Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Winny Akullo Nekesa
ID:
Adoption of Linked Data among University libraries in Uganda
REFNo: SS1338ES

The study will address the following specific objectives:
1. Determine the level of awareness of Linked Data among the professional librarians in Ugandan Universities.
2. Establish the extent of Linked Data adoption in Ugandan Universities.
3. Determine the potential benefits of adopting Linked Data in Ugandan Universities.
4. Investigate the factors that influence the professional librarians’ behaviour towards the adoption of Linked Data in Ugandan Universities.
5. Investigate the strategies to promote the adoption of Linked Data in Ugandan Universities.

 Uganda 2022-07-21 11:01:06 2025-07-21 Social Science and Humanities Non-Clinical Trial Degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
 A PHASE III, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF ADJUVANT ATEZOLIZUMAB OR PLACEBO AND TRASTUZUMAB EMTANSINE FOR HER2-POSITIVE BREAST CANCER AT HIGH RISK OF RECURRENCE FOLLOWING PREOPERATIVE THERAPY
REFNo: HS2173ES

8. To validate the ability of fertility biomarkers to diagnose and predict permanent loss of ovarian function, and to determine the impact of anti-cancer therapy on hormone levels,7. To evaluate health status utility scores of patients treated with atezolizumab when given in combination with trastuzumab emtansine compared with placebo and trastuzumab emtansine,6. To identify and/or evaluate biomarkers that are predictive of response to atezolizumab and trastuzumab emtansine (i.e., predictive biomarkers), are early surrogates of efficacy, are associated with progression to a more severe disease state (i.e., prognostic biomarkers), are associated with acquired resistance to atezolizumab and trastuzumab emtansine, are associated with susceptibility to developing adverse events or can lead to improved adverse event monitoring or investigation (i.e., safety biomarkers), can provide evidence of atezolizumab and trastuzumab emtansine activity (i.e., pharmacodynamic biomarkers), or can increase the knowledge and understanding of disease biology and drug safety,5. To evaluate the immune response to atezolizumab and trastuzumab emtansine,4. To characterize the PK profiles of atezolizumab and trastuzumab emtansine when given in combination,3. To evaluate the safety of atezolizumab when given in combination with trastuzumab emtansine compared with placebo and trastuzumab emtansine,2. To evaluate the efficacy of atezolizumab when given in combination with trastuzumab emtansine compared with placebo and trastuzumab emtansine in the PRO-evaluable analysis set,1. The secondary efficacy objective for this study is to evaluate the efficacy of atezolizumab when given in combination with trastuzumab emtansine compared with placebo and trastuzumab emtansine in both the ITT population and PD-L1-positive population,The primary objective for this study is to evaluate the efficacy of atezolizumab when given in combination with trastuzumab emtansine compared with placebo and trastuzumab emtansine in both the ITT population (all comers) and the PD-L1-positive population (defined as all patients from the ITT population with a centrally assessed PD-L1-positive status [i.e., PD-L1 status of IC1/2/3] at randomization),
 Uganda 2022-07-21 11:00:02 2025-07-21 Medical and Health Sciences Clinical Trial Non-degree Award
Sonia Michaelsen Ingrid
ID:
Sexual and gender-based violence against South Sudanese Refugees in Uganda: A mixed-methods case study
REFNo: SS1029ES

The overall objective is to explore and compare the perceptions and experiences of sexual and gender-based violence (SGBV) towards South Sudanese refugees in Uganda who live in designated settlements to those who self-settled. More specifically:
1.To estimate the prevalence of SGBV among South Sudanese refugees in Ugandan settlements vs. those who have self-settled in urban areas
2.To identify the risk and protective factors of SGBV amongst South Sudanese refugees in designated settlements vs. urban areas, from the perspective of South Sudanese refugees and local community leaders and decision makers
3.To explore the relationship between the estimated prevalence of SGBV in settlements and urban areas and the risk and protective factors identified by participants
4.To generate context-dependent, stakeholder-led solutions to reduce SGBV in each setting

 Canada 2022-07-21 10:50:50 2025-07-21 Social Science and Humanities Non-Clinical Trial Degree Award
Odoi. Agricola
ID:
Challenges of Diabetes Management in Rural and Urban Areas of Uganda
REFNo: HS2358ES

Our central hypothesis is that diabetics in rural and semi-rural areas of Uganda may not be storing insulin at the appropriate temperatures due to absence of refrigeration facilities. This may impact the efficacy of this life-saving medication resulting in poor diabetes management and potential complications. We also hypothesize that diabetes patients face other challenges that constrain proper disease management such as lack of knowledge on diabetes management, risk factors and complications. Thus, the specific aims of this study are to determine: (a) how diabetic patients in Tororo district, Uganda, manage their diabetes; (b) how the patients store their insulin; (c) general patient knowledge of diabetes management best-practices and complications; (d) the sources of medical advice used by diabetes patients; and (e) the patient-reported challenges of diabetes management. Tororo District has been chosen because it is one of the marginalized areas of the country and hence the burden of the problem in Tororo will be representative of the situation in other less advantaged parts of the country. The findings of this study will be useful for in a number of ways (a) guiding future studies in these resource poor populations; (b) guiding diabetes management and control programs; (c) since practicing physicians will be involved in the study, the findings will be useful in informing their own clinical practice and understanding of how best to help their patients; (d) development of contextually appropriate educational interventions that may be adapted and implemented across not only Uganda but the other East African countries to counteract the emerging diabetes epidemic.
 Uganda 2022-07-20 17:56:33 2025-07-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rebecca Tapscott
ID:
Uganda's Resistance Councils
REFNo: SS1322ES

Main objective - Study the process of establishment of the Resistance Councils and their institutional features, both during the war and especially in the immediate post-war years. Specific objectives - Explore the role of the Resistance Councils in areas beyond Luwero. - Document the institutional features of the first Resistance Councils. - Study the process of establishment of the Resistance Councils, especially in the immediate post-war years.
 USA 2022-07-20 17:49:18 2025-07-20 Social Science and Humanities Non-Clinical Trial Non-degree Award
Harriet Birabwa-Oketcho
ID:
SERVICE QUALITY AND PATIENT SATISFACTION WITH HEALTH SERVICES AT BUTABIKA HOSPITAL
REFNo: HS2275ES

General objective
The general objective of the study is to examine the relationship between service quality and patient satisfaction with health services at Butabika Hospital.




Specific Objectives
1. To determine the level of service quality of health services at Butabika Hospital.
2. To determine the level of patient satisfaction with health services at Butabika Hospital.
3. To determine the relationship between the service quality and patient satisfaction with health services at Butabika Hospital.
4. To assess the relationship between the patient related factors and patient satisfaction with health services at Butabika Hospital.

 Uganda 2022-07-20 17:46:10 2025-07-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ellie MacDonald Mae
ID:
Gender-Based Violence in Refugee Sites in East Africa and Southeast Asia
REFNo: SS1330ES

This project is the exploratory, early-stage phase of a research agenda which seeks to better understand patterns of gender-based violence in refugee sites in the developing world. The study’s main question is: why does the prevalence and type of GBV vary across refugee site and within the same site over time? There are two main objectives of this early-stage research in answering this question. First, the project will add to the PI’s understanding of prevalence, types, and causes of gender-based violence on refugee sites in Kenya, Uganda, and Thailand. This builds upon previous volunteer work on refugee camps in Greece. The second objective is to build partnerships with local actors working on gender issues in refugee sites. This exploratory research will provide the PI with insights and partnerships that they will draw upon for future research, which is likely to involve more data collection in Uganda.
 UK 2022-07-19 15:01:50 2025-07-19 Social Science and Humanities Non-Clinical Trial Degree Award
Dong Hyeok Kang
ID:
Tax evasion in customs: Firm-level evidence from Uganda
REFNo: SS1294ES

Our research would directly to Uganda’s policy objective to raise domestic revenues through improved tax administration to finance public investments for inclusive growth, especially by monitoring import tax(i.e., customs duty and import VAT). Despite the importance of trade taxes and ample anecdotal evidence on evasion this topic has received little attention so far. The identified clients for this study are the Research, Planning and Development Department and the Customs & Excise Department of the Uganda Revenue Authority.
South Korea 2022-07-19 14:38:17 2025-07-19 Social Science and Humanities Non-Clinical Trial Non-degree Award
JOSELYN RWEBEMBERA
ID: UNCST-2021-R013915
 Case Managers and Peer Support Groups (CAMPS) for Prophylaxis Adherence in Rheumatic Heart Disease
REFNo: SS1364ES

Primary Objective
To determine the impact of support strategies including case managers and peer support groups on BPG adherence and quality of life among children newly diagnosed with latent rheumatic heart disease in Uganda .

Secondary Objectives
1. To Determine the difference in 1-year BPG adherence rates of children newly diagnosed with latent rheumatic heart disease in Uganda randomized to either: (a) case manager only strategy (Arm 2) or (b) case manager + peer group (Arm 3) when compared to (c) usual care (Arm 1).
2. To explore differences in patient reported outcomes including treatment satisfaction, patient health-related quality of life, and care giver quality of life, in relation to support strategy and adherence.

 Uganda 2022-07-19 14:36:10 2025-07-19 Social Science and Humanities Non-Clinical Trial Non-degree Award
Anthony  Fuller
ID:
Comprehensive Neurology and Neurosurgery Care Country Level Assessment in Uganda
REFNo: HS2344ES

The main objective of this study is to complete a neurological care continuum evaluation of Uganda’s public hospitals and health centers for the purposes of informing the current gaps in Uganda’s health system to manage neurological patients, elucidating the availability and distribution of neurological care throughout the country, and allowing for examination of the current infrastructure of the health system to appropriately refer and treat acute and non-acute neurological patients.
USA 2022-07-18 14:41:02 2025-07-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Michael Bermudez
ID:
Perceptions of Makerspace Learning in Uganda: A Qualitative Study
REFNo: SIR121ES

To determine what technology-based products that can potentially help students with disabilities the student participants have collaboratively created during research makerspace sessions,To determine the positive and the negative features of the use of 3D printers and circuit boards according to the student participants’ perceptions,To determine the student participants’ perceptions regarding the use of makerspace technology,To determine the student participants' perceptions regarding the learning process associated with makerspace.,
 USA 2022-07-18 14:39:37 2025-07-18 Engineering and Technology Non-Clinical Trial Non-degree Award
SIMON KIZITO
ID:
Exploring variation in infants’ preference for infant-directed speech: Ugandan Evidence from a multi-site study in Africa.
REFNo: SS1342ES

1)To find out whether infants prefer Infant-directed speech (IDS) vs. Adult-directed speech (ADS).
2)To examine the relationship between maternal socio demographics (ethnicity, gender and the caregiver’s education level, general socioeconomic status) and infant language development.
3)To examine the relationship between maternal depression and infant language development.
4)To examine the relationship between maternal psychological distress and infant language development.
5)To examine the relationship between maternal relationship discord and infant language development.
6)To examine the relationship between maternal social support and infant language development.

Uganda 2022-07-18 14:37:19 2025-07-18 Social Science and Humanities Non-Clinical Trial Non-degree Award
Xavier Giné
ID:
Monitoring the Real Cost of Domestic Payments (Transaction Cost Index) - Uganda
REFNo: SS1358ES

Assess the impact of government policies and regulations on DFS by tracking costs over time, Measure customer service quality (including availability of fraud redress, customer service response time, accuracy of customer service response, and discrepancies between customer service and listed fees),Collect provider information (including provider types, market share, regulatory authority, product age, and website language),Collect data on fees (including fee schedule, fee schedule availability, location of fee information, currency, government tariffs, and time cost),Collect official, listed pricing data,Conduct a cost effectiveness analysis in year 1 (determining which of the three methods is most cost effective in developing the TCI),Measure the true costs of DFS transactions in Uganda by creating a price comparison index. ,
 Spain 2022-07-18 14:36:22 2025-07-18 Social Science and Humanities Non-Clinical Trial Non-degree Award
Amanyire Jordan Mutambi
ID:
Depression, associated factors and psychosocial interventions among elderly individuals living with HIV/AIDS in SW Uganda accessing services in Mbarara City
REFNo: HS2331ES

1. To document evidence on psychosocial interventions those have been effective in treatment of depression among elderly people in low and middle income countries.
2. To determine the prevalence of depression among the elderly living with HIV/AIDS in SW Uganda accessing HIV/AIDS care within selected health facilities in Mbarara city.
3. To explore the factors associated with depression among elderly people living with HIV/AIDS in SW Uganda accessing services in selected health facilities in Mbarara city
4. To assess the effectiveness of Behavioral Family Therapy (BFT) in reducing depressive symptoms among elderly HIV patients accessing HIV care in selected health facilities Mbarara city, southwestern Uganda.

 Uganda 2022-07-18 14:34:09 2025-07-18 Medical and Health Sciences Non-Clinical Trial Degree Award
Joseph Baluku B
ID: UNCST-2019-R000612
 Mycobacterium tuberculosis infection and DNA damage in HIV-associated lung cancer in Uganda
REFNo: HS2328ES

STUDY AIM 1: To determine the association between Mycobacterium tuberculosis
infection and HIV-associated lung cancer in Uganda.

STUDY AIM 2: To compare the degree of DNA damage and methylation among people
with HIV-associated cancer with and without Mycobacterium tuberculosis infection.


SECONDARY AIM: To determine the effect of tuberculosis preventive therapy (TPT) on
the six-month survival of people with HIV-associated lung Cancer and LTBI in
Uganda
 Uganda 2022-07-18 14:31:31 2025-07-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nelson Sewankambo K
ID: UNCST-2020-R014578
 Development and Evaluation of an Information Management and Communication System for Population-wide Point-of-Care Infant Sickle Cell Disease Screening (SIMCS)
REFNo: HS2333ES

1. To develop and evaluate a four module 3G or more cell phone app for a novel SCD screening information management and communication system (SIMCS) 2.To evaluate the impact of the SCD SIMCS on access to screening and care and outcomes of children with SCD.
Uganda 2022-07-18 14:29:19 2025-07-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Andrew Obuku Ekii
ID: UNCST-2024-R002288
 IMMUNOLOGICAL AND VIROLOGICAL FACTORS ASSOCIATED WITH VIROLOGICAL CONTROL IN ACUTE AND EARLY HIV-I INFECTION.
REFNo: HS2264ES

• To characterize the earliest host factors associated with plasma viral load decline from peak viremia to viral setpoint.
a) To determine the functional and molecular profile of innate immune cells at each stage of acute and early HIV infection.
b) To determine the functional and molecular profile of adaptive immune cells at each stage of acute and early HIV-I infection.
c) To determine the impact of early cART treatment on:
l) Size of translational competent viral reservoirs
Il) Development of HIV specific immune responses
d) To determine HIV evolution in acute and early HIV1 infection

Specific objectives are:
1 . To determine the association of CD8 T cell subsets with plasma viral load and CD4 trajectories following acute and early HIV-I infection.
2. To determine the association of cell death mechanism with T cells following acute and early HIV-I infection.
3. To determine the viral replicative inhibitory properties of CD8 T cell subsets following acute and early HIV-I infection.
4. To determine the TCR and BCR of the cells with the highest viral inhibition potency.
5. Predict antigen that induced the TCR and BCR specificity in the cellular subsets with the highest viral inhibition potency.
6. To associate HIV specific B cell phenotypes with viremia in acute and early HIV infection.
7. To associate complement proteins with viremia and development of broadly neutralizing antibody in acute and early HIV-I infection.


 Uganda 2022-07-18 14:27:23 2025-07-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Macdonald Isabel
ID:
Do anonymous ratings build trust in mobile money agents? Evidence from Uganda
REFNo: SS1344ES

The goal of the research is to determine if mobile money users in Uganda trust anonymous customer ratings, and if these ratings would make users more willing to trust unknown agents. Furthermore, the research will explore the extent to which social stigmas restrict information sharing about agent trustworthiness.
Specific Objectives
Establish whether anonymous reviews increase trust, both in behavioral games and in unknown mobile money agents
Investigate if social stigmas restrict info sharing about agent trustworthiness

 USA 2022-07-15 15:59:49 2025-07-15 Social Science and Humanities Non-Clinical Trial Non-degree Award
Polycarp Omara
ID: UNCST-2022-R011110
 CHILDREN’S EXPOSURE TO VIOLENCE IN REFUGEE EDUCATIONAL SETTINGS: MITIGATING THE EFFECTS ON EDUCATION AND SOCIAL WELLBEING IN WEST NILE, UGANDA
REFNo: SS1331ES

1. To analyse the various forms of VAC among the refugee children in Refugees Educational settings in West Nile.
2. To establish the common perpetrators of VAC in refugee education settings in West Nile.
3. To establish the effects of VAC in refugee education settings in West Nile.
4. To propose the strategies for preventing VACs in refugee education settings in West Nile.

Uganda 2022-07-15 15:56:51 2025-07-15 Social Science and Humanities Non-Clinical Trial Non-degree Award
Moses Joloba Lutaakome
ID: UNCST-2022-R011558
 Performance evaluation of the Molbio Diagnostics Truenat™ MTB Plus/COVID-19 for TB and COVID-19 case detection using prospectively collected NP swabs and sputum samples from participants with symptoms suggestive of TB.
REFNo: HS2346ES

To assess the feasibility and ease of use of self-sampled tongue swab,To determine the prevalence of COVID-19 (by RT-PCR) among patients identified as having TB by MRS,To determine the prevalence of COVID-19 (by RT-PCR) among presumptive TB patients investigated for COVID-19,To determine the diagnostic accuracy of Truenat™ MTB Plus/COVID-19 multiplex for TB detection compared to GeneXpert Ultra among presumptive TB patients using a MRS,To determine the diagnostic accuracy of Truenat™ MTB Plus/COVID-19 for COVID-19 detection among presumptive TB patients using a country-approved RT-PCR COVID-19 assay,To determine the diagnostic accuracy of Truenat™ MTB Plus/COVID-19 multiplex for TB detection among presumptive TB patients using a Microbiological reference standard (MRS),
 Uganda 2022-07-14 12:36:25 2025-07-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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