Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Andrew Mujugira
ID: UNCST-2019-R000871
 Preventing Intimate Partner Violence and Improving HIV Outcomes in Kampala, Uganda
REFNo: HS1843ES

AIM 1: Assess the reach, effectiveness, adoption, implementation and maintenance of national IPV guidance in HIV treatment and prevention settings in Uganda. We will conduct a cross-sectional evaluation using programmatic data from health facilities engaged in the parent study in order to determine the extent to which current national IPV guidance is implemented alongside existing HIV treatment and prevention services.

AIM 2: Identify provider-level barriers and facilitators to implementing national IPV guidance within HIV treatment and prevention settings in Uganda. We will conduct in-depth interviews with HIV providers from health facilities engaged with the parent study. Qualitative data will be thematically analyzed to explore opportunities to optimize and adapt strategies to more effectively intervene upon IPV in HIV care settings.

 Uganda 2022-03-16 2025-03-16 Medical and Health Sciences Non-Clinical Trial Degree Award
Solomon Wafula Tsebeni
ID: UNCST-2021-R013883
 Healthcare workers’ Proficiency and Quality of Management for Snakebites in high burden Districts in Uganda
REFNo: HS2121ES

To explore the barriers faced in the management of snakebites in high burden districts in Uganda. ,To assess the quality of management for snakebites in high burden districts in Uganda.,• To assess the knowledge of health workers on snakebite management in two high burden districts in Uganda.,The overall objective is to assess health worker proficiency and quality of management of snakebites and associated barriers in high burden districts of Arua and Gulu so as to guide design of appropriate interventions to improve the quality of patient management and enhance favourable clinical outcomes. ,
 Uganda 2022-03-16 2025-03-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joweria Nambooze
ID: UNCST-2019-R001118
 Socio-demographic inequities in the risk of and response to Covid-19 in Uganda: a comparison of slum and estate communities
REFNo: HS2059ES

To determine the associations of practice of preventive measures with key social-demographic factors and other study variables between slum communities and suburb resident,To assess the variation in Psychosocial and economic impacts of Covid-19 between slum communities and suburb resident,To determine the difference Knowledge, perceptions and access to Covid-19 information between slum communities and suburb resident,To assess the difference in adoption of Covid-19 preventive measures and access to health services between slum communities and suburb resident,To conduct a comparative analysis of slum dwellers with economically-advantaged communities,
 Uganda 2022-03-16 2025-03-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
 Integration of SARS-CoV-2 surveillance in the active and reactive screening activities of the Intensified Sleeping Sickness Elimination Program (ISSEP) in West Nile districts, Uganda
REFNo: HS2104ES

3. To demonstrate the feasibility of using a new tool to digitalize data capture and facilitate real-time data reporting of the HAT reactive and active community screening campaigns.,2. To conduct a serosurvey for antibodies against the SARS CoV-2 spike and nucleocapsid proteins to estimate the prevalence of community exposure.,1. To demonstrate the feasibility of integrating SARS-CoV-2 in the HAT reactive and active community screening campaigns to detect active symptomatic SARS-CoV-2 infection.,
 Uganda 2022-03-16 2025-03-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 Uganda Gender and Tuberculosis Key Populations Assessment
REFNo: HS1864ES

1. To establish the gender differences evident in TB care cascade (diagnosis through treatment) records in Uganda. 2. To determine the gender barriers and facilitators to TB prevention, diagnosis, treatment and treatment completion in Uganda. 3. To generate information to guide the listing of TB KVPs relevant to Uganda context, and for designing interventions for addressing the gaps among prioritized KVPs. 4. To determine to what extent the National TB response (NSP and policies/guidelines) addresses gender and KVP issues in Uganda.
 Uganda 2022-03-14 2025-03-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
 Exposure-Response Evaluation of IV Artesunate in Children with Severe Malaria
REFNo: HS2027ES

Primary:
• To determine the relationship between dihydroartemisinin (DHA) exposures following intravenous dosing and markers of physiologic dysfunction associated with severe malaria
Secondary:
• To determine the relationship between DHA exposures and time to hospital discharge
• To determine the relationship between DHA exposures and parasite clearance associated with treatment of severe malaria.
Exploratory:
• To determine the relationship between DHA exposures and neurodevelopmental outcomes associated with treatment of severe malaria outcomes and explore predictors that may affect this relationship
• To evaluate the role of parasite clearance as a mediator of the relationship between DHA exposures and markers of physiologic dysfunction associated with severe malaria
• To develop a score comprised of markers of physiologic dysfunction and describe its relationship to clinical outcomes
• To assess P. falciparum infections for artemisinin resistance

Uganda 2022-03-14 2025-03-14 Medical and Health Sciences Clinical Trial Non-degree Award
Danielle Falk
ID:
Educators in Emergencies: The Lived Experiences and Professional Identities of Refugee and National Primary School Teachers in Uganda and South Sudan
REFNo: SS1213ES

To determine in what ways teachers conceptualize their professional identities,To understand how protracted conflict, forced displacement, and recurrent migration influences teachers’ lived experiences in their classrooms, schools, and communities in refugee-producing and receiving countries,To explore the lived experiences and professional identities of refugee and National Primary School Teachers in Uganda and South Sudan,
 USA 2022-03-14 2025-03-14 Social Science and Humanities Non-Clinical Trial Degree Award
Mathias Wambuzi
ID:
Community Engagement Strengthening for future HIV Vaccice trial participation in fishing communities around Entebbe,Uganda( CEVAC)
REFNo: SS1201ES

1. To assess knowledge on HIV vaccine trials among people living in FCs around Entebbe, Uganda.
2. To assess willingness to participate in future HIV vaccine trials among people living in FCs around Entebbe, Uganda.
3. To understand HIV vaccine trials experiences and motivators to participation among former participants.
4. To explore communities’ experiences, perceptions and preferences for community engagement among FCs around Entebbe, Uganda.

 Uganda 2022-03-11 2025-03-11 Social Science and Humanities Non-Clinical Trial Non-degree Award
Ambrose Oruni
ID:
Impact of escalating insecticide resistance on malaria control tools and parasite transmission in An. funestus from Uganda
REFNo: HS2063ES


i. Temporal monitoring of super-resistance every 6 months for 3 years. The frequency of the known resistance markers, changes in transcription profiles of resistance genes and variations in the genome will be monitored.

ii. Assess the impact of super-resistance on the effectiveness of the current and novel bednets against An. funestus.

iii. Assess the impact of super-resistance on malaria entomological transmission indices.

 Uganda 2022-03-11 2025-03-11 Medical and Health Sciences Non-Clinical Trial Degree Award
Rahel Nkola
ID:
Depression, Suicidality and associated factors among people with Diabetes and/or Hypertension at a Tertiary Hospital in South Western Uganda.
REFNo: HS1818ES

To determine the prevalence and factors associated with Depression and Suicidality among individuals with DM and/or HTN at Mbarara Regional Referral Hospital, southwestern Uganda.
 Tanzania 2022-03-10 2025-03-10 Medical and Health Sciences Non-Clinical Trial Degree Award
Cissy  Kityo
ID: UNCST-2021-R013663
 Rapid Proof-of-Principle Study: Diversity in the Spike gene of Sars Cov-2 and duration of SARS-Co-2 infection in immunologically compromised People Living with HIV-1
REFNo: HS2006ES

1.To characterize the SARS-CoV-2 virus found in HIV positive patients
2.To assess the impact of HIV immunosuppression on SARS-CoV-2 diversity
3.Determining the duration of SARS-CoV-2 infection in HIV infection
Uganda 2022-03-10 2025-03-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Alison Kinengyere Annet
ID:
Communication of research findings: a case study of medical researchers at the College of Health sciences, Makerere University
REFNo: HS2030ES

To assess the facilitators and barriers of medical research communication by researchers at MAKCHS.,To develop video documentaries, cartoons, podcasts, webinars and research briefs to communicate research findings of selected research studies at the college of health Sciences, Makerere University,To assess the factors associated with communication of medical research findings by researchers at the college of health sciences, Makerere University,To determine communication channels used by Makerere University College of Health sciences (MAKCHS) researchers in disseminating their research findings ,To investigate communication of medical research findings to different stakeholders by researchers at the college of health sciences, Makerere University,
 Uganda 2022-03-10 2025-03-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ruth Nanyonga
ID:
The Impact of Health Cooperative Membership on Health Agency and Economic Status of Women in Uganda’ Study
REFNo: SS1121ES

The main objective of the study is to quantify the impact of health cooperative membership on women’s health agency and economic status. The specific objectives include:

1. The health care access
• Safe delivery/pre-natal care
• Access to health trainings/education
• Access to regular primary care/check-ups

2. The health knowledge level
• Knowledge about health care resources (location of nearest clinic, where to get information regarding health)
• Knowledge about health itself (self-efficacy)
• Knowledge about insurance

3. The ability to set goals
• Preference to have a role in making the decisions about family planning?
• Preference to make the decision about when to seek health care for yourself?
• Preference to have a role in making the decisions about seeking health care for your family members/children?

4. Perceived ability and control
a. Ability to make decisions about family planning
b. Ability to make the decision to seek health care without delay
c. Ability to make decisions to seek health care for family members/children without delay

5. Action taken
a. Demonstrated decision-making power to seek health care without delay
b. Demonstrated decision-making power about family planning
c. Demonstrated decision-making power in seeking health care for family/children

 Uganda 2022-03-09 2025-03-09 Social Science and Humanities Non-Clinical Trial Non-degree Award
Dianah Aharimpisya
ID: UNCST-2021-R012528
 Elder Abuse and Welfare Status: Interrogating the deterrent gerontological mechanisms. A case of selected districts in south-western Uganda.
REFNo: SS1015ES

1. To examine the effect of elder abuse on welfare status in 5 selected districts of south-western Uganda. 2. To examine the mediating role of quality relationships on the association between elder abuse and welfare status in 5 selected districts of south-western Uganda. 3. To analyse the mediating effect of gerontological services access on the relationship between elder abuse and welfare status in 5 selected districts of western Uganda.
Uganda 2022-03-07 2025-03-07 Social Science and Humanities Non-Clinical Trial Degree Award
Divya Rayamajhi
ID:
Child and Adolescent mental health services in Uganda
REFNo: HS1786ES

i. To explore the availability of child and adolescent mental health services (CAMHS) in health facilities of Mbale district. ii. To identify barriers that may prevent people from accessing child and adolescent mental health services in Mbale from the perspective of health care providers. iii. To identify possible solutions to those barriers which may encourage or improve people`s access to child and adolescent`s mental health services in Mbale from the perspective of health care providers.
 Nepal 2022-03-07 2025-03-07 Medical and Health Sciences Non-Clinical Trial Degree Award
Agnes Rwashana Semwanga
ID:
A WEB-BASED HISTOPATHOLOGY REPOSITORY SYSTEM FOR BREAST CANCER MANAGEMENT
REFNo: HS2002ES

To validate the slides to establish the intra and inter observer agreement in morphological assessment of breast core cancer cases using glass slides and digital slides.,To establish the requirements and develop a web-based Histopathology Repository System (NHRS) for breast cancer case,To digitize core breast cancer glass slides for morphological assessment of core breast cancer cases.,To develop a national digital histopathology reporting system storing digitized slides for assessment of morphological characteristics of core breast cancer.,
 Uganda 2022-03-07 2025-03-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Phillip Wanduru
ID: UNCST-2019-R000381
 Determining short and medium-term sequelae, their predicting factors, and experiences of caring for newborns with intrapartum hypoxic-ischemic insults: Studies in Eastern rural Uganda
REFNo: HS2057ES

To understand caregivers’ experiences of caring for newborns with encephalopathy.,To determine the risk, and predicting factors of NDD at 6 and 12 months of age among infants who survived hypoxic-ischemic insults at birth.,To understand the interaction between healthcare providers and caregivers in the Newborn Care Units (NCU) when caring for newborns with hypoxic-ischemic insults at two high-volume hospitals in Eastern Central Uganda,To determine the predicting factors of hypoxic-ischemic insults and encephalopathy among newborns at two high-volume hospitals in Eastern Central Uganda,
 Uganda 2022-03-07 2025-03-07 Medical and Health Sciences Non-Clinical Trial Degree Award
Sarah Kiguli
ID: UNCST-2021-R013020
 Sickle Pan-African Research Consortium (SPARCO) Uganda: Strengthening Capacity for Clinical Care, Research and Training in Sickle Cell Disease - SCRT Project.
REFNo: HS2012ES

The overall goal of the project is to join and become one of the sites of the Collaborative Consortium of the SCD in Sub-Saharan Africa Network (SPARCO) with a goal of strengthening capacity for clinical care research and training in sickle cell disease in Uganda through implementation of evidence-based interventions. We shall do this by: Aim 1: Developing a centralized, electronic, patient consented, sickle hemoglobinopathy registry for Uganda. AIM 2: To improve SCD patient outcomes in Uganda by establishing regional SCD standards of care. AIM 3. To advance SCD related research by conducting cohort studies and implementation science studies on patients enrolled in the SCD registry, and an additional study on transition from pediatric to adult care by SCD adolescents.
 Uganda 2022-03-07 2025-03-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Emma Riley-Green
ID:
Financial Diaries Uganda
REFNo: SS1178ES

Test if taking women through a report on their business highlighting areas of improvement and a comparison to similar businesses results in additional improvements in business outcomes,Test if the act of frequently asking the women about aspects of their businesses makes these dimensions more salient and results in improvements in business outcomes,Understand more about female-owned microenterprises using high-frequency data collected in the form of diaries.,To examine the impact of financial diaries for female entrepreneurs, with and without reports and comparisons to similar businesses, on a range of business outcomes.,
 UK 2022-03-07 2025-03-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
Mwangi Fridah Gakii
ID:
PREVALENCE OF DYSLIPIDEMIA AMONG WOMEN WITH PRECANCEROUS AND CANCEROUS LESIONS ATTENDING CERVICAL CANCER CLINIC AT UGANDA CANCER INSTITUTE
REFNo: HS2087ES

General objectives
1. To determine the prevalence of dyslipidemia and its association with precancerous and cancerous lesions among women attending cervical cancer clinic at Uganda Cancer Institute for screening
Specific objectives
1. To determine the prevalence of dyslipidemia among women with precancerous and cancerous
lesions attending cervical cancer clinic at Uganda Cancer Institute for screening.
2. To determine the association between dyslipidemia, and grades of precancerous lesions among women attending cervical cancer clinic at Uganda Cancer Institute for screening.
3. To determine the association between dyslipidemia and grades of cancerous lesions among women attending cervical cancer clinic at Uganda Cancer Institute for screening
 Kenya 2022-03-07 2025-03-07 Medical and Health Sciences Non-Clinical Trial Degree Award
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