkage to HIV care among men in two fishing communities in rural Uganda: a pilot intervention (PEST4MEN)
REFNo: HS2034ES

1. Assess uptake of HIV testing and determine the factors associated with HIV testing uptake among men reached through peer-led HIV self-testing 2. Determine the proportion of HIV-positive men who link to HIV care and the factors associated with linkage to HIV care after peer-led HIV self-testing 3. Assess negative outcomes of peer-led HIV self-testing (e.g. intimate partner violence, marital disruption, suicidal ideations) and document the existing supporting mechanisms in the community 4. Explore the barriers to and facilitators of linkage to and retention in HIV care following peer-led HIV self-testing within a fishing community setting 5. Assess the potential for peer-led HIV self-testing as a novel strategy for reaching high-risk HIV-negative men in the fishing communities with appropriate HIV prevention services (including referral for medical male circumcision, condom promotion/supplies and PrEP)
Uganda 2022-01-28 2025-01-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Tonny Kirabira Raymond
ID:
Assessing the Role of Actors in Transitional Justice: The cases of Myanmar and Uganda
REFNo: SS1082ES

The project aims to examine the Transitional Justice(TJ) processes in Myanmar and Uganda. The goal is to examine whether, and to what extent, TJ is influenced by international actors? It asks two principal questions. First, how have the actors influenced the current TJ initiatives. Second, how has this affected the legitimacy of the TJ processes?
The project aims to recommend more effective ways of implementing TJ.
Uganda 2022-01-27 2025-01-27 Social Science and Humanities Non-Clinical Trial Degree Award
Neil Scolding
ID: UNCST-2021-R012864
 The clinical neurology of chronic Nodding Syndrome: a proposal for a secondary usage of clinical data for research
REFNo: HS1848ES

To analyse and publish our previously-obtained clinical and neurological information on NS, gained from clinical encounters with NS suffers
 UK 2022-01-27 2025-01-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bob Rich Mwecumi  Muhereza
ID:
DIGITAL MIGRATION AND COVERAGE OF DIGITAL TELEVISION SERVICES IN UGANDA
REFNo: SIR85ES

i. To establish the relationship between cost of digital infrastructure and coverage of digital TV services in Uganda.
ii. To establish the relationship between consumer awareness and coverage of digital TV services in Uganda.
iii. To assess the effect of subscription payments on coverage of digital TV services in Uganda.
iv. To investigate the effect of special interactive services on coverage of digital TV services in Uganda.

 Uganda 2022-01-27 2025-01-27 Engineering and Technology Non-Clinical Trial Degree Award
Robert Newton Edward
ID: UNCST-2023-R006537
 International Prevalence Surveys of Helicobacter pylori in High and Low Risk Areas for Stomach Cancer Epidemiological iNvestigatIon of Gastric Malignancies – ENIGMA
REFNo: HS1891ES

Objectives of the research project: i. To estimate the age-specific prevalence of Helicobacter pylori infection as predictor of Gastric Cancer trends. ii. To investigate bacterial, host and environmental factors associated with differences between high and low Gastric Cancer risk areas. iii. To measure H. pylori antibiotic resistance to Metronidazole and Clarithromycin in the different geographic regions. iv. To further explore the association between H. pylori infection and child growth
UK 2022-01-27 2025-01-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Susan  Nabadda
ID: UNCST-2020-R014331
 Field Performance Evaluation of the Xpert® HIV-1 Viral Load assay for Viral Load (VL) monitoring in Uganda
REFNo: HS1977ES

To determine acceptability of the the Xpert® HIV-1 Viral Load assay by the study participants.,To determine changes in turn-around time and ease of clinic workflow integration,To determine the operational characteristics of the Xpert® HIV-1 Viral Load assay, such as ease of-use of the assay using the standardized system usability scale (SUS) by laboratory and no laboratory personnel ,To evaluate the diagnostic accuracy using the sensitivity, specificity, NPV, PPV, FPR and FNR of the Xpert® HIV-1 Viral Load assay in comparison to a reference assay, Roche COBAS 8800 in identifying HIV-VF at the WHO recommended threshold of 1000 copies/ml for HIV-1 infected. ,To evaluate the field performance of the Xpert® HIV-1 Viral Load assay in identifying virological failure (VF) in adults on ART. The performance will be compared to the reference assay, the Roche COBAS 8800 used at UNHLS. ,
 Uganda 2022-01-27 2025-01-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Andrew Mujugira
ID: UNCST-2019-R000871
 Designing an intervention to increase HIV self-testing uptake and clinic linkage among men in Uganda: A Discrete Choice Experiment
REFNo: HS1061ES

Aim 1: To pilot test two HIVST Discrete Choice Experiments on 1) distribution strategies and 2) linkage strategies to assess how well participants understand the questionnaire and inform final design.

Aim 2: To conduct a DCE to determine men’s preferred HIVST distribution strategy to increase uptake. We will assess men’s preference for mode of HIVST distribution (e.g. pharmacy, drug shop, clinic, partner, friend), pre-test support, and post-test support.

Aim 3: To conduct a DCE to determine men’s preferred intervention to increase clinic linkage for HIV care and prevention after HIVST. We will assess the potential of financial incentives, screening for other diseases, fast-track services, and peer navigators to motivate men to link to care.
 Uganda 2022-01-25 2025-01-25 Medical and Health Sciences Non-degree Award
Samuel Meyerson
ID:
From the Kraals to the Markets: A Pastoral World Beyond the State in East Africa
REFNo: SS1045ES

1. To analyze the transnational networks that have connected Ateker communities in East Africa from the precolonial era to the present day. 2. To examine the historical relationships between Ateker communities and state structures in East African countries during the colonial and post-independence periods. 3. To use historical analysis to identify ways of fostering national integration and sustainable development in Karamoja.
Canada 2022-01-25 2025-01-25 Social Science and Humanities Non-Clinical Trial Degree Award
FREDRICK MAKUMBI
ID:
Assessment of the Scale, Reach, Quality, and Cost of Service Delivery High Impact Practices in Family Planning in Uganda
REFNo: HS2005ES

To estimate the costs of implementing and sustaining service delivery, and identify the cost drivers, and efficiencies for selected HIPs in Uganda ,To assess the quality of services for selected service delivery HIPs, including policy-level intention and readiness of services to offer the HIP in Uganda ,To measure the current reach of selected service delivery HIPs to sub-populations by age, urban/rural location of service delivery points, and, if applicable, new FP users in Uganda,To measure the current horizontal and vertical scale of implementation of 3 service delivery HIPs in Uganda,The goal of this assessment is to develop and apply a replicable approach that measures the scale, reach, quality, and cost of HIPs, information which will help Uganda and other countries to critically analyze and maximize their investments in comprehensive FP strategies. ,
 Uganda 2022-01-25 2025-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jackson Mukonzo
ID: UNCST-2021-R013916
 Safety and Efficacy of COVIDEX™ Therapy in Management of adult Covid-19 Patients in Uganda: A randomized double-blind placebo controlled adaptive phase 2 B clinical trial.
REFNo: HS2041ES

3. To determine the plasma concentration of berberine in COVID-19 patients receiving COVIDEX. ,2. To determine the efficacy of COVIDEXTm for treatment of COVID-19 among adults in Uganda.,To determine the efficacy of COVIDEXTm for treatment of COVID-19 among adults in Uganda.,To validate the safety and determine the efficacy of COVIDEXTm therapy for treatment of COVID-19 in adult Ugandans. ,
 Uganda 2022-01-25 2025-01-25 Medical and Health Sciences Clinical Trial Non-degree Award
Timothy  Muwonge Ronald
ID: UNCST-2020-R014680
 Evaluating the implementation of assisted partner notification for HIV in refugee settlements in West Nile Uganda: An implementation Science approach
REFNo: HS1970ES

AIM 2.To explore barriers and facilitators to APN for HIV in refugee settlements in West Nile using qualitative methods to evaluate each stage of RE-AIM, guided by the Consolidated Framework for Implementation Research (CFIR) domains. ,AIM 1. To assess the reach, effectiveness, adoption, implementation, and maintenance of APN for HIV in refugee settlements in West Nile utilizing the RE-AIM framework. ,
 Uganda 2022-01-24 2025-01-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Esther Nanfuka Kalule
ID:
Resilience during and After quarantine: A qualitative study of people affected by Covid-19 in Uganda
REFNo: SS1047ES

1. To examine the socio-economic constraints faced during and after quarantine
2. To examine the psychological constraints faced during and after quarantine
3. To examine the protective factors that facilitated the successful management of the socio-economic and psychological risks faced during and after quarantine.

 Uganda 2022-01-21 2025-01-21 Social Science and Humanities Non-Clinical Trial Non-degree Award
Justine  Komunyena Tumusiime
ID: UNCST-2023-R008465
 Assessing willingness to pay for HIV self-testing and evaluation of distribution, linkages, and referral models for HIV self-testing in Uganda
REFNo: HS1982ES

1) To assess the knowledge and attitudes of the different categories of key populations with respect to HIV self-testing in the districts with STAR III project intervention (STAR III intervention districts) and selected districts without STAR project interventions (non-intervention districts)
2) To assess access and extent of use of different HIVST kits available in Ugandan market in districts with STAR III interventions and non-intervention districts
3) To understand respondents' preferences to blood-based and oral fluid-based HIVST kits in the districts selected (see section 2.2)
4) To assess willingness to pay and estimate the specific price points HIVST kit users and non-users are willing to pay for the different HIVST kits available in Uganda
5) To identify the constraints to HIVST adoption and WTP for HIVST kits in the districts selected
6) To assess and compare the different distribution models with respect to selected indicators of effectiveness and cost-effectiveness

 Uganda 2022-01-20 2025-01-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
AGATHA NSHABOHURIRA
ID:
FACTORS INFLUENCING LOW UPTAKE OF DPT3 AMONG INFANTS AGED 16 TO 52 WEEKS IN RUBIRIZI TOWN, RUBIRIZI DISTRICT
REFNo: HS1513ES

General objective for the study
To explore factors influencing uptake of DPT 3 Immunization amongst infants aged 16-52 weeks in Rubirizi Town, Rubirizi District.
Specific objectives of the study
• To find out individual level perceptions influencing uptake of DPT 3 Immunization amongst parents/caretakers of infants aged16-52 weeks in Rubirizi Town, Rubirizi District.
• To examine community influencing factors associated with uptake of DPT 3 Immunization amongst infants 16-52 weeks in Rubirizi Town, Rubirizi District.
• To explore the health service related factors influencing uptake of DPT 3 Immunization amongst infants aged 16-52 weeks in Rubirizi Town, Rubirizi District.

Uganda 2022-01-20 2025-01-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Keneth Kananura
ID:
Hematological Recovery among People Living with HIV after Cotrimoxazole prophylaxis discontinuation at Infectious Diseases Institute in Uganda
REFNo: HS1908ES

1.To determine the proportion of PLHIV with hematological complications of anemia and neutropenia who experience hematological recovery following discontinuation of CTX prophylaxis. 2. To determine the factors associated with hematological recovery among PLHIV after discontinuation of cotrimoxazole prophylaxis.
 Uganda 2022-01-20 2025-01-20 Medical and Health Sciences Non-Clinical Trial Degree Award
JAMES MULEME
ID: UNCST-2021-R012263
 Reservoirs, transmission and antibiotic resistance profiles of Extended Spectrum Beta Lactamase-producing Escherichia Coli at the human-animal-environment interface among farming communities in Wakiso district, Uganda
REFNo: HS1919ES

General Objective
To decipher the reservoirs and transmission pathways for ESBL-PE at the human-animal-environment interface among farming communities in Wakiso district

Specific Objectives
1. To determine the comparative distribution of ESBL-PE from humans, animals and environment among selected households in Wakiso district.

2. To describe the antibiotic susceptibility profiles of the ESBL-PE isolates obtained from humans, animals and their immediate environment among selected households in Wakiso district

3. To assess the pathways and drivers of transmission of the ESBL-PE among humans, animals and environment in selected households of Wakiso district.  

4. To explore factors influencing occurrence, transmission and management of AMR caused by ESBL-PE at the human-animal-environment interface in Wakiso district, Uganda


 Uganda 2022-01-20 2025-01-20 Medical and Health Sciences Non-Clinical Trial Degree Award
Cole Harris
ID:
Pentecostalism and Development: Explaining the Variation of Church-Led Community Programs in Kampala, Uganda
REFNo: SS1151ES

Complete program observation at the community programs of the three selected case study churches.,Create three Pentecostal-Charismatic church case studies that situate the churches within the broader Pentecostal movement.,Conduct interviews with church leaders regarding the availability of community programs and their selection of those programs.,Better understand Pentecostal leaders’ decision-making process in the selection of community programs.,Take an inventory of the availability of community programs offered by Pentecostal-Charismatic churches in Kampala, Uganda.,
 USA 2022-01-19 2025-01-19 Social Science and Humanities Non-Clinical Trial Non-degree Award
Susanne Guidetti Gittel Eleonora
ID: UNCST-2021-R012422
 Participation in everyday life - A randomized controlled trial of mobile phone-supported and family-centred rehabilitation after stroke in Uganda
REFNo: HS1528ES

General objective (Overall aim)
To implement and evaluate the effects a mobile phone supported and family-centred rehabilitation intervention F@ce 2.0 aiming to enable performance in daily activities and participation in everyday life among persons who have had a stroke and their family members both in urban (Kampala and its surroundings) and rural (Greater Masaka) areas.

Specific objectives
• To describe the perceived impact of stroke and perceived participation in everyday life in a sample of people with stroke in rural Uganda. (Study 1)
• To evaluate the effects of F@ce in comparison with ordinary rehabilitation among persons with stroke in urban and rural Uganda regarding a) self-efficacy b) perceived performance and participation in everyday activities c) independence in ADL, d) healthcare utilization and e)their families´ perceived participation in everyday activities.(Study 2)
• To explore and describe the experiences of people with stroke and family members of participating in the F@ce (Study 3)
• To evaluate the implementation process of F@ce and to gain knowledge on the mechanisms of impact as well as the contextual factors that might influence the implementation process and its outcome. (Study 4)
• To determine the cost of delivering the F@ce intervention in comparison with the usual rehabilitation (Study 5)

 Sweden 2022-01-19 2025-01-19 Medical and Health Sciences Clinical Trial Non-degree Award
Churchill Akena
ID:
; RECALL ASSESSMENT STUDY; HOW EFFECTIVE IS IT TO CARRY OUT RECALL OF PHARMACEUTICALS IN THE PRIVATE SECTOR? A CROSS SECTIONAL CASE ASSESSMENT OF GYNOZOL, EPICEPHIN AND APIDONE
REFNo: HS1916ES

1. To determine the extent of distribution of common pharmaceutical products in Uganda using examples of epicephin, gynozol and apidone.
2. To find out the percentage of distributors/customers who respond in time to class I, class II and class III recall alerts for all levels of recall.
3. To find out the percentage of wholesalers and retailers who keep adequate record of the medicines they distribute/dispense to facilitate a successful recall.

 Uganda 2022-01-19 2025-01-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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