Jennifer Serwanga
ID: UNCST-2024-R002056
|
Molecular, Serological and Immunological Characterisation of Clade 1b Mpox to Improve Diagnostics for Local and
Regional Epidemic Response.
REFNo: NS934ES
1. Genetic and Immunological Characterisation of Mpox Clade 1b: To characterise the genetic profile and immunological responses associated with the Clade 1b Mpox virus circulating in Uganda and neighbouring high-risk regions. This objective seeks to identify the molecular adaptations and immune response profiles associated with the virus's transmission dynamics and its ability to evade immunity, a critical component in understanding the virus’s spread.
2. Establish Molecular Linkage and Epidemiologic Pathways for Targeted
Interventions: To utilise molecular linkage studies to map transmission chains and epidemiologic pathways of Mpox Clade 1b within and across Uganda, the DRC, Burundi, and South Sudan. This objective will pinpoint high-risk transmission clusters and guide targeted public health interventions, particularly in vulnerable communities such as border regions and fishing populations.
3. Correlating Viral Load with Antibody Dynamics in Clade 1b Cases and Contacts:To comprehensively analyse viral load dynamics across multiple body compartments in Mpox-infected individuals and correlate these findings with IgM, IgG and IgA antibody responses, including both binding and neutralising antibodies. This investigation aims to elucidate the predictive value of antibody kinetics in Clade 1b Mpox infections, including in cases with low or undetectable viral loads. By integrating virological and immunological parameters, this study will enhance our
understanding of host-virus interactions, inform diagnostic sensitivity thresholds, and provide critical insights into the immunopathogenesis of Clade 1b Mpox.
4. Optimisation of Diagnostic Tools for Regional Mpox Response: To optimise, and validate advanced diagnostic methods, integrating molecular and serological tools tailored to Mpox Clade 1b. By leveraging UVRI's Mpox sample repository, this objective will enhance the diagnostic accuracy and timeliness essential for immediate outbreak containment, enabling Uganda and partner nations to identify cases and reduce transmission risk rapidly.
5. Facilitate Global Access to Clade 1b Resources for Vaccine and Diagnostic Development: To enhance global Mpox preparedness, this study will share well-characterized Clade 1b specimens with trusted international collaborating research partners, including World Health Organisation (WHO) and United Kingdom Health Security Agency (UKHSA), after putting in place all necessary material transfer agreements ironing outall policicies and legal issues concerning sample sharing.
These specimens will support the development of standardized reference panels for molecular and serological diagnostics, assay comparability, and the establishment of anti-Mpox reference materials to strengthen global surveillance and response efforts.
This objective aims to support global efforts in vaccine development and diagnostic advancements by providing access to Clade 1b isolates, thereby fostering robust Mpox response capacity worldwide and contributing substantially to epidemic containment.
6. Strengthening Regional Preparedness through Strategic Collaboration: To promote a coordinated Mpox surveillance network with neighbouring countries (DRC, Burundi, and South Sudan) for improved outbreak detection, data sharing, and joint response strategies. This objective aligns with regional health security goals and strengthens collaborative frameworks to combat the Mpox epidemic more effectively across East and Central Africa.
|
Uganda |
2025-02-25 18:19:08 |
2028-02-25 |
Natural Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Achilles Katamba
ID: UNCST-2019-R000540
|
RE-IMAGINING TB CARE: TRANSFORMING WHEN, WHERE, AND HOW TB SERVICES ARE ACCESSED AND DELIVERED IN UGANDA
REFNo: HS5570ES
Main Objective
1. To evaluate the effectiveness, implementation and cost of an Intervention strategy to improve Tuberculosis community awareness, screening, testing and linkage to care for TB and comorbidities
Specific Objectives
1. Develop a digital and AI-based strategy (intervention strategy) to enhance CHWs capacity to conduct community awareness, screening, testing and linkage to care for TB and other co- morbidities
2. Determine whether an intervention strategy improves awareness, screening, testing, and linkage to care for TB and other comorbidities
3. Evaluate reach, adoption and implementation of the Intervention strategy
4. Evaluate the incremental costs, outcomes, and cost-effectiveness associated with the Intervention strategy as compared to the Standard of care strategy from the health systems and participant perspectives
|
Uganda |
2025-02-24 12:02:35 |
2028-02-24 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Jakyoung Lee
ID: UNCST-2024-R016191
|
The Evaluation of the Capacity Building for Community Health Workers (CHWs) in Central Region of Uganda
REFNo: HS5548ES
? Assess progress relative to the project plan and suggest improvements in project execution.
? Establish strategies to enhance the quality of health worker training, community health activities, and other related actions.
? Review and adjust performance indicators based on the Project Design Matrix (PDM) and develop new key performance indicators.
? Formulate an exit strategy from a health system strengthening perspective to enhance the project's sustainability and effectiveness
|
South Korea |
2025-02-20 18:53:36 |
2028-02-20 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Nazarius Tumwesigye Mbona
ID: UNCST-2019-R000664
|
COBIHA- A COMMUNITY BASED INTERVENTION AGAINST HARMFUL USE OF ALCOHOL IN A RURAL SETTING: A pilot study around lake Bunyonyi in Kigezi, Uganda
REFNo: HS5521ES
2.To explore reasons for harmful use of alcohol, and perceptions on effective and acceptable ways of reducing this.,1.To conduct a pilot survey to establish the level of harmful use of alcohol and factors associated with the behaviour , to fill the evidence gap on effective community interventions, the current burden of harmful use of alcohol, and community perceptions of the burden of harmful alcohol use in rural Uganda,
|
Uganda |
2025-02-20 18:51:21 |
2028-02-20 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Alfred Jatho
ID: UNCST-2021-R011710
|
A Focus on Breast Cancer: Decentralizing Breast Cancer Early Detection
through addressing barriers to accessing timely and quality care in Uganda and Zambia
REFNo: HS5551ES
How effective is the developed generic breast cancer training package in equipping
Primary and Community Health Workers with knowledge and skills to train, handle and
refer cases of Breast cancer in Arua and Mbarara health regions?
2. How effective is support supervision and mentorship towards improving the quality of
breast cancer services at primary and community health level?
3. What is the level of awareness and practice of breast self-examination by women
attending HFs in Mbarara and Arua health regions?
4. What is the association between breast cancer screening knowledge and practices of
women attending health facilities ?
|
Uganda |
2025-02-20 18:31:56 |
2028-02-20 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Charlotte Bednarski Marie
ID: UNCST-2024-R003417
|
Transnational networks of care: international NGO management in Iganga, Uganda
REFNo: SS3628ES
PhD pre-dissertation research
|
USA |
2025-02-20 18:29:52 |
2028-02-20 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
|
KOBUSIINGYE FLORAH
ID: UNCST-2024-R001996
|
A MOBILE TEACHING-LEARNING FRAMEWORK FOR BRIDGING THE AGRICULTURAL EXTENSION GAP IN RESOURCE CONSTRAINED AREAS. A CASE STUDY OF KIGEZI SUB-REGION
REFNo: SIR464ES
Main Objective -To produce a comprehensive teaching-learning framework aimed at reducing the agricultural extension gap in the Kigezi region.
specific objectives
1. To evaluate current agricultural extension frameworks, identifying their strengths and weaknesses.
2. To design a mobile application framework that facilitates access to information, skills, and technology for farmers, extension officers, and other value chain actors.
3. To assess the feasibility and acceptability of the developed mobile agricultural extension application among farmers, extension officers, and other value chain actors.
|
Uganda |
2025-02-20 18:27:15 |
2028-02-20 |
Engineering and Technology |
Non-Clinical Trial |
Degree Award |
|
LOIS BAYIGGA
ID: UNCST-2024-R004310
|
PRE-CLINICAL TESTING OF FORWARD-ORIENTED GLOBIN-EXPRESSING LENTIVIRAL VECTOR
REFNo: HS5513ES
e) To determine the efficiency of magnetically assisted transduction in gene modified CD34+ cells, isolated from individuals with sickle cell disease or trait, using flow cytometry and real-time polymerase chain reaction (RT-PCR),d) To compare the efficiency of standard transduction to magnetically assisted transduction in CD34+ cells, isolated from individuals with sickle cell disease or trait, using a forward-oriented globin-expressing lentiviral vector using flow cytometry and real-time polymerase chain reaction (RT-PCR),c) To determine the presence of HbS mutation in the CD34 negative cells isolated from cord blood and red blood cell exchange products using hemoglobin electrophoresis.,b) To determine the yield, purity, and viability of CD34+ cells isolated from cord blood and red blood cell exchange products using multicolor flow cytometry ,a) To isolate hematopoietic stem and progenitor cells (CD34+) from cord blood and red blood cell exchange products using immunomagnetic-based method,To determine the efficacy of the forward-oriented globin-expressing lentiviral vector in HSPCs isolated from individuals with sickle cell disease or trait in Uganda,
|
Uganda |
2025-02-20 18:26:20 |
2028-02-20 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Stella Muyanja Zawedde
ID: UNCST-2021-R014037
|
Effect of non-communicable disease multimorbidity on TB treatment outcomes amogn TBHIV co-infected patients in Uganda
REFNo: HS5506ES
a) To determine the prevalence of, and factors associated with multimorbidity among people with TB and HIV
b) To determine the effect of NCD Multimorbidity on TB treatment outcomes among persons co-infected with HIV.
|
Uganda |
2025-02-20 17:58:06 |
2028-02-20 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Brenda Okech Apio
ID: UNCST-2022-R011031
|
Epidemiology of Malaria
Infection in Sub-Saharan
African Countries
REFNo: HS5543ES
Primary Objective
1.To estimate the site-specific IR of
P. falciparum infection by rapid
diagnostic test (RDT) testing,
overall and by age group (5-11
years, 12-17 years, 18-60 years)
during the active detection of
infection period.
Secondary objectives
1.To evaluate the agreement
between RDT and thick blood
smear (TBS), and to evaluate the
sensitivity and specificity of RDT
and TBS using quantitative
polymerase chain reaction (qPCR)
as the gold standard for the
identification of P. falciparum
infection, at baseline and at two
and six months after enrolment.
2.To estimate the site-specific IR of
P. falciparum infections detected
by both active and passive
surveillance over the complete follow-up period (0-6 months),
overall and by age group (5-11
years, 12-17 years, 18-60 years).
|
Uganda |
2025-02-20 17:55:11 |
2028-02-20 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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