Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Godfrey  Siu
ID: UNCST-2021-R005439
An Evaluation of the Effectiveness of the Parenting for Respectability Programme on Early Childhood Development among Children aged 0-6 years in Uganda
REFNo: HS4168ES

Main Objective
To conduct an effectiveness trial of an adapted (shorter) version of the PfR programme on ECD outcomes nested within wide scale implementation.
Specific Objectives
1.To estimate the effectiveness of the Parenting for Respectability programme on improving ECD specific outcomes (gross motor, fine motor, language and social development) among children aged 0-6 years after 6 months of intervention.
2.To estimate the observed improvement in parental knowledge, practices and parent-child relationships after 6 months of PfR programme interventions.

Uganda 2024-05-31 18:18:53 2027-05-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JUDITH AKELLO
ID: UNCST-2024-R003967
Unpacking the Influence of Women's Economic Empowerment Initiatives through Uganda Women’s Entrepreneurship Program on Livelihoods and Cultural Dynamics, Amolatar Sub-Region
REFNo: SS2635ES

Main objective
To explore whether and how economic impact of women's entrepreneurship program initiatives, is influenced by cultural norms and traditions on their engagement in entrepreneurial activities, in Amolatar sub-region.
Specific objectives
1. Analyse the economic impact of women's entrepreneurship programme initiatives in Amolatar sub-region. This involves tracking changes in women's income levels, employment opportunities, and access to financial services as a result of participating in these programs. The study will also evaluate the sustainability of economic improvements over time.
2. Explore the influence of cultural norms and traditions on women's engagement in women entrepreneurship programme activities within Amolatar sub-region. This will involve interviews to understand how cultural beliefs, roles, and expectations shape women's economic opportunities and choices. This study will also examine any shifts in these norms resulting from entrepreneurship program initiatives.
3. Establish the complex interplay between women's entrepreneurship program initiatives and cultural dynamics in Amolatar sub-region. This objective will involve a comparative analysis of the data gathered under the first two objectives to identify areas of alignment and tension between economic empowerment efforts and cultural norms. Additionally, we will investigate the strategies and mechanisms used by empowerment programs to navigate and influence these cultural dynamics.

Uganda 2024-05-31 18:05:38 2027-05-31 Social Science and Humanities Non-Clinical Trial Non-degree Award
ERIC WOBUDEYA
ID: UNCST-2019-R001047
Shortened RegiMen for Drug-susceptIbLE TB in Children
REFNo: HS4030ES

Primary
1. To determine if an 8-week HPZM regimen in children with presumed drug-susceptible TB disease has non-inferior efficacy to 8-weeks of HRZ(E) plus 8- or 16-weeks of HR(E) for achieving treatment success.
2. To evaluate the safety of the 8-week HPZM regimen in comparison to the 16- or 24- week HRZ(E) regimen among children with and without HIV.
Secondary
1. To evaluate the tolerability of the 8-week HPZM regimen in comparison to the 16- or 24- week HRZ(E) regimen among children with and without HIV.
2. To determine the weight-banded dosing of rifapentine and moxifloxacin taken as part of the HPZM regimen.
3. To evaluate the palatability and acceptability of the 8-week HPZM regimen in comparison to the 16- or 24-week HRZ(E) regimen among children with and without HIV.
4. To evaluate adherence to the 8-week HPZM regimen in comparison to the 16- or 24- week HRZ(E) regimen among children with and without HIV.
5. To evaluate clinical and laboratory characteristics and drug exposures associated with unsuccessful treatment outcomes (treatment failure or death).
6. To evaluate the cost and cost-effectiveness of the 8-week HPZM regimen relative to the 16- or 24-week HRZ(E) standard of care regimen, using a societal approach.
Exploratory
1. To characterize rifapentine and moxifloxacin PK parameters in malnourished children.
2. To evaluate the effect of rifapentine or rifampin, taken as part of the HPZM or HRZ(E) regimen, on the PK of dolutegravir.
3. To evaluate virologic control (less than 200 copies/mL) at 24- and 48-weeks among children with HIV taking a dolutegravir-based ARV treatment regimen co-administered with either HPZM or HRZ(E).
4. To collect and store biospecimens from consented participants for the purpose of future TB research.

Uganda 2024-05-31 18:02:19 2027-05-31 Medical and Health Sciences Clinical Trial Non-degree Award
Bernard Kikaire
ID:
Improving identification of new HIV infections and primary drug resistance among adolescents' girls, young women and their sexual partners in Uganda.
REFNo: HS4283ES

To improve identification of HIV infection, describe transmitted drug resistance mutations and HIV transmission network among AGYW and their sexual partners in Uganda.
Uganda 2024-05-31 17:57:30 2027-05-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Francis Eswap
ID:
Skepticism Over Refugee Quest to Realise the Right to Skills Development; the Case of South Sudan Adolescents in Adjumani-Uganda
REFNo: SS2659ES

1 To find out if adolescent refugees are accessing skills training programmes in a supportive social ecological system and if there are barriers and whether human rights legal regimes are effectively applied for their realisation of the right to skills development.
2 To assess skills training programmes for adolescent refugees to realise their right to skills development
3 To evaluate whether there is a Social Ecological System that supports adolescent refugees’ realisation of the right to Skills Development
4 To analyse the Barriers to adolescent refugees’ realisation of the right to skills development
5 To Examine the effectiveness of legal regimes in the Adolescent Refugee realisation of the Right to Skills Development

Uganda 2024-05-31 17:52:27 2027-05-31 Social Science and Humanities Non-Clinical Trial Degree Award
Ponsiano Ocama
ID: UNCST-2019-R001799
Assessment of Research Integrity Environment at Makerere University College of Health Sciences
REFNo: HS4131ES

To explore students and staff’s knowledge and attitudes towards research misconduct at MakCHS,To assess the magnitude of focus on research integrity issues among MakCHS regulatory structures,To determine the factors associated with research misconduct practices at MakCHS.,To identify the different types of research misconduct practices at MakCHS.,To assess the current research integrity frameworks at Makerere University College of Health Sciences and develop interventions to address research misconduct.,
Uganda 2024-05-31 17:48:32 2027-05-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Clovice Kankya
ID: UNCST-2020-R010154
Understanding the Barriers to Adoption and Active Use of Digital Services Provided via FarmDirect
REFNo: HS4305ES

Objectives (a) General Objective: The overarching objective of this study is to diagnose and solve the behavioral barriers and leverage enablers to the adoption and active use of FarmDirect’s services amongst farmers in Uganda. (b) Specific Objective: To explore how we increase the awareness of FarmDirect amongst unregistered farmers 1. To identify the sought-after attributes of their desired marketing channel 2. To explore the levels of comprehension and interest in a digital marketing channel 3. To understand the intention and willingness to undertake actions to use a digital marketing channel
Uganda 2024-05-30 11:30:32 2027-05-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Robert Downing George
ID: UNCST-2020-R014615
Usability Evaluation of the ANC Panel (Professional Use)
REFNo: HS4262ES

The primary objectives of this usability study are:
• To evaluate professional users’ ANC Panel test labelling comprehension (n=15 healthcare professionals). This evaluation will assess the professional users’ understanding of the key messages from the ANC Panel product packaging and labelling. The evaluation will be questionnaire-based and will comprise an evaluation of the users’ understanding of:
o The key warnings and test limitations and/or restrictions
o The test procedure
o The test result interpretation

• To evaluate the ability of professional users to interpret the ANC Panel test results (n=15 healthcare professionals). This evaluation will assess the professional users’ ability to interpret pre-prepared, static ANC Panel test results. The results will comprise a range of test results, including weak-positive results and tests with failed control lines. Each user will interpret five different test results, with three tests in each test result, in randomised order.

UK 2024-05-30 11:27:23 2027-05-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Emmanuel Awori Siryoyi
ID:
Determinants of export performance of maize farmer organizations in Busia district, Uganda
REFNo: A440ES

To establish the effect of import bans and tariffs on the export performance of maize farmer groups in Busia district, Uganda. ,To illustrate the effect of infrastructural development on the export performance of maize farmer groups in Busia district, Uganda,To demonstrate the effect of middlemen on the export performance of maize farmer groups in Busia district, Uganda,To establish the effect of farmer group capacity on the export performance of maize farmer groups in Busia district, Uganda. ,
Uganda 2024-05-30 11:26:40 2027-05-30 Agricultural Sciences Non-Clinical Trial Degree Award
Jerome  Barry Bamugaya
ID:
INCLUSIVE COMMUNITY GROUPS’ INITIATIVES TO SUSTAINABLE RURAL LIVELIHOOD SECURITY IN TESO SUB-REGION IN UGANDA
REFNo: SS2597ES

I. To establish the contribution of local community groups’ initiatives in reducing livelihood insecurities in Teso region in Uganda
II. To ascertain men and women’s perceptions and views on local groups’ initiatives towards rural livelihood security
III. To determine existing challenges, and threats that impede community initiatives to sustainable rural livelihoods among Iteso
IV. To establish applicable and tenable model for effective community groups’ operations

Uganda 2024-05-30 11:23:14 2027-05-30 Social Science and Humanities Non-Clinical Trial Degree Award
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