Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Patricia NAHIRYA Ntege Nahirya
ID: UNCST-2019-R001117
IMPACT OF SERIOUSFUN OVERNIGHT CAMP PROGRAMS ON ADHERENCE TO ANTI-RETROVIRAL THERAPY AND VIROLOGICAL SUPPRESSION AMONG CHILDREN AND ADOLESCENTS (9 to 19 YEARS) LIVING WITH HIVRECEIVING CARE AT BAYLOR-UGANDA COE CLINIC
REFNo: HS2580ES

General objective
To determine the effect and impact of attending camp on adherence to ART and virologic suppression among children and adolescents receiving care at Baylor Uganda COE.

Specific objectives
1. To retrospectively examine potential changes in viral load of ALHIV before, and a year after first attending overnight camp.

2. To compare viral loads of ALHIV who attended overnight camp to those who have never attended overnight camp.

3. To explore experiences and perceptions about overnight camp amongst ALHIV who have attended camp.

Uganda 2023-01-18 18:27:44 2026-01-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
Evaluation of the performance of novel molecular point of care diagnostics for SARS-CoV-2
REFNo: HS2588ES

To assess the ease of use of the molecular POC devices being evaluated using a System Usability Scale (SUS) questionnaire administered to platform’s operators (minimum 3, where possible)., To evaluate the diagnostic accuracy of such platforms in detecting SARS-CoV-2 on respiratory specimens, compared with reference standard RTPCR in specific subgroups defined based on disease stage (days since symptoms onset), RTPCR Ct values (as surrogate for viral load). Participant’s vaccination status, previous COVID-19 infection(s) and SARS-CoV-2 genetic variant causing participant’s infection, determined by sequencing of the viral genome, may also be considered as subgroups. , To evaluate the diagnostic accuracy of molecular POC devices in detecting SARS-CoV-2 on respiratory specimens, compared with reference standard RT-PCR (WHO EUL or FDA EUA approved), among COVID-19 symptomatic individuals,
Uganda 2023-01-18 18:21:06 2026-01-18 Medical and Health Sciences Clinical Trial Non-degree Award
Diana  Rutebarika Antonia
ID:
Child and Adolescent Research Moving towards Alternative Interventions.
REFNo: HS2525ES

1.To characterize the functionality of viral reservoir in early treated children who have been on ART for 7 or more years and are currently virally suppressed.
2.To investigate whether the profile of past response to ART and pre-ART characteristics are associated with small or less functional viral reservoirs.
3.To investigate whether there’s persisting immune dysregulation despite viral suppression and whether host genes and immune phenotypes including markers of immunosenescence and exhaustion, are associated with smaller and less functional viral reservoirs.
4.To investigate attitudes and beliefs, perceived social norms, perceived behavioral control, and intentions to participate in future trials that test interventions to achieve remission.

Uganda 2023-01-18 18:17:30 2026-01-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Andrew Edielu
ID:
Role of Schistosoma mansoni in development of Environment Enteric Dysfunction in Pre-School aged Children (SEEP) in the Albertine Region, Western Uganda
REFNo: HS2505ES

i. To determine the effect of Schistosoma mansoni infection, as diagnosed by urine Circulating Anodic Antigen (CAA), on serum/stool EED biomarkers of PSAC in Albertine region of Uganda. ii. To determine the effect of Environmental Enteric Dysfunction on Pharmacokinetics of praziquantel as measured by Area Under the Curve (AUC) in PSAC treated for Schistosoma mansoni infection iii. To describe individual and combined effects of S. mansoni infection and EED on gut microbiota in PSAC iv. To determine the accuracy and reliability of EED stool and serum biomarkers in predicting urine Lactulose-Mannitol ratio as the gold standard for diagnosis of EED
Uganda 2023-01-18 18:15:09 2026-01-18 Medical and Health Sciences Non-Clinical Trial Degree Award
Semitala Fred
ID: UNCST-2020-R014202
PULESA-Uganda: A stepped-wedge cluster randomized trial of implementation strategies to integrate hypertension care into HIV clinics of Kampala and Wakiso District, Uganda
REFNo: HS2398ES

To determine the effectiveness of HTN-BASIC and HTN-PLUS strategies to improve hypertension cascade metrics
To determine implementation outcomes of HTN-BASIC and HTN-PLUS strategies
To evaluate the economic and financial sustainability of the HIV-HTN integrated care strategies

Uganda 2023-01-18 18:13:10 2026-01-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Enoch Asiimwe Asiimwe
ID: UNCST-2022-R010482
The significance of Social Capital and Livelihoods of Urban Refugees “A Study of Democratic Republic of Congo (DRC) Refugees in Kampala city”
REFNo: SS1311ES

1. To investigate how Congolese refugees living in urban setting build their social capital
2. To explore how urban refugees, use social capital to sustain their livelihoods
3. 1.3.1.3 To investigate the impact of Covid 19 on the urban refugees’ social networks and livelihoods.
Uganda 2023-01-18 17:59:42 2026-01-18 Social Science and Humanities Non-Clinical Trial Degree Award
Martin Kizito -
ID:
A framework for enhancing the influence of evaluation in the implementation of the African Peer Review Mechanism (APRM).
REFNo: SS1568ES

i. To assess the role of the APRM evaluation process (inputs, activities, and outputs) in influencing the type of use or non-use in Uganda’s public policy. ii. To examine the contribution of participating stakeholders in determine the type of use of APRM data within Uganda’s public policy. iii. To analyse the extent to which the political context of the APRM system influences the type of use or non-use in Uganda’s public policy. iv. To generate strategies for enhancing the APRM framework so it that can positively influence integration of APRM finding into public policy at the National level of AU member states.
Uganda 2023-01-18 17:55:15 2026-01-18 Social Science and Humanities Non-Clinical Trial Degree Award
Cynthia Moffitt
ID: UNCST-2022-R011033
Improving Adherence to Malaria Treatment Guidelines in Children at a Ugandan Regional Hospital
REFNo: HS2633ES

1. To determine the current level of adherence to severe malaria treatment protocols at MRRH. 2. To determine the factors responsible for poor adherence to severe malaria treatment protocols. 3. To assess the treatment outcomes at the current severe malaria treatment protocol adherence. 4. To design an adherence improvement intervention
USA 2023-01-18 17:51:42 2026-01-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Naohiko Omata
ID:
Refugee Economies Programme in Uganda: Mobility, Shocks, and Livelihoods
REFNo: SS1584ES

How can refugees’ ability to cope with shocks be strengthened?,What are the main coping strategies used by refugee households in case of negative shocks? ,What types of shock do refugees face and what is the impact of these shocks? ,How do these movements contribute to refugees’ livelihood strategies and self-reliance, and thereby determine socio-economic outcomes? ,What are the patterns and drivers of refugees’ mobility? ,
Japan 2023-01-13 13:57:27 2026-01-13 Social Science and Humanities Non-Clinical Trial Non-degree Award
Stevens Bechange
ID: UNCST-2022-R009190
Rapid assessment of avoidable blindness Karamoja, Uganda
REFNo: SS1558ES

To analyse changes in the prevalence and causes of blindness and visual impairment, and the coverage of cataract surgical services, since 2015 and investigate the associated fac-tors. ,To explore the relationship between eye health status and access to cataract services, by other personal and health characteristics, and to identify those most at risk of poor eye health status and low coverage of services; ,To assess the coverage of refractive error and trachoma surgical services;,To determine the barriers to uptake of cataract services,To assess the coverage of cataract surgical services and visual outcomes from cataract surgery;,To determine the major causes of blindness and visual impairment;,To determine the prevalence and distribution of blindness and visual impairment in the study population;,To asses the eye health status, unmet eye health needs, and eye health service coverage among people aged ?50 years in Karamoja sub-region in Uganda, identify factors associated low coverage of services, and compare this with the situation in 2015.,
Uganda 2023-01-13 13:55:52 2026-01-13 Social Science and Humanities Non-Clinical Trial Non-degree Award
George William Ddaaki
ID: UNCST-2022-R009216
Cognitive Testing of a survey instrument to assess sexual practices, behaviours, and health-related outcomes.
REFNo: HS2540ES

To determine the ‘global applicability’ of this instrument within the general population, this study’s target population will be the general population, defined as those ages 15+ across diverse cultures.
Uganda 2023-01-13 13:50:13 2026-01-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Phoebe Mbabazi
ID: UNCST-2020-R014098
Prevalence, Clinical and Immunological Predictors and Outcomes of Frailty among Older Adults with HIV in Kampala
REFNo: HS2468ES

1.To compare the prevalence and clinical factors associated with frailty among older adults with HIV enrolled in the geriatric cohort at the IDI clinic and HIV uninfected older adults in the community in Kampala.
2.To determine the association of immune activation, immune senescence and frailty among older adults with HIV enrolled in the geriatric cohort at the IDI clinic
3.To compare the impact of frailty and comorbidity on the health-related quality of life of older adults with HIV enrolled in the geriatric cohort at the IDI clinic and HIV uninfected older adults in the community in Kampala.
4. To determine the impact of frailty and pre-frailty on morbidity and mortality among older adults with HIV enrolled in the geriatric cohort at IDI

Uganda 2023-01-13 13:47:13 2026-01-13 Medical and Health Sciences Non-Clinical Trial Degree Award
William Lumu
ID:
Hyperglycemia, Cardiovascular Risk and Clinical Outcomes among Patients with Coronavirus Disease 2019 Hospitalized in Mengo Hospital: A Retrospective study
REFNo: HS2627ES

i) To describe the magnitude and categories of hyperglycaemia among patients admitted with COVID-19 in Mengo Hospital COVID 19 patients from December 2020 to August 2021.
ii) To assess the correlation between hyperglycaemia and clinical outcomes (length of stay, ICU admissions, mortality) among COVID 19 patients admitted to Mengo Hospital CTU from December 2020 to August 2021
iii) To assess the magnitude of the CVD risk among COVID 19 patients admitted to Mengo Hospital CTU over the 9-month period from December 2020 to August 2021.
iv) To determine the correlation between CVD risk and the clinical outcomes among COVID19 patients admitted with hyperglycaemia in Mengo Hospital CTU from December 2020 to August 2021.

Uganda 2023-01-11 12:56:37 2026-01-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
ROSCO KASUJJA
ID: UNCST-2019-R000504
A PROOF-OF-CONCEPT STUDY OF THE PROACTIVE COMMUNITY CASE DETECTION TOOL PLUS FOR CHILDREN AGED 6-18 YEARS OLD IN NEED OF MENTAL HEALTHCARE SERVICES IN PALORINYA SETTLEMENT, UGANDA
REFNo: HS2609ES

The objective is to assess the implementation outcomes and potential added value in accuracy and utilization outcomes associated with CCDT+ compared to regular CCDT.,
Uganda 2023-01-11 12:55:06 2026-01-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Martin Buhamizo
ID:
Bureaucracies of National Digitisation and Citizen Certification in Uganda
REFNo: SS1551ES

1.To find out the bureaucratic policies, practices and procedures resulting from the introduction of a digitised national identification and citizen certification system in Uganda
2.To examine the experiences and interpretations by bureaucrats of their work and roles in implementing digitised national ID and registration systems at national and local levels.
3.To examine how citizens experience and interpret their encounters with identification registration bureaucracies at different levels.

Uganda 2023-01-11 12:51:34 2026-01-11 Social Science and Humanities Non-Clinical Trial Degree Award
Abishag Namutebi Matovu
ID:
Individual Characteristics, Social and Academic Integration as Predictors of Program Completion of PhD Students in Makerere University.
REFNo: SS1550ES

i. To examine individual characteristics of PhD students as predictors of program completion in Makerere university.
ii. To examine social integration as a predictor of program completion of PhD students in Makerere University.
iii. To examine academic integration as a predictor of program completion of PhD students in Makerere University.

Uganda 2023-01-11 12:49:08 2026-01-11 Social Science and Humanities Non-Clinical Trial Degree Award
Winnie  Muyindike R
ID: UNCST-2021-R013558
IeDEA East Africa Tuberculosis Sentinel Research Network (IeDEA-EA TB-SRN)
REFNo: HS2619ES

3. To describe post-TB lung disease (PTLD) and associations with HIV infection, diabetes, chronic lung disease, and tobacco and alcohol use, including measuring physiologic, structural, and functional impairment, health-related quality of life, and survival,2. To assess the individual-level effects of HIV and antiretroviral therapy (ART) on TB symptomatology, diagnosis, treatment response, and survival. ,1. To collect and analyze clinical and treatment data among people treated for pulmonary TB with or without HIV-co-infection, in order to improve understanding of the prognosis of TB disease and its health-related outcomes, including quality of life and survival.,The overarching objective/aim of the study is to assess pulmonary TB treatment and longer-term outcomes among people with and without HIV in TB-SRN sites in order to inform policy and practice around TB treatment and create a platform for additional TB research within IeDEA. ,
Uganda 2023-01-11 12:47:27 2026-01-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
HARRIET NAMBUYA NIL
ID: UNCST-2021-R013414
Burden, electrolyte derangement and nutritional recovery among children with pneumonia hospitalized with severe acute malnutrition Ref No: Mak-SOMREC-2021-123
REFNo: HS2597ES

1. To determine the burden and associated factors of pneumonia in children hospitalized with severe acute malnutrition.,5. To describe the clinical outcomes of children with pneumonia and electrolyte derangements hospitalized with severe acute malnutrition.,4. To assess the effect of pneumonia on nutritional recovery among children hospitalized with severe acute malnutrition.,3. To assess the effect of pneumonia on electrolyte derangements and normalization in children hospitalized with severe acute malnutrition. ,2. To determine the prevalence, associated factors and clinical outcomes of CMV- associated pneumonia in children hospitalized with severe acute malnutrition. ,
Uganda 2023-01-11 10:57:57 2026-01-11 Medical and Health Sciences Non-Clinical Trial Degree Award
Richard Echodu
ID:
ASSESSING THE GENOMIC EPIDEMIOLOGY OF EMERGING ARTEMISININ COMBINATION THERAPY RESISTANCE IN DISTRICTS WITHIN THE ACHOLI SUBREGION, UGANDA
REFNo: NS393ES

To assess the prevalence of kelch13 mutations in the Palabek refugee settlement in the Lamwo district. ,To evaluate samples from patients presenting to the Gulu Regional Referral Hospital for in vitro drug resistance assays,To assess the community-wide prevalence of kelch13 and partner drug resistance-associated mutations,Assessing the genomic epidemiology of emerging artemisinin resistance in Acholi district,
Uganda 2023-01-11 10:55:42 2026-01-11 Natural Sciences Non-degree Award
Hannah Kibuuka
ID: UNCST-2020-R014355
Secondary use of blood samples and de-identified clinical data from a severe infectious illness cohort for diagnostic prediction model and evaluation of a multiplex RTPCR platform for acute tick-borne infections detection
REFNo: HS2107ES

i. Develop a clinical prediction model for tick borne-illness incorporating host-derived biomarkers and
ii. Develop and validate an ultra-sensitive multiplex reverse transcription PCR method to detect acute tick-borne illness

Uganda 2023-01-11 10:54:26 2026-01-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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