Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Stephen Okoboi
ID: UNCST-2019-R001356
 Amplifying Community Voices and Lived Experience of the Perceived Impact of Climate Change on Health among Community Health Workers in Namayingo District, Uganda
REFNo: SS4546ES

1.Document CHW experiences of the intersection between climate change and health among individuals, families, and communities.
2.Assess CHW experiences of how climate change affects their role and the health system more broadly.
3.Describe CHW perspectives on community strength and resilience in the face of the climate crisis, including local solutions.
4.Explore CHW recommendations for developing a climate-informed health workforce and climate-resilient health systems and communities.
 Uganda 2025-11-04 13:34:31 2028-11-04 Social Science and Humanities Non-Clinical Trial Non-degree Award
Prosper Behumbiize
ID: UNCST-2025-R019986
 Uganda’s Digital Mental Health Leap Harnessing DHIS2 for Data-Driven Insights
REFNo: HS6407ES

The project seeks to address Uganda's mental health data quality, access and utilisation gap by leveraging the DHIS2 platform to digitise the depression and anxiety facility data pipeline, from data generation to analysis and insight generation. Primary objectives The specific objectives are; - Create a harmonised, digitised dataset to enable access of individual granular longitudinal mental health data. - Design and deploy an open-access digital tool and dataset repository to ensure transparency, scalability, and ease of access to analytical outputs. - Engage stakeholders in capacity-strengthening activities. Secondary objectives - Conduct secondary data analysis using open-source Artificial Intelligence (AI) and Machine Learning (ML) models to derive actionable insights from standardised datasets. - Generate policy-relevant outputs, including dashboards, open-source publications, and policy briefs, to inform decision-making at various levels.
Uganda 2025-11-04 13:33:24 2028-11-04 Medical and Health Sciences Non-Clinical Trial Non-degree Award
HOPE KANSIIME
ID: UNCST-2024-R004499
 Designing an optimised framework for effective usage and efficient access of Electronic resources in the consortium of Ugandan university libraries
REFNo: SIR561ES

To establish the acceptability and usability of the developed framework designed to enhance the access and usage of e –resources within the consortium of Uganda university libraries,To design and develop an optimised framework aimed at improving the accessibility and utilization of e-resources within the consortium of Uganda university libraries,To determine the necessary prerequisites for creating an optimized framework that will improve the accessibility and utilization of e-resources in the consortium of Uganda university libraries?,To conduct a cross-sectional study to evaluate how E-resources are utilised, examine access patterns and identify barriers and challenges to their usage within the consortium of Uganda university libraries,To optimise Electronic resource utilisation in Ugandan university consortium by developing an efficient access and usage framework,
 Uganda 2025-11-04 13:31:17 2028-11-04 Engineering and Technology Non-Clinical Trial Degree Award
Edwin Nuwagira
ID: UNCST-2021-R013488
 Improving Diagnostic Strategies for Post-Tuberculosis Lung Disease in Ugandan Primary Health Care Settings (IMPULSE-TB)
REFNo: HS6402ES

To test the feasibility and acceptability of the diagnostic algorithm in facilitating timely post-TB lung diseasediagnosis at primary healthcare facilities,To use qualitative methods to identify barriers and facilitators of diagnosis to post-TB lung disease,To develop, test and validate a clinical algorithm for diagnosing post-TB lung disease based on clinical and sociodemographic characteristics,
 Uganda 2025-11-04 13:29:51 2028-11-04 Medical and Health Sciences Non-degree Award
Francis Pebalo Pebolo
ID: UNCST-2022-R010630
 Incidence, risk factors and clinical outcomes of neonatal sepsis among HIV-exposed infants of mothers on dolutegravir-based antiretroviral therapy in Uganda
REFNo: HS6486ES

Comparing 28-day clinical outcomes of mothers with HIV on DTG-based ART compared with their HIV negative counterparts.,To compare 28-day clinical outcomes among HIV-exposed neonates of mothers on DTG-based ART and HIV-unexposed neonates.,To compare sepsis incidence risk factors among HIV-exposed neonates of mothers on DTG-based ART and HIV-unexposed neonates,To conduct a scoping review to describe the epidemiology of neonatal sepsis of neonates born to mothers with HIV comparing outcomes on DTG- and non-DTG-containing regimens,
 Uganda 2025-11-04 13:00:07 2028-11-04 Medical and Health Sciences Degree Award
ERIC WOBUDEYA
ID: UNCST-2019-R001047
 Phase I/II Dose Finding, Safety and Tolerability Study of Daily Rifapentine Combined with Isoniazid (1HP) for Tuberculosis Prevention in Children Less Than 13 Years of Age with and without HIV
REFNo: HS6555ES

Primary Objectives
Cohort 1 and Cohort 2
• To determine the weight-band dosing of RPT taken as part of the 1HP regimen by evaluating:
⎯ PK RPT exposures among children with and without HIV
⎯ Safety and tolerability of the 1HP regimen among children with HIV while receiving twice-daily DTG and children without HIV through 28 days of dosing
Cohort 2
• To evaluate the effect of RPT taken as part of the 1HP regimen on the PK of DTG
Secondary Objectives
Cohort 1 and Cohort 2
• To evaluate the effect of covariates including age, weight, sex, ethnicity, nutritional status, and HIV-1 status on the PK of RPT taken as part of the 1HP regimen
• To evaluate the safety of the 1HP regimen through 24 weeks of follow-up
• To evaluate the palatability and acceptability of the 1HP regimen
• To evaluate adherence to the 1HP regimen
Cohort 2
• To evaluate the safety and tolerability of twice-daily DTG through 42 days among children with HIV who are receiving 1HP
• To evaluate virologic control (less than 200 copies/mL) at Day 42 among children taking a DTG-based ARV treatment regimen co-administered with 1HP

Uganda 2025-11-04 12:59:17 2028-11-04 Medical and Health Sciences Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
 ConfiSign HIV/Syphilis Combo Self-Test: Evaluation of Clinical Performance and Usability in the hands of untrained users.
REFNo: HS6687ES

Untrained users will either take part in the label comprehension study and results interpretation study (part A) or in the observed untrained user study (part B). Untrained users enrolled for the label comprehension and results interpretation study (part A), shall not participate in the observed user study (part B) and vice versa.,The primary and overall objective of this study is to evaluate the performance and the usability of the ConfiSign HIV/Syphilis Combo Self-Test in the hands of untrained users from a low prevalence HIV region (< 5%) who have no, or limited experience in self-testing. ,
 Uganda 2025-10-29 16:22:26 2028-10-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Specioza Namakula
ID: UNCST-2025-R021710
 EMPOWERING MOBILITY: Assessing the Impact of Buffalo Bicycles on Refugee and host Communities in Uganda. A case study of Bidi Bidi, Rhino Camp and Palabek refugee settlements
REFNo: SS4566ES

I. To generate data that will support Learning and evidence-based decision making.
II. To provide systematic and objective information for bicycle usage in refugee communities.
III. Generating information that is required to inform advocacy and further bicycle provision for vulnerable communities.
IV. To determine the effectiveness, efficiency and relevance of bicycles in improving accessibility to essential services like education, health and economic empowerment.
 Uganda 2025-10-29 16:20:00 2028-10-29 Social Science and Humanities Non-Clinical Trial Non-degree Award
Victor Musiime
ID: UNCST-2021-R013794
 Enhancing Novel Research for Inflammation and Cognitive Health among Adolescents and Young Adults Living with Perinatally Acquired HIV and Adversity (ENRICH+)
REFNo: HS6607ES

Specific Aim 1: Investigate differences in ID and NCI in demographically matched, virally suppressed PHIV and HHIV, as well as HUU AYA (15-25 years old) in Uganda while controlling for chronic adversities. Hypothesis 1 (H1): Both ID and NCI will be respectively higher in PHIV vs. HHIV vs. HUU AYA. H2: Within the two HIV groups, those with delayed ART initiation and lower nadir CD4 cell count at ART initiation will have higher ID and worse NCI.

Specific Aim 2: Investigate the relationship between ID and NCI in AYA within all three groups (PHIV, HHIV and HUU) controlling for chronic adversities. H3: There will be a positive association between ID and NCI in each group. H4: In a subset of PHIV and HUU AYA with prior repeated measures of ID, worsening trajectories of ID in PHIV across 6 years will be associated with worse NCI.

Specific Aim 3: Investigate the effects of co-occurring adversities (i.e., profiles) on the relationships between HIV, ID, and NCI. H5: Adversity profiles will be more severe respectively in PHIV vs. HHIV vs. HUU. H6: The strength of association between medical and psychosocial (e.g., stigma, mental health) adversities, ID and NCI will be strongest in PHIV vs. HHIV vs. HUU, respectively.


 Uganda 2025-10-29 16:07:10 2028-10-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Henry Mugerwa
ID: UNCST-2019-R000420
 A5402 An Open-Label, Randomized Controlled Trial of Pramipexole versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD with Mild Neurocognitive Disorder (MND) in Persons with HIV
REFNo: HS6604ES

1.2 Primary Objectives

1.2.1 To compare pramipexole to escitalopram in the treatment of MDD (and comorbid MDD with MND) based on the Beck Depression Inventory-II (BDI-II/BDI-2) total score [Beck 1996] from baseline to week 24.

1.2.2 To evaluate the safety of pramipexole and escitalopram in PWH having MDD (and comorbid MDD with MND) from baseline to week 24.

1.3 Secondary Objectives

1.3.1 To compare pramipexole to escitalopram in the treatment of MDD using MDD caseness, neurocognitive outcomes, and functional status from baseline to week 24.

1.3.2 To compare the depression, neurocognitive, and functional status outcomes in PWH with MDD alone and with comorbid MDD with MND treated with pramipexole versus escitalopram from baseline to week 24.

1.3.3 To compare the impact of pramipexole and escitalopram on all outcomes above by female versus male sex (assigned at birth) from baseline to week 24.

1.3.4 To determine the impact of pramipexole compared to escitalopram on the measure of HIV-1 RNA viral load in the peripheral blood.

1.4 Exploratory Objectives

1.4.1 To characterize associations between escitalopram trough concentrations and treatment efficacy (BDI-II/BDI-2 total score) as well as participant adverse events (adverse event frequency, severity, and discontinuation rates).

1.4.2 To characterize associations between escitalopram trough concentrations and genetic polymorphisms that affect metabolizing enzymes of escitalopram (known metabolizing enzymes include CYP2C19, CYP2D6, and CYP3A4).

1.4.3 To explore associations between cerebrospinal fluid (CSF) concentrations of escitalopram and BDI-II/BDI-2 total score.

1.4.4 To evaluate adverse events potentially related to drug interactions between antiretroviral therapy (ART) and escitalopram and pramipexole, respectively.

1.5 Substudy Objective

1.5.1 CSF Substudy

To compare the impact of pramipexole and escitalopram on biomarker outcomes in a CSF substudy of participants with MDD alone.

 Uganda 2025-10-29 16:04:25 2028-10-29 Medical and Health Sciences Clinical Trial Non-degree Award
Abel  Kakuru
ID: UNCST-2022-R009193
 Dihydroartemisinin-piperaquine plus sulfadoxine-pyrimethamine versus sulfadoxine-pyrimethamine alone for the prevention of febrile illnesses in children with sickle cell anemia: a double-blind randomized controlled trial
REFNo: HS6294ES

1.
To compare the incidence of all-cause febrile illness among children with sickle cell anemia randomized to receive monthly SP vs. monthly DP+SP.
2.
To compare the incidence of adverse events among children with sickle cell anemia randomised to receive monthly SP vs. monthly DP+SP.
3.
To compare the prevalence of markers of antimalarial resistance, including those associated with SP and DP resistance, among parasitemic children with sickle cell anemia randomized to receive monthly SP vs. monthly DP+SP.
 Uganda 2025-10-29 15:55:44 2028-10-29 Medical and Health Sciences Clinical Trial Non-degree Award
Jane  Kabami
ID: UNCST-2021-R012588
 Peerled Dynamic Choice HIV Prevention for Women. The Peer-led DCP Study
REFNo: HS6556ES

To refine and pilot test a Peer-led Dynamic Choice HIV Prevention intervention for women at elevated HIV risk in southwestern Uganda
 Uganda 2025-10-29 12:53:43 2028-10-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Hannah Tusabe Not Applicable
ID: UNCST-2025-R022045
 EXPLORING THE IMPLEMENTATION OF EARLY GRADE READING METHODOLOGY IN UGANDA PRIMARY SCHOOLS
REFNo: SS4540ES

1.3.1 Main Objective

To explore the implementation of Early-Grade Reading Methodology in primary schools in Uganda.

1.3.2 Specific Objectives

To establish the current practices of Early-Grade Reading methodologies by teachers in primary schools in Uganda.

To identify the challenges teachers face in implementing Early-Grade Reading methodologies in their classrooms.

To determine strategies that can be adopted to improve the implementation of Early-Grade Reading methodologies in Ugandan primary schools.
 Uganda 2025-10-29 12:51:10 2028-10-29 Social Science and Humanities Non-Clinical Trial Degree Award
richard kasirye
ID: UNCST-2025-R018157
 Instructional Technologies for Teacher Education at Busitema University: Application of Skills to Practice
REFNo: SS4450ES

The study aims to answer: How do Busitema University’s teacher education alumni apply ICT knowledge and skills in the secondary schools where they teach? What are their experiences in using ICT in their classrooms? How can the university improve the teacher education program to better prepare graduates for technology-enhanced teaching?
 Uganda 2025-10-29 12:48:06 2028-10-29 Social Science and Humanities Non-Clinical Trial Degree Award
ALEX KAYONGO
ID: UNCST-2019-R001641
 Clonotyping Airway T-cells to Uncover Microbiome-Specific Inflammotypes in HIV-Associated COPD
REFNo: HS6625ES

Study Aim:
To investigate the airway microbiome-specific inflammotypes in COPD among HIV-infected individuals in a rural Uganda.

Specific objectives
1.To determine, in vitro, the CD4+T-cell clonotypic library specific to airway bacterial species associated with COPD among HIV-infected individuals in rural Uganda.

2.To determine, ex vivo, the microbiome-specific clonotypic landscape of BAL-derived CD4+T cells from a cohort of individuals stratified by HIV and COPD in rural Uganda.

3.To validate airway microbiome-specific inflammotypes among individuals with COPD transitioning from stable disease to exacerbation and back to stable disease.

 Uganda 2025-10-29 12:47:04 2028-10-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
AGNESS NATABA
ID: UNCST-2024-R002018
 Reclaiming Rights:Bunyoro Kitara Kingdom Women and their Quest for Reparative Justice from British Colonialism
REFNo: SS4501ES

1. To examine how historical injustices faced by women in the Bunyoro Kitara Kingdom during British colonial rule affected their cultural setting. 2. To evaluate existing reparative justice efforts for women in the Bunyoro Kitara Kingdom. 3. To assess how gender-responsiveness the existing reparative efforts are in fostering inclusive justice, healing, and environmental justice for women in the Bunyoro Kitara Kingdom.
Uganda 2025-10-29 12:44:59 2028-10-29 Social Science and Humanities Non-Clinical Trial Degree Award
JACOB BIBOHERE
ID: UNCST-2025-R021298
 Assessment of CDC Data Triangulation Activities to Enhance Immunization and Vaccine-Preventable Disease Surveillance Programs in Selected African Countries
REFNo: HS6596ES

1.To assess the extent to which data triangulation has been integrated into the existing immunization and/or VPD surveillance staff workload, program processes, and practices at national and sub- national levels. 2.To identify programmatic successes, challenges, enabling factors, and innovations reported by immunization and/or VPD program staff through the application of triangulation analytic tools. 3.To examine the immunization programmatic decisions, actions, and outcomes that have been informed by the use of data triangulation concepts. 4.To explore and identify sustainability strategies and recommendations for ensuring that data triangulation and existing tools remain integrated into routine program activities.
 Uganda 2025-10-29 12:42:52 2028-10-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Shivan Kamugisha Kaitesi
ID: UNCST-2025-R019815
 Socio-Ecological Systems Assessment of Factors Influencing the Lion population in the Greater Virunga Landscape
REFNo: NS989ES

1. Develop a population dynamics model for lions in the Greater Virunga Landscape 2. Assess the functionality of lion movement corridors within GVL 3. Examine the impacts of land use and climate change on the suitable habitat for lions 4. Evaluate factors of human-lion conflict and develop strategies for conflict mitigation and coexistence.
Uganda 2025-10-29 12:41:40 2028-10-29 Natural Sciences Non-Clinical Trial Degree Award
Michael Harvey
ID: UNCST-2025-R022115
 HERPETOFAUNAL DIVERSITY AND BASELINE ECOLOGICAL ASSESSMENT IN SELECT SITES OF NORTHERN AND WESTERN UGANDA
REFNo: NS1049ES

• Generate a list of reptiles and amphibians inhabiting Mount Kadam and surrounding areas
• Compare the distributions of reptiles and amphibians across different habitats within the boundaries of the research site.
• Establish a reference collection of vouchered specimens from the reserve in a local international research collection/museum.
• Tabulate baseline ecological data for each species (see data collection for details)
• Involve local community, students, and other stakeholders in survey methods and data recording
• Publish results of survey in peer-reviewed scientific journals

 USA 2025-10-24 17:36:31 2028-10-24 Natural Sciences Non-Clinical Trial Non-degree Award
DENISH  ONGOL OGWANG
ID: UNCST-2025-R022077
 THE IMPLEMENTATION OF THE PRISONERS’ RIGHT TO VOTE IN UGANDA. A CASE STUDY OF LUZIRA PRISONS, 1995-2021
REFNo: SS4502ES

1. To assess the adequacy of the legal framework for the implementation of prisoners’ right to vote in Uganda.
2. To identify the challenges that Luzira Prisons face in the implementation of the prisoners’ right to vote
3. To develop a framework for the implementation of the prisoners’ right to vote in Uganda.

Uganda 2025-10-24 17:35:10 2028-10-24 Social Science and Humanities Non-Clinical Trial Degree Award
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