Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Susan Adakun
ID:
Comparing adherence to MDR-TB treatment among patients on self-administered therapy and those on Directly Observed Therapy: Non Inferiority Randomized Controlled Trial
REFNo: HS1796ES

Primary Objectives
1. To determine if adherence to MDR-TB treatment among patients on self-administered therapy (measured by Medication Events Monitoring System (MEMS) technology) is non-inferior to that among patients on Directly Observed Therapy (DOT)
Secondary objectives

1. To determine the correlation between serum MDR-TB drug concentrations and adherence as measured by MEMS technology


2. To compare treatment outcomes between MDR-TB patients on self-administered therapy and DOT

 Uganda 2021-10-20 2024-10-20 Medical and Health Sciences Clinical Trial Non-degree Award
Winfred Naamara
ID:
Understanding social support for family caregivers of patients with schizophrenia in greater Kampala metropolitan area, Uganda
REFNo: SS1038ES

The overall objective of this study is to examine how family caregivers of patients with schizophrenia generate and experience social support in greater Kampala metropolitan area.
Uganda 2021-10-19 2024-10-19 Social Science and Humanities Non-Clinical Trial Degree Award
Sandra Lamwaka
ID:
TOWARDS A NEWS INDUSTRY FRAMEWORK FOR TACKLING THE VICE OF BROWN ENVELOPE JOURNALISM: PERCEPTIONS OF JOURNALISTS AND PUBLIC RELATIONS PRACTITIONERS IN UGANDA
REFNo: SS1014ES

1. To examine journalists and PR practitioners’ perception of the brown envelope. 2. To identify the various forms that BEJ takes in Uganda. 3. To find out journalists and PR practitioners' perceptions on why BEJ is prevalent and enduring in Uganda. 4. To find out journalists and PR practitioner's perspectives on the policies that the media industry can employ to address the practice of BEJ in Uganda.
Uganda 2021-10-19 2024-10-19 Social Science and Humanities Non-Clinical Trial Degree Award
JANISCH Judith Judith
ID:
Ecological influences on Locomotor Performance in Free-Ranging Primates: a phylogenetic investigation
REFNo: NS299ES

- to investigate the evolution of arboreal locomotion in primates and discern which aspects of the arboreal environment most directly influence their locomotor performance.
- to describe kinematics of different primate species (Cercopithecus mitis, Cercopithecus ascanius, Cercopithecus lhoesti, Chlorocebus aethiops,
Lophocebus albigena, Papio anubis, Colobus guereza and Piliocolobus badius) in
their natural habitat and analyze the variation in a phylogenetic context.

 Austria 2021-10-19 2024-10-19 Natural Sciences Non-Clinical Trial Non-degree Award
Sheila Balinda Nina
ID: UNCST-2021-R013804
 Exploration of the Virologic Characteristics of Recently Transmitted HIV-1 Viruses in Uganda and Kenya
REFNo: HS1635ES

1. To identify key unique molecular features of T/F virus strains and characterize them
2. To relate these unique genetic features to viral protein structures and in vitro virus phenotypes.
3. To determine the difference between HIV-1 co-receptor usage of the T/F virus variants and NT virus strains.
4. To determine particle infectivity of T/F virus strains in comparison to that of the NT virus strains.
5. To compare the resistance of T/F virus strains to the antiviral effects of type I interferons to that of the NT strains
6. To determine the sensitivity of T/F virus strains to broadly neutralizing antibodies in comparison to the non-transmitted virus strains.
 Uganda 2021-10-15 2024-10-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Noah Kalengo
ID:
LIVED EXPERIENCES OF UNCIRCUMCISED POKOT WOMEN IN AMUDAT DISTRICT
REFNo: SS1046ES

To explore the characteristics of uncircumcised Pokot women in Amudat District.

To explore the psychosocial experiences of uncircumcised Pokot women in Amudat District.

To analyze the protective factors/coping resources among the uncircumcised Pokot women that enable them to survive despite their experiences.

 Uganda 2021-10-15 2024-10-15 Social Science and Humanities Non-Clinical Trial Degree Award
Joseph  Matovu KB
ID: UNCST-2020-R014654
 Feasibility and acceptability of integrating PrEP and safer conception messaging into assisted partner notification
REFNo: HS1625ES

To examine the feasibility and acceptability of integrating gain-framed vs. loss-framed messages on PrEP and safer conception into the assisted partner notification (APN) program in Uganda
 Uganda 2021-10-14 2024-10-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nathan Kenya-Mugisha
ID: UNCST-2021-R013752
 Smart Triage + QI: A digital triaging platform to improve quality of care for critically ill children
REFNo: HS1745ES

To identify and examine opportunities for ongoing improvement to strengthen the health system. ,To enable healthcare workers to recognize the most urgent children more rapidly and allocate existing resources more efficiently,To implement Smart Triage + QI to improve the quality of care at three UCMB health care facilities and Gulu Regional Referral Hospital (a government facility). ,
 Uganda 2021-10-14 2024-10-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eleanor Namusoke Magongo
ID: UNCST-2021-R013199
 Uganda Paediatric and Adolescent HIV Cohort on Antiretroviral Therapy: Study Protocol (UP-ART)
REFNo: HS1699ES

The objectives of this study are to:
1) Describe the characteristics of children and adolescents living with HIV receiving paediatric care in the participating centres and coverage of ART
2) Describe the uptake of new antiretroviral drugs such as DTG across age groups and regions
3) Assess the effectiveness and safety of new antiretroviral drugs such as DTG, including viral suppression, incidence of adverse events, serious adverse events and discontinuation of drug
4) Assess broader clinical outcomes including retention in care, mortality, disease progression, immune response, viral suppression, overall and by age and treatment regimen/treatment history
5) Assess (i) the prevalence of HIV drug resistance among children/adolescents start of treatment and the impact on treatment response, and (ii) among those who experiencing virological failure on DTG to describe the risk of accumulation of drug resistance (see sub-study Section 4).

Uganda 2021-10-14 2024-10-14 Medical and Health Sciences Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
 Integration of phone-based data capture tool to support real-time reporting and quality assurance of SARS-CoV-2 Ag RDT in Uganda
REFNo: HS1723ES

1. To pilot the integration of phone-based data collection tool and real-time reporting via a dashboard
2. To monitor quality and post-market surveillance of the Ag RDT in Uganda
3. To demonstrate the use of remnant Ag RDT samples in the routine surveillance of SARS –CoV-2 variants in Uganda
 Uganda 2021-10-14 2024-10-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Miriam Nakalembe
ID: UNCST-2021-R014040
 Use of mobile Text Messaging Service information for mothers in situations of limited access to physical antenatal and postnatal services during the COVID-19 Pandemic
REFNo: HS1732ES

1. To elicit requirements for incorporating maternal and child health educative messages into the developed mobile-based transport technology for mothers.
2. To incorporate maternal and child health educative messages into the developed mobile-based transport technology for mothers.
3. To evaluate the usefulness of the information to the mothers through the mobile Text Messaging Service.

Uganda 2021-10-14 2024-10-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ivan Segawa
ID: UNCST-2021-R012795
 Nurse-led PrEP Delivery for Young Women Attending Family Planning Clinics in Uganda
REFNo: HS1740ES

Aim 1: To evaluate the feasibility and acceptability of nurse-led PrEP delivery to adolescent girls and young women attending a family planning clinic in Uganda.

Aim 2: To assess PrEP persistence among adolescent girls and young women receiving nurse-delivered PrEP at a family planning clinic.

Aim 3: To compare the characteristics of adolescent girls and young women who accept with those who decline PrEP and those who persist with those who discontinue PrEP at a family planning clinic in Uganda.
 Uganda 2021-10-14 2024-10-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
 Utility of a Liquid Blood Biopsy for Non-invasive Lung Cancer Diagnosis and Biomarker Testing at Uganda Cancer Institute.
REFNo: HS1743ES

1. To compare ctDNA sequencing to standard histopathologic diagnoses of lung cancer in patients with advanced stage lung cancer at the Uganda Cancer Institute (UCI).

2. To describe the tumor-specific molecular alterations present in lung cancer specimens and ctDNA in advanced stage lung cancer patients at UCI.
 Uganda 2021-10-14 2024-10-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ouma Simple
ID: UNCST-2021-R012820
 Childhood victimization and mental disorders among adolescents of sex-working and non-sex working mothers in post-conflict Gulu city in Northern Uganda - a cross-sectional study
REFNo: HS1769ES

The main goal of this study is to provide the evidence needed by the health care programmers and policymakers to inform appropriate policies and practices on prevention, screening, and management of victimizations among adolescents in Uganda. Specifically, the following are the study objectives:
1. To determine the prevalence of childhood victimization among adolescents.
2. To examine the relationship between sociodemographic characteristics and general health and childhood victimization among adolescents.
3. To examine the relationship between maternal sex work status and childhood victimization.
4. To examine the relationship between maternal major depression and childhood victimization among adolescents.
5. To determine the prevalence of selected childhood mental disorders among adolescents.
6. To examine the relationship between exposure to childhood victimization and childhood mental disorders in post-conflict Gulu City.

Uganda 2021-10-14 2024-10-14 Medical and Health Sciences Non-Clinical Trial Degree Award
Achilles Katamba
ID: UNCST-2019-R000540
 Interrupting HIV and TB Stigma in the Household during TB Contact Investigation in Uganda
REFNo: HS1788ES

This project aims to evaluate the effects of a complex intervention on household HIV stigma and uptake of HIV testing among household members undergoing TB contact investigation.
Uganda 2021-10-14 2024-10-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jonathan Izudi
ID: UNCST-2019-R000469
 Evaluating the impact of the COVID-19 pandemic restrictions on HIV care in Kampala, Uganda: a propensity-score matched and difference-in-differences analysis
REFNo: HS1709ES

Primary objective: To evaluate the impact of the COVID-19 pandemic restrictions on linkage to care, time to linkage, timely ART initiation, retention in care, viral load suppression, and mortality among people living with Human Immunodeficiency Virus (PLHIV) in the Kampala Capital City Authority (KCCA) health facilities in central Uganda

Secondary objective: To document and synthesize measures for continuity of service delivery for PLHIV during the COVID-19 pandemic
 Uganda 2021-10-12 2024-10-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Betty  Nambuusi Bukenya
ID:
Youth Wellbeing Champions: Piloting community-based, youth peer-led mental health and wellbeing support for young people in Uganda
REFNo: SS956ES

Study goal: To generate evidence around the effectiveness of a pilot community-based and responsive wellbeing / mental health intervention led by young people with lived experience of care and supported by social work practice/practitioners in Uganda. Specific objectives 1. Assess the level of knowledge and understanding of a trauma-informed approach to addressing mental health needs among social workers based on the Kirk Patrick pre-post questionnaire. 2. Assess the prevalence of clinical mental health, well-being, self-esteem/ self-worth, and depression symptoms among children and youth based on the WHO-5 / PHQ-9 and Rotter’s Locus of Control. 3. Examine the level of knowledge of mental health literacy, resilience, psychosocial support, and wellbeing practice among care leavers based on Kirk Patrick's pre-and post-assessments questionnaire.
Uganda 2021-10-12 2024-10-12 Social Science and Humanities Non-Clinical Trial Non-degree Award
Fred Ssewamala
ID: UNCST-2020-R014060
 Youth Health SMS: Using mobile technology to prevent HIV and related Youth Health problems: Sexual health, Mental health, and Substance use in southwest Uganda
REFNo: SS969ES

This study will result in the development of one of the first mobile phone-based interventions for Adolescents and Young Adults (AYA) in East Africa that begins to address the co-morbid HIV risk factors of sexual health, mental health, and alcohol use. AYA is a developmental period associated with the increased importance of peers, increased technology use, increased mobility, initiation of sex, emergence of mental health disorders (if at risk), and initiation of alcohol use. Consequently, AYA is a critical time for preventive interventions. Poor mental health and alcohol abuse are associated with increased risk for HIV infection. Thus, the proposed research will attempt to address these areas concurrently.

The proposed research will evaluate if adapting and updating the existing free and nationally available text message and interactive voice recognition (IVR) service included in *161 that was initially developed by FHI 360. Our work will test and tailor messages for AYA to disseminate pre-exposure prophylaxis (PrEP) information and pilot specific mental health and hazardous alcohol use screens. Symptomatic AYA will be referred to behavioral health counselors for further assessment and treatment as needed. AYA today rely heavily on mobile phones for information and services, thus we believe the proposed intervention could be applied and adapted across the region, and potentially in other under-resourced settings.

We will conduct formative research to evaluate and adapt an existing text-message and interactive voice recognition (IVR) platform. We will then pilot the new menus and examine if using this platform promotes HIV prevention (pre-exposure prophylaxis (PrEP), HIV testing, safer sexual behaviors) and increases mental health and alcohol use screening and linkage to counselors as needed for adolescents and young adults (AYA) in a rural Ugandan region with high HIV seroprevalence and limited resources.

2. State the study objective(s) and research question(s)
Aim 1: To adapt an evidence-based mobile phone-delivered sexual health program, to include PrEP information and deliver mental health and alcohol use assessments with the goal of increasing screening and referral, as well as linkage to counselors for AYA at HIV risk.

Aim 2: Evaluate through a pilot RCT (N=126 AYA, 15-19 years) intervention (a) acceptability and feasibility, and (b) impact on uptake of HIV prevention strategies, as well as screening and linkage to mental health and alcohol use school-based counselors.

 Uganda 2021-10-12 2024-10-12 Social Science and Humanities Clinical Trial Non-degree Award
Adeodata Rukyalekere Kekitiinwa
ID: UNCST-2019-R000799
 Mortality Surveillance Activity Protocol All-cause Mortality Surveillance in Bunyangabu, Kabarole and Kyenjojo districts, Uganda
REFNo: HS1755ES

the objective of establishing a mortality surveillance system is to enumerate and document all-cause mortality in the 3 districts of Bunyangabu, Kabarole, and Kyenjojo in Uganda. Specifically this will; a) determine HIV/AIDS related and proportionate mortality rate in the three districts, b) determine maternal and neonatal mortality rates in the three districts c) identify causes of death among HIV patients and causes of pregnancy-related deaths in the three districts and d) document the implementation process of mortality surveillance in order to inform future scale up.
 Uganda 2021-10-12 2024-10-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Waruiru Kolff Kayla Tinie
ID: UNCST-2021-R012291
 Turn-taking interactions in Eastern male Chimpanzees (Pan troglodytes schweinfurthii)
REFNo: NS295ES

Understanding the turn-taking systems of chimpanzees and how this relates to human language and it's origins. Hence, whether the turn-taking systems of chimpanzees are influenced by interpersonal contexts (social bonds & dominance rank).
 Netherlands 2021-10-12 2024-10-12 Natural Sciences Non-Clinical Trial Degree Award
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