Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Stella Nassolo
ID:
Improving mental health and resilience among children living with HIV in Uganda.
REFNo: SS1197ES

The baseline will establish the current status of mental health and wellbeing of children living with HIV in target districts before being exposed to the Stepping Stones with Children approach (using the short or longer version of the manual) and the existing perceptions, knowledge, attitudes and practices surrounding mental health in the target districts.,To determine the baseline quality of mental health among children living with HIV in three selected districts of Uganda.,
Uganda 2022-03-25 2025-03-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Nathan Nshakira
ID:
Accountability mechanisms, practices and challenges for RMNCAH services in Uganda’s health sector
REFNo: HS598ES

a) Document and analyze the current definition and structuring of health accountability mechanisms (structures and processes) at the different levels of the Uganda health system;
b) Examine the processes, progress and results of health accountability implementation; and the factors influencing these at the different levels of the health system;
c) Describe the specific relationships and influences between current health accountability processes and results; and RMNCAH service delivery and utilization.
d) Generate recommendations for strengthening health accountability and enhancing its specific influence on RMNCAH service delivery, utilization and results.

Uganda 2022-03-24 2025-03-24 Medical and Health Sciences Non-degree Award
Sharifah Nabambejja
ID:
Vitamin D levels and its potential role in COVID19 Pathogenesis in a Ugandan Population
REFNo: HS1572ES

1.To assess the serum Vitamin D3 levels in Uganda.
2.To establish the Ugandan reference range of Vitamin D3.


Uganda 2022-03-24 2025-03-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Susan  Nabadda
ID: UNCST-2020-R014331
COVID-19 rapid antigen test screening validation and diagnosis study in symptomatic and asymptomatic populations at border crossings in Uganda to support efficient testing practices
REFNo: HS2105ES

Secondary Objective 2 (Phase 1 and 2): Enhance truck driver awareness on COVID-19 symptoms, prevention and response.,(Phase 1): Provide evidence and advocate for policy change at a national level to: (a) permit Ag RDT COVID-19 screening in asymptomatic populations and (b) accept negative Ag RDT test results in asymptomatic individuals as proof they are not infected with COVID-19.,(Phase 2): Assess the feasibility, acceptability, efficiency, and cost-effectiveness of Ag RDTs for COVID-19 screening compared to RT-PCR testing in both symptomatic and asymptomatic individuals.,(Phase 1): Validate WHO EUL COVID-19 Ag RDTs for screening of asymptomatic truck drivers at border crossings (and optionally at a select site in Kampala) in Uganda.,
Uganda 2022-03-24 2025-03-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kukunda Bacwayo Elizabeth
ID: UNCST-2021-R011603
CONSPIRACY BELIEFS AND COVID-19 VACCINATION HESITANCY IN UGANDA
REFNo: SS1174ES

Objectives of study
(i) To measure the extent of the spread of conspiracy beliefs regarding vaccination against Covid-19 among Ugandans
(ii) To establish the relationship between conspiracy belief and vaccination hesitancy in Uganda;
(iii) To explore the interaction between exposure to COVID-19 conspiracy theories and individual vaccination decisions;
(iv) To examine the gendered impact of conspiracy belief on vaccination hesitancy; and
(v)To examine how the conspiracy beliefs of adults are likely to affect decision to vaccinate children for COVID-19.

Uganda 2022-03-23 2025-03-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
Tophil Odoy Owino
ID:
HUMAN RESOURCE MANAGEMENT PRACTICES AND HEALTH SERVICE DELIVERY IN UGANDA: A CASE STUDY OF TORORO DISTRICT LOCAL GOVERNMENT HC IV.
REFNo: SS1005ES

1. Examine the influence of hiring practices on Health service delivery in TDLG HC IV.
2. Determine the influence of staff development practices on Health service delivery in TDLG HC IV.
3. Assess the influence of performance evaluation practices on Health service delivery in TDLG HC IV.

Uganda 2022-03-22 2025-03-22 Social Science and Humanities Non-Clinical Trial Degree Award
Patience Kibbedi
ID:
Evaluating Positive Youth Development Intervention Programs Promoting Character Virtues AmongUgandan Youth Living in Poverty: Innovations using Idiographic Methods and Measures
REFNo: SS1110ES

To investigate methods and measures to capture the diverse and unique individual pathways towards character virtue development amongst Ugandan youth living in poverty
Uganda 2022-03-22 2025-03-22 Social Science and Humanities Non-Clinical Trial Non-degree Award
Patrick Kagurusi Tumusiime
ID: UNCST-2021-R012687
Integrated Sexual and Reproductive Health & Rights Programme in High Burden Districts of Uganda (ISPHD) or HEROES4GTA Project: Evaluation Study Protocol
REFNo: SS1194ES

Main objective
1. The purpose of the study is to benchmark and monitor the status of key performance areas as defined in the program key outcome indicators; conduct a power mapping of stakeholders and service providers; carry out a gender and vulnerability analysis in relation to access/utilisation of improved Sexual Reproductive Health and Rights (SRHR) and Gender Based Violence (GBV) services; and to enhance sustainability measures of the programme.


Specific objectives:
i. Assess the level of knowledge, beliefs, perceptions, attitudes, and norms (empirical and normative) about SRHR and SGBV across key structures and beneficiaries in the ISPHD districts

ii. Establish baseline values for specific Programme key performance outcome indicators as stipulated in the ISPHD Programme Results framework.

iii. Establish the power dynamics and influence concerning the program overall objective – (stakeholder and power mapping) of stakeholders and service providers in the target districts.

iv. Establish the current level of commitment of key structures to gender equity and SRHR services. This should be based on the minimum intervention services package, capacity including the quality of services, resources, and protocols, among others.

v. Assess the extent of involvement of beneficiary groups in implementation, monitoring and improving services, satisfaction and/or perceptions of beneficiary groups about the quality of existing mechanisms in meeting their needs.

vi. Identify existing policies, laws, and ordinances and establish how these impact on power inequity in relation to SRHR and GBV service provision and utilization.

vii. Identify SGBV and SRHR inequality hot spots in the target districts to facilitate differentiated implementation and targeting.

viii. Assess the relevance, validity, and sustainability measures for the ISPHD program including validation of risks and assumptions concerning the Theory of Change(TOC)
Uganda 2022-03-22 2025-03-22 Social Science and Humanities Non-Clinical Trial Non-degree Award
David Kyaddondo
ID: UNCST-2020-R014906
Enhancing Community Training for Student Mental Health Nurses in Uganda
REFNo: SS1199ES

1) Identify students’ class-based community nursing learning needs;
2) identify community MH nurse CPD support needs;
3) Plan a CPD curriculum deliverable online by educators at BPSN
Uganda 2022-03-22 2025-03-22 Social Science and Humanities Non-Clinical Trial Non-degree Award
DAVID AGABA COLLINS
ID: UNCST-2019-R000301
PREVALENCE OF AND FACTORS ASSOCIATED WITH ABNORMALOBSTETRIC SHOCK INDEX AMONG IMMEDIATE POST-PARTUMWOMEN AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS2138ES

1. To determine the prevalence of abnormal obstetric shock index among women in the immediate post-partum period following vaginal delivery at Mbarara Regional Referral Hospital
2. To determine the factors associated with abnormal obstetric shock index among women in the immediate post-partum period following vaginal delivery at Mbarara Regional Referral Hospital
Uganda 2022-03-22 2025-03-22 Medical and Health Sciences Non-Clinical Trial Degree Award
Raymond Odokonyero Felix
ID: UNCST-2020-R014183
ALCOHOL USE, GENDER, AND HIV IN UGANDA: YOUNG PEOPLE’S RISK OF HIV, LIVED EXPERIENCES, PROVIDERS’ PERCEPTIONS, AND FUTURE CARE OUTCOMES.
REFNo: HS2001ES

This study aims to: 1) Systematically review literature on the risk of HIV infection by gender among young people who use alcohol in Low and Middle Income Countries (LMIC); 2) Explore the lived experiences of alcohol use by gender among young people living with HIV (YPLH); 3) Explore the perceptions of HIV care providers regarding the care of young people living with HIV who use alcohol by gender; and 4) Determine the association between age at initiation of alcohol use and health related quality of life and viral suppression rates among PLWH in Southwestern Uganda.
Uganda 2022-03-21 2025-03-21 Medical and Health Sciences Non-Clinical Trial Degree Award
SIMON ARUNGA
ID: UNCST-2021-R013498
Cluster randomised controlled trial of a complex intervention package to reduce blindness from severe microbial keratitis in Uganda.
REFNo: HS1814ES

To determine if a complex intervention package delivered at the Primary Health Centres (PHCs) including early recognition, prompt chlorhexidine 0.2% treatment and rapid referral can result in reduced rates of blindness from severe MK at three months
Uganda 2022-03-21 2025-03-21 Medical and Health Sciences Clinical Trial Non-degree Award
Johanna  Blomgren
ID: UNCST-2021-R012309
MIDWIZE - Strengthening midwives to implement and sustain quality improvements to optimise maternity care: A longitudinal observational study in Uganda
REFNo: HS1885ES

This PhD project aims to explore how midwives can take the lead in implementing or enhancing QI components within maternal health care in Uganda. The overall goal of this project is to improve the health of women and newborns. The way to achieve this is through enhancing the quality of care by capacitating midwives. Sub-study 1 - Co-creating and developing the intervention and the implementation Specific objectives: To explore multisectoral stakeholders' perspectives and ideas on how to strengthen midwives' capacity to implement QI components. To explore which QI components the midwives will implement or enhance. Sub-study 2 - Implementation and evaluating the sustainability of the implementation Specific objectives: -To measure the uptake of evidence-based QI components when midwives lead, organise and provide enhanced intra- and postpartum care. -To measure the long-term sustainability of the midwives' QI projects. Sub-study 3 – Process evaluation Specific objective: To evaluate the process of strengthening midwives' capacity to implement QIs in maternal care.
Sweden 2022-03-21 2025-03-21 Medical and Health Sciences Clinical Trial Degree Award
John  Kirabira Baptist
ID:
Evaluation of nanoscale materials as candidate adjuvants and delivery systems for SARS CoV-2 subunit vaccine
REFNo: HS2103ES

a) To green synthesize and evaluate the physio-chemical properties of silver nanoparticles (AgNPs)
b) To design Lipid nanoparticle (LNP) and Chitosan nanoparticles (CNPs)
c) To develop nano adjuvant vaccine delivery system
d) To evaluate the immunogenicity of nano adjuvants (CNPs, LNPs and AgNPs) loaded with SARS CoV-2 sub-unit vaccine in mice.
e) To determine the safety of designed nano vaccine delivery systems using mice.

Uganda 2022-03-21 2025-03-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Pontiano Kaleebu
ID: UNCST-2021-R013577
A Randomized, Observer-Blind, Phase 2 Clinical Trial of COVAC-2 in Generally Healthy Adults
REFNo: HS2124ES

Primary Objective:
• To evaluate the safety and tolerability of the COVAC-2 vaccine (25 ?g dosing of S1 antigen) in generally healthy adults ages 18+.
Secondary Objectives:
• To determine spike-binding and pseudovirus neutralizing antibody responses against the Wuhan strain of SARS-CoV-2 induced by COVAC-2; and
• To determine a cellular immune response induced by COVAC-2.
Exploratory Objectives:
• To determine Receptor-Binding Domain (RBD)-binding antibody responses induced by COVAC-2; and
• To determine the neutralizing antibody response induced by COVAC-2 against one or more Variant(s) of Concern (VOC) and/or Variant(s) of Interest (VOI).


Uganda 2022-03-21 2025-03-21 Medical and Health Sciences Clinical Trial Non-degree Award
Richard Ntwari
ID: UNCST-2022-R004889
Model for enhancing security in a Bring Your Own Device (BYOD) environments
REFNo: SIR40ES

The main objective: - To improve mobile devices security and integration in enterprises through the development of a security model for the usage of BYOD devices.


Specific Objectives

i.To identify key BYOD security issues and existing models through literature review with the aim of identifying their strengths, shortcomings, and functional requirements for the proposed model.

ii. To design a security model for usage of BYOD devices in SMEs through defining relationships of the components identified in objective I above.

iii. To examine the usability of the developed model through expert reviews to enable establish whether it provided satisfactory performance

Uganda 2022-03-18 2025-03-18 Engineering and Technology Non-Clinical Trial Degree Award
Brenda Okech Apio
ID: UNCST-2022-R011031
Using Implementation Research to Understand the Impact and Effectiveness of the Pediatric Breakthrough Partnership in Mozambique, Nigeria and Uganda.
REFNo: HS2119ES

Objective 1: To evaluate the acceptability and feasibility of the SDF implementation strategies used within the PBP.

Objective 2: To assess adoption of the SDF implementation strategies.

Objective 3: To document lessons learned to support potential scalability of the PBP and SDF.

The effectiveness objective of this study is to: Objective 4:
To assess the impact of the SDF implementation strategies on pediatric HIV outcomes as measured by the percent change in locating, testing and linking to care undiagnosed children, adolescents and pregnant women living with HIV before, during and after the PBP implementation

Uganda 2022-03-18 2025-03-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Florence Tushemerirwe Basiimwa
ID: UNCST-2020-R014552
The Extent and Nature of food advertising targeted to children and adolescents in Uganda (FACe-U Project)
REFNo: HS1990ES

General objective: To examine the extent, nature, attitudes and perceptions around food and non-alcoholic beverages advertised to children and adolescents in Uganda between January 2018 and December 2019. Specific objectives i. To identify and categorise advertising channels and types of food and non-alcoholic beverages advertised to children ii. To analyse the food and non-alcoholic beverages advertising content used to persuade children to consume advertised food on TV, radio, print media and outdoor school zones. iii. To describe the trends of food and non-alcoholic beverages advertising to children in Uganda. iv. To establish the association between children’s self-reported exposure to advertised foods and their nutritional status v. To explore children, parental and policy stakeholder attitudes and perceptions towards food and non-alcoholic beverages advertising to children
Uganda 2022-03-17 2025-03-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Annet Kabanyoro Kasigwa
ID:
Innovative Teaching and Learning Strategies for Large Classes of Undergraduate Nursing Students in Uganda
REFNo: SS1142ES

4. Design innovative strategies that could guide teaching and learning for large classes of undergraduate nursing students in Uganda.,3. Identify the available strategies employed by nurse educators while teaching large classes of undergraduate nursing students.,2. Explore the challenges that undergraduate nursing students face while learning in large classes,1. Explore the challenges that nurse educators face while teaching large classes of undergraduate nursing students,The purpose of the study is to develop innovative strategies that could be used to enhance teaching and learning in large classes of undergraduate nursing students in Uganda.,
Uganda 2022-03-17 2025-03-17 Social Science and Humanities Non-Clinical Trial Degree Award
Rhoda Wanyenze
ID: UNCST-2021-R013352
Willingness for COVID-19 vaccination, adherence to non-pharmaceutical interventions and associated factors among adults in Uganda: a computer assisted telephone interview survey
REFNo: HS1742ES

To determine the influence of vaccine introduction on adherence to COVID-19 NPIs among adults in Uganda.,To determine the influence of trust on willingness to vaccinate and adherence to NPIs among adults in Uganda.,To determine the adherence to COVID-19 NPIs and associated factors among adults in Uganda.,To determine the willingness for COVID-19 vaccination and associated factors among adults in Uganda.,To assess willingness for COVID-19 vaccination, adherence to NPIs and associated factors including trust among adults in Uganda to identify strategies to improve uptake of these interventions for COVID-19 prevention and control. ,
Uganda 2022-03-16 2025-03-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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