Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Charles Kiyaga
ID:
Establishing universal screening and early interventions for SCD within the selected clinical networks for prevention of early mortality in Uganda.
REFNo: HS1362ES

Primary Objectives

a)To pilot newborn screening for SCD within the clinical networks of Jinja and Lira regional referral hospital in Uganda.

b)To register patient data and medical history of babies diagnosed with SCD within the first three months of life in a shared database.

c)To initiate antibacterial and antimalarial prophylaxis among the identified SCD infants within the first three months of life.

d)To ensure that the identified SCD infants are each immunized against pneumococcus and Haemophilus influenzae type b.

e)To monitor each patient at required intervals (every three months until age two years; every four to six months from age three to five years) and update patient record in registry after each visit.

f)To estimate the incidence of SCD among infants and children identified in Jinja and Lira regional referral hospitals and identify the specific hemoglobin genotypes.

Secondary Objectives

a)To measure the 5-year survival rate of children enrolled in the newborn screening cohorts.

b)To assess the costs of newborn screening and early interventions for each site or network

 Uganda 2021-07-14 2024-07-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Susan Babirye
ID: UNCST-2021-R013201
 Using realist evaluation principles to explore existing local innovations for improving timely attendance of first antenatal care among slum dwellers of Kampala, Uganda
REFNo: SS869ES

1) To identify the existing local innovations for increasing timely attendance of first antenatal care visit and their perceived success.
2) To describe the theories of change for the innovations perceived to be successful at increasing timely attendance of first antenatal care visit.
3) To explore the underlying mechanisms (generalizable contextual factors) that favored success of innovations perceived to be successful at increasing timely attendance of first antenatal care visit among slum dwellers.

Uganda 2021-07-14 2024-07-14 Social Science and Humanities Non-Clinical Trial Non-degree Award
Naome Wandera Namakula
ID:
Assessing the effectiveness of a course for men on Women’s Land Rights Social Norms in Kenya, Tanzania and Uganda- Endline Assessment in Uganda
REFNo: SS889ES

To document the current status of knowledge, attitudes, self-efficacy, intentions and perceptions of peer norms related to women’s land and property rights among men that participated in the SYFF course in Kenya and Uganda. The changes at end-line, if any, in knowledge, attitudes, self-efficacy, intentions and perceptions of peer norms related to women’s land and property rights among participants in the SYFF course in each country will be compared to baseline status.
 Uganda 2021-07-14 2024-07-14 Social Science and Humanities Non-Clinical Trial Non-degree Award
Janet SEELEY
ID:
Menstrual health interventions, schooling and mental health symptoms among Ugandan students (MENISCUS): a school-based cluster-randomised trial.
REFNo: HS1525ES

1. To evaluate whether the MENISCUS intervention improves educational attainment and reduces mental health symptoms (primary outcomes) among Secondary girls in Uganda.

2. To evaluate whether the MENISCUS intervention improves: i) knowledge of puberty and menstruation; attitudes towards menstruation (girls and boys); ii) menstrual practices at last menstrual period (LMP); iii) knowledge and practice of pain management during LMP; iv) self-efficacy in addressing menstrual needs experiences at LMP; v) quality of life and happiness; vi) school and class absence during menses (nested cohort); vii) school and class absence overall (nested cohort); viii) prevalence of urogenital infections (bacterial vaginosis, vaginal yeast and urinary tract infections)
3. To evaluate the costs of setting up and running the intervention package, the unit cost per female student reached, and the incremental cost-effectiveness of the intervention per unit increase in selected policy-relevant outcomes, relative to optimised usual care
4. To assess whether the intervention was implemented with fidelity, and to understand the contextual factors affecting implementation, the acceptability to participants, and the intervention mechanisms. We will achieve this through a process evaluation including quantitative indicators and qualitative data collected from in-depth interviews and focus group discussions.
5. To assess the policy environment around menstrual health in Uganda, focusing on how implementing the intervention contributes to, and aligns with, the attainment of the Government policy objectives on menstruation management in schools. We will assess the policy/regulatory frameworks to which the outcomes of the intervention contribute, identify the supportive and constraining factors to the implementation of the policy guidelines and how the findings of the intervention inform refinement of current policy.

 UK 2021-07-14 2024-07-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Damalie Nakanjako
ID: UNCST-2019-R000383
 Mobile Phone-based patient follow-up Package with Medical Intervention for HIV-infected adults to promote social distancing during and after the COVID19 pandemic lockdown crisis
REFNo: HS945ES

Objectives
1.To pilot use of a Mobile Phone-based patient follow-up Package with virtual Medical Interventions (PMI) among adults receiving antiretroviral therapy (ART) at the Mulago ISS clinic.
2.To determine the effect of a PMI on the number of physical clinical visits by patients receiving ART at the Mulago ISS clinic during the one-year study period.
3.To determine the effect of PMI on continuity of ART medication during the COVID19 pandemic crisis period.
4.To determine the acceptability of the PMI approach to follow up of patients receiving long-term ART by patients and care providers at the Mulago ISS clinic

Uganda 2021-07-13 2024-07-13 Medical and Health Sciences Non-degree Award
Christina Bergey Marie
ID: UNCST-2020-R014338
 Genetic survey of bloodborne pathogens and investigation of malaria response in sanctuary chimpanzees
REFNo: NS139ES

Our proposed study has three main objectives:

1. To determine which blood-borne pathogens sanctuary chimpanzees carry, with a particular interest in those which can be transmitted from human to chimpanzee (anthroponoses) and vice versa (zoonoses);

2. To diagnose malaria infection in sanctuary chimpanzees and determine which malaria parasite species are present, with a particular interest in human malaria that may be infecting the chimpanzees; and

3. To describe the genetic mechanisms underlying the chimpanzee immune system response to malaria, and contrast this with that of humans.
 USA 2021-07-13 2024-07-13 Natural Sciences Non-degree Award
Anthony  Fuller
ID:
Assessment of Accuracy, Precision, and Feasibility of a Handheld Near-Infrared Light Device (InfraScanner 2000â„¢) in Detecting Subdural and Epidural Hematomas in Patients Admitted to Mbarara Regional Referral Hospital
REFNo: HS1010ES

Aim 1: Determine whether the InfraScanner 2000â„¢ detects epidural and/or subdural hematomas with adequate precision relative to CT scans to be used as a diagnostic tool for epidural and/or subdural hematomas.

Aim 2: Use these findings to inform the feasibility of conducting a future trial in which the InfraScanner 2000â„¢ is used as a stand-alone diagnostic tool for intracranial hematomas, and therein, to determine candidacy for decompressive craniotomies in patients who suffer TBIs in places where CT scans are not available.
 USA 2021-07-13 2024-07-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Vittorio Bassi
ID:
Covid-19 and the value of relationships in informal economies
REFNo: SS633ES

The overall goal of the study is to implement two exploratory phone surveys of a representative sample of Micro, Small and Medium enterprises (MSMEs) and their employees in Uganda. The survey is designed to document challenges firms are facing in investing and hiring workers during the covid-19 pandemic. In addition, the first phone survey will also embed a nudging experiment aimed at helping workers search for jobs and regain employment in the wake of the pandemic. This is an urgent study that forms a continued commitment of the researchers under BRAC Uganda partnership with Ministry of Trade, Industry and Cooperatives under Directorate of Micro and Small Medium Enterprises (MSMEs) to provide insights and learning on how the covid-19 shock has affected firm owners and employees’ relationships during the lockdown.
 Italy 2021-07-13 2024-07-13 Social Science and Humanities Non-degree Award
Ismay Milford Milford
ID:
The ‘Information Sector’ in East Africa, 1950s-70s: The professionalisation of journalism, broadcasting and information officers
REFNo: SS730ES

This project is a history of the ‘information sector’ as it emerged in dialogue with global patterns over the period of decolonisation in East Africa (c. 1950s-70s). I understand information not as a given technology inevitable to the language of the developmentalist state in mid-twentieth century Africa, but as a culturally constructed and moulded idea through which we can access connections that East African people of various ‘information professions’ forged with the wider world. This is in some sense a pre-history of the global debates around information that resulted in the call for a ‘New World Information and Communication Order’ in the 1970s. It argues that East Africa played an important role in the disciplinary shift from ‘information science’ to ‘mass communication’, and in the understandings of knowledge production that informed postcolonial theory.
UK 2021-07-13 2024-07-13 Social Science and Humanities Non-degree Award
Pierre ABOMO
ID:
Strengthening national capacity for tsetse control in Uganda
REFNo: SS725ES

1) Conduct semi-structured interviews with key personnel at COCTU and the District level to fully understand the current level of execution of the action plan for strengthening the capacity to for implementing tsetse control in Uganda

2) Conduct participatory workshops at COCTU and the District level to collaboratively assess the progress towards the establishment of a stronger and independent tsetse control system in Uganda (based on findings from objective 1).
UK 2021-07-13 2024-07-13 Social Science and Humanities Non-degree Award
Eddie Wampande Mujjwiga
ID:
An evaluation of African swine fever presentation and distribution in Uganda
REFNo: NS266ES

i. Conduct a serologic, clinical, pathological, and molecular diagnostic survey of swine at a large slaughterhouse near Entebbe and Kampala, Uganda to understand the relationship between the disease status and the diagnostic status of the animals as related to Africa swine fever.
ii. Conduct a serologic analysis slaughterhouse swine to measure the immune response against exposure to the Ornithodoros moubata tick, the ASF reservoir vector in Africa.
iii. Conduct trace back to hotspots to evaluate biosecurity and conduct training of veterinarians and producers on the clinical and pathological signs of Africa swine fever.
iv. Sequence PCR positive samples to better characterize the ASF genotype and strain and its disease presentation.
v. Discuss the findings with the Ministry of Agriculture, Animal Industries, and Fisheries.

 Uganda 2021-07-13 2024-07-13 Natural Sciences Non-degree Award
Charles Batte
ID:
ASSESSING THE SOCIO-ECONOMIC IMPACT OF COVID-19 PANDEMIC ON SMALLHOLDER FARMERS’ HOUSEHOLDS AND SCHOOL-GOING CHILDREN IN BUDUDA DISTRICT, UGANDA.
REFNo: SS789ES

To assess the impact of the COVID-19 pandemic on school-going children in Bududa district.,To assess the socio-economic impact of the COVID-19 pandemic on smallholder farmers’ households in Bududa district.,
 Uganda 2021-07-13 2024-07-13 Social Science and Humanities Non-degree Award
omia Obel Francis Patrick
ID:
MULTI-STAKEHOLDER PARTICIPATION IN NATIONAL BUDGETING IN UGANDA By Francis Patrick Omia
REFNo: SS870ES

The purpose of this study is to assess the effect of multi-stakeholder participation in national budget preparation
The specific objectives of the study are as follows;
1. To examine mechanisms for Multi-stakeholder participation in budget preparation planning.
2. To analyze Multi-stakeholder participation in budget deliberation.
3. To assess Multi-stakeholder participation in budget preparation outcomes.

Uganda 2021-07-13 2024-07-13 Social Science and Humanities Non-Clinical Trial Degree Award
Nitin Wadhwa
ID:
Investigating crop raiding and ranging of habituated mountain gorillas close to park boundaries in the Buhoma sector of Bwindi National Park, Uganda.
REFNo: NS263ES

1. In this proposed study, we will walk jungle trails taken by forest rangers in the Buhoma sector to find and map signs of gorilla presence and human related activity. 2. Based on the spatial mapping exercise and density of recorded signs in a particular area, we will identify areas of high gorilla movement and ascertain how close to park boundaries gorillas are venturing and also how high are disturbance factors like human activity along the boundaries of the park. 3. We will also walk and survey the approximately 10 kms of park boundary relevant to our study (See Figure 3 in Appendix) in the Buhoma sector to map land use and cropping pattern along the edges of park (upto 150 metres). 4. Based on the the survey excersise along the boundaries of the park, we will map the land use patters and crops planted along the boundaries to create a spatial map to understand human activities along the edge park. 5. We will use data obtained from previous objectives and extrapolating it in conjunction with already existing research, we will draw conclusions and give recommendations.
India 2021-07-13 2024-07-13 Natural Sciences Non-Clinical Trial Non-degree Award
Eve  Namisango
ID: UNCST-2021-R014038
 Mapping service pathways across the cancer disease trajectory in Kampala; a retrospective cohort study of timing and access to services
REFNo: HS805ES

1. To determine the number of patients accessing cancer services at Uganda Cancer Institute, Mulago Palliative care Unit, Kawempe Home Care and Hospice Africa Uganda from 2018 across 2019
2. To Identify source of referrals and target of onward referrals across these above services
3. To determine case mix across cancer services
4. To determine median number of days between referral to cancer care services and death for the study sample
5. To Identify variation in access to and referrals to cancer services by sex, age, ethnicity, diagnosis, and geographical location of residence
6. To Depict cancer pathway for patients from diagnosis to death in Kampala, Uganda

Uganda 2021-07-12 2024-07-12 Medical and Health Sciences Non-degree Award
Franklin Higenyi
ID:
Gender and Public Health Space:A case of Female Doctor's career progression in Uganda Public Medical Services
REFNo: SS732ES

The study will investigate the factors that determine FDs’ career progression in UPMS.
1.4.1. Specific Objectives
1.4.1.1. To assess gender differences in career progression of female and male doctors in UPMS.
1.4.1.2. To analyze the socio-cultural and institutional factors that influence career progression of FDs in UPMS space.
1.4.1.3. To asses lived experiences of those who have managed to have career progression.
 Uganda 2021-07-12 2024-07-12 Social Science and Humanities Degree Award
Cosmas Mwikirize
ID:
Efficacy of a Deep Learning-aided Platform for Diagnosis of Breast Cancer using Ultrasound Images in the Ugandan Population
REFNo: SIR57ES

General Objective: To develop and evaluate the efficacy of a deep learning-based computer-aided platform for screening of breast cancer in the Ugandan population. Specific Objectives: 1. To collect, and curate and label breast US data from ECUREI Radiology department. 2. To develop deep learning models for lesion detection and pixel-wise segmentation in breast US images. 3. To integrate the learned models in an offline computer-aided detection platform for breast cancer, and clinically evaluate its performance. 4. To develop and integrate learned models for breast cancer detection, in a real-time portable ultrasound imaging platform.
Uganda 2021-07-12 2024-07-12 Engineering and Technology Non-degree Award
Onesmus  Ahabwe Magezi
ID:
COMMON CAUSES OF ABNORMAL VAGINAL DISCHARGE AND ANTIBIOTIC SUSCEPTIBILITY AMONG WOMEN ATTENDING THE GYGAECOLOGICAL OUTPATIENT CLINIC OF MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS1456ES

1.To determine the common bacterial isolates among women with abnormal vaginal discharge attending the gynecological outpatient clinic of Mbarara Regional Referral Hospital.
2.To describe the antibiotic susceptibility patterns of bacterial isolates among women with abnormal vaginal discharge attending the gynecological clinic of Mbarara Regional Referral Hospital.
3.To identify the factors associated with antibiotic resistance to commonly used antibiotics among women with abnormal vaginal discharge attending the gynecological outpatient clinic of Mbarara Regional Referral Hospital

 Uganda 2021-07-12 2024-07-12 Medical and Health Sciences Non-Clinical Trial Degree Award
Josylin Ekochu Arimpa Bananuka
ID:
Corporate Governance Practices and Performance of Pharmaceutical Manufacturing Firms in Uganda
REFNo: SS571ES

i. To analyze the effect of corporate leadership on the performance of pharmaceutical manufacturing firms in Uganda
ii. To assess the effect of boards of directors on the performance of pharmaceutical manufacturing firms in Uganda
iii. To investigate the consequences internal control systems have on the performance of pharmaceutical manufacturing firms in Uganda

Uganda 2021-07-09 2024-07-09 Social Science and Humanities Degree Award
Francis Ocheng
ID:
Helichrysum odoratissimum: Isolation and identification of bioactive compounds and their effects on oral bacteria
REFNo: HS1441ES

2-To determine whether the isolated and purified compounds from Helichrysum odoratissimum maintain their antibacterial effects on oral bacteria,1-To isolate and identify the bioactive compounds in the plant Helichrysum odoratissimum plant extracts ,The general objective of the study is to isolate and identify the bioactive compounds in the Helichrysum odoratissimum plant extracts and also further investigate the effects of the isolated compounds on oral bacteria ,
 Uganda 2021-07-09 2024-07-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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