Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
John Mukisa
ID:
Host genetic variation and association with HIV disease progression among pediatric cohorts in Botswana and Uganda
REFNo: HS1841ES

1) To identify common host genetic variants associated with HIV disease progression among pediatric HIV cohorts from Botswana and Uganda. 2.) To evaluate the performance of genotype imputation methods with whole genome sequences as a gold standard for determining missing genotypes among samples from Botswana and Uganda. 3.) To identify and validate KIR genotypes among children with HIV in Botswana and Uganda. 4.) To determine the KIR haplotypes associated with HIV disease progression among children with HIV from Botswana, and Uganda.
Uganda 2022-05-13 7:48:00 2025-05-13 Medical and Health Sciences Non-Clinical Trial Degree Award
Agnes Kiragga
ID:
SARS-CoV-2 international biorepository and diagnostic test performance
REFNo: HS1808ES

Primary:
• To create a biorepository to test retrospectively the performance of investigational, emerging diagnostic technologies in the intended population or setting compared to a reference comparator for diagnosing SARS-CoV-2 infection using frozen samples.
Secondary
• To test prospectively the accuracy of investigational, emerging diagnostic technologies in the intended population or setting compared to a standard comparator for diagnosing SARS-CoV-2 infection
• To determine agreement between self-collected nasal swabs, saliva and clinician-collected nasopharyngeal swab samples for the diagnosis of SARS-CoV-2 using a reference test in Uganda.
• Determine the proportion of non-reportable results (unresolved, indeterminate and incomplete) and turn-around time compared to reference test.
• To assess acceptability of self-collected nasal swab tests and saliva for testing SARS-CoV-2 in both participants and healthcare workers in Uganda.
• To explore socio-demographic, behavioural and clinical factors associated with positive SARS-CoV-2 diagnosis.


Uganda 2022-05-13 7:45:44 2025-05-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kristina Roesel
ID:
Boosting Uganda's investments in livestock development (BUILD)
REFNo: A139ES

The program is divided into four different components that will be aligned and integrated, especially on activities that involve national stakeholder engagement and capacity building. Component 1 on Peste de petits ruminants (PPR) combines socio-economic studies, vaccine targeting and delivery, regional Pan-African networking activities (e.g. PENAPH, PPR alliance GPRA) and capacity development at the Biosciences eastern and Central Africa (BecA)-Hub at ILRI Nairobi: Objective1: Develop a socio-economic framework to assess the impact of PPR interventions Activities: Household survey in different livestock production systems; Longitudinal study-sentinel households; System dynamic modeling; Focus group discussions Outputs: Livelihoods impacts of different PPR control options Objective 2: Update the epidemiological status of PPR to allow assessment of control options Activities: Cross-sectional survey in different livestock productions systems; Post vaccination sampling; Genetic characterization of PPRV isolates; Participatory disease search; Slaughter house surveillance; Develop PPR risk maps Outputs: Updated risk map of PPR, circulating PPR genotypes, other important SR diseases Objective 3: Capacity development Activities: Support review of National PPR control strategy; Review of animal health services; Multi-stakeholder platform for AH service delivery to discuss gaps and define new mechanisms for control and surveillance; Strengthen passive surveillance system; Awareness creation of farmers; Post vaccination sampling Outputs: Novel models of animal health service delivery, strengthened surveillance system, capacity enhanced Component 2 on Rift Valley fever (RVF) includes the characterization of animal and human samples from outbreaks in 2016 and 2018, socio-economics, development of a risk and vulnerability map for Uganda as a decision-making tool Objective 1: Improved knowledge on RVF epidemiology Activities: Genotyping (RVF and other viruses); Serology (establish Gn/Gc distribution); Outbreak response; Entomological studies; Risk mapping Objective 2: Socio-economic studies Activities: Ex-ante analyses of control options; KAP questionnaire surveys; Gender assessments – exposure and constraints on uptake of interventions Objective 3: Develop National action plans/policy work and extension Activities: Contingency plans/decision support tools; Community trainings Outputs: RVF risk map, genetic characterization of circulating strains (informs vaccine interventions), Improved RVF national action plans, Training and communication materials, capacity building, improved capacity on vector sampling/surveys and biological sampling; PhD/MSc training Component 3 on Antimicrobial resistance (AMR) will contribute to the finalization of the National AMR action plan, describe and quantify the use of antimicrobials in the peri-urban poultry value chain. Objective 1: Understand knowledge, attitude, practices, and incentives for AMU in poultry value chains in Uganda, and the role of formal and informal markets Activities: Literature review on AMR and AMU in the poultry sector in Uganda; Gender sensitive rapid appraisal with AMUSE tool; Identify possible intervention entry points to improve AMU Objective 2: Assess risks to humans from poultry-associated AMR: Research on AMR transmission risks at the human-animal-environmental interface in different poultry production systems (smallholder and commercial; rural and peri-urban) in Uganda Activities: Map possible transmission pathways within the production system; Conduct AMR and residue prevalence surveys; In-depth AMR transmission studies that include environmental samples, and farm workers, and samples from other animal species potentially housed together with poultry; Outline risk pathways for human exposure to AMR from poultry production Objective 3: Design and evaluate interventions to reduce AMU in poultry value chains in Uganda Activities: Design interventions (co-design with poultry producers), closely monitor implementation over time to understand incentives to motivate change; Establish drug use monitoring system in poultry farms to allow M&E; Qualitative and quantitative analysis of intervention impact Objective 4: Support evidence-based policy dialogue for antimicrobial surveillance and AMR strategies Activities: Organise multi-stakeholder workshops to discuss feasibility, challenges, and constraints in implementing NAP in poultry sector, involve representatives from other countries and support continued review of NAP Objective 5: Build capacity in value chain actors, implementers, researchers Activities: Conduct capacity development need assessment; Develop capacity development plan for different stakeholder groups Component 4 on Veterinary Public health (VPH) at the point of slaughter includes scaling of already piloted butcher training curricula and implementation of abattoir-based sentinel studies for animal disease surveillance Objective 1: development of curriculum for capacity building of meat handlers on good hygienic practices (slaughter house personnel, butchers, meat transporters); meat inspectors on carcass inspection and mobile reporting; Public engagement of consumers; laboratory personnel (GLP and quality assurance) Activities: Baseline assessment of meat handlers’ knowledge and practices; hygiene indicators, selected pathogens; Consolidation and adaptation of existing materials for training of butchers; assessment of suitability of consolidated training materials and delivery mode with stakeholders; delivery of the training; endline study to assess success of the intervention Objective 2: proof-of-concept slaughterhouses as sentinels for zoonotic disease Activities: Mapping slaughterhouses through key informants and GIS; grey and published literature review; prioritization of disease in slaughterhouses/ identification of critical control points – KII and FGD with vets, meat inspectors, public health staff; Ethnographic observation of slaughterhouses; biological survey in animals and humans
Germany 2022-05-13 7:44:12 2025-05-13 Agricultural Sciences Non-Clinical Trial Non-degree Award
REBECCA CLAIRE LUSOBYA
ID:
Knowledge, Attitudes and Practices of Pediatricians, Neonatal Nurses and Parents of Preterm Infants towards Retinopathy of Prematurity in Tertiary Hospitals Uganda.
REFNo: HS2228ES

To determine the attitudes and practice patterns regarding ROP and its risk factors among pediatricians, neonatal nurses and caregivers at Kawempe National Referral Hospital and Mulago Specialized Women’s and Neonatal Hospital.,2 To determine the level of knowledge of ROP and its risk factors among caregivers attending Kawempe National Referral Hospital and Mulago Specialized Women’s and Neonatal Hospital.,1. To determine the level of knowledge of ROP and its risk factors among pediatricians and neonatal nurses in Kawempe National Referral Hospital and Mulago Specialized Women’s and Neonatal Hospital.,To determine the knowledge, attitude and practice patterns regarding ROP among the pediatricians, neonatal nurses and the preterm caregivers at Kawempe National Referral Hospital and the Mulago Specialised Women’s and neonatal Hospital.,
 Uganda 2022-05-13 16:09:48 2025-05-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JUSTUS BARAGEINE KAFUNJO
ID: UNCST-2020-R014150
 Identifying Opportunities for Prevention of Adverse Outcomes Following Female Genital Fistula Repair
REFNo: HS2033ES

Identify predictors of post-repair fistula breakdown and recurrence

Identify predictors and characteristics of post-repair incontinence

Identify feasible and acceptable strategies for modifying key risk factors of adverse
outcomes
 Uganda 2022-05-13 16:09:08 2025-05-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Emmanuel Rukundo NSHAKIRA
ID: UNCST-2021-R012277
 COVID-19 Risk,Electoral Violence and Civic Participation in the 2020/2021 Ugandan General Elections
REFNo: SS1218ES

To establish the extent to which COVID-19 fear affected civic participation in the 2021 elections,Compare the level of fear of Covid-19 and fear of electoral and post-electoral violence on voter turn-out,Assess the effect or concern and fear of COVID-19 affect voter turnout,Assess the effect of COVID-19 on campaign rally participation and candidate interface,
 Uganda 2022-05-13 15:52:13 2025-05-13 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jackson Orem
ID: UNCST-2021-R012016
 Factors that affect the timely diagnosis and treatment of neutropenic fever in Ugandan patients with cancer and HIV
REFNo: HS2175ES

1. To understand the current process of antibiotic initiation for patients with cancer and neutropenic fever at the UCI. 2. To identify factors that influence timely initiation of guideline-recommended antibiotics which can be addressed using targeted implementation strategies. 3. To identify the unique barriers to diagnosis and treatment of neutropenic fever for patients with HIV who are receiving treatment for cancer at UCI.
 Uganda 2022-05-13 10:09:59 2025-05-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Charles Batte
ID: UNCST-2021-R013587
 Validation of the Chronic Obstructive Pulmonary Disease Assessment Tool (CAT) Among COPD patients in rural Uganda.
REFNo: HS2145ES

To validate CAT among COPD patients in Nakaseke, Uganda. Specific objectives: • To determine the validity of CAT in assessing quality of life among COPD patients in rural Uganda using Saint George Respiratory Questionnaire (SGRQ) as the gold standard • To determine the internal reliability of the CAT in diagnosis of QOL among COPD patients in rural Uganda. Secondary objective: • To determine factors associated with poor QoL among patients with COPD in rural Uganda.
Uganda 2022-05-13 10:05:27 2025-05-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Claude Raisaro
ID:
Driving Behaviors, Monetary Incentives and Norms: Experimental Evidence from the Ugandan Transit Industry
REFNo: SS1217ES

• To better understanding the underlying mechanisms to understand and incentivize safe driving behaviors for bodaboda drivers
• Examine how financial incentives affect driving behavior and to which extent is road safety impacted on an individual basis?.
• To learn whether beliefs about safe driving change in the presence of financial incentives.

 Italy 2022-05-13 10:01:06 2025-05-13 Social Science and Humanities Non-Clinical Trial Degree Award
Travis Baseler Andreas
ID:
The Effects of Voluntary Relocation and Forced Displacement by Natural Disasters: Evidence from Ugandan Landslides
REFNo: SS1263ES

We intend to study the economic effects of displacement following environmental disasters, with a focus on the displaced population. Our goal is to identify mechanisms behind economic outcomes for the displaced, to inform future adaptation policy and humanitarian responses. The setting of this study is landslide episodes in Eastern Uganda in 2010-2019, which have displaced nearly 10,000 people.
 USA 2022-05-12 8:00:58 2025-05-12 Social Science and Humanities Non-Clinical Trial Non-degree Award
Stella Neema
ID: UNCST-2019-R000814
 Knowledge, acceptability and Perception of Schistosomiasis and its treatment in Pre-school aged Children in Uganda
REFNo: SS1269ES

To ascertain knowledge on and perception of (pediatric) Schistosomiasis and acceptability of its treatment in PSAC on different levels To identify the demand of health education to inform the social mobilization and advocacy WP2 To analyse facilitators and barriers towards implementation of L-PZQ distribution for PSAC on different levels To inform planned interventions of the subsequent work packages on advocacy, social mobilization and communication strategies for the L-PZQ rollout based on the above-mentioned outcomes and assess L-PZQ implementations in the study sites
Uganda 2022-05-12 7:59:47 2025-05-12 Social Science and Humanities Non-Clinical Trial Non-degree Award
Femke Bannink Mbazzi Bannink
ID: UNCST-2023-R008308
 YOUNG AFRICA WORKS: DISABILITY INCLUSION RESEARCH PARTNERSHIP.
REFNo: SS1195ES

• To examine the policy environment and available programmes related to employment, education of youth with disabilities
• To explore the lived experiences around inclusion in education and employment from the perspective of youth with disabilities
• To identify key challenges, facilitators, gaps and opportunities relating to inclusion in education and employment for youth with disabilities

 Netherlands 2022-05-10 9:21:32 2025-05-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Herbert Kayiga Kayiga
ID:
EFFECTIVENESS, ACCEPTABILITY AND UPTAKE OF EARLY VERSUS STANDARD INTRAUTERINE CONTRACEPTION FOLLOWING PROVISION OF FIRST TRIMESTER MEDICAL POST ABORTION CARE IN CENTRAL UGANDA
REFNo: HS2111ES

1. To determine the proportion of women who take up IUC after mPAC for 1st trimester incomplete abortion. 2. To compare the expulsion rates at six months between early versus standard IUC insertions post mPAC treatment for first trimester incomplete abortion. 3. To compare the IUC continuation rates at six months between early versus standard IUC insertion post mPAC treatment for first trimester incomplete abortion. 4. To explore the women and their spouses' perception on Long Acting Reversible Contraceptives (LARC) and IUC following mPAC treatment. 5. To explore the Healthcare providers' perception on LARC and IUC following mPAC treatment.
Uganda 2022-05-10 9:21:09 2025-05-10 Medical and Health Sciences Clinical Trial Degree Award
Kizito Omona
ID: UNCST-2022-R011106
 Exploring Child-based Strategies in addressing Child-to-Child Violence in Primary Schools in Kitgum District, Northern Uganda
REFNo: SS1277ES

3) To find out how children use formal peer group-based strategies to overcome child-to-child violence in primary schools in Kitgum district.,To investigate how children involve their teachers and counsellors to overcome child-to-child violence in primary schools in Kitgum district.,To find out how children use formal peer group-based strategies to overcome child-to-child violence in primary schools in Kitgum district,To establish how children apply informal peer group-based strategies to overcome child-to-child violence in primary schools in Kitgum district.,To find out the individual child-based strategies used to overcome child-to-child violence in primary schools in Kitgum district,The general objective is to explore child-based Strategies in addressing child-to-child violence in Primary Schools in Kitgum District. ,
 Uganda 2022-05-10 9:19:59 2025-05-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Toke Wolff Moldrup
ID:
CERTIZENS: Certifications of Citizenship in Africa
REFNo: SS958ES

CERTIZENS is concerned with the ways in which states and citizens respectively get made, remade or unmade through inter-related systems, policies and practices associated with citizen classification, identification and certification.
 Denmark 2022-05-10 9:14:40 2025-05-10 Social Science and Humanities Non-Clinical Trial Degree Award
Victoria Nankabirwa
ID: UNCST-2021-R011871
 A multi-country, epidemiologic study to assess the interferon gamma release assay (IGRA) positivity, and to build capacity to conduct a tuberculosis (TB) vaccine efficacy study, in populations with a high TB disease burden
REFNo: HS2187ES

•To describe the proportion of IGRA positivity by site.
•To assess the association of age with proportion of IGRA positivity, by site.
•To describe the overall incidence of suspected and laboratory-confirmed pulmonary TB (disease).
•To describe changes in the proportion of IGRA positivity, by site.
•To describe the association between IGRA interferon gamma (IFN???concentration at screening and progression to pulmonary TB.


 Uganda 2022-05-10 9:13:30 2025-05-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Emmanuel Musisi
ID: UNCST-2020-R004472
 IDENTIFICATION AND EVALUATION OF BIOMARKERS FOR MYCOBACTERIUM TUBERCULOSIS DETECTION AND MONITORING RESPONSE TO ANTI-TUBERCULOSIS THERAPY
REFNo: HS1378ES

(i) To measure the accuracy of TB-MBLA in detecting TB in sputum and non-sputum samples with reference to standard of care tests (Xpert MTB/ RIF/Ultra, sputum microscopy and culture)

(ii) To determine accuracy and utility of TB-MBLA in monitoring TB treatment response and predicting treatment outcomes in comparison with standard of care tests

(iii) To examine the correlation of TB-MBLA-measured sputum bacillary load and host gene markers for monitoring treatment response and outcome

Uganda 2022-05-10 18:22:50 2025-05-10 Medical and Health Sciences Non-Clinical Trial Degree Award
Agnes  Nakakawa
ID:
Towards an ICT-driven Community-based Nutrition Education network for increasing awareness and knowledge transfer on Maternal Nutrition (NEMAT)
REFNo: SS1224ES

AIM:
The research aims at increasing community-level awareness on maternal nutrition and adoption of healthy nutrition practices among women of reproductive age, through establishing an ICT-driven community-based nutrition education network for supporting transfer of information/knowledge on maternal nutrition aspects.

SPECIFIC OBJECTIVES
Specifically, this research will:
1) Increase availability and accessibility of maternal nutrition information/knowledge, through developing an ICT platform for disseminating IEC materials on maternal nutrition.
2) Enable timely sharing of information/knowledge on challenges in maternal nutrition and solution/best practices, through supporting interactive dialogue between health and nutrition specialists and women at community level.
3) Enable contextual understanding of maternal nutrition aspects and required interventions, through prompting women to provide feedback on IEC materials and devising control measures for continuous improvement of IEC materials.
4) Ensure existence of an operational multidisciplinary and community-based stakeholder network, through leveraging on the role of community health extension workers to establish the network and continuously monitor its performance.

 Uganda 2022-05-10 17:20:25 2025-05-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Samuel Okech George
ID:
Assessing ethical conflicts and moral distress among veterinarians in Uganda.
REFNo: A177ES

1. Establish the awareness of veterinarians in Uganda about ethical dilemmas and moral distress
2. Determine causes, nature and extent of ethical dilemmas and the degree of moral distress they cause.
3. Determine coping mechanisms employed by veterinarians against ethical dilemmas and moral distress.
 Uganda 2022-05-09 19:06:32 2025-05-09 Agricultural Sciences Non-Clinical Trial Non-degree Award
Angela Gallego Sala Victorina
ID:
TroPeaCC: Tropical Peatlands and the Carbon Cycle
REFNo: NS310ES

Tropical peatlands are the most carbon-dense ecosystems in the world and they store the equivalent of ~10 years of global anthropogenic CO2 emissions. Despite their importance, crucial questions remain about carbon cycling in tropical peatlands and improving understanding is critical as they are at high risk from deforestation and drainage for oil palm cultivation.
TroPeaCC will provide a step-change gain in our understanding of tropical peatland functioning and in projecting their response to climate change.
PI Gallego-Sala will use her unique background that bridges peatland modelling and observations to deliver a novel interdisciplinary approach to tackle four outstanding questions about tropical peatlands:
Q1: What controls the geographical distribution of peatlands in the tropics? TASK1: To assess the tropical peatland extent using a combination of models
Q2: How large is the tropical peatland CO2 sink and what are its main climatic drivers? TASK2: To characterize the drivers of carbon accumulation rates in tropical peatlands using the palaeo-archive.
Q3: How large is the methane flux in tropical peatlands? What are the main controls at the intercontinental scale? TASK3: To determine the main controls on methane fluxes in tropical peatlands, using eddy covariance, chamber-based gas flux measurements, and ground penetrating radar.
Q4: What is the overall carbon balance of tropical peatlands and how will this change in the future? TASK4: To forecast future changes of the extent of tropical peatlands, of their carbon store and of methane emissions, using the results of tasks 1-3 to parameterise and evaluate a global dynamic vegetation model that includes tropical peatlands for the first time.

The interdisciplinary approach will lead to a comprehensive understanding of the role of tropical peatlands in the global carbon cycle, allowing their inclusion in earth system models, and improving their management to optimise provision of ecosystem services including carbon capture and storage.

 Spain 2022-05-09 19:05:30 2025-05-09 Natural Sciences Non-Clinical Trial Non-degree Award
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