Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Radhika Sundararajan Lu
ID:
A pilot study of adherence support delivered by informal health providers to improve entry to and retention in HIV care in rural Uganda
REFNo: HS1747ES

: Pilot test the adapted intervention to evaluate implementation and impact on linkage/retention in HIV and ART adherence among individual PLWH,Adapt an evidence-based layperson adherence support curriculum for delivery by TH.,
USA 2021-10-01 2024-10-01 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Hannah Kibuuka
ID: UNCST-2020-R014355
Evaluation of Clinical Chemistries from Biospecimens Collected with a Painless Capillary Blood Collection TASSO SST Among a Subset of Patients Enrolled in an Observational Study of Sepsis in Uganda
REFNo: HS1751ES

We plan to compare capillary chemistry values collected via the painless Tasso collection device to standard serum chemistry values collected via venipuncture at a single study visit (Day 28 of the main study(HS 2292)) for each consenting participant. We plan to evaluate the correlation between chemistry values from capillary versus venous blood collection and identify any scenarios where the values diverge such as for high or low values or for specific analytes collected in a remote field location. We plan to review the failure rate and causes for failure for the Tasso device
Uganda 2021-10-01 2024-10-01 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Moses Ntaro
ID: UNCST-2020-R014133
Effect of student community engagement on sanitation behavior: a case of Community Led Total Sanitation in Kabale District
REFNo: HS1135ES

To evaluate the effect of students community engagement on household level ODF status in Kabale District, Uganda so as to demonstrate the contribution of students in improving CLTS implementation and outcomes
Uganda 2021-09-29 2024-09-29 Medical and Health Sciences Degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
Infant extended safety follow-up study – an observational study of brain imaging and child development in infants (DolPHIN-2 PLUS)
REFNo: HS1639ES

1. To determine if there are developmental differences following exposure to DTG or EFV. 2. To examine brain structure and microstructure of HEU children. 3. To determine developmental outcomes. 4. To validate the Hyperfine, low-field MRI system 5. To explore the impact of environmental factors such as antenatal iron-deficient anaemia on brain development in a high-risk birth cohort
Nigeria 2021-09-29 2024-09-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Tom  Ngabirano Denis
ID: UNCST-2020-R014491
Effect of Enhanced Neonatal Jaundice Education on Knowledge, Early Detection and Care Seeking by Postnatal Mothers at Jinja Regional Referral Hospital
REFNo: HS1479ES

Objectives General objective To improve mothers’ knowledge of neonatal jaundice for early detection, proper care and prevention of severe neonatal jaundice. Specific objectives 1. To assess the level of mothers’ knowledge about neonatal jaundice at JRRH. 2. To implement an enhanced neonatal jaundice education package for postnatal mothers at JRRH. 3. To assess the effect of an enhanced neonatal jaundice education package on the level of knowledge, early detection and care seeking by postnatal mothers at JRRH.
Uganda 2021-09-29 2024-09-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Lukia Namaganda Hamid
ID:
Malnutrition as a probable predictor of mortality in cerebral palsy (CP), and the effect of positive deviance and parent facilitator training strategies to malnutrition and caregiving among children and adolescents with CP in the Iganga, Mayuge and Bugweri rural districts of eastern Uganda
REFNo: HS1427ES

Specific Objectives:
1. To assess mortality and whether malnutrition is one of the predictors among a population based sample of children and adolescents with cerebral palsy the Iganga Mayuge-Health and Demographic Surveillance Site (IM-HDSS), Uganda
2. To assess the difference in the change in nutritional status in 2015 and 2019 among children with CP compared to their age and sex matched controls without CP at the IM-HDSS, Uganda.
3. To explore positive and negative nutrition practices among caregivers of well-nourished and under-nourished children with cerebral palsy respectively at the IM-HDSS, Uganda.
4. To determine the difference in the effectiveness of the positive deviance strategy and parent facilitator trainings on CP child and adolescent malnutrition and caregiving within the Iganga, Mayuge and Bugweri districts, Uganda.

Uganda 2021-09-29 2024-09-29 Medical and Health Sciences Clinical Trial Degree Award
Scholastic Ashaba
ID: UNCST-2023-R007613
Self-management among adolescents living with HIV in Uganda
REFNo: HS1697ES

Aim 3: Assess feasibility, acceptability, and preliminary effects of the self-management intervention on HIV outcomes for ALHIV transitioning to adult HIV care,Aim 2: Develop a self-management intervention that will enable ALHIV to successfully transition to adult HIV care,Aim 1: Use qualitative research to elaborate a conceptual model of the barriers faced by ALHIV transitioning to adult HIV care in Uganda,
Uganda 2021-09-29 2024-09-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Willy Ssengooba
ID: UNCST-2022-R001801
Evaluation of a new stool-based qPCR for TB diagnosis in children and people living with HIV: a multicentre study in Eswatini, Mozambique and Uganda
REFNo: HS1615ES

To create a biorepository of well characterized pediatric samples at each of the study sites to support the future development and evaluation of novel biomarker research. ,To evaluate the quantitative stool qPCR platform as a tool to monitor treatment response in children and PLHIV,To compare the diagnostic performance of the stool qPCR platform to individual sputum and stool Xpert Ultra, urine LAM, sputum smear, sputum (MGIT) culture results against a clinical diagnosis and bacteriological reference standard,To evaluate the diagnostic accuracy of the stool Mtb qPCR tool compared to a composite reference standard (sputum and stool Xpert Ultra, sputum culture and urine TB-LAM) and clinical diagnosis. ,
Uganda 2021-09-29 2024-09-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Lillian Wambuzi Ogwang
ID: UNCST-2021-R013189
Seroprevalence of SARS-CoV-2 based on antibody testing among HIV infected mothers and their children in the PROMOTE Cohort at the MU-JHU Research Collaboration: July 2020 through June 2021 SUBSTUDY Version 2.0 Dated 16 Jun 2021
REFNo: HS1658ES

1. To determine the seroprevalence of COVID-19 IgG antibody among PROMOTE women living with HIV on antiretroviral therapy, and their HIV exposed children enrolled in PROMOTE; based on Roche ELISA antibody testing of plasma samples collected July 2020 to Jun 2021• To determine the association of COVID-19 exposure and PROMOTE participant characteristics such as age, CD4 count, BMI, maternal ARV therapy, pregnancy, Breast feeding, maternal Viral load, hospitalization in the past year with SARS-CoV-2 antibody positivity, comorbidity diagnosis (e.g. hypertension, obesity, asthma, TB, pulmonary, cardiac, renal disease, sickle cell disease).

3• To use PROMOTE data to determine maternal and pregnancy outcomes among PROMOTE women who were found to have had COVID-19 infection during pregnancy based on antibody testing during the period July 2020 - June 2021.

Uganda 2021-09-29 2024-09-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
Evaluation of the performance of the Salmonella Biolineâ„¢ typhi IgG/IgM Fast test in a near-patient testing environment, including evaluation of usability
REFNo: HS1700ES

To evaluate the usability of the Biolineâ„¢ Salmonella typhi IgG/IgM Fast test in the near-patient environment using a questionnaire based survey. ,To establish the performance of the Biolineâ„¢ Salmonella typhi IgG/IgM Fast test in a near-patient setting compared to the performance in a professional lab (i.e. Central Public Health Laboratory) using venous whole blood samples. ,
Uganda 2021-09-29 2024-09-29 Medical and Health Sciences Clinical Trial Non-degree Award
Martin Ariapa
ID: UNCST-2021-R013296
Play and Learning in Children’s Eyes
REFNo: SS1022ES

To develop the Children’s Experiences of LtP Protocol (CELP) with its corresponding modules and items, intended for use by a coach or instructional support staff, by soliciting direct insights from children about their LtP experiences. To develop the Formative Observation and Reflection Assessment (FORA) with its corresponding modules and items, intended for use by ECD and primary education teachers as they implement a LtP practice in the classroom. To develop and validate a set of formative tools designed to help teachers in low-and middle-income countries assess and improve their practice in Learning through Play (LtP), through a deeper understanding of how children experience LtP in their classrooms,
Uganda 2021-09-29 2024-09-29 Social Science and Humanities Non-Clinical Trial Non-degree Award
herbert  Itabangi Itabangi
ID:
Metabolic and Molecular ecological evolution of opportunistic Pulmonary fungal co-infections (MeMoF project)
REFNo: HS1233ES

1. To determine the burden and aetiological profiles of fungal-co-infections among patients with chronic pulmonary disease suspected for Tuberculosis
2. To establish and characterise microbial communities associated with chronic pulmonary disease.
3. To characterise potential interaction relationships established between fungal and bacterial communities.

Uganda 2021-09-27 2024-09-27 Medical and Health Sciences Non-degree Award
Emmanuel Sendaula
ID: UNCST-2020-R014767
Utilization of ART and TB treatment during the COVID-19 pandemic: A case of Kampala District
REFNo: HS1471ES

To determine the level of ART and TB treatment utilization among patients during the COVID-19 pandemics in Kampala district
To determine the factors associated with ART and TB treatment utilization among patients during the COVID-19 pandemic in Kampala district
To estimate the incidence rate of loss to follow-up among patients during the COVID-19 pandemics in Kampala district

Uganda 2021-09-24 2024-09-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Paul Kiondo
ID:
RISK FACTORS OF GENETIC CONSTITUTION, AND PREDICTORS PERSISTENT DISEASE IN WOMEN WITH MOLAR PREGNANCY ADMITTED AT MULAGO HOSPITAL, KAMPALA, UGANDA: A CASE-CONTROL STUDY
REFNo: HS1442ES

1. To determine the social, medical and obstetric risk factors of HM in women admitted at Mulago hospital, Kampala, Uganda.
2. To outline the outcomes of HM in women admitted in Mulago hospital, Kampala, Uganda.
3. To describe the genetic constitution of HM in women admitted at Mulago hospital, Kampala, Uganda.
4. To determine the predictors of persistent disease in women with HM admitted at Mulago hospital.

Uganda 2021-09-24 2024-09-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
FIONA ASIIMWE
ID:
DIAGNOSTIC ACCURACY OF ULTRASOUND AND ADVERSE NEONATAL OUTCOMES AMONG WOMEN WITH A DIAGNOSIS OF NUCHAL CORD DELIVERING AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS1531ES

General Objective
To determine the diagnostic accuracy of ultrasound in diagnosing nuchal cord and to compare the proportion of adverse neonatal outcomes between women with and without a diagnosis of nuchal cord among women delivering at Mbarara Regional Referral Hospital.

Specific Objectives
1.To determine the diagnostic accuracy of ultrasound in diagnosing nuchal cord among women delivering at Mbarara Regional Referral Hospital.

2.To compare the proportion of adverse neonatal outcomes between women with and without a diagnosis of nuchal cord delivering at Mbarara Regional Referral Hospital.

Uganda 2021-09-24 2024-09-24 Medical and Health Sciences Non-Clinical Trial Degree Award
Lawrence Mugisha
ID:
Evaluation of Wastewater-Based Epidemiology (WBE) tool for surveillance of COVID-19 in selected wastewater treatment plants and channels in Kampala-Entebbe Area, Uganda
REFNo: HS1725ES

Overall Objective: To provide COVID-19 surveillance data for a wider population based on wastewater monitoring as an early warning tool to inform outbreak response strategies
Specific Objective
1. To detect and characterize the SARS-CoV-2 virus in wastewater from wastewater treatment plants, channels and septic tanks of hospitals in Kampala and Entebbe
2. To evaluate and standardise the molecular detection methods for WBE


Uganda 2021-09-24 2024-09-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
COMPARISON OF PERFORMANCE OF CAPILLARY BLOOD VS VENOUS BLOOD ON SYPHILIS ULTRA TEST DEVICE/ TEST REF: ISY-U402 AND CAPILLARY BLOOD VS VENOUS BLOOD ON SYPHILIS ULTRA RAPID TEST STRIP) REF: ISY-U401 USING SD BIOLINE VERSION 3.0 AS A REFERENCE
REFNo: HS1643ES

The objective of this evaluation is to demonstrate the equivalence of capillary (fingerprick) whole blood and venous whole blood on the Syphilis Ultra test device/ Test strip (Whole Blood/Serum/ Plasma) and strip.
2.4 Exploratory Objectives
• To determine the diagnostic accuracy of the Syphilis Ultra test device/ Test (Whole Blood/Serum/ Plasma) and strip.

Uganda 2021-09-23 2024-09-23 Medical and Health Sciences Clinical Trial Non-degree Award
Christopher Dolan Gerald
ID:
Improving access and retention in inclusive education for refugee children with disabilities
REFNo: SS937ES

I.To explore stakeholder’s understanding of the processes, challenges and opportunities for refugee children in accessing and progressing in inclusive education
II.To establish the current capacity of the education system to deliver safe and inclusive quality education for refugee children with special needs and disabilities
III.To describe the extent to which RCSN and their caretakers access timely and appropriate support to improve their physical, psychological and social functionality
IV.To establish the extent to which Key stakeholders effectively champion social accountability and implementation of policies and commitments on inclusive education
V.To examine the daily needs of RCWD and their carers

UK 2021-09-23 2024-09-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
Robens Mutatina
ID: UNCST-2021-R013633
Psychosocial challenges and Coping Strategies among Caregivers of Children with Cerebral Palsy in South Western Uganda
REFNo: SS762ES

To determine the psychosocial challenges faced by caregivers of children with cerebral palsy attending MRRH in southwestern Uganda.

To describe the coping strategies of caregivers of children with cerebral palsy attending MRRH in southwestern Uganda.

Uganda 2021-09-22 2024-09-22 Social Science and Humanities Non-degree Award
Samuel Biraro
ID:
Assessing the impact of COVID-19 on routine immunization demand and uptake, and understanding COVID-19 attitudes and perceptions in Uganda
REFNo: HS1679ES

1. Identify the range of factors affecting routine immunization uptake during the COVID-19 pandemic in order to inform key areas for mitigation intervention; and
2. Generate timely data on the range of factors that may influence demand and uptake of the COVID-19 vaccines among HCW and the public to identify strategies to promote optimal uptake of the COVID-19 vaccines.


Uganda 2021-09-22 2024-09-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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