Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Lydia Nakiyingi
ID: UNCST-2022-R010102
Multi-pathogen wastewater surveillance in Uganda with CRISPR Cas 12/13 assay: A pilot study
REFNo: HS4139ES

The proposed research will test the overarching hypothesis that wastewater pathogen burden measured by SHINE and CARMEN CRISPR-based platforms will positively correlate with the prevalence (for routine pathogens) and incidence (for outbreak pathogens) within our catchment areas,Our second objective involves leveraging the massive multiplex CARMEN assay to broadly survey for high-priority outbreak pathogens such as Ebola, yellow fever, Vibrio cholera and Mycobacterium tuberculosis in regional Kampala wastewater sources (East Bugolobi treatment plant and Nakivubo channels). As an advantage, CARMEN reactions have already been developed for all of these pathogens, which are also shed in human excrement,As our first objective, we propose to assess the performance of the field-deployable SHINE CRISPR assay (benchmarked against CARMEN) in estimating the prevalence of diverse respiratory and food-borne pathogens such as Mycobacterium tuberculosis, common respiratory viruses, and antimicrobial-resistance genes (e.g. Carbapenem-resistant Enterobacteriaceae [CRE], vancomycin-resistant enterococci [VRE]) using wastewater samples from a local sewage line (Mulago Hospital). ,
Uganda 2024-05-23 13:32:28 2027-05-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Namujulirwa Carolyn
ID:
PASTORAL CARE AND HOLISTIC EDUCATION IN CATHOLIC SECONDARY SCHOOLS: A CASE OF THE COMBONI MISIONARIES IN KAMPALA ARCH DIOCESE AND LIRA DIOCESE
REFNo: SS2550ES

iii. What are the legacies of Comboni missionary pastoral care models applied in secondary schools in Kampala arch diocese and Lira diocese and how can they be applied in other catholic dioceses in Ugandan catholic secondary schools?,ii. To what extent do pastoral care structures and strategies influence the promotion of holistic education in the Comboni Missionaries secondary schools in Lira and Kampala arch diocese and Lira diocese?,i. What are the unique characteristics of pastoral care employed in the promotion of holistic education in Comboni missionary secondary schools in Kampala arch diocese and Lira Diocese? ,The purpose of the study is to investigate the role Comboni missionaries played in the promotion of holistic education through pastoral care in Catholic secondary schools in Kampala Arch diocese and Lira diocese,
Uganda 2024-05-23 13:14:19 2027-05-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
Christine  Wiltshire Sekaggya
ID: UNCST-2019-R000578
Therapeutic Drug Monitoring for Antimicrobial Agents for People Living with HIV (TAP trial)
REFNo: HS3909ES

1.To determine the concentrations of selected antimicrobial agents in people living with HIV requiring antimicrobial therapy. 2. To assess the utility of therapeutic drug monitoring in achieving therapeutic targets for people living with HIV receiving rifampicin and isoniazid for treatment of tuberculosis. 3. To develop and validate a population pharmacokinetic-pharmacodynamic model for use during therapeutic drug monitoring for selected antibiotics used among PLWH
Uganda 2024-05-23 13:12:37 2027-05-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
CATHERINE ABBO
ID:
Implementing the MHPSS Minimum Service Package for infectious disease outbreaks in Uganda – an evaluation study
REFNo: HS3915ES

. To evaluate the feasibility, acceptability, appropriateness, fidelity and uptake of a set of MHPSS interventions in outbreak response in Uganda (through live implementation or SimEx), ,. To develop an implementation plan that includes capacity strengthening activities necessary to implement a set of MHPSS interventions for outbreaks in Uganda successfully ,1. To conduct a gap analysis and prioritization, using MSP, to successfully identify a contextualized set of interventions for outbreak response in Uganda ,To develop, implement and evaluate a suite of tailored MHPSS interventions supporting outbreak preparedness and response in Uganda using the Minimum Service Package. ,
Uganda 2024-05-23 10:29:39 2027-05-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sam Ononge
ID: UNCST-2020-R000328
THE ENHANCED PRODUCT DEVELOPMENT AND PILOT TESTING OF A SMART POSTPARTUM HAEMORRHAGE VOLUMETRIC DRAPE FOR EARLY DETECTION OF POSTPARTUM HAEMORRHAGE DURING CHILD BIRTH.
REFNo: HS3959ES

4. To conduct safety testing of the electronic blood sensing module of the SMART PVD.,3. To evaluate the usability of the SMART-PVD with the midwives.,2. To assess the acceptability of the SMART-PVD among the women and midwives.,1. To determine the performance of the SMART PVD device in accurately estimating the volume of blood lost during delivery as well as timely alerts on the onset of a PPH case. ,To conduct a pilot feasibility study to evaluate the viability of the SMART PVD as a diagnostic device for timely and accurate diagnosis of Postpartum Haemorrhage after delivery.,
Uganda 2024-05-23 10:25:06 2027-05-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssinabulya
ID: UNCST-2021-R004352
An mHealth implementation strategy to address the syndemic of mental illness, hypertension, and HIV in Uganda [Formative Phase: Syndemic Adapted Medly Uganda (SAMU)]
REFNo: HS3992ES

To determine through field testing, if the SAMU intervention is acceptable to patients and providers, Safe for patients, technically functional, stable, and reliable.  ,To adapt the Medly Uganda application for use with PLWH with HTN in Uganda, to address screening, diagnosis and linkage to care for common mental health conditions including anxiety disorder alcohol use disorder and depression,
Uganda 2024-05-23 10:22:58 2027-05-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Anthony Mugeere Buyinza
ID:
In search of green jobs: voices of (unheard) young people and their aspirations, barriers and negotiations with work
REFNo: SS2539ES

motivations of seeking green jobs in Uganda.
2. To explore the key barriers that prevent young people from accessing green jobs.
3. To examine the ways young people navigate the barriers they encounter in their quest for green jobs and how the local, national, and international policy environment levels shape their opportunities to access green jobs.
4. To propose policy changes that could be implemented to better support the aspirations and needs of young people as regards green jobs.
Uganda 2024-05-23 10:20:52 2027-05-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
Arthur  Mpimbaza
ID: UNCST-2022-R008866
A model health systems strengthening strategy to reduce malaria mortality in the Busoga sub-region, Uganda: a proof-of-concept trial
REFNo: HS3927ES

General Objective
To determine the viability of a model health system strengthening (HSS) strategy in improving the quality of malaria management services and empowering communities in Bunya East HSD, Mayuge district, Busoga sub-region.

2 Specific objectives
1. To determine the feasibility of implementing a model HSS strategy in improving the quality of malaria management services offered at facilities in Bunya East HSD.
2. To assess the acceptability of a model HSS strategy in improving the quality of malaria management services offered at facilities in Bunya East HSD.
3. To develop a process of engaging and empowering communities’ to take-up appropriate malaria health seeking behavior at a village in Bunya East HSD.
4. To assess the preliminary effectiveness of the model HSS strategy on outcomes related to appropriate malaria case management at facilities and the community in Bunya East HSD.


Uganda 2024-05-15 18:19:15 2027-05-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sunny Okoroafor C
ID:
ASSESSMENT OF PATIENT SAFETY PRACTICES IN UGANDA
REFNo: SS2596ES

To determine the status of the patient safety practices in Uganda.,
Nigeria 2024-05-14 9:17:02 2027-05-14 Social Science and Humanities Non-Clinical Trial Non-degree Award
Racheal Angom
ID: UNCST-2023-R007485
ELECTRONIC TREATMENT SCHEDULING AND PSYCHOSOCIAL INTERVENTIONS TO REDUCE TREATMENT ABANDONMENT AMONG CHILDREN AND ADOLESCENTS WITH CANCER IN UGANDA.
REFNo: HS3944ES

To develop a comprehensive psychosocial support program through collaboration among UCI, UCCF and other civil society organizations to decrease treatment abandonment. ,To determine factors that influence treatment abandonment for UCI patients,To determine parent/caregiver reasons for treatment abandonment ,To Create a tracking system for patient treatment appointments to identify initial missed treatment visits (risk for treatment abandonment) and actual treatment abandonment using a time-sensitive electronic system [Research Electronic Data Capture (REDCap)] , To Create a tracking system for patient treatment appointments to identify initial missed treatment visits (risk for treatment abandonment) and develop a comprehensive psychosocial support program through collaboration among UCI, UCCF and other civil society organizations to decrease treatment abandonment. actual treatment abandonment using a time-sensitive electronic system [Research Electronic Data Capture (REDCap)] and,
Uganda 2024-05-14 9:12:26 2027-05-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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