Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Pontiano Kaleebu
ID: UNCST-2021-R013577
A behavioural Science Research to Determine Factors that Facilitate Future Uptake of HIV Prevention Products and Multi-Purpose Prevention Technologies to Prevent HIV and Unwanted Pregnancy in Sub-Saharan Africa Universally Accessible HIV Prevention Technologies for African Girls and Young Women through Knowledge Applied from Behavioural Economics (UPTAKE)
REFNo: HS1540ES

Multi-purpose Prevention Technologies (MPTs) to prevent HIV and unwanted pregnancy in Sub-Saharan Africa

i. To understand facilitators of and barriers to uptake and retention of injectable and implantable long acting pre-exposure prophylaxis (LA-PrEP) and MPT to inform product development, using formative behavioural research methods
ii. To design interventions to impact the uptake of new biomedical HIV prevention products, as part of a suite of self-care and self-screening products for sexual and reproductive health, using quantitative behavioural research methods
iii. To test the effectiveness of the alternate design/interventions and strategies, using marketed LA contraceptive products as proxies for LA HIV prevention products in development
iv. To estimate the cost of retention interventions and the cost effectiveness of products and delivery methods among adolescent girls and young women (AGYW) and female sex workers (FSWs) for prevention of pregnancy and/or HIV, using modelling

Uganda 2021-08-31 2024-08-31 Medical and Health Sciences Clinical Trial Non-degree Award
Emmy Okello
ID: UNCST-2020-R009792
“Active Case Detection and Decentralized Dynamic Registry to Improve the Uptake of Rheumatic Heart Disease Secondary Prevention” (ADD-RHD)
REFNo: HS1561ES

Secondary objectives include technical proficiency, acquisition times, global image quality, and user satisfaction and confidence. Each of these parameters will be reported for the entire training group and a sub-group analysis will look for differences between curriculum groups. Acquisition times and image quality will be compared between trainees and expert sonographers.,To determine the impact of a pragmatic RHD primary prevention program in Uganda,
Uganda 2021-08-30 2024-08-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Comfort Mukasa Hajra
ID:
Real-time access to sanitation information for improved management of sanitation services: A case Study in Kawempe division.
REFNo: HS1458ES

Main Objective:
To test if timely access to sanitation information leads to improved sanitation planning, increased access to safely managed sanitation services and improved multi-sectoral collaboration.

Specific Objectives:
1. To design and test the effectiveness of timely access to sanitation information for planning, coordination and access to improved sanitation services.
2. To validate user needs for sanitation service provision in Uganda.
3. To document scalable best practice mechanisms for improved multi-sectoral planning and coordination on sanitation.
Uganda 2021-08-30 2024-08-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eric Awich Ochen
ID: UNCST-2021-R013266
Preventing Gender-based Violence: Video Game Intervention Designed as an Educational Tool to Address Child Marriage in Uganda
REFNo: SS880ES

To assess the effectiveness of the game (Peace) in promoting pro-social attitude/behavior change and empathic capacity among young people to prevent violence.
• Help young people understand what sexual exploitation is and how it is linked to gender inequalities.
• Increase young people’s understanding about how adult power is misused to abuse and silence them.
• Show young people that perpetrators will seek out and exploit young women’s vulnerabilities.
• Help young people understand the impact that sexual coercion has on everyone involved.
• Empower young people in reporting incidents of child sexual abuse and sexual coercion.
• Increase awareness of the role of various agencies/individuals that can help.
• Help young people understand ways in which adults may groom them using various tactics.
• Help young people understand the relationship between sexual coercion and child marriage.
• Give young people the opportunity to develop skills, knowledge, and competencies that can help them make sound decisions for themselves or others in real life situations.
• To support and empower young people in avoiding child marriage


Uganda 2021-08-30 2024-08-30 Social Science and Humanities Non-Clinical Trial Non-degree Award
NAMANDE MUGERWA SARAH
ID:
“EKISAAKAATE” (ROYAL ENCLOSURE) PEDAGOGY AND EARLY CHILDHOOD MORAL LEARNING OUTCOMES IN BUGANDA KINGDOM IN UGANDA
REFNo: SS975ES

To establish the mediating relationship between multiculturalism and early childhood moral learning outcomes.,To examine the relationship between “ekisaakaate” role play instruction pedagogy and early childhood moral learning outcomes.,To determine the relationship between “ekisaakaate” traditional story telling instruction pedagogy and early childhood moral learning outcomes.,To establish the relationship between “ekisaakaate” living values-based contextual instruction pedagogy and early childhood moral learning outcomes.,To find out the relationship between “ekisaakaate” native language instruction pedagogy and early childhood moral learning outcomes. ,
Uganda 2021-08-30 2024-08-30 Social Science and Humanities Non-Clinical Trial Degree Award
Lazaaro Mujumbusi
ID: UNCST-2023-R007470
Exploring understandings of and attitudes towards Covid-19 in Mayuge district Uganda
REFNo: SS977ES

1. To explore community members' perceptions of COVID-19 and its transmission, with a focus on ideas about responsibility.
2. To investigate how ideas about responsibility intersect with existing inequalities around occupation, tribe, and gender.
3. To examine whether, and how, understandings of COVID-19 transmission have impacted everyday WaSH practices.
4. To develop insight that may be of value to developing interventions aimed at reducing transmission and/or stigma.

Uganda 2021-08-30 2024-08-30 Social Science and Humanities Non-Clinical Trial Degree Award
Patrick  Vudriko
ID:
Survey to identify priority livestock diseases and diagnostic needs of animal health professionals and farmers in Central and Southwestern Uganda
REFNo: A84ES

Specific objectives
1. To identify the priority livestock and poultry diseases for which diagnostic services and diagnostic kits/aids are needed by various stakeholders (farmers, vets).
2. To assess the perception and attitudes of key stakeholders in the animal industry on the value and quality of existing animal diagnostic services in Uganda

Uganda 2021-08-27 2024-08-27 Agricultural Sciences Non-degree Award
Suzanne  Kiwanuka N
ID: UNCST-2020-R014671
Using High Impact Communication Strategies to increase blood donation awareness among secondary school students in Uganda
REFNo: SS802ES

1. To increase knowledge and awareness about blood donation among secondary school students in Uganda using targeted communication strategies.
2. To increase willingness to donate blood among secondary school students in Uganda using targeted communication strategies
3. To increase intention to donate blood among secondary school students in Uganda using targeted communication strategies

Uganda 2021-08-27 2024-08-27 Social Science and Humanities Non-degree Award
Christine Akello Kalumera Kalumera
ID: UNCST-2021-R013514
OPTIMISING USER INVOLVEMENT IN USER STORIES COLLECTION, ANALYSIS AND DESIGN TASKS FOR EHIS DEVELOPMENT: APPLYING COLLABORATION ENGINEERING PRINCIPLES TO HUMAN CENTRED DESIGN
REFNo: SIR62ES

The main of objective of this research is to develop a collaborative engineering process to improve user involvement in requirements gathering, analysis and design and stages of the user centred design approach, when developing electronic health information systems
Uganda 2021-08-27 2024-08-27 Engineering and Technology Non-Clinical Trial Degree Award
Olive Kobusingye Chifefe
ID:
Assessing the impact of COVID-19 on the mobility patterns in Kampala Metropolitan Area
REFNo: HS1636ES

To explore the socio-economic impact of implementing the regulations on transportation.,To describe ways in which transporters coped with the COVID-19 related restrictions on transport. ,To identify ways in which commuters coped with the threat of COVID-19., The overall objective of this study is to examine the impact of the COVID-19 pandemic on mobility patterns in the Kampala Metropolitan area so as to inform planning transportation during the pandemic and in the post-COVID-19 period. ,
Uganda 2021-08-27 2024-08-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
BRENDA GATI MIREMBE
ID: UNCST-2021-R013390
A Phase 3, Randomized, Active Controlled, Double-blind Clinical Study to Evaluate the Efficacy and Safety of Oral Islatravir Once Monthly as Pre-Exposure Prophylaxis in Cisgender Women at High Risk for HIV 1 Infection.
REFNo: HS1631ES

Primary Objectives:
1. To evaluate the efficacy of oral ISL QM compared to FTC/TDF QD for the
prevention of HIV-1 infection as assessed by the incidence rate per year of confirmed
HIV-1 infection.

2. To evaluate the safety and tolerability of oral ISL QM compared to oral FTC/TDF QD as assessed by review of the accumulated safety data

Secondary Objective
1. To evaluate the efficacy of oral ISL QM in reducing the incidence per year of HIV-1
infection relative to the background rate.

Uganda 2021-08-27 2024-08-27 Medical and Health Sciences Clinical Trial Non-degree Award
ROSCO KASUJJA
ID: UNCST-2019-R000504
Treating Depressive Symptomatology in Congolese Refugees in Uganda and Rwanda: Adapting and Evaluating Community-based Socio-therapy
REFNo: SS263ES

1. Develop implementation guidance for adapting, delivering, supervising and monitoring aCBS for refugees across diverse settings. 2. Build research capacity for evaluating complex interventions in Rwanda and Uganda. 3. Enhancing knowledge about a scalable and inclusive form of intervention aimed at supporting the mental and wellbeing of refugees – a group at high risk of experiencing mental disorders who are markedly underserved in terms of services and support at both the local and global level.
Uganda 2021-08-25 2024-08-25 Social Science and Humanities Non-degree Award
James Bugeza Katamba
ID: UNCST-2021-R013970
EPIDEMIOLOGY OF BRUCELLOSIS AT THE HUMAN LIVESTOCK INTERFACE IN UGANDA
REFNo: HS1377ES

The general objective is To characterize Brucella infections in ruminants, swine and slaughterhouse workers in Uganda. The specific objectives are 1.To determine the seroprevalence of Brucella antibodies in cattle, shoats, and pigs at selected slaughterhouses in Uganda. 2.To determine the seroprevalence of Brucella antibodies and associated risk factors among slaughterhouse workers in Uganda 3.To determine the Brucella species, biovars circulating in cattle, shoats, swine and slaughterhouse workers and their epidemiological interrelatedness 4.To determine resistance of Brucella to first line antimicrobial agents (Rifampicin and streptomycin)
Uganda 2021-08-25 2024-08-25 Medical and Health Sciences Non-Clinical Trial Degree Award
Hakim Sendagire
ID:
Clinical chemistry, hematology and other laboratory profiles of COVID 19 patients, as surrogate markers in management of severe disease
REFNo: HS1339ES

1. To describe the characteristics of peripheral blood cells in patients with varying severity of COVID-19 as compared to those who are negative
2. To describe the characteristics of the clinical chemistry and inflammatory markers in patients with varying severity of COVID-19 as compared to those who are negative
3. To establish the relationship between peripheral blood cells, clinical chemistry and cytokines and the clinical manifestation of COVID 19 and describe the potential markers for disease monitoring.

Uganda 2021-08-25 2024-08-25 Medical and Health Sciences Non-degree Award
Stella Muyanja Zawedde
ID: UNCST-2021-R014037
Prevalence and Outcomes of Mycobacterium bovis infection in Karamoja sub-region, North Eastern Uganda
REFNo: HS1405ES

The primary objective of this study is to determine the prevalence of M. bovis strains among patients diagnosed with TB disease in Karamoja region.,To compare six-month treatment outcomes between patients diagnosed with mycobacterium tuberculosis (M. tb) and those diagnosed with other mycobacterial species including M. bovis. ,To describe the susceptibility patterns of all mycobacterial isolates to first line medicines used in the management of drug susceptible TB. ,To describe the factors associated with having M. bovis among patients diagnosed with TB in the Karamoja region. ,
Uganda 2021-08-25 2024-08-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Janestic Twikirize
ID:
Social Traditional Norms and child Marriage research in Zombo, Nebbi, Packwachi and Adjuman Districts, West Nile
REFNo: SS852ES

What are the roles of (Parents, Clans and relatives, Religious leaders
Cultural leaders, Boys and men in the communities and women and girls in the communities) in a) Promoting Child Marriage b) Preventing child marriage? Elaborate the roles, the specific practices and norms as well as how effective their efforts for and against CEFM are

What is the involvement of the bride-to-be in the decision-making process about her marriage?

What has been and being done to address social norms and practices that promote child early and forced marriages by boys, girls, parents, clan leaders, religious leaders, cultural leaders and community leaders?

Assess the effectiveness of what has been and being done women and girls, men and boys, parents, clan leaders, community and religious leaders to mitigate socio-cultural practices that promote child early and forced marriages

Assess the functionality and effectiveness of Community Child Protection systems from the community, district and national level. Identify strength, weakness and make recommendations to inform project intervention
Uganda 2021-08-25 2024-08-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Catherine Abaasa N
ID:
Quality, Safety, community perceptions and Practices on Drinking water from selected water sources in Mbarara City , South Western Uganda
REFNo: HS1469ES

i. To assess the physical chemical and microbiological quality of drinking water from selected water sources and establish the water quality index for Mbarara city.
ii. To establish the occurrence of virulence genes associated with Esherichia coli pathotypes isolated from drinking water samples from selected water sources in Mbarara city.
iii. To establish the seasonal variation in safety, quality and water quality index of water from selected water sources in Mbarara city.
iv. To explore the communities’ and water service providers’ perceptions and practices about the quality and safety of drinking water and establish possible mitigation strategies at community level.

Uganda 2021-08-25 2024-08-25 Medical and Health Sciences Non-Clinical Trial Degree Award
Lordrick Alinaitwe
ID:
Transmission and Occurrence of Leptospira infection among humans and livestock in Uganda
REFNo: HS1563ES

To determine the extent, risk factors and potential pathways for Leptospira transmission and infection among potential reservoir animals and human populations in Uganda.,To describe potential pathways and drivers for Leptospira transmission at the animal-human-environmental interface in Uganda, based on statistical modelling,To identify Leptospira species and serogroups that circulate in humans, livestock, and environmental sources in Uganda.,To determine Leptospira seroprevalence and infection among slaughter ruminants and swine in Uganda,To determine Leptospira seroprevalence and associated risk factors among slaughter workers in Uganda,
Uganda 2021-08-25 2024-08-25 Medical and Health Sciences Non-Clinical Trial Degree Award
Mary Goretti Nakabugo Goretti
ID: UNCST-2021-R013051
Are our Children Learning? Uwezo Basic Assessment of Literacy and Numeracy.
REFNo: SS959ES

Uwezo Uganda intends to undertake the 2021 assessment of basic learning outcomes in literacy and numeracy in order that:
i) Independent evidence on learning levels in literacy and numeracy of children aged 4-16 in Uganda is generated.
ii) The data generated from conducting the learning assessments increases knowledge, awareness and understanding of policy actors, practitioners and the public of children’s learning outcomes and their distribution and that the evidence is used to improve resource allocation and the delivery of education.

Uganda 2021-08-25 2024-08-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Patrick  Vudriko
ID:
Innovations to Address Rampant Vaccine Failures, Shortages and Low Uptake for Sustainable Livestock Disease Control and Productivity in Uganda
REFNo: A136ES

The Proposal is designed to address selected immunizable diseases that affect health and productivity of poultry, small ruminant and cattle in Uganda. The study objectives include;
1. To assess the current animal vaccine supply chain and identify actors, distribution channels, use and constraints that affects animal vaccine utilization in Uganda.
2. To evaluate the level of protective Gumboro & IB virus disease antibodies among vaccinated chicken flocks in commercial farms.
3. To assess the sero-conversion of FMD vaccine and strengthen vaccination efficacy monitoring lab service at Research Center for Tropical Diseases and Vector Control (RTC) Laboratory at COVAB.
4. To assess the current PPR vaccination regimen and the clinical performance of combined PPR- SGP virus vaccine under field situations in small ruminants and develop a vaccination technical framework for effective control of the two diseases in Uganda.

Uganda 2021-08-25 2024-08-25 Agricultural Sciences Non-Clinical Trial Non-degree Award
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