Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Holly Koogler
ID:
Social Relationships and Child Labor Migration from Karamoja, Uganda: An Exploratory Study
REFNo: SS1302ES

•Investigate the social risk factors related to child labor migration •Explore the nuances of the social lives of child labor migrants, including both strengths and negative aspects of social relationships •Propose policies and potential interventions that reflect the true structure and dynamics of social networks for preventing child labor migration, mitigating the most dangerous forms, and withdrawing migrant children from labor
 USA 2022-05-30 17:20:41 2025-05-30 Social Science and Humanities Non-Clinical Trial Non-degree Award
ALICE GITAU WANGARI
ID:
FACTORS ASSOCIATED WITH CUMULATIVE INCIDENCE OF GESTATIONAL RHINITIS, AND ITS EFFECTS ON QUALITY OF LIFE AMONG MOTHERS ATTENDING MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS2239ES

1.To determine the cumulative incidence of gestational rhinitis in Mbarara Regional Referral Hospital
2.To determine the factors associated with gestational rhinitis among mothers attending Mbarara Regional Referral Hospital
3.To assess the quality of life among mothers with symptoms of gestational rhinitis attending Mbarara Regional Referral Hospital

 Kenya 2022-05-30 17:17:54 2025-05-30 Medical and Health Sciences Non-Clinical Trial Degree Award
Ahamya William
ID:
A Framework to Enhance Confidentiality and Privacy of Data in Motion.
REFNo: SIR102ES

Carryout a preliminary study to measure the effectiveness and efficiency of the designed framework.,To design a framework aimed at enhancing confidentiality and privacy of data in motion,To find out the weaknesses in the existing frameworks and establish requirements to improve the confidentiality and privacy of data in motion.,The main objective of this study will be to improve the existing frameworks by designing one with enhanced confidentiality and privacy of data in motion in car sensors.,
 Uganda 2022-05-30 17:16:31 2025-05-30 Engineering and Technology Non-Clinical Trial Degree Award
George Mpanga Lutwama
ID:
Ugandan Veterans and the First World War
REFNo: SS1209ES

To identify the names of Ugandans who fought and died during the First World War.
 Uganda 2022-05-30 17:14:58 2025-05-30 Social Science and Humanities Non-Clinical Trial Non-degree Award
Kizito Muwonge
ID: UNCST-2022-R011250
 Methicillin Resistant Staphylococcus aureus Carriage among selected livestock species in designated Districts in Uganda
REFNo: A187ES

1. Determine the burden of MRSA in cattle, goats, sheep and swine in the study districts
2. Determine the burden of MRSA in high - risk human categories in the study districts
3. Determine the knowledge, attitudes and practices of antimicrobial users towards antimicrobial resistance in the study districts
 Uganda 2022-05-30 17:14:03 2025-05-30 Agricultural Sciences Non-Clinical Trial Degree Award
Joshua Muhumuza
ID:
Effect of chewing gum on duration of postoperative ileus following laparotomy for gastroduodenal perforations; a multi centre study.
REFNo: HS1665ES

i. To compare the time taken for post-operative ileus to resolve in the two groups. ii. To compare the duration of hospital stay in the two groups. iii. To determine other factors associated with the duration of post-operative ileus in the study population.
 Uganda 2022-05-30 17:10:09 2025-05-30 Medical and Health Sciences Clinical Trial Degree Award
JUSTUS KIRABIRA
ID:
ASSOCIATION BETWEEN HIV SEROSTATUS AND PREMALIGNANT CERVICAL LESIONS AMONG WOMEN ATTENDING CERVICAL CANCER SCREENING CLINIC AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS2258ES

1. To determine the prevalence of HIV among women attending cervical cancer screening Clinic at MRRH
2. To determine the prevalence of premalignant cervical lesions among HIV positive and HIV negative women attending cervical cancer screening Clinic at MRRH
3. To establish the association between HIV and premalignant cervical lesions among women attending cervical cancer screening Clinic at MRRH.

 Uganda 2022-05-27 19:02:21 2025-05-27 Medical and Health Sciences Non-Clinical Trial Degree Award
Rukiya salim Abdillahi
ID:
Prevalence, clinical manifestations of pregnancy dermatoses and their effect on quality of life among women attending MRRH
REFNo: HS2238ES

To establish the prevalence of pregnancy dermatoses among women attending ANC clinic at MRRH.

To describe the clinical manifestations of pregnancy dermatoses among women attending ANC clinic at MRRH.
To assess the effect of pregnancy dermatoses on the quality of life of women attending ANC clinic at MRRH.

 Kenya 2022-05-27 18:57:18 2025-05-27 Medical and Health Sciences Non-Clinical Trial Degree Award
Adam Hewitt Smith
ID: UNCST-2019-R001658
 African Surgical Outcomes Study in Paediatric patients (ASOS-Paeds)
REFNo: HS2179ES

In paediatric surgical patients < 18 years in Africa: To determine the association between pre-operative, intra-operative and facility factors with postoperative complications and death. ,In paediatric surgical patients < 18 years in Africa: To determine the incidence of intraoperative severe critical incidents,,In paediatric surgical patients < 18 years in Africa: To determine the in-hospital postoperative mortality rate up to 30 days post-surgery,,To determine the incidence of in-hospital postoperative complications up to 30 days post-surgery in paediatric surgical patients <18 years in Africa,
 UK 2022-05-27 18:55:24 2025-05-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Emmanuel  Arinaitwe
ID: UNCST-2021-R011754
 Measuring imported infections and contributions to local transmission in Uganda and Zimbabwe: Uganda studies
REFNo: HS2048ES

To quantify and characterize imported malaria infections in two border sites in sub-Saharan Africa.

To determine the impact of importation on local transmission and identify appropriate targeted interventions in two border sites in sub-Saharan Africa

 Uganda 2022-05-27 18:52:11 2025-05-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Samuel Davidoff-Gore Asher
ID:
Socioeconomic Inclusion of Migrant and Forcibly Displaced Women in Cities in West Africa and the Horn of Africa: What Opportunities and Challenges Exist in a Post-COVID-19 World?
REFNo: SS1300ES

This study seeks to understand what the challenges are across these urban contexts, and how development and humanitarian actors need to adapt their programming approaches along with modus operandi. In particular, it explores the following three levels:
• The gender effects of the COVID-19 pandemic and specific challenges faced by female migrants and forcibly displaced women in terms of access to services and livelihoods depending on the urban context, in West Africa and in the Horn of Africa.
• How donors, humanitarian and development actors, as well as national and local governments, the private sector, and civil society have provided economic and social assistance during the health crisis, to what extent these interventions and policies have addressed the socioeconomic challenges faced by migrant and forcibly displaced women and contributed to gender equality.
• Moving forward, how development actors can work towards better including forcibly displaced and migrant women in recovery efforts and overcome the barriers to their inclusion, and how these initiatives should differ based on the urban context (e.g., capital city; border town; small city).

USA 2022-05-26 9:04:08 2025-05-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Grace Muzanyi
ID: UNCST-2021-R013731
 ASSESSMENT OF ISONIAZID HAIR DRUG LEVELS A MONG DRUG SUSCEPTIBLE PULMONARY TUBERCULOSIS PATIENTS: A STUDY TO MONITOR EXPOSURE, ADHERENCE AND TREATMENT OUTCOMES
REFNo: HS2231ES

General objective: To assess hair levels of Isoniazid among TB patients as a tool to monitor exposure, adherence and treatment outcomes
Specific objectives
1. To determine the acceptability of hair harvest as a method of therapeutic drug monitoring among TB patients in the context of their life experiences, perspective and culture.
2. To determine how hair drug levels relate to plasma drug levels for a fixed Isoniazid dose of 300mg at the 28th ,56th &192nd reference doses in DOT patients compared to patients on SAT at the time points of weeks 4, 8&26 .
3. To specifically determine the mean lowest hair drug level at which TB sputum culture conver-sion occurs by 8 weeks and adverse drug reactions at 4,8&26 weeks of treatment.
4. To determine how each of the factors: diabetes, age, acetylator status, gender, smoking, weight and alcohol affect hair drug levels at the time point of 8 weeks.

 Uganda 2022-05-26 9:02:08 2025-05-26 Medical and Health Sciences Non-Clinical Trial Degree Award
Fatumah Mirembe
ID:
Iron Production Technologies in Butiru, Eastern Uganda: An Archaeometallurgical Investigation
REFNo: SS1299ES

-To examine the types of iron smelting furnaces and tuyere forms at Butiru
-To establish the relationship between iron slags and vegetational changes
-To investigate the rituals associated with iron production at Butiru
-To determine the chronology of Butiru iron production
 Uganda 2022-05-26 8:14:11 2025-05-26 Social Science and Humanities Non-Clinical Trial Degree Award
Gertrude Nakigozi
ID: UNCST-2023-R007979
 Long-term impact of universal treatment and dolutegravir on population HIV virologic and incidence outcomes in Africa: The LONGVIEW Study
REFNo: HS2249ES

Aim 1: Assess population-level dynamics of HIV viremia and drug resistance before and after COVID-19 emergence. Longitudinal HIV VLs will be obtained for all HIV-positive RCCS participants from 2013 to 2025. Group-based multi-trajectory analysis will be used to assess VL suppression patterns over time, including durable VL suppression. Deep sequence phylogenetic data will be generated for all viremic participants (>1,000 HIV copies/mL) to assess HIVDR. Bayesian non-parametric methods will be used to assess spatiotemporal trends in viremia and HIVDR. We hypothesize that there will be substantial reductions in durable VL suppression, increases in HIVDR, and emergence of DTG resistance following COVID-19. Aim 2: Use quantitative and qualitative methods to assess the impact of COVID-19 on HIV treatment seeking, utilization and care provision. We will embed questions on health status, social distancing, and impact of COVID-19 on HIV care utilization, including ART adoption and adherence, in the RCCS survey. Using RCCS survey data collected in 2015-2021, we will identify HIV-positive individuals who are viremic and/or who report interruptions in HIV care and conduct in-depth interviews to assess the extent and nature of ART care disruption, including disruption due to COVID-19 and for other reasons. We will also conduct focus group discussions and in-depth interviews with HIV service providers (e.g., health care workers, pharmacists, and program implementers) to assess the impact of COVID-19 on provision of HIV care and treatment. We hypothesize that COVID-19 will result in substantial and widespread health systems disruptions impacting individual-care seeking and HIV service availability. Aim 3: Evaluate trends in HIV incidence and transmission risk across the infection and care continuum before and after COVID-19 emergence: We will use longitudinal data from the RCCS to estimate HIV incidence trends at the population-level as well as HIV transmission and acquisition risk within cohabitating sexual partnerships. Deep sequence viral phylogenetic data will be used to reconstruct directed transmission networks and to identify source-recipient transmission pairs with infection timing. These data will be combined with information on diagnosis, ART use, and VL at the estimated time of transmission to determine the attributable fraction of transmissions occurring before and after diagnosis and treatment. We hypothesize that there will be an increase in HIV incidence, primarily due to a loss of durable VL suppression in those already on ART and failure to initiate ART by newly diagnosed cases, following service disruption due to COVID-19.
Uganda 2022-05-26 8:12:30 2025-05-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jane  Kabami
ID: UNCST-2021-R012588
 The nature of kidney disease and elevated blood pressure in Uganda and Kenya
REFNo: HS2247ES

1. Determine the significance of leukocyturia and hematuria observed among individuals living in rural Uganda and Kenya
2. Examine potential risk factors for CKD that may explain the geographic variation in CKD prevalence in rural Uganda and Kenya,
3. Define BP phenotypes among participants with CKD (~half HIV-positive) by obtaining standardized single time-point BP measurement followed by 24-hr ambulatory blood pressure measurement.
 Uganda 2022-05-26 14:42:56 2025-05-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Milton Oyuku
ID:
Factors Influencing Compliance with Chemotherapy Handling and Administration Standard Operating Procedures Among Nurses and Pharmacists At UCI-Fred Hutch Cancer Centre
REFNo: HS2224ES

2. Determine the organizational, occupational, and individual factors at UCI-Fred Hutch Cancer Centre that influence the nurses and pharmacists to comply or not comply with the SOPs for dispensing, general preparation/reconstituting, and administration of parenteral chemotherapy drugs in the Pharmacy Safety Policy and Procedure Manual ,I. Determine the extent nurses and pharmacists working in the UCI-Fred Hutch Cancer Centre comply or not comply with the SOPs for dispensing, general preparation/reconstituting, and administration of parenteral chemotherapy drugs in the Pharmacy Safety Policy and Procedure Manual ,The general objective of this research is to establish factors influencing compliance with identified chemotherapy handling and administration standard operating procedures among nurses and pharmacists at UCI-Fred Hutch Cancer Centre. ,
 Uganda 2022-05-25 8:28:03 2025-05-25 Medical and Health Sciences Non-Clinical Trial Degree Award
Helen Ndagije Byomire
ID: UNCST-2021-R013939
 MEDICINE QUALITY, MATERNAL HEALTH AND THE FINAL MILE – UGANDA
REFNo: HS2051ES

1. To assess the pharmaceutical quality of samples collected from the sales and dispensing points in selected pilot districts in Uganda
2. To identify the pathways and motivations for entry of substandard oxytocin into Uganda
3. To assess whether transportation and storage conditions influence tracer medicine quality.
4. To explore the experiences of oxytocin on end-users. We shall answer this by interviewing mothers and midwives
5. To determine conformance to cold chain storage and light protection (for Oxytocin) at various retail outlets in Uganda.


 Uganda 2022-05-25 16:04:41 2025-05-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rhoda Wanyenze
ID: UNCST-2021-R013352
 Assessment of the Implementation Processes and Outcomes of the HIV Self-Testing Program, Ministry of Health, Uganda
REFNo: HS2244ES

7. To establish existing opportunities that can inform the future scale-up of the HIV self-testing program to other target groups in Uganda.,6. To explore the barriers to and facilitators of successful HIV self-testing implementation and the challenges implementers faced during HIVST implementation.,5. To determine the positive and negative outcomes of HIV self-testing services in Uganda, and the support mechanisms available for those who experience negative outcomes.,4. To assess the extent to which the existing service delivery environment might influence the delivery of HIV self-testing services.,3. To determine implementation level fidelity to HIV self-testing implementation standards.,2. To determine the level of uptake of HIV self-testing services and the factors associated with uptake of these services among the targeted populations. ,1. To determine the accessibility and availability of HIV self-testing services across the different distribution channels in Uganda,To assess the implementation processes, experiences, outcomes, and existing opportunities for the HIV self-testing Program to inform the scale-up in Uganda.,
 Uganda 2022-05-25 16:02:41 2025-05-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Patrick Tumwine
ID:
Exploration of senior teachers' perception on in-class instructional supervision and the use of lesson plan at a secondary school level in Western Uganda
REFNo: SS1052ES

To establish the importance of instructional supervision to a professional teacher at a secondary school level
To exploration the integral value of instructional supervision in the life of a teacher with a longer classroom experience at a secondary school level
To establish the senior teachers’ understanding of the importance of the lesson plan use during instructional activities at a secondary school level

 Uganda 2022-05-25 15:09:07 2025-05-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Tonny Kiyimba
ID:
Exploring Uganda’s Indigenous Food Species with Cardiometabolic Health Protective Effects
REFNo: HS2248ES

General Objective This study seeks to map out the diversity of indigenous food species with cardiometabolic health benefits in Uganda and understand consumption intentions. Specific Objectives 1. Conduct an inventory of Ugandan indigenous foods around greater Kampala metropolitan area 2. To understand barriers and facilitators for consumption of foods in (1) 3. To determine the bioactive polyphenolic composition of the identified foods in (1) and identify the foods with cardiometabolic health protective effects
Uganda 2022-05-24 12:39:01 2025-05-24 Medical and Health Sciences Non-Clinical Trial Degree Award
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