Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
EDIMOND SERWANGA
ID: UNCST-2025-R017659
 ASSESSING THE SITUATION OF TEACHERS IN PRIMARY AND SECONDARY SCHOOLS IN UGANDA
REFNo: SS3797ES

General objective To assess the teaching and learning situation of primary and secondary school teachers in both refugee and non-refugee settings across Uganda's West Nile and Karamoja sub-regions. 1.2.2. Specific objectives The study aims to address the following specific objectives: (i) To explore how teachers create, promote and utilise a supportive teaching environment that enhances their professional growth and well-being. (ii) To establish school and community practices that enhance child protection, well-being, and inclusion. (iii) To assess teachers’ practices on classroom management, instruction and assessment. (iv) To establish teachers’ understanding of the curriculum and how it informs teachers’ practices. (v) To establish language support strategies used by teachers to promote learning in schools.
Uganda 2025-04-09 17:19:38 2028-04-09 Social Science and Humanities Non-Clinical Trial Non-degree Award
Lolem Lucy Chegem
ID: UNCST-2024-R004656
 Nature and Degree of Karamojong Pastoral Community Participation and Integration in Wildlife Conservation Interventions in Kidepo Valley National Park, North Eastern Uganda
REFNo: SS3755ES

1. To conduct a policy review towards the establishment of national (Uganda) wildlife conservation policies and guidelines on community participation and integration of Indigenous peoples' social and cultural practices
2. To examine the Karamojong Indigenous and traditional wildlife conservation values, practices, and livelihood needs associated with KVNP
3. To explore the nature of the Karamojong participation in wildlife conservation practices in the management of KVNP
4. To determine the degree of the Karamojong participation in wildlife conservation activities in KVNP
5. To explore the nature of the Karamojong integration in wildlife conservation practices in the management of KVNP
6. To determine the degree of the Karamojong integration in wildlife conservation activities in KVNP

 Uganda 2025-04-09 17:01:55 2028-04-09 Social Science and Humanities Non-Clinical Trial Degree Award
REBECCA NANTANDA
ID: UNCST-2019-R001533
 Optimization and testing of ALRITE, a clinical decision support tool for management of respiratory illnesses in young children in primary care health facilities in Uganda
REFNo: HS5721ES

To pilot test ALRITE in 4 Ugandan health facilities after an optimization phase of iterative testing and ALRITE improvement.

1. To optimize ALRITE for health worker use through multiple cycles of reversal single-case experiments29,30* with 6-8 health workers per cycle.
2. Pilot-test study feasibility and the effectiveness of the optimized ALRITE tool on the diagnosis and management of wheezing illness and pneumonia in young children using interrupted time series (ITS) design.
3. Assess outcomes of implementation following ALRITE deployment and determinants of successful adoption using a sequential quant-> QUAL mixed methods design.
 Uganda 2025-04-09 16:40:46 2028-04-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Peter Olds
ID: UNCST-2023-R006240
 Evaluation of NT-proBNP in outpatient heart failure care in southwestern Uganda
REFNo: HS5796ES

Main Objective 1. Create and evaluate an algorithm for nurses using a point-of-care biomarker of heart failure (N-terminal-pro hormone B-type natriuretic peptide, NT-proBNP) to support heart failure management in Uganda. Specific Objectives 1. Identify an average baseline NT-proBNP for patients with HFrEF in the MRRH outpatient cardiology clinic. 2. Develop and compare the use of an algorithm for diuresis based on the NT-proBNP with standard of care diuretic plans for patients with HFrEF in the MRRH outpatient cardiology clinic 3. Evaluate the feasibility and acceptability of implementing an NT-proBNP based algorithm for heart failure care in Uganda
 USA 2025-04-09 16:31:41 2028-04-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jennifer Serwanga
ID: UNCST-2024-R002056
 VacICoP: Chimpanzee Adenovirus Type 3-Vectored Marburg Glycoprotein (GP)-Expressing Vaccine (ChAd3-MARV)-Induced Correlates of Protection
REFNo: HS5469ES

This study aims to identify the immune correlates of protection (ICoPs) against Marburg virus disease (MVD) through comprehensive analyses of humoral and cellular responses in both vaccinated and infected individuals. ICoPs will be identified by studying human and non-human
primates (NHPs) that have either survived infection, succumbed to it, or been successfully immunised. The research aims to expedite regulatory approval and licensure by identifying the most effective and durable ICoPs against MVD.
Key objectives and deliverables include:
1. Identifying the MVD ICoPs
2. Detailed humoral and cellular immune profiles distinguishing protective from nonprotective anti-MARV immunity
3. Reference reagents and scalable high-throughput screening assays
4. Predictive statistical models for forecasting vaccination effectiveness
5. Integrated clinical, immunological, and demographic datasets
6. Regulatory guidance for new vaccines approval
7. Global collaborative data exchange framework
 Uganda 2025-04-09 16:29:46 2028-04-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Erisa Mwaka Sabakaki
ID: UNCST-2019-R001625
 Stakeholder perceptions and ethical considerations in gene therapy clinical trials for sickle cell disease in Uganda
REFNo: SS3570ES

Aim 1: To determine stakeholder perceptions of somatic gene therapy for SCD. We shall engage patient support and advocacy groups to ascertain knowledge gaps, expectations, and preferences regarding gene therapy. This will facilitate patient education and smooth implementation of research and development of affordable and accessible gene therapy in LMICs.

Aim 2: To examine the ethical, legal, and social considerations in somatic gene therapy clinical trials for SCD in a resource-limited setting. We shall use deliberative focus group discussions and key informant interviews to explore the ethical and social considerations in somatic gene therapy research in low-resource settings.

 Uganda 2025-04-09 16:28:31 2028-04-09 Social Science and Humanities Non-Clinical Trial Non-degree Award
Willbroad Byamukama
ID: UNCST-2022-R010646
 RURAL LANDLESSNESS AND FOOD INSECURITY IN UGANDA; A CASE OF KIGEZI SUB-REGION (KABALE, RUBANDA, RUKIGA, AND KISORO DISTRICTS)
REFNo: A561ES

iii. To establish workable strategies to address food insecurity in Kigezi sub-region (Kabale, Rubanda, Rukiga, and Kisoro).,ii. To examine the effect of rural landlessness on food insecurity in Kigezi region (Kabale, Rubanda, Rukiga, and Kisoro).,i. To examine the causes of rural landlessness in Kigezi sub-region (Kabale, Rubanda, Rukiga, and Kisoro).,The purpose of the study is to examine the effect of rural landlessness and food insecurity in, Uganda case of Kigezi region and come up with strategies to increase food security in Kigezi sub region with the rural landlessness.,
 Uganda 2025-04-09 16:09:36 2028-04-09 Agricultural Sciences Non-Clinical Trial Non-degree Award
DICKSON NIWASASIRA
ID: UNCST-2024-R003949
 The Effectiveness of Electronic Media on Utilization of Health Services in a Rural Setting
REFNo: SS3705ES

I. Establish the electronic media channels used by different demographic segments of the rural population to access health information.
II. Determine the impact of electronic media on overall utilization of facility- based Health services in a rural setting.
III. Establish the effectiveness of different electronic media channels on utilization of facility-based health services among different demographic segments of the rural population.

 Uganda 2025-04-08 7:35:22 2028-04-08 Social Science and Humanities Non-Clinical Trial Degree Award
Glenn Ogolah
ID: UNCST-2025-R017145
 Asset Financing and Micro Leasing in Agriculture
REFNo: SS3726ES

1. Examining barriers and opportunities in asset financing and micro-leasing
adoption for smallholder farmers and microenterprises:
a. Identifying and analyzing the barriers and opportunities affecting the access of
asset financing solution amongst smallholder farmers
b. Examine gender differences in barriers to accessing asset financing for
smallholder farmers
c. Explore interactions among key stakeholders, including farmers,
microenterprises, SACCOs, and MFIs, to assess their roles and influences in
the asset financing landscape
2. Examining the role of clean energy assets in meeting farmers most urgent needs:
a. Identifying and analyzing the barriers and opportunities affecting the adoption
of clean energy assets by farmers
b. Exploring available productive assets in the market and their distribution
channels for rural farmers

 Kenya 2025-04-07 7:58:51 2028-04-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
Josephine  BIRUNGI
ID: UNCST-2024-R003480
 A Roadmap towards the successful deployment of a fixed dose combination of Artemether-Lumefantrine+Amodiaquine (FDC ALAQ) in Uganda (DeTACT Study)
REFNo: SS3706ES

Main Objective: to identify and address obstacles in implementation and deployment of FDC ALAQ at an early stage, and contribute to the smooth introduction of FDC ALAQ in Uganda.
Specific Objectives:
To identify and engage with key national stakeholders involved in Malaria control and introducing new antimalarials in Uganda;
ii. To obtain understanding into relevant policy, regulatory and implementation procedures of new antimalarials and to identify areas that require strategic attention before any new antimalarials are introduced in Uganda;
iii. To develop a practical roadmap that can be used for the effective introduction and deployment of FDC ALAQ in Uganda aiming to control and contain artemisinin resistance in Uganda.

 Uganda 2025-04-03 16:55:55 2028-04-03 Social Science and Humanities Non-Clinical Trial Non-degree Award
Robinson Amanyiraho
ID: UNCST-2024-R016357
 Impact of the Growing Expertise in E-health Knowledge and Skills (GEEKS) Program in Reducing Immunization Defaulters and Enhancing Timely Reporting of Vaccine-Preventable Disease Cases in Uganda
REFNo: HS5737ES

Goal:
The goal of this study is to evaluate the contributions and sustainability of GEEKS Cohort 1 projects, while also providing actionable recommendations to enhance the effectiveness of current and future implementations of the GEEKS program.
Specific Objectives
1.
To document and analyze the contributions of GEEKS Cohort 1 projects in strengthening Vaccine Preventable Disease Surveillance (VPDS) and routine immunization coverage.
2.
To assess the sustainability of GEEKS Cohort 1 projects and identify factors influencing their long-term impact.
3.
To provide evidence-based recommendations for strengthening the design and implementation of current and future GEEKS program initiatives.
 Uganda 2025-04-02 9:37:17 2028-04-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Geofrey Musinguzi
ID: UNCST-2024-R015961
 HIV Prevention Program Outcomes: Measurement of accessibility, and utilization of key HIV prevention services and linkage to care among adolescent girls and young women, female sex workers, and people who inject drugs in Uganda – A Rapid Coverage Survey
REFNo: HS5730ES

Main objective
The survey’s main objective is to measure the HIV prevention program outcomes among key and priority populations, particularly the AGYW, FSWs, and PWIDs, to inform ongoing and future HIV prevention programs (among such populations) in Uganda.

Specific objectives
1. To assess access to key HIV prevention services and products among AGYW, FSWs, and PWIDs in Uganda.
2. To assess the utilization of key HIV prevention products and services among AGYW, FSWs, and PWIDs in Uganda.
3. To measure the proportion of HIV-positive AGYW, FSWs, and PWIDs linked to HIV/AIDS, STD care and desired health services.

 Uganda 2025-04-02 9:35:25 2028-04-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Stella Achen
ID: UNCST-2025-R016855
 PARTICIPATORY INTERVENTION RESEARCH TO ADDRESS CHILD EXPLOITATION IN KARAMOJA, UGANDA
REFNo: SS3733ES

i. Explore the main forms of exploitation and modern slavery in Napak and Moroto Districts;
ii. Assess interventions and program components that should be prioritized concerning child exploitation, bearing in mind the major intersecting issues such as gender discrimination, food security, and climate change;
iii. Explore the traditions, narratives, and cultural beliefs that could be mobilized as assets to the program; and lastly,
iv. Map out the key actors and influencers in the child exploitation debate.

 Uganda 2025-04-02 9:26:44 2028-04-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Sebastian Linnemayr
ID: UNCST-2021-R012696
 R01 Study “INcentives and ReMINDers to Improve Long-term Medication Adherence” (INMIND)
REFNo: SS3732ES

Main Objective
1. We propose to optimize an adaptive intervention using the INMIND approach in a Stage III efficacy randomized trial using a two-stage SMART design in Uganda. All clients (including the control group) will receive information about the importance of behavioral routines, as is part of the standard adherence counseling for treatment initiators and create personalized ART adherence anchoring strategies. We will first enroll patients into an Wisepill use only phase for one month. We will then randomize them to receive either usual care / information only or low-cost daily text messages. All clients will have the opportunity to select a new anchoring plan in the first two months, so that they then have another 4-month period during which to establish a routine. Those who if fail to take their ART pills very regularly, meaning at the same time for at least 80% of the days at the end of month three will be re-randomized to one of two more intensive interventions for the subsequent three months: monthly or monthly escalating prizes.

The Specific Aims are to:
SA1 (Primary): Test the first-stage main effect of Messages vs. Control on the maintenance of ART adherence (primary outcome) and viral suppression (secondary outcome).
SA2 (Secondary): Examine (a) the second-stage main effect of receiving monthly vs. monthly escalating incentives on the primary and secondary outcomes among first-stage non-responders, and (b) whether changing one’s anchoring plan at month two moderates the effect of monthly and monthly escalating incentives.
SA3. Synthesis Phase: Perform a cost-effectiveness analysis including a comparative analysis of the INMIND components among first-stage responders and non-responders and conduct information dissemination activities in Uganda after completion of the trial.

 USA 2025-04-02 9:23:18 2028-04-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Henry Kyobe Bosa
ID: UNCST-2021-R013941
 UNDERSTANDING THE SOCIO-ECOLOGICAL AND BEHAVIORAL DRIVERS OF MPOX DISEASE IN AFRICA
REFNo: HS5719ES

General Objective
To assess the state of knowledge, attitudes, and practices, including socio-ecological and behavioral determinants of health considerations, regarding MPXV acquisition and vaccine uptake in Uganda.
Specific Objectives
1. To assess the determinants of the Mpox disease spread and modes of transmission
2. To determine the community’s knowledge, attitude, practices, and perception on Mpox disease
3. To evaluate health-seeking behavior for Mpox disease
4. To identify the barriers and facilitators to Mpox vaccine uptake

 Uganda 2025-04-02 9:21:50 2028-04-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Walter Akwat
ID: UNCST-2024-R003452
 Uganda Multi-Sectoral Needs Assessment (MSNA) 2024
REFNo: SS3727ES

• Conduct a thorough inter-sectoral analysis to assess the magnitude and
severity of humanitarian needs and conditions among refugee and host
community households across all 13 formal refugee settlements across
the country and refugee concentrations in Kampala.
• Identify variations in humanitarian needs across different areas of study,
population groups, and household vulnerability profiles.
• Compare key findings of the 2024 MSNA with the Vulnerability and
Essential Needs Assessment (VENA) (2019) and 2018 MSNA.
• Offer insights into inter-sectoral needs to inform prioritization of refugee
response efforts and strategic planning.
Uganda 2025-04-02 9:20:09 2028-04-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Agrace Atwikirize
ID: UNCST-2024-R002716
 Stressors, Coping Strategies, Hope and Academic Perfomance of Teacher-Trainees in Universities in Central Region, Uganda
REFNo: SS3485ES

i. To find out the variations of stressors with biodata among teacher-trainees in universities in Central Region, Uganda.
ii. To investigate the relationship between stressors and coping strategies among teacher-trainees in universities in Central Region, Uganda.
iii. To establish the relationship between coping strategies and academic performance among teacher-trainees in universities in Central Region, Uganda.
iv. To assess if the relationship between stress and academic performance is mediated by coping strategies among teacher-trainees in universities in Central Region, Uganda.
v. To determine the mediating effect of coping strategies and hope on the relationship between stressors and academic performance among teacher-trainees in universities in Central Region, Uganda.

Uganda 2025-04-02 9:18:20 2028-04-02 Social Science and Humanities Non-Clinical Trial Degree Award
Mohamed  Ali Bashir
ID: UNCST-2024-R002641
 PREVALANCE AND FACTORS ASSOCIATED WITH IMMEDIATE ADVERSE PERINATAL OUTCOMES AMONG WOMEN WITH UNINTENDED PREGNANCIES DELIVERING AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS5383ES

General Objectives
To determine prevalence and factors associated with immediate adverse perinatal outcome among women with unintended pregnancies delivering at Mbarara Regional Referral Hospital.
Specific Objectives
1. To determine prevalence of immediate adverse perinatal outcomes among women with unintended pregnancies delivering at Mbarara Regional Referral Hospital.
2. To determine factors associated with immediate adverse perinatal outcome among women with unintended pregnancies delivering at Mbarara Regional Referral Hospital.

 Somalia 2025-04-02 9:16:24 2028-04-02 Medical and Health Sciences Non-Clinical Trial Degree Award
Cecilia Akatukwasa
ID: UNCST-2024-R002112
 Feasibility and acceptability of the Vxnaid-Immunization Information System (Vxnaid-IIS) for improved Immunization Monitoring and Data Management through Digitization in Wakiso district.
REFNo: SS3734ES

4. To explore stakeholder’s insights and perspectives into future use of Vxnaid-Immunization Information System including sustainability,3. To assess the barriers and enablers to implementation of the Vxnaid-Immunization Information System across four HSDs and four Municipal councils in Wakiso district.,2. To explore key stakeholders’ perceptions, attitudes and acceptance of the Vxnaid-Immunization Information System,1. Explore key stakeholders’ perspectives on practicality, ease of use and overall experience with integrating Vxnaid into current Immunization Information systems across four HSDs and four Municipal councils in Wakiso district.,
 Uganda 2025-04-02 9:08:21 2028-04-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
William Blackmon
ID: UNCST-2025-R017006
 Consumer Protection Surveys - Uganda
REFNo: SS3650ES

The project aims to:
• Measure consumer protection risks associated with digital financial services (DFS) usage in Uganda
• Track consumer protection risks across two survey rounds
• Create a comparable cross-country analysis (the survey is also carried out in 10 other countries)

 USA 2025-04-02 9:06:12 2028-04-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Maxensia owor
ID: UNCST-2021-R014003
 An open-label randomised controlled trial comparing novel combination and currently used antibiotic regimens for the empiric treatment of neonatal sepsis with a run-in confirmatory pharmacokinetic phase: NeoSep1
REFNo: HS5639ES

In Part 2, a secondary objective is to provide a ranking of clinically relevant antibiotic regimens based on other efficacy and safety secondary outcomes, as well as on health economic measures and the potential selection of resistance. The trial data will provide data to inform the balance between efficacy, safety, costs (and cost-effectiveness and equity, using health economic analysis) and propensity for resistance selection (based on microbiology tests) that will influence facility-level and national decision-making about adoption of studied regimens, and potential future inclusion in WHO guidelines.,In Part 2, the primary objective is to provide a ranking of eight different clinically relevant antibiotic regimens for first-line empiric and second-line (after lack of response/deterioration) treatment in terms of 28-day mortality as the primary outcome measure. It will flexibly compare these multiple different relevant treatment regimens to enable the trial to be run in sites worldwide with very different background rates of different pathogens, of resistance and patterns of routine clinical care by randomising each participant to locally relevant antibiotic regimens agreed prior to site initiation. The trial will ensure generalisability by focusing inclusion based on clinical symptoms associated with high mortality risk in the NeoOBS study, which have been developed into a novel neonatal sepsis severity score – the NeoSep Severity Score.,
 Uganda 2025-04-02 9:04:16 2028-04-02 Medical and Health Sciences Clinical Trial Non-degree Award
Gloria Lubega
ID: UNCST-2025-R017180
 A retrospective review of patients admitted with SARS-COV-2 at Entebbe regional referral hospital in Uganda across multiple waves.
REFNo: HS5695ES

I. To evaluate the mortality rate, risk factors associated with mortality and prolonged hospital admission among patients admitted with severe COVID-19 disease at ERRH.
II. To determine the time to discharge of patients admitted with severe COVID-19 disease at ERRH.
III. To describe the characteristics of patients across different age groups admitted with severe COVID-19 at Entebbe Regional Referral Hospital
IV. To describe treatment options offered to patients admitted with severe COVID-19 disease with reference to Uganda MoH and WHO recommended treatment options.
V. To compare characteristics of patients who were vaccinated against COVID-19 admitted with severe disease and unvaccinated patients admitted with severe COVID-19 disease.

 Uganda 2025-04-02 9:01:54 2028-04-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Mark Kaddumukasa
ID: UNCST-2020-R001798
 Building a Collaborative Research and Training Platform for HIV and Rheumatic and Musculoskeletal Diseases in Uganda
REFNo: HS5606ES

Objective 1. Establish the Ugandan Registry of RMDs in HIV (GEMINI), to create a foundation for future prospective studies on HIV and RMDs.
Objective 2. In a pilot study, among a subset of participants from GEMINI with both RA and HIV, compared to participants with HIV only and RA only, explore the impact of co-morbid disease status on markers of bone metabolism, bone mineral density, as well as quality of life and functional disability.
Uganda 2025-04-02 9:00:14 2028-04-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sylvia Kusemererwa
ID: UNCST-2019-R001717
 A phase III, multi-center, randomized, placebo-controlled, double-blind study to assess efficacy and safety of crizanlizumab (5 mg/kg) versus placebo, with or without hydroxyurea/hydroxycarbamide therapy, in adolescent and adult Sickle Cell Disease patients with frequent vaso-occlusive crises
REFNo: HS5607ES

To assess the efficacy and safety of crizanlizumab (5 mg/kg) versus placebo, with or without
hydroxyurea (HU)/hydroxycarbamide (HC) , on VOC rate in Sickle Cell Disease (SCD) patients aged 12 years and older who experience frequent vaso-occlusive crises (VOCs)
Primary Objective
1. To compare the efficacy of 5 mg/kg of crizanlizumab versus placebo, with or without hydroxyurea/hydroxycarbamide, on the annualized rate of VOCs* that are HCP managed (including VOCs leading to management at a health care facility or those via remote consultation) over the planned 52-week treatment period in SCD patients aged 12 years and older with a history of frequent VOCs (4-12 events in 12 months prior to the screening visit).
Secondary Objectives
1. To compare the efficacy of 5 mg/kg of crizanlizumab versus placebo, with or without
hydroxyurea/hydroxycarbamide, on the annualized rate of all VOCs including VOCs that are HCP-managed (including VOCs leading to management at a health care facility or those managed via remote consultation) and VOCs that are self-managed without recommendations from HCP during the event over the planned 52-week treatment period in SCD patients aged 12 years and older with a history of frequent VOCs (4-12 events in the 12 months prior to the screening visit).
2. To evaluate the annualized rate of VOCs by type of management between treatment arms over the planned 52-week treatment period:
 VOCs that are HCP-managed at a health care facility
 VOCs that are HCP-managed via remote consultation
Page 4 of 18
 VOCs that are self-managed without recommendations from HCP during the event
 VOCs that are HCP-managed via remote consultation or self-managed without recommendations from HCP during the event
 Uganda 2025-04-02 8:58:47 2028-04-02 Medical and Health Sciences Clinical Trial Non-degree Award
Aloysious Ssemaganda
ID: UNCST-2023-R008046
 Clinical Performance of i.Mune CD4 diagnostic assay amongst people living with Human immunodeficiency virus (HIV) in Uganda (CPHL-CPSP_001)
REFNo: HS5680ES

The primary objective of this study is to evaluate the clinical performance and validity of the i.Mune CD4 diagnostic assay compared to WHO pre-qualified and CE-marked Abbott PIMA CD4 test using matched liquid and dried venous blood as well as capillary dried blood specimen
collected from people living with HIV in Uganda.

Secondary objectives of this study are:
-To validate the i.Mune CD4 diagnostic assay using the Applied Biosystems™ QuantStudio 5 PCR System in Uganda to support WHO pre-qualification.
-To establish trueness of measurement of the i.Mune CD4 diagnostic assay using the LightCycler 480 Instrument II and the LightCycler PRO in comparison to the reference method (Abbott CD4 PIMA) to support CE-marking of the assay.
 Uganda 2025-04-02 8:53:21 2028-04-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
CAROLYNE OLEO
ID: UNCST-2024-R003845
 CHARACTERIZATION OF CLINICAL OUTCOMES AMONG AMBULATORY GYNECOLOGY SURGERY RECIPIENTS AT KYABIRWA SURGICAL CENTER, BUDONDO SUB COUNTY, JINJA CITY
REFNo: HS5656ES

3. To disaggregate the clinical outcomes of among ambulatory gynecological surgery recipients at Kyabirwa surgical center, with their characteristics ,2. To develop a typology of the clinical outcomes among ambulatory gynecological surgery recipients at Kyabirwa surgical center, Budondo sub county, Jinja city,1. To classify the clinical outcomes among ambulatory gynecological surgery recipients at Kyabirwa surgical center, Budondo sub county, Jinja city,To characterize the clinical outcomes among ambulatory gynecological surgery recipients at kyabirwa surgical center, Budondo sub county, Jinja city,
 Uganda 2025-04-02 8:52:03 2028-04-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Adoke Yeka
ID: UNCST-2021-R004300
 Assessing durability of PermaNet Dual and PermaNet 3.0 under field conditions in Northern Uganda.
REFNo: HS5657ES

1. To compare the attrition and physical integrity of PermaNet Dual nets to PermaNet 3.0 nets in multiple locations across Northern Uganda over a three-year period, and to estimate median LLIN survival.
2. To characterize the chemical and entomological attributes of PermaNet 3.0 and PermaNet Dual nets over a period of three years after the mass distribution campaign.
3. To provide insight into the community acceptance of PermaNet Dual relative to PermaNet 3.0, and describe social and behavioural aspects related to net use and net care.
4. To assess the impact of net use and net care practices on the functional survival and insecticidal activity of the LLINs across the districts and across time.

 Uganda 2025-04-02 8:50:02 2028-04-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Stephen Asiimwe
ID: UNCST-2019-R000059
 Uganda Lung Health Study
REFNo: HS5678ES

To identify individuals at highest risk for COPD early in the disease course and intervention targets for preventing disease progression among young adults.
 Uganda 2025-04-02 8:46:08 2028-04-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Henry Mugerwa
ID: UNCST-2019-R000420
 A phase III, Multicenter, Randomized, Placebo Controlled, Double-blind Study to Assess Efficacy and Safety of Crizanlizumab (5 mg/kg) versus placebo, with or without Hydroxyurea/Hydroxycarbamide Therapy, in Adolescent and Adult Sickle Cell Disease Patients with Frequent Vaso-Occlusive Crises
REFNo: HS5274ES

Primary Objective: To compare the efficacy of 5 mg/kg of crizanlizumab versus placebo, with or without hydroxyurea/hydroxycarbamide, on the annualized rate of VOCs* that are HCPmanaged (including VOCs leading to
management at a health care facility or those managed via remote consultation) over the planned 52-week treatment period in SCD
patients aged 12 years and older with a history of frequent VOCs (4-12 events in 12 months prior to the screening visit).

Secondary Objective: Key secondary objective:

To compare the efficacy of 5 mg/kg of
crizanlizumab versus placebo, with or without
hydroxyurea/hydroxycarbamide, on the
annualized rate of all VOCs including VOCs that are HCP-managed (including VOCs leading to
management at a health care facility or those managed via remote consultation) and VOCs that are self-managed without recommendations from HCP during the event over the planned 52-week treatment period in SCD patients aged 12 years and older with a history of frequent VOCs (4-12 events in the 12 months prior to the screening visit).

To evaluate the annualized rate of VOCs by type of management between treatment arms over the planned 52-week treatment period:
VOCs that are HCP-managed at a health
care facility
• VOCs that are HCP-managed via remote
consultation
• VOCs that are self-managed without
recommendations from HCP during the
event
• VOCs that are HCP-managed via remote
consultation or self-managed without
recommendations from HCP during the
event

• To evaluate the time to first VOC that is HCPmanaged (including VOCs leading to
management at a health care facility or those managed via remote consultation) between treatment arms over the planned 52-week treatment period.

To evaluate the proportion of participants free from VOCs that are HCP-managed (including VOCs leading to management at a health care facility or those managed via remote consultation) between treatment arms over the planned 52-week treatment period.

To evaluate the duration of VOCs that are HCP-managed (including VOCs leading to management at a health care facility or those managed via remote consultation) between treatment arms over the planned 52-week treatment period.

To evaluate the safety and immunogenicity of crizanlizumab 5 mg/kg over the 2-year study
period.

To explore the efficacy of crizanlizumab 5 mg/kg over the 2-year study period.

To explore the proportion of VOCs that are selfmanaged without recommendations from HCP during the event, versus VOCs that are HCP-managed (including VOCs leading to
management at a health care facility or those managed via remote consultation) between treatment arms over the planned treatment period of 52 weeks.

To explore the proportion of VOCs that are HCP-managed via remote consultation versus VOCs that are HCP-managed at a healthcare facility between treatment arms over the planned 52-week treatment period.

To explore the incidence rates of all VOCs,
VOCs that are HCP-managed at a healthcare
facility, VOCs that are HCP-managed via remote consultation, VOCs that are HCP-managed,VOCs that are self-managed without
recommendations from HCP during the event,
VOCs that are HCP-managed via remote
consultation or self-managed without
recommendations from HCP during the event, by treatment arm.

To explore quality of life in each treatment arm (ASCQ-Me Short Forms: emotional impact, sleep impact, and joint stiffness).

To explore healthcare facility resource utilization (inpatient hospital admission, emergency room visit, urgent care/clinic visit, infusion center visit)between treatment arms over
the planned 52-week treatment period.

To explore the pharmacokinetics (PK) profile of crizanlizumab at 5 mg/kg.

To explore the pharmacodynamics (PD) (Pselectin inhibition) of crizanlizumab at 5 mg/kg.

To explore biomarkers [p-selectin (free and
total)] and CRP].

To explore exposure-response relationship.
 Uganda 2025-04-02 8:43:56 2028-04-02 Medical and Health Sciences Clinical Trial Non-degree Award
Taremwa Danison Danison
ID: UNCST-2024-R002981
 AN OPTIMIZED ENSEMBLE DEEP LEARNING MODEL FOR MAIZE YIELD PREDICTION
REFNo: SIR375ES

General Objective of the Study

The general objective of the study will be to develop an optimized ensemble deep learning model to improve the accuracy of maize yield prediction, thereby enhancing decision-making by stakeholders in the agriculture sector.
Specific Objectives of the Study

i. To investigate the challenges of the current yield forecasting models and remote sensing technologies that will be used to generate variables for predicting maize yields using remote sensing data.
ii. To design and develop an optimized CNN-LSTM model using Bayesian approaches for the prediction of maize yields in Uganda.
iii. To evaluate the performance of the developed model for maize yield estimation.

 Uganda 2025-04-02 8:32:18 2028-04-02 Engineering and Technology Non-Clinical Trial Degree Award
Moses Sembatya Nixon
ID: UNCST-2024-R015771
 Baseline Study of Norms and Behavioral Drivers of Child Marriage and Female Genital Mutilation in Uganda
REFNo: SS3765ES

This study aims to provide crucial insights into the prevalence, drivers, and consequences of child marriage (CM) and female genital mutilation (FGM) in Uganda through a comprehensive baseline study. By assessing social norms, knowledge, attitudes, and practices related to CM and FGM, the study seeks to inform targeted interventions and policy decisions.
Uganda 2025-04-02 10:33:36 2028-04-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Rogers Ssebunya
ID: UNCST-2025-R016712
 Supporting Health System Readiness and Quality for Scaled Delivery of Self-Injectable Contraception: The Delivering Innovation in Self-Care (DISC) 2.0 Study Version 1.1
REFNo: HS5767ES

1. To describe health facility readiness to provide voluntary DMPA-SC SI within the existing contraceptive method mix in DISC-supported facilities in Uganda.
2. To describe quality of contraceptive counseling and client experiences among clients receiving injectables at DISC-supported facilities in Uganda.
3. To understand clients’ self-efficacy and confidence around DMPA self-injection immediately post-training and at 4-months follow-up in Uganda.
4. To improve understanding of DMPA-SC ‘take home’ units, including dispensation practices, provider and client preferences, storage, and usage, and disposal at initiation and 4-months follow-up.
 Uganda 2025-04-02 10:31:32 2028-04-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Susan  Nabadda
ID: UNCST-2020-R014331
 Field Performance Evaluation of the Genbody ConfiSign HIV Self-Test in Uganda
REFNo: HS5760ES

To evaluate the field diagnostic performance and operational characteristics; usability, acceptability, and feasibility of the Genbody ConfiSign HIV ST in Uganda.

Specific objectives
a) To determine the field diagnostic accuracy (sensitivity, specificity, positive predictive value, and negative predictive value) of the Genbody ConfiSign HIV Self Test compared with the Wondflo HIV Self test (Guangzhou, China).

b)To evaluate the operational characteristics; feasibility, acceptability, and usability of the Genbody ConfiSign HIV ST in selected health facilities.

 Uganda 2025-04-02 10:25:15 2028-04-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Robert Odendi Gideon
ID: UNCST-2024-R002130
 MENTAL HEALTH CHALLENGES, ADVERSE CHILDHOOD EXPERIENCES AND INTERPERSONAL PSYCHOTHERAPY AMONG ADOLESCENTS AT KAMPIRINGISA NATIONAL REHABILITATION CENTER, CENTRAL UGANDA
REFNo: HS5763ES

1. To determine the prevalence of mental health challenges (Depression, PTSD, and alcohol substance use disorders) and adverse childhood experiences (ACEs) among adolescents at Kampiringisa National Rehabilitation Centre (KNRC).
2. To examine the relationship between ACEs and mental health challenges, with social support as a mediator among adolescents at KNRC.
3. To explore the experiences and perceptions of adolescents regarding the effectiveness of existing counseling practices in reducing depressive symptoms among adolescents at KNRC.
4. To identify the socio-cultural factors, institutional policies, and individual characteristics that influence the feasibility, acceptability, and effectiveness of Group Interpersonal Therapy (Group IPT) in reducing depressive symptoms at KNRC.
5. To evaluate adolescents' experiences and perceptions of the feasibility, acceptability, and effectiveness of Group IPT compared to the existing counseling practices at KNRC.

 Uganda 2025-04-02 10:00:01 2028-04-02 Medical and Health Sciences Non-Clinical Trial Degree Award
Felix Bongomin
ID: UNCST-2020-R014224
 Chronic Pulmonary Aspergillosis: Optimization of Therapy, Immunogenetic Screening, and Diagnosis in Uganda [CPA_OPTIONS_Phase I: A Prospective Cohort Study]
REFNo: HS5799ES

The primary objective of this study is to establish a longitudinal cohort comprising individuals who have recently been diagnosed with CPA. The main aim is to comprehensively document various aspects of the disease progression and its impact on patients\' health over a span of 12 months.,The primary objective of this study is to establish a longitudinal cohort comprising individuals who have recently been diagnosed with CPA. The main aim is to comprehensively document various aspects of the disease progression and its impact on patients\' health over a span of 12 months.,
 Uganda 2025-04-01 17:44:43 2028-04-01 Medical and Health Sciences Non-Clinical Trial Degree Award
Stella Muyanja Zawedde
ID: UNCST-2021-R014037
 The Integrated Management of Chronic Lung Illnesses in Uganda
REFNo: HS5728ES

Aim 1: To determine the prevalence of and factors associated with chronic respiratory illnesses e.g., asthma, chronic obstructive pulmonary disease among presumptive TB patients who test negative for TB on GeneXpert testing

Aim 2: (a) To determine the prevalence of, factors associated with post TB lung disease (PTLD) among patients who complete TB treatment (b) To determine the effect of post TB lung care on health related QoL among patients with PTLD

Aim 3: To determine barriers and facilitators for linkage to treatment for patients referred for chronic lung care

Aim 4: To document the cost per asthma/COPD case found during integrated community-based screening.
 Uganda 2025-04-01 17:31:43 2028-04-01 Medical and Health Sciences Non-Clinical Trial Non-degree Award
george paasi
ID: UNCST-2020-R014619
 THE CLINICAL SPECTRUM, GEOSPATIAL DISTRIBUTION AND GENETIC MODIFIERS OF SEVERE MALARIA AMONG CHILDREN WITH SICKLE CELL DISEASE IN EASTERN UGANDA.
REFNo: HS5714ES

i) To determine the effect of host RBC polymorphisms on the risk and severity of malaria.
ii) To determine the Geospatio-temporal distribution of the malaria-sickle cell disease syndemic in Uganda.
iii) To determine the clinical spectrum of severe malaria among children with SCA in eastern Uganda.

 Uganda 2025-04-01 17:21:57 2028-04-01 Medical and Health Sciences Non-Clinical Trial Degree Award
ERICK SSEGUJJA
ID: UNCST-2021-R012964
 Partnerships for Stronger Knowledge Systems in Africa (KNOSA): Lessons from Uganda
REFNo: HS5716ES

Specifically, the implementation research has the following objectives;
1. To characterise the nature and functioning of the different components of the current national knowledge system, ??with a focus on the health sector.
2. To explore constraints and challenges affecting the capacity of Uganda’s national knowledge systems.
3. To document and assess the current interventions to strengthen the national knowledge system?
4. To explore opportunities for strengthening the capacity of the national knowledge system to advance evidence-informed decision making in Uganda’s health sector.

Uganda 2025-03-25 11:14:05 2028-03-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ronald Moses Galiwango
ID: UNCST-2024-R015239
 INTEGRATED FEMALE SEXUALLY TRANSMITTED INFECTION TESTING FOR HIV EPIDEMIC CONTROL THROUGH PREP (IN-STEP)
REFNo: HS5715ES

a) To conduct an individually randomized effectiveness implementation trial of SRST plus cSTI testing to increase PrEP use among African women at high HIV risk.
b) To perform a mixed-methods, implementation science evaluation of female cSTI testing for improving PrEP use for HIV prevention.
c) To determine the most efficient, population-level female cSTI testing strategies to reduce HIV incidence in African settings.

Uganda 2025-03-25 11:13:20 2028-03-25 Medical and Health Sciences Clinical Trial Non-degree Award
Prudence Beinamaryo
ID: UNCST-2023-R007239
 Developing a robust interdisciplinary-informed WASH framework for the prevention and elimination of the wicked public-health problem of schistosomiasis (WickedSchisto)
REFNo: HS5707ES

I. What are the true health, economic and societal impacts of schistosomiasis?
a) Characterise what quality of life means to individuals living in Schistosoma endemic areas in Cameroon and Uganda, and how this is affected by infections, WASH access, environmental, spatial, social and other determinants.
b) Measure the diverse impact of schistosomiasis on individual’s and household’s quality of life.
c) Quantify the economic costs associated with schistosomiasis to individuals and society.
d) Develop and validate a field-suitable morbidity marker for mapping and monitoring disease resolution.
II. What are the most cost-effective combinations of WASH and MDA interventions?
a) Test the hypothesis that MDA refusal, due to fear of side effects, is linked with latrine access.
b) Characterise relative contributions of existing WASH on reducing reinfection post MDA: risk to self.
c) Quantify environmental force-of-infection and the impact of ‘risk to self’ and ‘risk to
Uganda 2025-03-25 11:11:44 2028-03-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Riley Derby Nicholas
ID: UNCST-2025-R017680
 Impacts of early social life on social and physical development in mountain gorillas
REFNo: NS946ES

Study social and physical change in immature mountain gorillas in Bwindi Impenetrable National Park, in collaboration with Bwindi Gorilla Project, through combining behavioral, hormonal, and non-invasive growth measures
 USA 2025-03-25 11:02:11 2028-03-25 Natural Sciences Non-Clinical Trial Non-degree Award
Erika Sininärhi
ID: UNCST-2025-R017295
 Physiological correlates of variation in personality traits in the banded mongoose Mungos mungo
REFNo: NS942ES

1) To determine the relationship between social rank, prenatal androgen exposure, and personality. 2) To investigate whether individual differences in facial thermal patterns are connected to personality, behaviour and stress reactivity.
Finland 2025-03-25 11:01:27 2028-03-25 Natural Sciences Non-Clinical Trial Degree Award
David Hayman T. S.
ID: UNCST-2023-R006403
 One Health, multiple factors: an interdisciplinary investigation of emerging infectious disease
REFNo: NS924ES

Infectious diseases significantly impact global health, affecting both humans and animals. Zoonotic diseases, which are transmitted between animals and humans, pose particular risks in regions with high human-wildlife interaction. One such region is Uganda, specifically around Bwindi Impenetrable National Park (BINP), where communities live in close proximity to domestic and wild animals.

The objectives of this research are to:

Identify and quantify zoonotic pathogens in fecal samples from various animal species.

Assess pathogen prevalence across different species.

Analyze microbial community structures and antimicrobial resistance genes.
 New Zealand 2025-03-25 11:00:19 2028-03-25 Natural Sciences Non-Clinical Trial Non-degree Award
Joan Mutyoba Nankya
ID: UNCST-2021-R010992
 Using patient journey mapping approach to understand and improve post-abortion care within routine health care services
REFNo: HS4137ES


General objective

The general objective of this study is to use a journey mapping approach to understand client experiences as they navigate abortion services, and gaps in services, in order to improve PAC service delivery, client experiences and outcomes within the health care system.
Specific objectives

The specific objectives of the journey mapping approach include:

1. To document client experiences at different stages of post-abortion care-seeking.
2. To understand the current service provision processes for clients seeking post-abortion care services and identify gaps and unmet needs in these services.
3. To evaluate comprehensiveness of care and identify interventions to improve care.
4. To compare patient experiences with established standards of care

The specific objectives of the survey include:
1. To characterize the type and range of contraceptive and abortion-care services available for women who seek care at health facilities.
2. To determine whether women, including young women, receive comprehensive counseling on choices related to manual vacuum aspiration (MVA), medical abortion (MA) and contraception and which factors are related to receipt of such counselling.
3. To determine whether family planning and abortion services are provided with respect and compassion.

 Uganda 2025-03-25 10:56:04 2028-03-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Karen Bailey M.
ID: UNCST-2024-R003544
 Understanding invisible socio-environmental systems through pesticides across human-wildlife interactions
REFNo: SS3710ES

To model simulations of the interactions within the SES, illustrating the feedback mechanisms between pesticide use, environmental changes, and human-wildlife well-being,To quantify pesticide exposure and associated health outcomes in humans and wildlife, with a focus on spatial and temporal trends,To assess socio-economic and environmental factors influencing farmers\' decisions regarding pesticide use,To investigate the socio-environmental drivers and molecular-level impacts of pesticide use in a tropical forest-agricultural mosaic and develop strategies that balance agricultural productivity with biodiversity conservation among communities around the Kibale National Park ,
 USA 2025-03-25 10:53:06 2028-03-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Kamya Moses
ID: UNCST-2020-R014203
 Integrating management of alcohol use, intimate partner violence, and menopausal transition into HIV care for women living with HIV in Uganda
REFNo: HS5750ES

To explore the unique health challenges faced by women living with HIV in Uganda related to intimate partner violence, menopausal transition, and alcohol use disorder (AUD), focusing on distinct age groups to inform targeted health interventions
 Uganda 2025-03-19 13:02:04 2028-03-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Abel  Kakuru
ID: UNCST-2022-R009193
 Epidemiology of Malaria Infection in Sub-Saharan African Countries
REFNo: HS5638ES

To estimate the site-specific IR of P. falciparum infection by rapid diagnostic test (RDT) testing, overall and by age group (5-11 years, 12-17 years, 18-60 years) during the active detection of infection period.
 Uganda 2025-03-19 12:57:39 2028-03-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Noeline Nakasujja
ID: UNCST-2019-R001428
 Clonal Hematopoiesis: A Global Perspective on the Impact of CH on Alzheimer’s Disease in Sub-Saharan Africa
REFNo: HS5533ES

Main Objective
1. The aim of this proposed work is to compare the frequency and type of clonal hematopoiesis (CH) mutations in age-matched African American and Ugandan populations. We intend to determine the correlation between specific CH-associated mutations and development of Alzheimer’s Disease in both a Ugandan and African-American population.

Specific Objectives
1. Compare the frequency of CH in an elderly African American versus elderly Ugandan population.
2. Compare the types of CH mutations in an elderly African American versus elderly Ugandan population.
3. Determine the correlation between specific CH-associated mutations and the development of AD in a Ugandan population.
 Uganda 2025-03-19 12:53:37 2028-03-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
STEVEN SEBBALE
ID: UNCST-2023-R006063
 PARTICIPATION OF FEMALE DOCTORATE HOLDERS IN SCIENCE, TECHNOLOGY AND INNOVATION: AN EXAMINATION ON GENDER EQUITY, INCLUSIVITY AND INTERSECTIONALITY IN UGANDA
REFNo: SS3712ES

a) To examine the demographic and professional characteristics of female doctorate holders in Uganda
b) To assess the intersectional challenges faced by female doctorate holders in Uganda
c) To provide data-driven insights for integrating intersectionality into UNCST’s grants system
 Uganda 2025-03-18 13:09:22 2028-03-18 Social Science and Humanities Non-Clinical Trial Non-degree Award
Richard Wismayer
ID: UNCST-2019-R000483
 The microbiome as an aetiological factors in colorectal carcinoma in Ugandan patients
REFNo: HS5644ES

1. To investigate the frequency of carriage of faecal P. micra in Ugandan CRC patients and controls by 16S rRNA sequencing and PCR and assess its potential as a non- invasive biomarker compared to other bacteria (Study 1).

2. To explore the associations of P.micra and F.nucleatum, the general tumour microbiome, the intra-tumour immune response and the tumour MSI status within the tumour itself. P.micra and F.nucleatum will be determined by PCR, the tumour microbiome by 16S rRNA sequencing and the tumour immune response both pathologically and by the numbers of infiltrating lymphocytes a key prognostic marker. MSI and MSS status will also be identified (Study 2).

3. To analyse the bacterial content of faeces using 16S rRNA sequencing in relation to the clinical features and MSI/MSS status of CRC in Ugandan patients and controls using network analysis in Ugandan patients. To identify bacteria positively and negatively associated with Ugandan bowel cancer carriage (Study 3).

4. To determine the prevalence of cancer related stool toxins, pks, FadA, and ETBF in Ugandan colorectal cancer patients and controls using quantitative PCR assays on faeces (Study 4).

5. To compare the above findings with those of CRC patients and controls from the international microbiome network in Ghana, India, Vietnam, Argentina and England (Study 5).

 Malta 2025-03-18 13:03:54 2028-03-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Shahiid Kiyaga
ID: UNCST-2021-R007055
 Genetic Diversity and Transmission Intensity Heterogeneity of Plasmodium falciparum in Malaria Endemic Regions in Uganda
REFNo: HS5697ES

General Objective
To analyze the genetic diversity of P. falciparum and the heterogeneity in malaria transmission intensity in high-endemic areas of Uganda.
Specific Objectives
1. To assess the genetic diversity and population substructure of P. falciparum in high endemic areas of Uganda by quantifying allelic variation and estimating population structure parameters using F_ST (fixation index) and principal component analysis (PCA).
2. To characterize the heterogeneity in transmission intensity in high endemic areas of Uganda using P. falciparum targeted amplicon genomic data and malaria epidemiological parameters.
3. To develop and apply advanced machine learning models to predict geographical origins of P. falciparum parasites in Uganda using whole-genome sequence data.
 Uganda 2025-03-14 19:14:47 2028-03-14 Medical and Health Sciences Non-Clinical Trial Degree Award
Racheal Ninsiima
ID: UNCST-2020-R014564
 Effect of blockchain technology on the performance of barley farmers in eastern Uganda
REFNo: A536ES

i) To determine farmers’ behavioural intention to accept BCT in Uganda’s eastern barley producing region.
ii) To examine the factors that influence adoption and extent of use of BCT among barley farmers in eastern Uganda.
iii) To determine the effect of BCT on barley farmers’ productivity and gross margin in eastern Uganda
iv) To develop suitable BCT implementation framework among barley farmers in eastern Uganda.

 Uganda 2025-03-14 19:13:35 2028-03-14 Agricultural Sciences Non-Clinical Trial Degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 SURVEY, SAFETY AND EFFICACY OF HERBAL PRODUCTS USED FOR MALARIA PROPHYLAXIS AND TREATMENT IN UGANDA.
REFNo: HS5468ES

To conduct a survey of herbal medicinal products used for malaria prophylaxis and treatment, evaluate their safety and prophylactic efficacy among school-age children (8-15yrs) in Kibuku district, Uganda.
1. To identify herbal medicinal products used by communities for malaria prophylaxis and treatment in Uganda.
2. To evaluate the artemisinin content of herbal medicinal products used by communities for malaria prophylaxis and treatment in Uganda.
3. To determine the antiplasmodial activity (IC50) of herbal medicinal products used for malaria prophylaxis and treatment in Uganda.
4. To evaluate the safety of herbal medicinal products used for malaria prophylaxis among school age children (8-15 years) in Kibuku district in eastern Uganda.
5. To determine malaria incidence among school age children (8-15 years) receiving selected herbal medicinal products for malaria prophylaxis compared to monthly Dihydroartemisinin-Piperaquine (DP) in Kibuku district in eastern Uganda.
6. To determine prevalence of parasitaemia among school age children (8-15 years) receiving selected herbal medicinal products for malaria prophylaxis compared to monthly Dihydroartemisinin-Piperaquine (DP) in Kibuku in eastern Uganda.

 Uganda 2025-03-14 19:08:33 2028-03-14 Medical and Health Sciences Clinical Trial Non-degree Award
Irene  Vries de
ID: UNCST-2024-R003372
 A pilot Study for introducing a Point of Care Ultrasound (POCUS) device (Baby Checker), supported by Artificial Intelligence (AI), in peri-urban UgandaVersion 1.3 August
REFNo: SS3581ES

Objective and Research Questions
The objective of this research is to assess the technical performance and health outcomes resulting from the introduction of the BabyChecker device in peri-urban Uganda. Specifically, the study aims to evaluate its impact on enhancing timely ANC, including routine care and referrals, thereby potentially reducing maternal and perinatal morbidity and mortality rates. This evaluation will inform developers and implementers on the effective and responsible deployment of the BabyChecker Point-of-Care Ultrasound Scan (POCUS).

2.1 Research Questions per Component
A. Technical Performance
Health Worker performance research questions:
1. What is the initial scanning performance of health workers by cadre on their first day of using BabyChecker?
2. What is the average scanning performance over the study period for health workers by cadre (e.g., certificate, diploma, degree nurses, midwives, clinical officers)?
3. Is there a correlation between the average scanning performance of health workers and their cadre or years of experience?
4. How much time do health workers require to navigate the BabyChecker application and complete a scan on their first day?
5. What is the average time required by health workers to navigate the BabyChecker application and complete a scan over the study period?
6. How well is the BabyChecker equipment maintained throughout the study period?
Artificial Intelligence (AI) research questions:
1. What is the specificity and sensitivity of BabyChecker's AI in estimating gestational age during the first and second trimesters?
2. What is the specificity and sensitivity of BabyChecker's AI in identifying non-cephalic fetal presentation and low placental localization or placenta previa during the third trimester (36+ weeks)?
B. Health Effectiveness
The hypothesis posits that the introduction of BabyChecker will increase ANC attendance during the first trimester and improve access to imaging services, leading to early detection of risk factors and subsequent referrals. The study focuses on observing changes in ANC attendance, risk factor identification, and referral initiation as direct outcomes of the POCUS intervention.
Health Effectiveness of BabyChecker (AI + Remote Read Results) research questions:
1. Does the introduction of the BabyChecker and other VHE community interventions contribute to an increase in pregnant women first attending ANC during the first trimester?
2. Does the introduction of the BabyChecker and mobilization contribute to an increase in pregnant women that come for the 8th ANC visits?
3. Does the introduction of BabyChecker contribute to an increased overall number of ANC visits?
4. Does the introduction of BabyChecker increase the detection rate of pregnancy risk factors such as multiple pregnancies, placenta previa, breech presentation, or non-longitudinal fetal positions?
5. Does the introduction of BabyChecker increase referrals for multiple pregnancies, placenta previa, breech presentation, or non-longitudinal fetal positions?
6. Do women follow through on referrals, and do these referrals lead to improved health outcomes among women in the private sector?

 Netherlands 2025-03-14 18:58:29 2028-03-14 Social Science and Humanities Non-Clinical Trial Non-degree Award
Isaac Mugwano
ID: UNCST-2024-R002967
 IMMEDIATE AND LONG TERM OUTCOMES OF PATIENTS WITH SEVERE MITRAL STENOSIS UNDERGOING BALLOON MITRAL VALVULOPLASTY (BVM) AT THE UGANDA HEART INSTITUTE.
REFNo: HS5507ES

1. To describe the immediate (post-operative) outcomes of patients who underwent BMV at UHI during the study period.

2. To describe the long term (1 year and 5 year) outcomes of patients with severe mitral stenosis who underwent BMV at Uganda heart institute during the study period.

Uganda 2025-03-14 18:51:15 2028-03-14 Medical and Health Sciences Non-Clinical Trial Degree Award
Fiona  Nakabugo Kabuuka
ID: UNCST-2024-R003631
 UTILIZATION AND DETERMINANTS OF HIV TESTING AND COUNSELING SERVICES AMONG YOUTH IN KAWAALA VILLAGE, LUBAGA PARISH, LUBAGA DIVISION
REFNo: HS5339ES

To assess the health-facility determinants influencing the utilization of HIV Testing and Counseling services among youths in Kawaala village, Lubaga Parish, Lubaga Division in May 2024.,To assess the environmental related determinants influencing the utilization of HIV Testing and Counseling services among among youths in Kawaala village, Lubaga Parish, Lubaga Division in May 2024.,To determine the individual determinants influencing the utilization of HIV Testing and Counseling services among youths in Kawaala village, Lubaga Parish, Lubaga Division in May 2024.,To determine the level of utilization of HIV Testing and Counseling services among youths in Kawaala village, Lubaga Parish, Lubaga Division in May 2024.,To assess the utilization and determination of HIV testing and Counseling services youths in Kawaala village, Lubaga Parish, Lubaga Division in Kampala District in May 2024.,
 Uganda 2025-03-14 18:37:36 2028-03-14 Medical and Health Sciences Non-Clinical Trial Degree Award
Murezi Mereth
ID: UNCST-2023-R007640
 Effects of Lifestyle and Environmental Change on the Human Epigenome
REFNo: HS5243ES

To advance our understanding of the epigenomic mechanisms that mediate the acclimatization to major transitions in lifestyle and environment to understand how populations adapt, both in the past and in the future.
Characterize how extreme lifestyle and environmental transitions affect patterns of gene regulation.

 Uganda 2025-03-14 18:36:41 2028-03-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joyce Kambugu Balagadde
ID: UNCST-2020-R014996
 International classification, cancer and care: Accounting for the diagnostic potential of low- and middle-income countries
REFNo: SS3561ES

NOTES: The overall project is guided by three research questions, given here with their related objectives. Specific objectives for research activities in Uganda are also described. RESEARCH OBJECTIVE 1: What are the “on-the-ground realities” of brain tumour diagnosis and care in Sub-Saharan Africa and how does diagnostic practice in brain tumours differ across the region? OBJECTIVE 1: To develop three detailed empirical case studies of diagnostic work and brain tumour care in Uganda, Nigeria and South Africa that are embedded in understandings of care23, national policy, socio-technical infrastructures, and international classification. OBJECTIVE 2: To compare empirical case studies to develop rich understandings of how practitioners in Sub-Saharan Africa use, refuse, or adapt WHO classifications, or mobilise to establish their own terms of reference. OBJECTIVE 3: To generate critical perspectives on diagnostic value, where diagnosis might not be assumed an essential condition of good care. RESEARCH QUESTION 2: How are the diagnostic contexts of LMICs considered by experts writing international cancer classifications? OBJECTIVE 4: To examine how international cancer classifiers understand diagnostic approaches and infrastructures in LMICs. OBJECTIVE 5: To examine the individual values and institutional principles that guide how classifiers consider these approaches in their decision-making about cancer classification. RESEARCH OBJECTIVE 3: How are local medical practitioners, cancer advocates, and international organisations mobilising in a regional network to improve brain tumour outcomes across Sub-Saharan Africa? OBJECTIVE 6: To explore how local medical practitioners, advocates, and international organisations in Sub-Saharan Africa are collaborating in a new professional network, Society for Neuro-Oncology Sub-Saharan Africa (SNOSSA), to improve brain tumour diagnosis and care across Sub-Saharan Africa. OBJECTIVE 7: To examine how members understand unity and diversity among Sub-Saharan African countries, and establish common aspirations and strategies concerning diagnosis and classification. OBJECTIVE 8: To explore how members understand their work on a disease which is considered rare, yet its true incidence unknown, and which is de-prioritised in national and international funding. The specific research objective for research conducted in Uganda is to develop a thorough ethnographic understanding of how brain tumour diagnosis happens in practice; how diagnostic work relates to local sociotechnical infrastructure, national policy, and international classification; and how diagnosis relates to care and treatment decision-making.
 Uganda 2025-03-14 18:29:40 2028-03-14 Social Science and Humanities Non-Clinical Trial Non-degree Award
ssonko jackson
ID: UNCST-2022-R009683
 SOCIAL SECURITY POLICY IMPLEMENTATION AND CLIENTS' SATISFACTION: A CASE OF NATIONAL SOCIAL SECURITY FUND BENEFICIARIES IN UGANDA .
REFNo: SS2326ES

To investigate the contribution of the Social Security Policy Implementation on NSSF Clients’ Satisfaction in Uganda,To assess the influence of Legal framework for social security on NSSF clients’ satisfaction in Uganda.,To analyze the congruence between of Social Security Policy Implementation andLegal framework for social security with particular reference to NSSF in Uganda,To investigate the contribution of the Social security policy to NSSF clients’ satisfaction. The donation is regarded as mediating the Legal Framework for Community Safety with a particular focus on Kampala and the surrounding areas of Uganda.,
 Uganda 2025-03-14 18:26:08 2028-03-14 Social Science and Humanities Non-Clinical Trial Degree Award
GWOKYALYA EDITH BAAGALA
ID: UNCST-2023-R005596
 Academic staff workload and Quality management in private chartered universities in Uganda
REFNo: SS3509ES

i. To examine the effect of the academic staff workload on total quality management in Private chartered universities in Uganda.
ii. To evaluate the effect of academic staff workload on faculty development programs in private chartered universities in Uganda.
iii. To examine the effect of faculty development programs on total quality management in Private chartered universities in Uganda.
iv. To assess the mediating effect of faculty development programs in the relationship between academic staff workload and total quality management in Private chartered universities in Uganda

 Uganda 2025-03-14 18:24:15 2028-03-14 Social Science and Humanities Non-Clinical Trial Degree Award
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