Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Adelline Twimukye
ID: UNCST-2019-R000117
 HIV CARE AND ANTENATAL HEALTH SEEKING BEHAVIOUR PATTERNS OF PREGNANT AND BREAST-FEEDING WOMEN DURING PREVIOUS COVID-19 PANDEMIC IN UGANDA
REFNo: SS3219ES

To document the challenges faced by pregnant and breastfeeding women with HIV in accessing healthcare services in the COVID-19 period.,To interrogate the effects of COVID-19 pandemic to adherence to routine clinic appointments and antiretroviral therapy (ART) among pregnant and breast-feeding women living with HIV.,To examine the social or cultural norms that influence access to care among pregnant or breast-feeding women HIV during the COVID-19 pandemic.,To investigate health care worker’s knowledge, attitude, and practices about COVID-19 among pregnant and breast-feeding women living with HIV in Uganda.,The purpose of the study is to explore HIV care and antenatal seeking behavior patterns of pregnant and breast-feeding women during response and control of COVID-19 pandemic in Uganda.,
 Uganda 2024-12-10 14:37:39 2027-12-10 Social Science and Humanities Non-Clinical Trial Degree Award
VICENT MWESIGYE
ID: UNCST-2024-R002866
 LYMPHEDEMA: CAUSATIVE AGENTS, PATIENT AND CARETAKER KNOWLEDGE, SELF-REPORTED HEALTHCARE NEEDS AND PREVENTIVE STRATEGIES IN KAMWENGE DISTRICT.
REFNo: HS5335ES

3. To explore the lymphedema-related knowledge, lived experiences and healthcare needs of patients and their caretakers and preventive strategies in Kamwenge district, South Western Uganda.,2. To determine the causative agents of lymphedema among patients with lymphedema in Kamwenge district, South Western Uganda.,1. To describe the Preventive strategies, their effectiveness in patients with Lymphedema based on Scoping review globally.,To determine the causative agents, patient and caretaker knowledge, self-reported healthcare needs and preventive strategies amongst Lymphedema patients in Kamwenge District South Western Uganda.,
 Uganda 2024-12-10 14:35:45 2027-12-10 Medical and Health Sciences Non-Clinical Trial Degree Award
Tess Lallemant
ID: UNCST-2023-R007159
 How do Firms Hire? A Demand-Side Experiment to Reduce Matching Frictions in Uganda Labor Markets
REFNo: SS3487ES

1. Answer the research question: How do firms navigate the hiring process for graduate workers?
2. Answer the research question: How are firms identifying their employment needs?
3. Answer the research question: How are firms communicating their employment needs?
4. Answer the research question: To what extent are these hiring frictions affecting match quality?
5. Answer the research question: Do firms learn about hiring and adapt their search strategies to achieve higher match quality?
 USA 2024-12-10 14:24:53 2027-12-10 Social Science and Humanities Non-Clinical Trial Degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 Optimizing the Implementation and Scale-Up of the WHO Treatment-Decision Algorithms for Children with Pulmonary Tuberculosis in Sub-Saharan Africa (OPTIC-TB)
REFNo: HS5246ES

1) To compare the effectiveness of TDA versus the Standard of Care strategies in routine non-research programmatic conditions.
2) To identify processes and contextual factors that influence the effectiveness and fidelity in the implementation of TDA.
3) To compare the costs, cost-effectiveness, and population-level impact of the TDA strategies on the burden of TB.
4. To estimate/validate the diagnostic performance (sensitivity, specificity, negative and positive predictive values) of the TDAs for TB in children under 10 years old in various healthcare system settings and in various clinical contexts (i.e, such as HIV, malnourished children, facility level, gender, rural, urban etc.

Uganda 2024-12-10 14:06:31 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Vianney Tushabe John
ID: UNCST-2024-R015708
 Development of Multiplex Molecular Test for S. mansoni and P. falciparum Duplex using LAMP assay and Pit Latrine metagenomic sampling for community assessment
REFNo: SIR445ES

- Development of the Multiplex Malaria – Schistosomiasis assay
- Latrine Metagenomics for community diagnostics assessment 
- Validation of Molecular duplex assay technology 
 Uganda 2024-12-10 14:04:09 2027-12-10 Engineering and Technology Non-Clinical Trial Degree Award
Manon Delvaux Alizee
ID: UNCST-2024-R002311
 Cultivating Cooperation: The Impact of Formalizing Land Rental Contracts on Refugee-Host Interactions and Agricultural Production in Rural Uganda
REFNo: SS3408ES

In northern Uganda, food insecurity is high for many refugees, who cultivate land for their subsistence in the vicinity of the settlements. A large majority of these refugees do not have a formal written land rental contract with their landlords. While informal institutions and agreements can have enforcement power in socially and culturally homogeneous groups, their efficiency tends to decrease with social and cultural distance. In this setting of cohabitation between Ugandans and refugees, the absence of clearly defined terms of trade often limits successful farming outcomes, as refugees’ rights to what they earn, produce, and consume are more vulnerable to changes. Suggestive evidence indicates that formal land contracts grant greater security, which can lead to increased farm profitability, investment and credit opportunities, and greater economic diversification and growth.

We will conduct a randomized pilot evaluation to measure the impact of formalized land rental contracts between refugee tenants and host community landlords. In the treatment groups, the landlords and tenants will receive support to formalize their land rental agreement. In the control group, landlords and tenants will remain with verbal and informal land rental agreements. We will evaluate indicators such as trust, social cohesion, agricultural practices, and food security. The study will also investigate why formalized land rental contracts are not more widespread in rural Uganda. The sample will include tenants from the Bidibidi, Imvepi and Rhino refugee settlements and landlords from the host communities.
 France 2024-12-10 14:03:00 2027-12-10 Social Science and Humanities Non-Clinical Trial Degree Award
SAM ALI
ID: UNCST-2020-R014824
 A Noncontact Bed-Based Platform for Passive Longitudinal Monitoring of Maternal and Fetal Cardiovascular Physiology in Uganda
REFNo: HS5320ES

Main objective
• To monitor maternal and fetal heart rate, respiratory rate, fetal movement, and sleep patterns among selected pregnant women enrolled in the iTECH study using noncontact bed sensors with the goal of better understanding both maternal and fetal physiology.

Specific objectives
1. To describe the maternal respiratory and heart rate profiles among selected pregnant women enrolled into the iTECH study.
2. To describe the fetal respiratory and heart rate profiles among selected pregnant women enrolled into the iTECH study.
3. To demonstrate the feasibility of measuring and extracting fetal movement signals among selected pregnant women enrolled into the iTECH study.
 Uganda 2024-12-09 13:22:54 2027-12-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
DAVID KATEETE PATRICK
ID: UNCST-2020-R004018
 Disentangling the population structure of MRSA in an urban low-income settings
REFNo: HS4699ES

1. To define the population structure of MRSA in hospital and community settings in Kampala, and identify risk factors for MRSA carriage among inpatients and individuals in the community.

2. To Investigate the probable coexistence between HA-MRSA and CA-MRSA in hospital and community in Kampala.
 Uganda 2024-12-02 17:33:35 2027-12-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Brian Turigye
ID: UNCST-2021-R012569
 QUALITY OF MATERNAL AND NEWBORN CARE; A CASE STUDY OF KASESE AND BUNDIBUGYO DISTRICTS, MIDWESTERN UGANDA
REFNo: HS5213ES

1. To describe existing evidence on the quality of Provision of Obstetric and newborn care in Uganda
2. To establish the quality of provision of Obstetric and newborn care in Midwestern Uganda
3. To explore the determinants and drivers of the quality of provision of Obstetric and newborn care in Midwestern Uganda
4. To analyze critically the existing strategies on improving the provision of Obstetric and newborn care in Midwestern Uganda and develop relevant alternatives

 Uganda 2024-12-02 17:32:38 2027-12-02 Medical and Health Sciences Non-Clinical Trial Degree Award
Damari Atusasiire
ID: UNCST-2024-R002645
 Lively Minds Together Range and Listenership Estimation
REFNo: SS3435ES

To gather data on the signal strength of radio programs of interest,To provide evidence-based recommendations on geographic locations and radio programming for the future rollout and evaluation of the Lively Minds Together project.,To understand preferences, popularity, and other media sources related to radio programming.,To collect general information on radio listenership habits.,To gather data on the number of listeners for the radio programs of interest.,
 Uganda 2024-12-02 17:31:19 2027-12-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Idris Sanusi
ID: UNCST-2024-R003856
 EVALUATION OF THE CONCENTRATIONS OF PHARMACEUTICALS AND HEALTH RISK ASSESSMENT IN GROUND AND SURFACE WATERS IN KAMPALA AND MBARARA REGIONS OF UGANDA
REFNo: HS5235ES

I. To assess the physicochemical parameters (pH, water temperature, electrical conductivity, total dissolved solids, total suspended solids, total solids, chlorides, nitrate, phosphate and sulphate) in the collected water samples from the selected areas as pollution indices. II. To determine the concentrations of iron, copper, mercury, cadmium, manganese and lead in surface water and groundwater of the study regions. III. To determine the concentrations of the pharmaceuticals (sulfamethoxazole, ciprofloxacin, ibuprofen, amoxicillin, cotrimoxazole, metronidazole, artemether/lumefantrine, acetaminophen, caffeine, and carbamazepine) in surface water and groundwater of the study regions. IV. To assess the spatio-temporal variation of heavy metals and pharmaceuticals in the water samples collected from the regions. V. To assess the health risks associated with the exposure to pharmaceuticals and heavy metals in the water samples collected.
Nigeria 2024-12-02 17:29:38 2027-12-02 Medical and Health Sciences Non-Clinical Trial Degree Award
Ibrahim Kasujja
ID: UNCST-2021-R013169
 Food Insecurity and Mental Health among Children and Adolescents: Mixed Methods Study in Uganda
REFNo: HS4997ES

Objectives:

(1) to conduct a formative qualitative study to explore the children’s and teachers’ perceptions of food insecurity experiences and child and adolescent mental health
(CAMH) to ultimately build a framework which links food insecurity and CAMH in schools in Uganda,

(2) to conduct a reliability and validation study to assess the psychometric properties of the day scholars food insecurity experience scale (DSFIES) by examining test-retest reliability and criterion validity in
schools in Uganda, and

(3) to conduct a prospective cohort study to unpack the causal mechanisms linking food insecurity and CAMH by examining bidirectional temporal associations among seven to 13 years old children in Uganda.
 Uganda 2024-12-02 17:28:44 2027-12-02 Medical and Health Sciences Non-Clinical Trial Degree Award
Timothy Opobo
ID: UNCST-2023-R006042
 The Prevalence of Violence against Children in School and the Effectiveness of Reporting, Tracking, Referral and Response Mechanisms in Schools in Karamoja Sub-Region
REFNo: SS3414ES

1. Establish the prevalence and nature of VAC/VACiS among children, including their age, sex, grade, and vulnerability/disability status.
2. Identify, describe and quantify structures that children report cases of violence to when they occur
3. Identify existing mechanisms for referral, response and tracking cases of violence against children in schools?

 Uganda 2024-12-02 17:24:47 2027-12-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Godfrey Ejuu
ID: UNCST-2021-R013978
 IMPACT OF THE UNLOCK LITERACY PROJECT MODEL ON THE READING RESULTS FOR GIRLS AND BOYS IN EARLY GRADES IN UGANDA
REFNo: SS3379ES

7. To find out the challenges to implementing the Unlock literacy model in primary schools,6. To determine the cost of the UL model in the Ugandan setting,5. To identify the key lessons so far learned during implementation of the UL model.,4. To establish whether the Unlock literacy model contributes to increased support by education authorities for children\'s reading,3. To assess the extent to which the Unlock literacy model interventions are influencing support by parents or guardians and communities for children\'s reading.,2. To establish whether the Unlock literacy model contributes to strengthened teaching instruction in Primary 1–3.,1. To determine the extent to which the Unlock literacy model contributes to increased reading results of children.,The main purpose of this study is to examine the impact of the UL Project Model on the reading results for girls and boys in early grades in selected World Vision implementing districts in Uganda.,
 Uganda 2024-12-02 17:21:46 2027-12-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Salvatore Ssemmanda
ID: UNCST-2024-R004583
 KNOWLEDGE OF ALARM SIGNS OF STROKE AMONG CARETAKERS OF STROKE PATIENTS AND FIRST CONTACT HEALTH CARE PROVIDERS AT TWO TERTIARY REFERRAL HOSPITALS IN UGANDA
REFNo: HS5181ES

General objective.

To describe how well the alarm stroke signs summarized in the BE-FAST mnemonic are known by acute stroke patients’ caretakers and first contact stroke health care providers and how this knowledge by the acute stroke patients’ caretakers affects time of arrival of stroke patients to stroke services in the two major stroke referral hospitals in the country.

Specific objectives:

> To describe the knowledge of the BE-FAST acute stroke symptoms and signs by the first contact stroke health care providers in the two major stroke referral hospitals in Kampala, Uganda

> To describe the knowledge of the BE-FAST acute stroke symptoms and signs by the acute stroke patients’ bedside caretakers in the two major stroke referral hospitals in Kampala, Uganda.

> To demonstrate the relationship between knowledge of BE-FAST acute stroke alarm signs by stroke patient caretakers and time of arrival of their stroke patients to hospital stroke services in in
the two major stroke referral hospitals in Kampala, Uganda.
 Uganda 2024-12-02 17:19:44 2027-12-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Obinna Barah Onyebuchi
ID: UNCST-2024-R002664
 Investigation of Tribomechanical Properties of Aluminium (AA6061) Reinforced with Hybridized Agro-Marine Waste for Automotive Applications
REFNo: SIR428ES

Main Objective
This research aims to investigate the tribomechanical properties of Aluminum (AA6061) reinforced with hybridized agro-marine waste particle composites (AMWPCs) for enhanced automotive applications.
Specific Objectives
1. To assess tensile, compressive strength, and hardness characteristics of AMWPCs for ascertaining the material\'s strength under various loading conditions, and resistance to indentation or scratching respectively.
2. To investigate flexural strength, impact, and fatigue resistance of AMWPCs under dynamic loading conditions.
3. To evaluate the tribological effects and wear resistance of AMWPCs in enduring wear and friction.
4. To examine the material\'s microstructure and elemental composition using FTIR, SEM/EDS.
5. To Analyze AMWPCs phase transitions and thermal stability using DTA, and TGA.
 Nigeria 2024-12-02 17:18:19 2027-12-02 Engineering and Technology Non-Clinical Trial Degree Award
Hannington Ngabirano
ID: UNCST-2024-R003312
 Improving Pesticide Use in Food Crop Growing in Kigezi Sub-Region in South-western, Uganda. RefNo: KABREC-2024-238
REFNo: NS873ES

2. Training farmers and dealers in agro-inputs on pesticide use in food crops in Kabale, Rukiga, Rubanda, Kisoro, Kanungu and Rukungiri Districts.,1. Investigate pesticide use in food crops in south-western Uganda,
 Uganda 2024-12-02 17:16:00 2027-12-02 Natural Sciences Non-Clinical Trial Non-degree Award
Waiswa Peter
ID: UNCST-2020-R014921
 NEOSEPSIS Project: Reducing neonatal and maternal mortality by rapid detection of sepsis in resource-limited environments
REFNo: HS5058ES

1) Explore and evaluate potential distribution channels and market entry strategies for the NeoSep SAA test. 2) Identify and analyze the barriers that may impede the widespread adoption of the NeoSep SAA test. 3) Determine the cost-effectiveness of implementing the NeoSep SAA test in clinical settings in healthcare resource limited settings and systems. 4) Assess the NeoSep SAA test’s performance as compared to CRP test. 5) Evaluate the applicability of the NeoSep SAA test for the detection of maternal sepsis occurring after the first five days of birth. 6) Assess the NeoSep SAA test’s utility in monitoring response to antibiotic therapy in neonates who have undergone treatment for sepsis.7) Evaluate the diagnostic performance of the optimized NeoSep SAA test for neonatal sepsis by evaluating its sensitivity, specificity, PPV, and NPV.
 Uganda 2024-12-02 17:12:10 2027-12-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Emmanuel Katende
ID: UNCST-2023-R006954
 ASSESSMENT OF THE CURRENT STATE OF CHILD TRAFFICKING INTO WORST FORMS OF CHILD LABOUR IN NAPAK AND KAMPALA DISTRICT, UGANDA
REFNo: SS2547ES

i. To assess the current nature and dynamics of child trafficking in Napak and Kampala districts.

ii. To indentify the current key factors contributing to child trafficking in Napak district.

iii.To evaluate the community awareness and acceptance levels regarding child trafficking in Napak district.

 Uganda 2024-12-02 17:10:31 2027-12-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Patrick Kagurusi Tumusiime
ID: UNCST-2021-R012687
 PROJECT MID TERM EVALUATION OF WATER SANITATION AND HYGIENE FOR SEXUAL REPRODUCTIVE HEALTH AND RIGHTS IN AMURU DSITRICT, NORTHERN UGANDA (PIWA Maleng II Project).
REFNo: SS3385ES

1.2 Purpose of the research study/study protocol
To highlight the evaluation process that will be followed during the mid-term evaluation that aims at determining the access and utilization of SRHR services among youths, establishing the barriers and enablers to SRHR services and establish the effect of integration of SRHR and WASH on Menstrual hygiene management among adolescents and youths in communities and schools in Lamogi and Pabbo sub counties in Amuru district.

1.3 Specific objectives of the mid-term evaluation
This mid-term evaluation will aim to achieve the following broad objectives;
i. Determine the level of access and utilization of SRHR services among adolescents and youths in target communities of Pabbo and Lamogi sub counties.
ii. Establish the barriers and enablers of SRHR services uptake among adolescents, youths and women at target communities in Lamogi and Pabbo sub counties.
iii. Establish the effect of integration of SRHR and WASH on Menstrual Hygiene Management among adolescents and youths in target communities and schools of Lamogi and Pabbo sub counties.

 Uganda 2024-12-02 17:09:15 2027-12-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Ivan Sserwadda
ID: UNCST-2022-R009568
 Respiratory Microbiome: insights into the diagnosis and pathogenesis of Tuberculosis
REFNo: HS4329ES

To understand the role of bacterial, viral and fungal colonization or infection (other than Mycobacterium tuberculosis) in pulmonary TB and in the clinical performance of potential TB triage tests.,To employ the Sanity Respiratory Pathogen Panel (RPP36) for culture and sensitivity testing to identify clinically relevant respiratory pathogens in presumptive tuberculosis patients,To determine the association of the respiratory microbiota and socio-demographic characteristics among presumptive and confirmed tuberculosis patients,To determine the correlation between the clinically significant microbiota and clinical presentation among presumptive and confirmed tuberculosis patients,To determine the clinically significant pathogens co-infecting the presumptive tuberculosis patients ,A systematic review of the respiratory microbiome changes in relation to Tuberculosis,
 Uganda 2024-12-02 17:07:10 2027-12-02 Medical and Health Sciences Non-Clinical Trial Degree Award
Betty Akurut Enyipu
ID: UNCST-2021-R013556
 Prevalence of Anxiety and Depression Among Students of Uganda Christian University
REFNo: SS3474ES

Development of Innovative Psychotherapy Models: The project will result in the development of group-based psychotherapy models specifically designed to address depression and anxiety among university students. These models will draw upon evidence-based practices while also incorporating culturally relevant elements to ensure effectiveness within the Ugandan context.,
 Uganda 2024-12-02 17:06:13 2027-12-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
JUDITH NASSAAZI
ID: UNCST-2023-R007664
 ASSESSING THE KNOWLEDGE AND ATTITUDES OF CAREGIVERS TOWARDS PAEDIATRIC ORTHOPAEDIC SURGERY AT CORSU HOSPITAL
REFNo: HS5217ES

primary objectives;
-To assess the knowledge and attitude of caregivers towards paediatric orthopaedic surgery at CoRSU Hospital

Secondary Objectives
1. To determine the caregivers’ knowledge towards paediatric orthopaedic surgery at CoRSU hospital.
2. To determine the caregivers’ attitude towards pediatric orthopedic surgery at CoRSU hospital 3. To identify factors influencing caregiver decision-making in pediatric orthopaedic surgery
 Uganda 2024-12-02 17:05:18 2027-12-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Robert Ssekitoleko
ID: UNCST-2019-R001716
 Affordances of makerspaces influencing biomedical undergraduate engineering students' design learning and curriculum localization in Uganda and the USA
REFNo: SIR448ES

Main Objective
To explore and compare how the affordances of the DesignCube makerspaces at Makerere University and Duke University influence biomedical engineering students' design learning and the localization of curriculum by the end of the study period.

Specific Objectives
1.To determine the perceived affordances of the DesignCube makerspaces among undergraduate biomedical engineering students at Makerere University and Duke University within the first four weeks of their engagement in the design coursework.

2.To assess the actual affordances of the DesignCube maker spaces after students’ full engagement with the prototyping and design coursework by the end of the academic term.

3.To identify the factors that foster or limit student engagement with the DesignCube makerspaces at Makerere University and Duke University by the completion of the study.

4.To evaluate how the affordances identified in each context (Makerere and Duke) inform the localization and adaptation of curriculum and pedagogy for design learning in biomedical engineering by the final stage of the study.
 Uganda 2024-12-02 17:04:31 2027-12-02 Engineering and Technology Non-Clinical Trial Non-degree Award
Abel Mucunguzi
ID: UNCST-2023-R006397
 LEVERAGING THE TEA VALUE ADDITION CHAIN PROJECTS FOR COMMUNITY DEVELOPMENT AND POVERTY REDUCTION: EVALUATING NAADS SUPPORT TO TEA INDUSTRY IN GREATER BUSHENYI, UGANDA
REFNo: SS3382ES

1.4.1 To ascertain the number of transformative community projects /value addition SMEs that have sprung up in the tea producing communities of Greater Bushenyi since the onset of NAADS assistance
1.4.2 To assess the socio-economic impact that has been realized from the transformative community projects /value addition SMEs that strung up in Greater Bushenyi since the onset of NAADS assistance
1.4.3 To establish the challenges/obstacles that have hindered the formation/operation of transformative community projects/value addition SMEs in Greater Bushenyi since the onset of NAADS assistance
1.4.4 To generate alternative approaches by which the government and partners (recipients) of NAADS assistance should have used in order to encourage more transformative community projects /value addition SMEs to spring up and grow in Greater Bushenyi

 Uganda 2024-12-02 17:03:29 2027-12-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jacob  Mutazindwa Kasabunga
ID: UNCST-2024-R015547
 Agriculture and Livelihoods in Uganda
REFNo: SS3430ES

Main objective/ purpose
The purpose of the baseline study is to determine baseline values related to the current state of agricultural production, productivity, and the levels of access to commercialization facilities and to affordable and sustainable rural microfinance for value chain development in Uganda.

Specific Objectives
Specifically the baseline study aims: -
i. To assess the feasibility of investments in the coffee, rice, oil seed (sunflower and soybean), simsim (sesame), dairy (milk and milk products), and goats and sheep value chains to improve farmer incomes, and the feasibility of investments in cassava, maize and beans to improve food security as well as the cross-cutting themes of climate change as well as gender.

ii. To obtain qualitative data through conducting stakeholder interviews, facilitating focus group discussions, and obtaining quantitative data through a survey in targeted regions in Uganda.
iii. To assist in other research activities, including assisting the project team in identifying survey subjects that meet project inclusion criteria and respondents that can inform the feasibility study.
iv. To assist in piloting and refinement of data collection instruments and contribute to analysis to inform the Baseline Report and Feasibility Study

 Uganda 2024-11-27 15:38:15 2027-11-27 Social Science and Humanities Non-Clinical Trial Non-degree Award
Stella Neema
ID: UNCST-2019-R000814
 Understanding the processes and acceptability of a child-friendly paediatric formulation of Praziquantel for the treatment of schistosomiasis among preschool-aged children in endemic districts in Uganda
REFNo: SS3420ES

The overall aim of this study is to analyse the factors surrounding the pilot introduction of arPZQ among PSAC in communities in Uganda at the macro, meso and micro levels.

Objectives

1. To evaluate the acceptance, appropriateness and perception of paediatric schistosomiasis treatment and distribution (delivery) among caregivers and other community members

2. To analyse the acceptance and perception of the paediatric praziquantel distribution methods among implementation personnel

3. To evaluate advocacy, social mobilisation and communication strategies and toolkits supporting the delivery of paediatric schistosomiasis treatment

4. To evaluate the pilot implementation of the weight-based dosing protocol


Uganda 2024-11-26 19:48:25 2027-11-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
JOSEPHINE  BAYIGGA
ID: UNCST-2024-R003757
 Understanding preferred Tuberculosis Treatment adherence interventions among persons identified with Alcohol use Disorder in Kampala, Uganda: A mixed methods study
REFNo: SS3228ES

The study aims to elicit the preferred tuberculosis treatment adherence interventions among persons with alcohol use disorder in Kampala, Uganda,
 Uganda 2024-11-26 19:46:58 2027-11-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Eve  Namisango
ID: UNCST-2021-R014038
 Improving end-of-life care for dying patients and their families in Ugandan ICUs
REFNo: HS4832ES

5. Synthesise the findings to produce recommendations for future end-of-life care in ICU practice, research and policy.,To explore clinicians’ experiences of end-of-life care provision in Ugandan ICUs and the use of person-centred outcome measures.,3. To utilise the Integrated Palliative care Outcome Scale (IPOS) staff version as a tool in identifying symptoms and important concerns at the end of life in ICU,2. To assess symptoms and important concerns at end=of-life in ICU using the integrated palliative care outcome scale ,1. To explore ICU clinician’s perspectives of factors influencing the provision of quality end-of-life care through a survey,To explore factors influencing the provision of end-of-life care in Ugandan ICUs test and evaluate the use of person-centred outcome measures in improving end-of-life care in dying patients and their families,
 Uganda 2024-11-26 19:41:46 2027-11-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Fred Nalugoda
ID: UNCST-2021-R013343
 Improving understanding of Capacity to consent to sensitive biomedical Research among adolescents in Rakai Uganda (ICARE)
REFNo: SS3447ES

Aim 1: Sampling from RCCS-experienced and RCCS-naïve households, and using the MacCAT-CR, examine adolescent capacity to consent to biomedical research and correlates of that capacity.
1.a: Compare capacity to consent among early, middle, and late adolescents and their guardians.
1.b: Assess correlates of capacity, including actionable factors such as health literacy and education and biomedical-related factors such as PrEP eligibility, use, awareness, beliefs, peer norms, and stigma.
Aim 2: Using a systematic qualitative analysis – guided by our conceptual framework for mapping age differences – examine processes of decision-making around biomedical prevention and biomedical research (e.g., stigma, understanding of biomedical prevention and research risks and benefits and constructs like randomization, privacy, safety and autonomy) among guardians and early, middle and late adolescents.
Aim 3: In partnership with US and Uganda researchers, and IRB members, construct a digital toolkit to support decision making regarding key aspects of minor consent in low-resource settings.

 Uganda 2024-11-26 19:40:05 2027-11-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jacklyn Arinaitwe Makaaru
ID: UNCST-2024-R015354
 Examining the combined effects of a two-generation model involving childcare and financial support interventions to vulnerable businesswomen in urban refugee and host communities in Kampala
REFNo: SS3367ES

i) To understand the status of childcare burden and its attendant constraints on livelihoods for urban refugee women.
ii) To design interventions that alleviate the childcare burden for urban refugee women while at the same time improving their social and economic welfare.
iii) To evaluate the effects of these interventions on reducing the burden of childcare as well as business growth, productivity, profitability, livelihoods, and the wellbeing of urban refugee women/caregivers.

Uganda 2024-11-25 17:30:05 2027-11-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Edgar Mulogo Mugema
ID: UNCST-2023-R008170
 Viral causes of acute respiratory illness among hospitalized children in Kasese District, Uganda:an observational cohort study.
REFNo: HS5218ES

Primary Objectives

The primary objective of this study is to test the feasibility of implementing rapid molecular diagnostic test and assess the burden and epidemiology of influenza subtypes A and B, SARS- CoV-2, and RSV among pediatric patients hospitalized for ARI in Kasese District, Uganda.

Specific Aims

Determine the feasibility of implementing a rapid molecular diagnostic testing program at peripheral health centers in rural western Uganda. We will measure the number of eligible children consenting to testing, the number of tests performed, the median time from sample collection to result, and the number of invalid test results due to either operator error or equipment issues.

Measure the proportion of pediatric hospitalizations for ARI attributable to SARS-CoV-2, influenza subtype A and B, and RSV in communities with different population densities in Kasese district. We will enroll children admitted with ARI, test a nasopharyngeal swab for influenza, SARS-CoV-
2 and RSV using the Cepheid GeneXpert platform, and document participant demographic information.

Describe the clinical presentation and management for patients admitted with respiratory illness to health facilities in Kasese District. We will record the vaccination history, presenting symptoms, diagnoses, and treatments administered, including antibiotics. We will also follow-up all enrolled participants two weeks after admission to determine illness outcomes. We will compare these variables between those who test positive and those who test negative for SARS-CoV-2, influenza, and RSV.

 Uganda 2024-11-25 17:28:46 2027-11-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JULIET BABIRYE ALLEN
ID: UNCST-2023-R005641
 PREVALENCE AND ASSOCIATED FACTORS OF DYSLIPIDEMIAS AMONG PLHIV AT GOMBE HOSPITAL, IN RURAL UGANDA
REFNo: HS5050ES

ii. To determine the factors associated with dyslipidemia among PLHIV in rural Uganda.,i. To determine the prevalence of dyslipidemia among PLHIV in rural Uganda,To determine the prevalence of dyslipidemia and the associated factors among PLHIV attending the HIV clinic at Gombe hospital.,
 Uganda 2024-11-25 17:25:45 2027-11-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Dorit Stein Talia
ID: UNCST-2022-R010349
 Modeling Health and Welfare Impacts of National Health Insurance in Uganda
REFNo: SS2522ES

To advance the use of routinely collected administrative data and simulation modeling for health policy decision-making in Uganda. ,To support evidence-based policy debates around what outcomes a national health insurance program should achieve, for whom, how, and at what cost. ,To quantify the distributional health and financial risk protection benefits that may occur from scaling-up a benefits package of health interventions for the most common chronic diseases in Uganda (i.e., cardiovascular diseases, cancers, diabetes).,This study aims to generate empirical evidence on the potential population health, poverty alleviation, and equity impacts of increasing public expenditure on health in the form of a national health insurance scheme in Uganda.,
 USA 2024-11-25 17:24:28 2027-11-25 Social Science and Humanities Non-Clinical Trial Degree Award
ERIC WOBUDEYA
ID: UNCST-2019-R001047
 Rapid Research for Diagnostics Development TB Network in children and Assessing Diagnostics at POC for TB in children (R2D2_ADAPT Kids)
REFNo: HS5144ES

1. To validate the diagnostic accuracy of design-locked novel TB tests in children with presumptive intrathoracic TB overall and in key sub-groups to inform policy development.
2. To assess the usability and acceptability of design-locked novel TB tests for children.

 Uganda 2024-11-25 17:23:03 2027-11-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rono Josea Josea
ID: UNCST-2024-R002148
 Private Sector DMPA-SE Market survey in Uganda
REFNo: SS3402ES

1. To map out the journey of WRA in accessing contraception in urban settings and identify critical touchpoints, pain points, and unmet needs.
2. To segment clients into distinct groups based on demographics, behaviours, motivations, and unmet needs and understand on how each group experiences the contraceptive journey and perceives available options.
3. To explore fit of potential DMPA-SC “concept” offerings to unmet needs from client segments and identify features, benefits, and service components that address specific pain points or desires of the target segments.
4. To explore and develop value propositions associated with each DMPA-SC “concept” offering and explore how the product concept meets the identified needs and motivations of different client segments.
5. To test the appeal, relevance, and potential effectiveness of DMPA-SC concepts. Focus on obtaining detailed feedback on value propositions, potential narratives and identify trade-offs that clients are willing to make when considering different options
6. To develop and refine DMPA-SC messaging strategies that resonate with client segments, addressing their unmet needs and supporting informed choice and self-care.

 Uganda 2024-11-25 16:25:42 2027-11-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Patience Kinengyere Bemanya
ID: UNCST-2024-R004964
 Evaluation of Diabetic Retinopathy Detection Strategies in Urban Kampala, Uganda
REFNo: HS5046ES

To assess WHO DR detection protocols and facilitate the adoption of a customised early DR detection strategy among DM patients in Urban Kampala, Uganda, to enhance management outcomes,
 Uganda 2024-11-25 14:19:24 2027-11-25 Medical and Health Sciences Non-Clinical Trial Degree Award
David Okot Pakono
ID: UNCST-2019-R000417
 Change Management Framework for Information and Communication Technology Integration in Teaching and Learning in Uganda: A Case of Gulu University
REFNo: SS3361ES

Objectives
1)To explore the process constituting the SC eLIM in the PBL–Hybrid Learning Project at FBDS in GU.
2)To explore how the activities within the PBL–Hybrid learning project unfold at FBDS in GU.
3)To explore how the PBL–Hybrid project’s SC eLIM changes the learning environment at FBDS in GU.
4)To develop a change management framework for systematic ICT integration in teaching and learning in universities in resource–constrained settings.

 Uganda 2024-11-25 13:28:05 2027-11-25 Social Science and Humanities Non-Clinical Trial Degree Award
Okwarampe  Millicent
ID: UNCST-2024-R002469
 Teachers Mentoring Teachers - An Exploration into Effective Peer Support Models & Their Impact
REFNo: SS3386ES

To assess the effectiveness of self-initiated peer mentoring systems
in supporting teachers with their UCatchUp implementation in government and government-aided
primary schools

Uganda 2024-11-25 13:27:02 2027-11-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Immaculate  Nakazibwe
ID: UNCST-2023-R006394
 Agronomic Status of Finger Millet Production Amidst Climate Variability and its Yield Response to Different Soil Fertility Treatments in South Western Uganda
REFNo: A535ES

Map land suitability for sustainable finger millet production in South western Uganda,Predict the finger millet grain yield using the QUEFTS model for the varying soil fertility treatments at varying spatial and temporal scales,Determine the nutrient use efficiency of finger millet under differing soil fertility treatments at varying spatial and temporal scales,Explore and establish farmers’ knowledge, attitudes and practices for finger millet production within and across agricultural production zones,Assess the agronomic status of finger millet production amidst climate variability and its yield response to different soil fertility treatments in South western Uganda,
 Uganda 2024-11-25 13:25:39 2027-11-25 Agricultural Sciences Non-Clinical Trial Degree Award
Marisa Boller
ID: UNCST-2023-R005654
 Development and validation of a tool to measure experiences of water, sanitation, and hygiene insecurity in institutional settings
REFNo: SIR300ES

To develop a tool that can measure WASH insecurity levels within institutions by identifying a set of items that comparably and reliably measure WASH insecurity within schools and health care facilities across different settings, climates, and participant characteristics.
 Switzerland 2024-11-25 13:24:06 2027-11-25 Engineering and Technology Non-Clinical Trial Non-degree Award
Jane Nabikyu Rosette
ID: UNCST-2024-R002380
 Consumer preference for novel and nutritious black rice in Wakiso district, Uganda: information, willingness to pay and affordability
REFNo: SS3279ES

Determine the cost and affordability of an optimal black rice-based diet in Wakiso District.,Determine the effect of nutrition information on consumers’ willingness-to-pay for black rice in Wakiso District.,Determine consumer acceptance of black rice in Wakiso District.,To examine consumer demand for and affordability of black rice in Wakiso District, Uganda.,
 Uganda 2024-11-22 17:35:05 2027-11-22 Social Science and Humanities Non-Clinical Trial Degree Award
MONICA AHABWE
ID: UNCST-2023-R006462
 Teachers' experiences in Implementing the Lower Secondary Curriculum in Mbarara City in Uganda
REFNo: SS2973ES

1. To examine secondary school teachers’ experiences of planning for teaching using the Lower Secondary Curriculum in Mbarara City in Uganda?
2.To examine secondary school teachers’ experiences of teaching using the Lower Secondary Curriculum in Mbarara City in Uganda?
3. To examine secondary school teachers’ experiences of assessment using the Lower Secondary Curriculum in Mbarara City in Uganda?

Uganda 2024-11-22 17:28:45 2027-11-22 Social Science and Humanities Non-Clinical Trial Degree Award
John Tabuti Robert Stephen
ID: UNCST-2024-R002181
 Agroforestry for People, Ecosystems and Climate (AfPEC)
REFNo: NS818ES

AfPEC aims to document the effects of agroforestry in terms of ecosystem services and livelihood benefits, to understand motivating factors for long-term sustainable development and to support science-based agroforestry in practice.
 Uganda 2024-11-22 17:26:03 2027-11-22 Natural Sciences Non-Clinical Trial Non-degree Award
Jennifer Serwanga
ID: UNCST-2024-R002056
 mAb Therapeutics for Sudan ebolavirus: Discovery, Isolation, and Target-Epitope Mapping of Monoclonal Antibodies from Sudan ebolavirus Convalescent Survivors in Uganda (mATSu)
REFNo: HS5212ES

This study aims to improve understanding and enhance the development of potent immune-based tools for detection, treatment, and vaccination strategies, strengthening readiness for future Viral Hemorrhagic Fever (VHF) epidemics. It will address five specific objectives:

Objective 1: Collect, process and screen samples from Viral Hemorrhagic Fever (VHF) survivor acute and convalescent cases along with their close contacts.

Objective 2: Isolate and characterise functionalities of the monoclonal antibodies.

Objective 3: Establish partnerships to facilitate transfer advanced technologies.

Objective 4: Build local capacity for immune therapies.

Objective 5: Describe molecular determinants underpinning the presence or lack of potent mAbs.
 Uganda 2024-11-22 17:23:36 2027-11-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Pontiano Kaleebu
ID: UNCST-2021-R013577
 Open-label, Multicenter Immunogenicity and Safety Trial of MVA-BN® Vaccine in Children From 2 Years to Less Than 12 Years of Age Compared to Adults for the Prevention of Smallpox, Mpox, and Related Orthopoxvirus Infections
REFNo: HS5281ES

To assess immunogenicity of the MVA-BN standard regimen in eliciting neutralizing antibodies against vaccinia virus in children compared to adults. To assess the safety and reactogenicity of the MVA-BN standard regimen in children and adults. To assess neutralizing antibody response to the MVA-BN standard regimen. To assess durability of neutralizing antibody response to the MVA-BN standard regimen.
Uganda 2024-11-22 17:19:29 2027-11-22 Medical and Health Sciences Clinical Trial Non-degree Award
Florence  Ebila
ID: UNCST-2021-R013444
 TASO-2024-401 Beyond Gendered textbooks: An investigation into gender(ed) discourses in secondary English language classrooms in India and Uganda.
REFNo: SS3317ES

3.To analyse the extent to which engaging teachers with gendered classroom practices and learners’ gendered experiences shape their reflections the development of gender responsive pedagogies.,2. To assess how the gendered discourses in the EL classroom influence male and female students’ learning. experiences, self-perception and aspirations,1. To find out how teachers and students engage with gendered texts in the EL classroom.,The aim of this study is to investigate how gender is (co-)constructed in secondary school English language (EL) classrooms in India and Uganda with the view of identifying patterns which would inform gender responsive English language teaching and teacher education.,
 Uganda 2024-11-19 7:35:59 2027-11-19 Social Science and Humanities Non-Clinical Trial Non-degree Award
Andrew Mujugira
ID: UNCST-2019-R000871
 Needs and Experiences of Transgender Women Using Gender-Affirming Hormone Therapy in Uganda: A Mixed Methods Study
REFNo: HS5137ES

Aim 1: Assessment of needs and experiences to determine gaps in access to gender-affirming treatment in Uganda Aim 2: Use photovoice methods to gain a better understanding of the real-world healthcare experiences of trans women in Uganda
Uganda 2024-11-19 7:34:06 2027-11-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Benson Juma Ouma
ID: UNCST-2023-R005718
 ESTABLISHMENT AND EVALUATION OF NON-INVASIVE WHITE CELL MONITORING (NICEM) IN UGANDA
REFNo: HS5245ES

To compare the total white blood counts and differential white blood cell subtypes obtained by the Non-Invasive White Cell Monitoring prototype with conventional CBC testing using vein puncture in healthy volunteers,
 Uganda 2024-11-19 7:32:44 2027-11-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Natalie Carter Lauren
ID: UNCST-2023-R005867
 Existing in the periphery: narrating gendered dynamics of conservation in Karamoja, northern Uganda
REFNo: SS3258ES

The objectives of this research are as follows: • To map the position of community members in a conservation corridor by narrating their relationship to land and the environment, exploring how their daily lives may shape the production of the corridor space from within • To explore how a conservation corridor shapes the lives and relationships of community members, with particular attention to expanding an understanding of the relationship between connectivity conservation and intersecting experiences of violence (i.e., human-wildlife/human conflict) • To constructively challenge emergent scientific narratives about connectivity conservation by mapping friction between territorial claims for biodiversity conservation in the abstract against the unruly practices within a corridor • Applied aim: To translate shared narratives into formats and fora which could influence the ethical and just transformation of connectivity conservation practice
 Australia 2024-11-19 7:31:10 2027-11-19 Social Science and Humanities Non-Clinical Trial Degree Award
NAKAJUBI SHAMUSI
ID: UNCST-2024-R003579
 “BLOCKCHAIN-BASED FRAMEWORK FOR INTRA-DATA SHARING IN SAVINGS AND CREDIT COOPERATIVE SOCIETIES (SACCOS)” A CASE OF WAZALENDO SACCO - UGANDA
REFNo: SIR412ES

To Evaluate the framework for intra-data sharing in SACCOS.,To develop a Blockchain-based Framework for intra-data sharing in SACCOS.,To examine the challenges faced in the current intra-data sharing processes in SACCOS,To establish the current state of the art and Intra-data sharing practices in SACCOS,The general objective of this study will be to develop a Blockchain-based Framework for intra-data sharing in SACCOS. ,
 Uganda 2024-11-19 7:28:29 2027-11-19 Engineering and Technology Non-Clinical Trial Degree Award
EBENEZER DEBRAH LARTEY
ID: UNCST-2023-R007570
 Artificial Intelligence-Based Enhancement of Mammography Interpretation for Early Breast Cancer Diagnosis
REFNo: SIR368ES

d. To evaluate the acceptability and usability of the developed model.,c. To test and validate the developed algorithms for accurate and timely diagnosis and classification of breast cancer from x-ray mammograms.,b. To develop AI-based algorithms for accurate and timely diagnosis and classification of breast cancer from x-ray mammograms.,a. To establish the extent to which artificial intelligence has been adopted in breast cancer diagnosis and classification from x-ray mammograms.,The main objective is to improve the accuracy and timely diagnosis of breast cancer from X-ray mammograms in resource-constrained areas.,
 Ghana 2024-11-19 7:25:26 2027-11-19 Engineering and Technology Non-Clinical Trial Degree Award
Sam Ononge
ID: UNCST-2020-R000328
 Evaluating utilization of VAYU Bubble Continuous Positive Airway Pressure (CPAP) device piloted among health facilities participating in Saving Women and Preterm Babies (SWAP) Project in Uganda: Ref UNHL-2024-91
REFNo: HS5148ES

To determine the acceptability, feasibility, and sustainability of the Vayu bCPAP among healthcare providers in the five SWAP project-supported facilities as part of the routine care for newborns with respiratory distress, primarily preterm newborns. ,4. To draw recommendations for the scale-up to other facilities in Uganda, 3. To explore the sustainability of Vayu bCPAP in health facilities in Uganda ,2. To determine the key factors that facilitate or hinder the successful implementation of Vayu bCPAP,1. To assess health providers\' acceptability and feasibility of Vayu bCPAP in selected health facilities in Uganda ,To determine the acceptability, feasibility, and sustainability of the Vayu bCPAP among healthcare providers in the five SWAP project-supported facilities as part of the routine care for newborns with respiratory distress, primarily preterm newborns. ,
 Uganda 2024-11-19 7:24:21 2027-11-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssinabulya
ID: UNCST-2021-R004352
 ImpleMEntation of a Digital-first care deLiverY model for heart failure in Uganda (MEDLY Uganda)
REFNo: HS4581ES

In this study, we will implement a digital-first, multi-component strategy for HF (Medly Uganda) and evaluate both implementation and clinical outcomes. The primary objective is to assess the implementation and clinical effectiveness of a digital-first implementation strategy to improve HF self-care in Uganda. We will conduct a stepped-wedge, cluster randomized trial in outpatient departments at 6 Ugandan RRH. The co-primary outcomes will be the Self-Care of HF Index (implementation) and the composite of mortality and HF hospitalization (clinical effectiveness). The secondary objectives will include the following. Conduct a mixed method process evaluation to inform iterative adjustments to the implementation process. We will use a community-engaged approach to systematically collect qualitative and quantitative process data at pre-determined time points based on the Learn-As-You-Go design and make contextually appropriate implementation adaptations. Prior to recruitment, we will also explore patients’ journeys to heart failure diagnosis in Uganda through a qualitative component by conducting in-depth interviews. The aims of this work will be to explore factors associated with patient’s journeys to heart failure diagnosis, including descriptions of initial symptoms, progression, health care referral journey, barriers and facilitators to care, and role of health education and self-care awareness. We will assess the implementation fidelity and sustainability of Medly Uganda with a focus on reach, adoption, and maintenance. Using Medly Uganda meta data from patients (app) and providers (dashboard), we will identify patterns and predictors of usage. We will interview patients and providers to explore these findings, and ensure implementation fidelity. We will also explore patient and provider perspectives on the sustainability of Medly Uganda, using semi-structured interviews to explore patient and provider barriers and facilitators of long-term use, to surface strategies that would optimize Medly Uganda implementation over time. We shall explore cost, cost effectiveness, and sustainability factors for Medly Uganda. We will collect and examine cost data from patients and facilities examining the unit cost (cost per HF patient treated and per HF patient controlled) of control and Medly Uganda scenarios both from a financial and societal perspective. Primary outcomes for cost effectiveness analysis will be the Incremental Cost-Effectiveness Ratio per patient treated and per death averted.
Uganda 2024-11-18 22:56:37 2027-11-18 Medical and Health Sciences Clinical Trial Non-degree Award
MUTEEBWA LABAN
ID: UNCST-2022-R010550
 Barriers and facilitators of the intention to use, and the preferred model for HIV Self-Testing among young women in the Kampala Metropolitan Area
REFNo: HS5167ES

4. To assess factors associated with the intention to use HIVST services among AGYW in KMA.,3. To determine the preferred model for delivering HIVST services among AGYW in KMA.,2. To explore the barriers and facilitators influencing the use of HIVST services among AGYW in KMA,1. To determine the level of intention to use HIVST services among AGYW in KMA ,To determine the level of intention to use HIVST services, the influencing barriers and facilitators, associated factors and the preferred model for delivering HIVST services among AGYW in the KMA, Uganda.,
 Uganda 2024-11-18 22:50:43 2027-11-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Hannah Kibuuka
ID: UNCST-2020-R014355
 Secondary Analysis Protocol entitled “Biomarker-guided patient stratification for diagnosis, prognosis, and monitoring of severe infectious disease at the point of need"
REFNo: HS5187ES

Transition existing host-based biomarker classifiers to protein and nucleic acid based fieldable detection devices to validate and optimize performance
 Uganda 2024-11-18 22:47:28 2027-11-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Edgar Mulogo Mugema
ID: UNCST-2023-R008170
 Getting Malaria “off the backs” of women and children in western Uganda
REFNo: HS4758ES

The scientific objective is to demonstrate the protective effect of permethrin-treated lesus against P. falciparum malaria in infants and young children.,
 Uganda 2024-11-18 13:40:11 2027-11-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Catherine Nabbumba
ID: UNCST-2024-R002912
 Genome wide association studies and polygenic prediction of major depressive disorder in samples of African ancestry from Uganda
REFNo: HS5159ES

1) investigate the prevalence and sociodemographic and clinical correlates of MDD among general outpatients attending care at 5 hospitals in Uganda
2) undertake a systematic review on common genetic variants associated with MDD among respondents of non-European ancestry using different datasets from PGC
3) explore common genetic variants associated with MDD in 2 African samples (ED6 study (n=150 cases, 150 controls) (A) and NeuroGAP study (n=324 cases, 876 controls) (B))
4) optimise a PRS for MDD initially developed from MDD-PGC datasets for use in the African setting of Uganda

 Uganda 2024-11-18 13:36:01 2027-11-18 Medical and Health Sciences Non-Clinical Trial Degree Award
THOMSON LAKWO LURONI
ID: UNCST-2023-R007843
 Evaluating the specificity and cross-reactivity of Mansonella perstans sera against biomarkers for Onchocerca volvulus and Wuchereria bancrofti
REFNo: HS4889ES

To evaluate the specificity and cross-reactivity of M. perstans sera against biomarkers of O. volvulus and W. bancrofti.
 Uganda 2024-11-18 13:34:32 2027-11-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rogers Kalyetsi
ID: UNCST-2024-R004177
 GENETIC DIVERSITY OF PLASMODIUM FALCIPARUM AND VECTOR SPOROZOITE INFECTIVITY RATES IN SELECTED FLOOD PRONE VILLAGES IN KASESE DISTRICT, WESTERN UGANDA
REFNo: HS4978ES

d. Generate maps for the spatial distribution of infected Anopheles mosquitoes and identify the hot spots in the flood-prone selected villages in Kasese district.,C. To determine vector species composition and sporozoite effectivity rates in selected flood-prone villages in Kasese district,b. Describe the genetic diversity of P. falciparum species responsible for malaria epidemics in selected flood-prone villages in Kasese district.,a. To establish the positivity rates of P. falciparum among children ≤ 12 years in selected flood-prone villages in Kasese district ,To determine the genetic diversity of Human Plasmodium falciparum species and vector sporozoite effectivity in selected flood-prone villages in Kasese district, western Uganda,
 Uganda 2024-11-18 13:24:42 2027-11-18 Medical and Health Sciences Non-Clinical Trial Degree Award
Noah Nyende Robert
ID: UNCST-2024-R003575
 Health-Seeking Behaviour and Utilization of Sexual and Reproductive Health Services by Adolescents in Uganda: An Analysis of Attitudes, Perceptions and Preferences in The Busoga Region.
REFNo: SS3374ES

4. To assess how personal factors moderate the effect of health-seeking behaviours and the utilization of SRH services by adolescents in the Busoga region of Uganda,3. To examine the relationship between health-seeking preferences and the utilization of sexual and reproductive health (SRH) services by adolescents in the Busoga region of Uganda.,2. To explore the influence of health-seeking perceptions on the utilization of sexual and reproductive health (SRH) services by adolescents in the Busoga region of Uganda.,1. To investigate the effect of health-seeking attitudes on the utilization of sexual and reproductive health (SRH) services by adolescents in the Busoga region of Uganda.,This study aims to investigate the influence of health-seeking behaviours on the utilization of sexual and reproductive health (SRH) services by adolescents in the Busoga region of Uganda. The ultimate objective is to contribute to the creation of an evidence-based model that improves the delivery and acceptance of SRH services among adolescents in Uganda.,
 Uganda 2024-11-18 13:22:16 2027-11-18 Social Science and Humanities Non-Clinical Trial Degree Award
LADY MARY KABAPAGASA
ID: UNCST-2024-R002479
 DIGITAL LITERACY COMPETENCIES AND SKILLS AMONG INFORMAL SMALL-SCALE WOMEN TRADERS IN THE RWENZORI REGION, UGANDA
REFNo: SS3371ES

5. To develop a policy brief to empower informal women traders with digital literacy skills and competencies in the country.,4. To examine the support systems available to informal small-scale women traders to optimally use digital devices and platforms to enhance their businesses in Rwenzori region,3. To examine the factors that influence the use of digital devices and platforms by informal small-scale women traders to boost trade in Rwenzori region,2. To establish digital literacy competencies and skills among informal small-scale women traders that enhance their use of digital devices and platforms for trade in Rwenzori region,1. To establish the types and application of digital devices and platforms that informal small-scale women traders use to enhance performance of their trade in Rwenzori region.,To examine the digital literacy competencies and skills among informal small-scale women traders in Rwenzori region, Uganda aiming to develop a national policy brief for empowering them with relevant digital literacy competencies and skills.,
 Uganda 2024-11-14 9:11:43 2027-11-14 Social Science and Humanities Non-Clinical Trial Degree Award
Deo Wabwire Ogema
ID: UNCST-2021-R013932
 A Phase 2 Randomized, Adaptive, Dose-Ranging, Open-Label Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis (RAD-TB) Version 2.0, Dated 21 Mar 2024
REFNo: HS5088ES

Primary objectives

(i)To compare Mycobacterial Growth in Tube (MGIT) liquid culture Time to Positivity (TTP) slope over the first 6 weeks of treatment for each experimental treatment arm to the standard of care (SOC) arm.

(ii)To compare new Grade 3 or higher adverse events (AEs) (safety) over the first 8weeks of treatment for each experimental treatment arm to the SOC arm.

Secondary Objectives

i)To compare time to stable culture conversion by MGIT liquid culture by week 8
for each experimental treatment arm to the SOC arm.

ii)To compare MGIT liquid culture TTP slope over the first 8 weeks of treatment for
each experimental treatment arm to the SOC arm.

iii) To compare new Grade 3 or higher AEs (safety) over 26 weeks of treatment for
each experimental treatment arm to the SOC arm.

iv) To compare discontinuations of anti-TB drugs for any reason prior to 8 and 26
weeks of treatment for each experimental treatment arm to the SOC arm.

v) To determine the dose- and exposure-response relationships between experimental drug estimated pharmacokinetic (PK) parameters with safety and efficacy.
vi) To compare a composite of efficacy and safety outcomes using a risk-benefit
approach for each experimental treatment arm to the SOC arm.

vii) To compare MGIT liquid culture TTP slope over the first 6 weeks of treatment for Arms 3A-3B and Arms 4A-4B compared to Arm 2.

viii) To compare durable cure by 52 weeks after treatment initiation in each
experimental treatment arm to the SOC arm.

 Uganda 2024-11-13 18:02:04 2027-11-13 Medical and Health Sciences Clinical Trial Non-degree Award
JOSAPHAT KAYOGOZA BYAMUGISHA
ID: UNCST-2019-R001680
 Heat-stable carbetocin for the treatment of postpartum haemorrhage: a phase III, randomized, double-blind, active controlled, multicountry, multicentre, non-inferiority trial
REFNo: HS5151ES

To evaluate the cost-effectiveness of the PPH treatment with HSC compared to PPH treatment with oxytocin, if HSC is proven non-inferior. ,To evaluate the comparative effects of HSC versus oxytocin on haemodynamic outcomes when used for PPH treatment in women receiving HSC for prophylaxis; ,The primary objective of this trial is to evaluate whether HSC is non-inferior to oxytocin for treatment of PPH in women who receive HSC for PPH prophylaxis, in the prevention of additional blood loss of 500 ml or more at 90 min following randomization. ,
 Uganda 2024-11-13 17:36:53 2027-11-13 Medical and Health Sciences Clinical Trial Non-degree Award
Gertrude  Namazzi
ID: UNCST-2024-R002568
 Mapping the Bottlenecks and Challenges of the At-Risk Surveillance System for Child Developmental Disabilities in Uganda
REFNo: HS5106ES

To map the bottlenecks and challenges of the At Risk Surveillance system for child developmental conditions and disabilities in order to inform targeted strategies to improve the overall effectiveness of the ARSS system,
 Uganda 2024-11-13 17:34:14 2027-11-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
ANTHONY NUWA
ID: UNCST-2022-R011102
 Across Sectional Survey to improve the capacity of the healthcare system to detect, report, and respond to arboviral threats in Uganda.
REFNo: HS5063ES

1. To ascertain the availability and density of mosquito vector species involved in virus
transmission and their bionomics in Uganda.
2. To describe and document the current practices on diagnosis and management of
arboviral diseases in Uganda and provide recommendations for improvement and
strengthening.
3. To describe the current arboviruses data collection, reporting and data use system for
decision making in Uganda.
4. To evaluate current arboviral outbreak detection and response mechanisms in Uganda
To evaluate outbreak hotspots and human/animal cluster susceptibilities to identify
appropriate target sentinel sites.
6. To determine the Yellow Fever, Chikungunya, O’nyong nyong epidemic potential based
on findings from the entomological and historical data collected during the study.
7. To assess knowledge, attitudes and practice among target communities regarding
arbovirus awareness and risk behavior.
 Uganda 2024-11-13 17:30:13 2027-11-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Moses Joloba Lutaakome
ID: UNCST-2022-R011558
 Clinical Performance Evaluation of POC BVBLUE Test for Diagnosis of Bacterial Vaginosis in Uganda
REFNo: HS5231ES

To evaluate the performance of the BVBlue test, a point-of-care test, compared to Amsel, Nugent and Allplex Bacterial Vaginosis plus Assay. ,
 Uganda 2024-11-13 17:27:22 2027-11-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
RUKUNDO  LYDIA LYDIA
ID: UNCST-2023-R005547
 PSYCHOSOCIAL CHALLENGES AND COPING STRATEGIES OF CARE - GIVERS OF CHILDREN WITH SICKLE CELL DISEASE AGED 0-9, ATTENDING MULAGO SICKLE CELL CLINIC
REFNo: HS4975ES

To document the coping strategies adopted by care-givers of children with sickle cell disease, attending MSCC. ,To explore the psychosocial challenges experienced by care-givers of children with sickle cell disease, attending MSCC. ,To explore the psychosocial challenges and coping strategies of care-givers of children with sickle cell disease, attending MSCC. ,
 Uganda 2024-11-13 17:19:00 2027-11-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JOSELYN RWEBEMBERA
ID: UNCST-2021-R013915
 Rapid AI-assisted Echocardiography Detection and Analysis of Rheumatic Heart Disease (RADAR) Tool – Evaluation of Acceptability and Feasibility for Field Deployment
REFNo: HS4948ES

Specific Objective 1: To assess the acceptability of this AI tool by the team members (echo nurses) in the echo screening environment.

Specific Objective 2: To evaluate the feasibility of this tool in the echo screening setting. These measures include evaluating time from screening to results, reliability of real-time image transfer from
the echo device to the RADAR tool, and functionality of the device in this environment (i.e. battery life, heat tolerance).
 Uganda 2024-11-13 17:17:03 2027-11-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
STELLA KIZANYE
ID: UNCST-2024-R003321
 Design and Fabrication of a Plastic Processing Machine for Recycling High-Density Polyethylene and Polypropylene Plastic Waste- A Means of Environment Reclamation.
REFNo: SIR399ES

1. To collect data about plastic waste collected daily by Kampala waste management centres so as to inform the extent of plastic waste accumulation and show the need for collection of this problem. 2. To determine the design parameters of the components of the plastic processing/recycling machine in relation to the industry standards and need requirements. 3. To fabricate the plastic processing machine so that the recycling process can be initiated. 4. To test the machine by processing a sample of HDPE and PP plastic waste into plastic products.
Uganda 2024-11-13 17:08:35 2027-11-13 Engineering and Technology Non-Clinical Trial Non-degree Award
Priscilla Namaganda
ID: UNCST-2019-R001653
 Oncogenic viral proteins associated with lymphomas at the Uganda Cancer Institute, Uganda, a comparison between HIV-associated and non-HIV-associated lymphomas.
REFNo: HS4342ES

To describe the oncogenic viral protein patterns among lymphomas at the Uganda Cancer Institute (UCI), comparing HIV-associated and non-HIV-associated lymphomas.,To determine the effect of oncogenic viral proteins on treatment outcomes of lymphoma among patients, HIV infected and uninfected at the UCI. ,
 Uganda 2024-11-13 17:04:50 2027-11-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rosalind  Parkes-Ratanshi Parkes
ID: UNCST-2019-R000717
 CROWDSOURCING A TRAINING DATASET OF QUESTION-AND-ANSWER PAIRS FOR ARTIFICIAL INTELLIGENCE-ENABLED HEALTH INFORMATION TOOLS ON SEXUALLY TRANSMITTED INFECTIONS
REFNo: HS5173ES

To provide to the public, an open-access, contextualized training dataset of question-and-answer pairs (Q&A pairs) on sexual health and Sexually Transmitted Infections (STIs) in English. ,To process and curate and the question-and-answer pairs into a training dataset for AI-enabled sexual health information tools.,To provide accurate, evidence-based answers, based on the World Health Organization Guidelines, to questions collected on sexual health and Sexually Transmitted Infections (STIs) from the general public in English in Sub-Saharan Africa.,To collect contextualized English questions on sexual health and Sexually Transmitted Infections (STIs) from the general public using the internet and public events in Sub-Saharan Africa over a period of six months.,The study’s main objective is to engage communities so as to develop an open-access, contextualized question-and-answer-pair training dataset on sexual health in English for AI-enabled health information tools.,
 UK 2024-11-13 16:57:49 2027-11-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
David Onyango
ID: UNCST-2024-R004067
 Stress Coping Mechanism and Trauma of Poverty among Adolescent in Information Settlements Tororo Municipality Tororo District Uganda
REFNo: SS2799ES

To investigate stress coping mechanisms and trauma of poverty among adolescents living in informal settlements in Tororo Municipality, Tororo District, Ugandan,
 Uganda 2024-11-13 16:54:19 2027-11-13 Social Science and Humanities Non-Clinical Trial Degree Award
Patrick Kyamanywa Edrin
ID: UNCST-2024-R004239
 Burden, access to care and health seeking behaviour for surgical diseases among refugees in Uganda
REFNo: HS4764ES

iii. To explore the health seeking behavior among refugee populations in Nakivale refugee settlement in Uganda ,ii. To assess the drivers and barriers of access and utilization of surgical care among refugee populations in Nakivale refugee settlement in Uganda ,i. To estimate the burden (prevalence, nature, mortality) due to of surgical conditions among refugee populations in Nakivale refugee settlement in Uganda ,To describe the surgical disease burden, assess access to surgical care and explore the health seeking behavior for surgical care and the social determinants of health influencing access to surgical care among refugees in Nakivale Refugee Settlement in Uganda. ,
 Uganda 2024-11-13 16:50:43 2027-11-13 Medical and Health Sciences Non-Clinical Trial Degree Award
Robert Bagumisiriza
ID: UNCST-2024-R003812
 Evaluating the effectiveness of collaborations between TVET institutions and industry in the enhancement of employability in Uganda
REFNo: SIR447ES

To evaluate the effectiveness of collaborations between TVET institutions and industry on the enhancement of employability skills of TVET graduates.,To determine the impact of collaboration on the training opportunities for TVET trainers.,To determine the influence of collaboration in promoting sharing of training resources between industry and TVET training institutions.,To assess the impact of collaboration on enhancement of participation of industries in practical training in TVET training institutions.,To evaluate the extent of collaboration in curriculum development between TVET training institutions and industry on the enhancement of the employability skills of TVET graduates.,
 Uganda 2024-11-13 16:43:59 2027-11-13 Engineering and Technology Non-Clinical Trial Degree Award
Ezekiel Mupere
ID: UNCST-2024-R003962
 A Randomized Clinical trial: Supplemental choline to prevent and treat learning and memory deficits of early iron deficiency. The SupCHO study
REFNo: HS4915ES

Conduct a randomized, placebo-controlled clinical trial to test whether nine months of daily choline supplementation improves hippocampus-dependent neurobehavioral outcomes in 6-month-old infants with iron deficiency anemia.,
 Uganda 2024-11-13 16:35:35 2027-11-13 Medical and Health Sciences Clinical Trial Non-degree Award
Birungi Edwin Mutahunga Rwamatware
ID: UNCST-2021-R004880
 Bantu Social Networks and Health-Seeking Behaviours: Semi-Structured Interviews on Practices and Substantive Beliefs in the Buganda and Kigezi Communities of Uganda
REFNo: SS3337ES

The second objective of the study is to use the scientifically-gathered local information to ensure future clinical tools used in hospitals and by village health workers fit the communities studied in the regions of Buganda and Kigezi; the tool we have in mind is for stroke patients,The purpose our study is to gather first-hand accounts of practices and substantive beliefs that shape what actions people take when they face health challenges so that communities can be healthier.,The first objective is to gather local knowledge with rigor and systematic data-gathering practices so that communities can better understand themselves through their health/life-seeking behaviours and thereby better assist one another when facing health challenges.,
 Uganda 2024-11-13 16:32:43 2027-11-13 Social Science and Humanities Non-Clinical Trial Non-degree Award
Joseph Akol
ID: UNCST-2024-R003662
 Framing the Policies and Strategies for Accountability to Beneficiaries of Relief Service Non-Governmental Organizations (NGOs) in Uganda: A cross-case study of Uganda Red Cross Society (URCS) And Lutheran World Federation
REFNo: SS3086ES

General Objective:
The study seeks to generate Knowledge on the policies and strategies Relief Service NGOs in Uganda use for accountability to their project beneficiaries.
1.4.2 Specific Objectives
The specific objectives of the study are to:
1. Assess policies used by Relief Service NGOs for accountability to beneficiaries.
2. Determine how Relief service NGOs implement their policies for accountability to their beneficiaries.
3. Establish how accountability policies and strategies of Relief Service NGOs promote the effectiveness and relevance of interactions between them and their project beneficiaries.
4. Characterize the benefits of accountability to Relief Service NGOs and their project beneficiaries in Uganda.

 Uganda 2024-11-13 14:12:50 2027-11-13 Social Science and Humanities Non-Clinical Trial Degree Award
FREDDIE SSENGOOBA Peter
ID: UNCST-2021-R011834
 Strengthening accountability in Strategic Health Purchasing arrangements for Primary Health Care in Uganda to promote effective resource utilization: A Case study design
REFNo: SS3419ES

• To assess effectiveness of the accountability arrangements in strategic health purchasing between purchasers and providers on service delivery in the context of PHC,• To explore the key accountability arrangements and contextual factors in strategic health purchasing functions between purchasers and providers in the context of PHC,The overall aim of the study is to enhance accountability in strategic health purchasing mechanisms for PHC in Uganda.,
 Uganda 2024-11-13 14:09:10 2027-11-13 Social Science and Humanities Non-Clinical Trial Non-degree Award
orikiiza joshua
ID: UNCST-2023-R005914
 ICU-related Out of Pocket Expenses (ICOPE) - a multinational prospective study in African and Asian countries
REFNo: HS5125ES

To identify coping strategies for OOPE and CHE during ICU stay and follow up,To identify risk factors for CHE,To quantify ICU care related OOPE in African and Asian LMICs and the proportion of patients/families facing CHE, comparing patients receiving invasive ventilation to non-ventilated patients,
 Uganda 2024-11-12 14:27:15 2027-11-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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