Mark Okwir
ID: UNCST-2021-R013417
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PREVENTION OF MOTHER-TO-CHILD TRANSMISSION OF HEPATITIS B VIRUS BY ESTABLISHING AN ANTENATAL SCREENING AND VIRAL LOAD TESTING UNIT AND TENOFOVIR DISOPROXIL FUMARATE TREATMENT IN LIRA, NORTHERN UGANDA
REFNo: HS3861ES
To assess the viral load and effectiveness of the TDF therapy.,To assess and enhance knowledge and perceptions of hepatitis B, with the aim of reducing stigma and improving awareness among pregnant women. ,To optimise linkage to care and engagement in the recommended care after receiving a positive HBsAg test during the antenatal period.,To determine the prevalence and risk factors associated with hepatitis B virus infection among pregnant women attending the antenatal clinic in Lira University Hospital and Lira Regional Referral Hospital. ,To assess the implementation of the HBV DNA viral load threshold of ≥10,000 IU/mL for initiating TDF treatment in pregnant women during gestation week 24 or beyond in order to prevent HBV mother-to-child transmission in Lira, Northern Uganda.,
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Uganda |
2024-08-22 12:33:06 |
2027-08-22 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Francis Mutekanga
ID: UNCST-2020-R014725
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GEC II Uganda Project
REFNo: SS3024ES
What were the implementation factors behind the GEC-T projects\' success or lack of success? ,To what extent and how did external contextual factors for different projects across the GEC-T portfolio influence their performance?,What were the unexpected or unintended results across the GEC-T portfolio?,What intermediate outcomes did the GEC-T portfolio deliver?,What results did the GEC-T portfolio deliver between the baseline and end line?,The primary objective of the Effectiveness Evaluation will be to assess the effectiveness of the GEC II projects that were designed and implemented through the GEC-T Window. ,
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Uganda |
2024-08-22 12:28:28 |
2027-08-22 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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Grace Kisitu Paul
ID: UNCST-2024-R004102
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Universal2: Pharmacokinetics, safety and acceptability of a solid paediatric fixed-dose combination of darunavir/ritonavir (DRV/r) 120/20mg for children living with HIV
REFNo: HS4762ES
To evaluate the pharmacokinetics and safety of DRV/r 120/20 mg tablets in children greater than or equal to 3 years of age and weighing 10 to less than 25 kg
To evaluate the pharmacokinetics and safety of DRV/r 120/20 mg tablets in children greater than or equal to 3 years of age and weighing 10 to Less than 25 kg
To evaluate the acceptability of DRV/r tablets in children greater than or equal to 3 years of age and weighing 10 to less than 25 kg
To evaluate the short-term efficacy of the DRV/r 120/20 mg tablets in children greater than or equal to 3 years of age and weighing 10 to less than 25 kg
To describe RTV PK parameters as well as darunavir unbound plasma concentrations.
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Uganda |
2024-08-22 11:45:22 |
2027-08-22 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Ioana Lungu
ID: UNCST-2024-R004378
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Study protocol for baseline data collection on sexual and reproductive health outcomes in Wakiso district
REFNo: SS3049ES
At baseline and prior to the intervention, assess the uptake of HIV testing, ART and PrEP for AYP in our sample in study locations.,At baseline and prior to the intervention, assess the knowledge, perceived norms and attitudes towards contraception and HIV services (testing, ART and PrEP) for AYP in our sample in study locations.,At baseline and prior to the intervention, assess the modern Contraceptive Prevalence Rate (mCPR) for young women and girls in our samplein study locations.,At baseline and prior to the intervention, assess the level of access to high quality, youth friendly health services for AYP in our sample in study locations.,At baseline and prior to the intervention, assess the share of unintended pregnancies for our sample.,
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Romania |
2024-08-22 11:39:54 |
2027-08-22 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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Agaba Katureebe Ishmael
ID: UNCST-2024-R004089
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Getting a GRIP on Hypertension in Uganda: Giving Repetitive Isometric Exercise for Blood Pressure Control (GRIP in Uganda)
REFNo: HS4712ES
To assess knowledge, attitudes, and practices (KAP) about HTN and experience with IHT (if applicable) ,To measure HTN medication adherence for those prescribed HTN medication during their follow-up, which will be measured through pill counting (counting the remaining amount of pills for prescribed medication).,To assess the need for HTN medication at endline, as per clinical and MOH guidelines, which will be measured through changes in BP levels at week 12,To evaluate the effects of Isometric Hand Training (IHT) on resting diastolic Blood Pressure when compared to standard care after 12 weeks ,To evaluate the effects of Isometric Hand Training (IHT) on resting Systolic Blood Pressure when compared to standard care after 12 weeks ,To determine the efficacy of Isometric Hand Training (IHT) in a population of Hypertension (HTN) patients compared to standard care after 12 weeks of care,
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Uganda |
2024-08-22 11:38:26 |
2027-08-22 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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JOSELYN RWEBEMBERA
ID: UNCST-2021-R013915
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ASSESSING THE CONTEMPORARY ECHOCARDIOGRAPHIC DIAGNOSIS AND SECONDARY PROPHYLAXIS OF EARLY-STAGE RHEUMATIC HEART DISEASE
REFNo: HS4694ES
a) To determine the diagnostic accuracy of the 2023 World Heart Federation (WHF) echocardiographic screening criteria for RHD, estimate the cost of RHD screening using the WHF 2023 active case finding algorithm, and a cost analysis of two RHD screening models in Uganda; b) To compare patient-reported outcomes (i.e, treatment adherence, treatment satisfaction and health-related quality of life) among children receiving intramuscular and oral forms of penicillin prophylaxis; and c) To evaluate the cost effectiveness of oral versus intramuscular penicillin for treating early-stage RHD.
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Uganda |
2024-08-22 11:35:35 |
2027-08-22 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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Wilson Mathembele
ID:
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School Inspection and the Quality of Education in Secondary Schools in Uganda: A case Study of Kasese District
REFNo: SS2957ES
To assess the influence of school inspection on the quality of education in secondary schools in Kasese District,To evaluate the quality of education in secondary schools in Kasese District ,To examine the quality of inspection in the secondary schools in Kasese District,The purpose of this study is to determine the effectiveness of school inspection in ensuring the quality of education in secondary schools in Kasese District in order to improve educational standards and quality outcomes.,
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Uganda |
2024-08-22 11:30:39 |
2027-08-22 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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Bruce Kirenga J
ID: UNCST-2019-R001460
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Assessment of Longitudinal Lung Function and Sleep Disordered Breathing in COPD Patients in Uganda
REFNo: HS4817ES
1.Assess longitudinal lung function and respiratory symptoms among adults with COPD in Uganda.
2.Determine whether baseline radiographic imaging and inflammatory markers can predict exacerbations at one year among those with COPD.
3.Assess nocturnal sleep patterns and the association between sleep disordered breathing and quality of life.
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Uganda |
2024-08-22 11:27:08 |
2027-08-22 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Proscovia Nabunya
ID: UNCST-2019-R000970
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Testing the Feasibility and Acceptability of a Combination Intervention to Address Mental Health among Refugee Youth in Uganda
REFNo: SS2834ES
This proposed two-year study will be conducted in two phases. The first phase seeks to understand whether the COVID-19 pandemic had differential impact on refugee youth living in different settings. The second phase will test the feasibility and acceptability of an innovative combination intervention that has not been previously tested among refugee youth to address psychological problems that have increased since the onset of the COVID-19 pandemic.
Aim 1. To examine the mental health impact of COVID-19 on refugee youth living in Bidibidi refugee settlement compared to refugee youth living in urban centers (Arua town) in northern Uganda.
Aim 2. To test the feasibility, acceptability and preliminary short-term impact of an innovative intervention combining the youth readiness intervention (YRI) with youth development accounts and financial literacy training (YDA-FLT) to address the mental health impact of COVID-19 among refugee youth living in Bidibidi refugee settlement in northern Uganda.
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Uganda |
2024-08-19 11:03:04 |
2027-08-19 |
Social Science and Humanities |
Clinical Trial |
Non-degree Award |
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Peter Olupot-Olupot Olupot
ID: UNCST-2020-R014798
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SMAART-MAP trial
Severe Malaria A Research and Trials
consortium - Multisite Adaptive Platform
trial
REFNo: HS4547ES
OBJECTIVES
The objective of the SMAART-MAP trial is to identify promising adjunctive therapies to take forward into a large Phase III trial in severe malaria with a mortality endpoint. The adaptive platform design enables additional domains to be added so a range of adjunctive therapies can be tested, across multiple clinical presentations of severe malaria, in a timely manner.
PRIMARY OBJECTIVE(S)
To explore within each domain the therapeutic efficacy of the intervention using an early indicator such as a biomarker or clinical assessment at 24-72 hours.
SECONDARY OBJECTIVE(S)
To assess the impact of the interventions on clinical outcomes (readmission and
mortality) on all children 28 days and 90 days after randomization
To assess the impact of the interventions on Grade 3 or 4 adverse events, and adverse
events of any grade related to the interventions or comparators.
To assess the impact of proposed definitions for severe malaria based on platelet counts
≤150,000/µL and plasma pfHRP2 concentrations ≥800 ng/mL on differences between
randomized groups
In a sub study, to determine the performance characteristics of a POC pfHRP2 test
compared with quantitative plasma pfHRP2 concentrations determined from plasma.
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Uganda |
2024-08-16 11:01:14 |
2027-08-16 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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