Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Jonathan Kayondo
ID: UNCST-2021-R008325
 Contained laboratory studies of the genetically-modified, non-gene drive, self-limiting male bias Anopheles gambiae strain Ag(PMB)1.
REFNo: HS2601ES

• Establishing and maintaining wild-type Anopheles strains Ag(WT) for use in the study.
• Importing and maintaining of the Ag(PMB)1 strain from Target Malaria partner laboratories into the insectary in accordance with ACL2 standard operating procedures for this strain.
• Further Introgression and maintaining the Ag(PMB)1 strain in a local genetic background.
• Confirmation of the genotype of the Ag(PMB)1 strain by molecular methods, including storage of samples.
• Conducting experiments on specific insect life history parameters under containment including:
o Effect of the transgenes on lifecycle parameters
o Female feeding avidity
o Fecundity
o Egg hatch
o Confirming the male bias phenotype by observing the distortion of sex ratio and proportions of transgenic vs. non transgenic individuals
o Accuracy of mosquito sorting methods
o Larval development rate and adult hatching (eclosion)
o Adult eclosion (emergence of an adult insect from a pupa) and adult longevity
• Conducting a colony augmentation exercise, to temporarily increase colony numbers.
• Assessment of mating competitiveness between Ag(WT) and strain Ag(PMB)1 males.
• Assessment of insecticide susceptibility status of the Ag(PMB)1 strain compared with the non-transgenic wild-type An. gambiae, using standard World Health Organization protocols.
• Conducting experiments to optimize mosquito rearing methods.
All studies will be performed using the imported Ag(PMB)1 strain and local wild-type Ag(WT), no genetic transformation of either of these two strains will be done in country.

 Uganda 2022-12-23 18:02:42 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Robert Downing George
ID: UNCST-2020-R014615
 Sample collection for the development of a new Abbott Rapid Diagnostics COVID- 19/ Flu A&B Rapid Panel
REFNo: HS2592ES

Influenza (Flu) and COVID-19 are both contagious respiratory illnesses - they share some similar symptoms but are caused by different viruses. Because some of the symptoms of flu and COVID-19 are similar, distinguishing infection between these viruses cannot be made based on symptoms alone. Diagnostic testing is needed to determine which of the two viruses is the cause of the illness.
Abbott Rapid Diagnostics is developing a new COVID-19 / Flu A&B rapid test device that can detect both flu and COVID-19 viruses in a patient sample and distinguish between them. The test is being developed on an improved lateral flow platform, to be conducted at the point-of-care. This study is intended to collect samples to aid in the research and development process for this new test. The study will provide standard-of-care PCR testing and potentially molecular sequencing for patient management at clinical sites in Uganda.

UK 2022-12-23 18:01:38 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
DARIUS OWACHI
ID: UNCST-2022-R009373
 KNOWLEDGE, ATTITUDE AND PRACTICES OF HEALTH WORKERS TOWARDS ANTIMICROBIAL RESISTANCE AND ANTIMICROBIAL STEWARDSHIP – A CROSS-SECTIONAL SURVEY IN KAMPALA, UGANDA
REFNo: HS2598ES

To determine the knowledge, attitude and practices of antimicrobial prescribers at Kiruddu Hospital towards antimicrobial resistance ,
 Uganda 2022-12-23 18:00:14 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
EUNICE Ndyareeba
ID:
Achievement Goal Orientation, Self-efficacy and Academic Engagement among Compassion and Non-compassion supported Adolescent students in Secondary Schools in Southwestern Uganda
REFNo: SS1562ES

1.Assess the relationship between achievement goal orientation and academic engagement 2.Determine the relationship between self-efficacy and academic engagement 3.Examine the mediation role of self-efficacy on the relationship between achievement goal orientations and academic engagement 4. Examine whether there is a significant difference between achievement goal orientation and academic engagement among compassion-supported and non-compassion supported adolescents
Uganda 2022-12-23 17:58:52 2025-12-23 Social Science and Humanities Non-Clinical Trial Degree Award
Joyce  Nankumbi
ID:
Effect of the healthy baby tool kit on the maternal-infant and young child feeding practices among HIV-positive/exposed mother-baby dyads
REFNo: HS2491ES

Assess the maternal, infant, and young child feeding practices among HIV-positive/exposed mother-baby dyads
Evaluate the effectiveness of the healthy baby tool kit on the maternal-infant and young child feeding practices
assess the barriers and facilitators to implementation of the Healthy baby tool kit
 Uganda 2022-12-23 17:54:26 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joseph Mugisha Okello
ID: UNCST-2022-R009461
 Functional Needs Assessment Survey in Kalungu District, Uganda
REFNo: HS2495ES

1. To pilot test the Functional Needs Assessment Tool (FNAT) survey methodology and bespoke data collection app. 2. Across the domains of vision, hearing, mobility, cognition, communication, self-care and mental health to estimate the: a. prevalence of functional difficulties b. unmet and total need for rehabilitation services c. unmet and total need for AP
Uganda 2022-12-23 17:50:49 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Cecilia  Nantume
ID:
An evaluation of DMPA-SC Self Injection Interactive Voice Response (IVR) Training for Family planning Providers in 5 Districts in Uganda
REFNo: HS2593ES

To determine how the IVR approach compares traditional in-person training in terms of costs and effectiveness. ,To determine whether the IVR approach is an acceptable method of training health workers on new contraceptive method ,To determine feasibility and effectiveness of using IVR approach to train health providers on administering a new contraceptive method,
 Uganda 2022-12-23 17:46:55 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Julius Ssendiwala
ID:
Strengthening of Infection Prevention and Control in PEPFAR-supported Facilities during COVID-19 Pandemic in Uganda
REFNo: HS2564ES

1) Develop IPC indicators to support routine IPC reporting and performance monitoring.
2) Develop a centralized IPC reporting mechanism for streamlining IPC data collation, analysis, and reporting.
3) Validate data reported to the centralized database, perform data quality assessments, and implement quality improvements (QI) activities.
4) Monitor adherence to IPC policies, guidelines, and standards across all levels of the healthcare system.
5) Support the implementation of IPC capacity building interventions (trainings, mentorships, support supervision, IEC materials and Job aides, WASH supplies/PPEs) at all levels of the healthcare system.
6) Enhance surveillance systems for COVID-19 infections among HCW

 Uganda 2022-12-23 17:43:55 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Micheal Mwebaza
ID:
Leadership Styles and Organisational Commitment of Academic Staff in Selected Universities in Uganda
REFNo: SS1543ES

To establish the extent to which laissez faire leadership styles influence organisational commitment of academic staff in Kyambogo and Uganda Christian Universities, To establish the extent to which autocratic leadership style influence organisational commitment of academic staffs in Kyambogo and Uganda Christian Universities,To establish the extent to which democratic leadership style influence organisational commitment of academic staffs in Kyambogo and Uganda Christian University,
 Uganda 2022-12-23 17:42:41 2025-12-23 Social Science and Humanities Non-Clinical Trial Degree Award
John Bosco Isunju
ID: UNCST-2019-R001803
 Impact of a community-level advocacy intervention on HIV, TB, and malaria-related knowledge, attitude, and practices (KAP) among most at-risk populations in Uganda
REFNo: HS2577ES

Broad objectives
To assess the impact of a community-level advocacy intervention on the uptake of HIV, TB and Malaria prevention services among the most-at-risk populations in Uganda

Specific objectives
1. To determine the impact of a community-level advocacy intervention on uptake of HIV prevention services among most-at-risk populations in Uganda
2. To establish the impact of a community level advocacy intervention on knowledge on TB among most-at-risk populations in Uganda
3. To determine the impact of a community level advocacy intervention on uptake of malaria prevention services most-at-risk populations in Uganda
4. To explore the facilitators and barriers for uptake of HIV, TB and malaria prevention services among most-at-risk populations in Uganda

 Uganda 2022-12-23 17:33:21 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Lawrence Okello Rafaih
ID:
Evaluation practices and strategy performance of local NGOs in Uganda
REFNo: SS1561ES

4. To determine the relationship between organizational evaluation steering process and strategy performance of NGOs in Uganda,3. To establish the relationship between organizational evaluation technical expertise and strategy performance of NGOs in Uganda,2. To determine the relationship between evaluation planning process and strategy performance of NGOs in Uganda,1. To validate the contextual relevance of organizational effectiveness competency model for strategy evaluation of NGOs in Uganda.,The purpose of this study is to validate the extent to which evaluation practices influence strategy performance of national NGOs in Uganda.,
 Uganda 2022-12-19 12:19:45 2025-12-19 Social Science and Humanities Clinical Trial Degree Award
Daniella Ferguson
ID:
A Retrospective Analysis of Suramin Treatment forStage 1 Trypanosoma Brucei Rhodesiense Human African Trypanosomiasis (S1 TBR HAT) in Uganda and Malawi
REFNo: HS2582ES

Primary objectives
The primary objective is to determine whether standard of care treatment with suramin, as currently practiced in Uganda and Malawi, leads to better health outcomes in patients with S1 TBR HAT than observed in an untreated natural history cohort with source data from a published epidemiologic study.

Secondary objectives
The secondary objective is to evaluatethe safety and tolerability of suramin.

 South Africa 2022-12-19 12:17:26 2025-12-19 Medical and Health Sciences Clinical Trial Non-degree Award
THOMAS EBOYU
ID:
COVID – 19 PANDEMIC ON ACCESS TO HEALTH CARE SERVICES AMONG PEOPLE LIVING WITH HIV/AIDS AT SOROTI REGIONAL REFERRAL HOSPITAL
REFNo: HS2579ES

iv. To determine the factors that have affected adherence to antiretroviral therapy by people living with HIV/AIDS, three months before and during the first total lockdown of COVID – 19 pandemic at Soroti regional referral hospital.,iii. To evaluate the views of the patients on accessibility, availability, affordability and acceptability of HIV/AIDS services, three months before and during the first total lockdown of COVID – 19 pandemic at Soroti regional referral hospital.,ii. To determine the trends of patients that continued attending for treatment of HIV/AIDS, three months before and during the first total lockdown of COVID – 19 pandemic at Soroti regional referral hospital.,i. To determine the trends of patients that have been diagnosed with HIV/AIDS, three months before and during the first total lockdown of COVID – 19 pandemic at Soroti regional referral hospital.,To determine the influence of COVID – 19 Pandemic on access to health care services and associated factors among people living with HIV/AIDS at Soroti regional referral hospital.,
 Uganda 2022-12-19 12:15:58 2025-12-19 Medical and Health Sciences Non-Clinical Trial Degree Award
Freddy Kitutu Eric
ID: UNCST-2020-R014751
 Factors associated with COVID19 misinformation and vaccine hesitancy in Ugandan communities
REFNo: HS2566ES

3. To explore the mechanisms of effect among factors that affect vaccine hesitancy and vaccine uptake at household level in Uganda.,2. To assess the factors associated with prevalence of COVID19 misinformation, COVID19 vaccine hesitancy, and COVID19 vaccine uptake at household level?,1. To determine the prevalence of COVID19 misinformation, COVID19 vaccine hesitancy, and COVID19 vaccine uptake at household level?,
 Uganda 2022-12-19 12:03:01 2025-12-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Samuel Kabbera
ID:
SUSTAINABLE PRACTICES, STAKEHOLDER ENGAGEMENT AND THE GROWTH OF SMALL AND MEDIUM AGRO-PROCESSING ENTERPRISES IN UGANDA.
REFNo: SS1301ES

Main Objective: To establish a link between sustainable practices, stakeholder engagement and the growth of SMEs in Uganda's agro-processing subsector. Specific Objectives: a) To examine the relationship between environmental sustainable practices and growth of agro-processing SMEs. b) To examine the relationship between social sustainable practices and growth of agro-processing SMEs. c) To assess the relationship between economic sustainable practices and growth of agro-processing SMEs. d) To investigate the mediating role of stakeholder engagement on the adoption of sustainable practices and the growth of agro-processing SMEs. e) To explore the experiences with the application of sustainable practices and growth in agro-processing SMEs in Uganda. f) To suggest a suitable sustainable framework that is applicable to a developing country context, with particular reference to Uganda that can predict the growth of agro-processing SMEs.
Uganda 2022-12-19 11:42:06 2025-12-19 Social Science and Humanities Non-Clinical Trial Degree Award
DAISY NABADDA
ID:
GENDER AND OTHER DETERMINANTS INFLUENCING THE EFFECTIVE RESPONSE, CONTROL, AND MANAGEMENT OF EBOLA VIRUS DISEASE IN UGANDA
REFNo: HS1176ES

i) Describe the community's level of knowledge, attitude, and perceptions (KAPs) of EVD in Uganda.
ii) Explore contextual factors affecting the effective response, control, and management of EVD in Uganda.
iii) Assess the gender relations in the access of treatment and control during EVD outbreaks.
iv) Describe the influence of myths, practices, and experiences of EVD affected communities in Uganda.
v) Examine how the performance of EVD response and control programs are influenced by policymakers at national, and community levels.


 Uganda 2022-12-19 11:39:09 2025-12-19 Medical and Health Sciences Degree Award
Dan Kajungu
ID: UNCST-2019-R000786
 Integrating Minimally Invasive Tissue Sampling (MITS) into the IMHDSS mortality-surveillance system for determining cause of death in children below 5 years of age
REFNo: HS2572ES

a) To identify and enumerate all under-5 deaths in the surveillance area
b) To determine cause of death using laboratory, histopathologic, clinical, maternal, and verbal autopsy data.
c) To obtain verbal autopsies and available maternal and infant clinical data on all eligible notified under-5 deaths in the site’s surveillance area and Eastern Uganda
d) To generate high quality cause-of-death data that informs policy and health actions
e) To build in-country capabilities and enable MITS Surveillance Alliance sites to leverage MITS investment to prevent under-5 child mortality.


 Uganda 2022-12-14 14:22:30 2025-12-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Fiona Atim -
ID: UNCST-2020-R015040
 Primary Health Care Services and Health-Related Quality of Life Among Elderly Persons with Non-communicable Diseases in Uganda: The Case of Central Region
REFNo: SS1528ES

iii. To evaluate the mediating effects of home factors on health-related quality of life of the elderly persons with NCDs in selected districts in central Uganda.,ii. To assess the mediating effects of psychosocial support on the health-related quality of life of the elderly persons with NCDs in selected districts in central Uganda.,i. To analyze the effect of primary health care services on Health-related quality of life of elderly persons with NCDs in selected districts in central Uganda.,The main objective of this study is to investigate the influence of primary health care services on the HRQoL among elderly persons with NCDs in the central region of Uganda, to develop an intervention and a corresponding model to support the improvement of primary health care services and enhance HRQoL of the elderly persons.,
 Uganda 2022-12-14 14:20:03 2025-12-14 Social Science and Humanities Non-Clinical Trial Degree Award
Moses Joloba Lutaakome
ID: UNCST-2022-R011558
 Automated smartphone-based cough audio classification for rapid tuberculosis triage testing (Cough Audio triaGE for TB; CAGE-TB)
REFNo: SS1536ES

To generate and separately validate a cough audio classifier that meets WHO triage test TPP sensitivity and specificity criteria.,
 Uganda 2022-12-14 14:15:43 2025-12-14 Social Science and Humanities Non-Clinical Trial Non-degree Award
Peter Ferrarone Timothy
ID:
Helping nurses overcome structural drivers of absenteeism in Uganda: A survey and discrete choice experiment
REFNo: HS2529ES

4.2 Objectives and research questions
1. To explore factors internal to the Ugandan health care sector that may be leading nurses to be absent from work
a) What job characteristics or conditions of employment are most influential in encouraging nurses / managers / midwives to not attend work?
b) Are there non-monetary job characteristics that are particularly important to nurses?
c) Are there substantial differences between nurses / managers / midwives that lead to differences in attendance and are there incentives to address these differences?
d) If so, does the effectiveness of interventions to overcome absenteeism vary according to these differences between nurses / managers / midwives?
e) Are there incentives encouraging nurses to be absent across the system and do these affect different groups of nurses / managers / midwives differently?
f) What effect, if any, does employment setting (urban versus rural) have on absenteeism and an individual’s decision to be absent?

2. To explore factors external to the Ugandan health care sector that may be leading nurses to be absent from work
a) What individual, social, structural, and contextual factors are most influential in encouraging nurses / managers / midwives not to attend work?
b) How do health worker characteristics influence service provider preferences in relation to incentives and other potential policy interventions to overcome absenteeism?
c) Are there substantial differences between nurses / managers / midwives that lead to differences in attendance and are there incentives to address these differences?
d) Does the effectiveness of interventions to overcome absenteeism vary according to these differences between nurses / managers / midwives?
e) Are there incentives encouraging nurses to be absent across the system and do these affect different groups of nurses / managers / midwives differently?
f) How does intrinsic and extrinsic motivation affect attendance at work?
g) What do health workers believe and perceive (from personal experience of word-of-mouth) is currently being done to combat absenteeism and what do they believe will be the most feasible policy solutions in the future?
3. To identify feasible policy interventions that are most likely to be taken up and impact behaviour
a) What are the experiences and perceptions of health care service providers of monetary and non-monetary incentives and other factors affecting service provider motivation and performance to inform the design of policy interventions to overcome absenteeism and ensure the delivery of quality health care services in Uganda?
b) Are there characteristics of health facilities that influence service provider preferences in relation to incentives and other potential policy interventions to overcome absenteeism?
c) What proportion of health workers would choose to attend work rather than be absent if presented with specific (hypothetical) job characteristics? How does this vary across the population?
d) What trade-offs, if any, are nurses willing to make between these attributes to identify the optimal combination of these factors for packages of policy interventions that can be implemented in light of local resource constraints to align the incentives facing frontline health care providers especially in rural settings to address the issue of absenteeism?
e) Are nurses / managers / midwives willing to trade between “carrot” and “stick” interventions to reduce absenteeism?
f) Is salary the main incentive? Are there non-monetary incentives that are likely to have an impact on nurse absenteeism?
g) What is the range of feasible and affordable policy interventions that are likely to be effective in addressing health worker absenteeism?
h) Is changing individual or group incentives likely to lead to less absenteeism?

 USA 2022-12-14 14:10:49 2025-12-14 Medical and Health Sciences Non-Clinical Trial Degree Award
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