Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Mbisi Muhindo Enosh
ID:
HOST COMMUNITIES’ RELATIONS AND REFUGEE ADAPTABILITY AT KYAKA II AND KYANGWALI SETTLEMENTS IN WESTERN UGANDA
REFNo: SS2953ES

To examine the role of social cohesion within host communities in facilitating refugee adaptability at Kyaka II and Kyangwali settlements,To investigate how Attitudes and Perceptions of host communities influence Refugee Adaptability at Kyaka II and Kyangwali settlements,To assess the socio-economic and political factors contributing to refugee adaptability at Kyaka II and Kyangwali settlements,To examine the impact of legal and policy framework on Refugee Adaptability within Host communities at Kyaka II and Kyangwali settlements in Uganda,To examine the dynamics and factors influencing the relationship between host communities and refugees, and to understand the impact of this relationship on the adaptability and integration of refugees at Kyaka II and Kyangwali settlements,
Uganda 2024-07-26 15:59:56 2027-07-26 Social Science and Humanities Non-Clinical Trial Degree Award
Doris Kwesiga
ID:
Implementer’s Voices: An input to the Lancet Commission on Evidence-based Implementation in Global Health
REFNo: HS4408ES

To examine the insights and experiences of LMIC health sector implementers on the use of evidence in their work, so as to identify barriers and enablers and design interventions to increase evidence-based implementation.,ii. What are the gaps between evidence and implementation, and how can these be closed?,i. How and why, do (or don’t) implementers use evidence? ,
Uganda 2024-07-26 15:58:42 2027-07-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ismail  Draguma Legason
ID: UNCST-2021-R012130
Molecular profiling of Epstein-Barr virus genome and expression in endemic Burkitt Lymphoma (EBVL study)
REFNo: HS4198ES

1. The main goal of the study is to examine the molecular architecture of EBV, its expression pattern, and the determinants of viral pathogenesis in endemic Burkitt lymphoma. ,Perform differential gene expression and protein analysis on formalin fixed-paraffin embedded BL tissues using RT- PCR or NanoString and analyse the data for: i) differentially expressed genes and proteins ii) gene and protein expression levels iii) correlation with tumour stage and viral strains ,Perform whole genome sequencing of EBV from clinical samples (ctDNA for eBL and plasma for healthy controls) and analyse data for: i) viral strains and co-infection ii) Mutations (SNVs, Indels, and structural variants) and compare frequencies iii) mutational signatures iv) viral population structure -phylogenetics and decomposition matrices to infer evolutionary relatedness with publicly available strains. ,
Uganda 2024-07-26 15:56:08 2027-07-26 Medical and Health Sciences Non-Clinical Trial Degree Award
Sarah  Mayanja
ID:
Effect of the Triple S technology on farmers' food security in northern and eastern Uganda
REFNo: A438ES

3. To compare the extent to which sweetpotato augments smallholder’s food availability amongst users and non-users of the Triple S technology ,2. To assess the values which motivate use and uptake of the Triple S technology by smallholder farmers,1. To compare the Knowledge, Attitudes and Perceptions towards the Triple S technology by users and non-users of the technology ,Overall objective: To assess the contribution of the ‘Triple S’ technology on farmers food security in the northern and eastern regions of Uganda.,
Uganda 2024-07-26 15:54:12 2027-07-26 Agricultural Sciences Non-Clinical Trial Degree Award
Adam Lichtenheld
ID: UNCST-2024-R004326
Re:Build – Building Business and Social Networks to Strengthen Refugee Economic and Social Integration
REFNo: SS2803ES

The effect of the intervention on approaches of collaboration and information sharing,The effect of the intervention on psychological and social dimensions for each individual,The effect of the intervention on business outcomes (profit, savings, business growth),The effect of the intervention on network constellations in participants’ egocentric business networks,1. How can interventions support the development of business networks for refugees and nationals in urban markets of developing countries? ,
USA 2024-07-26 15:50:47 2027-07-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Grace Kaweesa
ID:
THE EFFICACY OF BIOCHAR AND VERMICOMPOSTS INTEGRATED WITH NPK BLENDED FERTILIZER ON SOIL BIOCHEMICAL PROPERTIES, NUTRIENT USE EFFICIENCY, YIELD AND GRAIN QUALITY OF UPLAND RICE (Oryza Sativa L.) IN CENTRAL UGANDA
REFNo: A447ES

To contribute to improved food security by increasing upland rice yields through optimizing fertilizer use efficiency using biochar and vermicomposts in central Ugandai. To ascertain the effect of Biochar and the different rates of NPK blended fertilizers integrated with VCs on growth and yield of upland riceii. To ascertain the effect of Biochar and the different rates of NPK blended fertilizers integrated with diverse VCs on selected soil biochemical properties. iii. To ascertain the effect of Biochar and the different rates of NPK blended fertilizers integrated with diverse VCs on nitrogen and phosphorus use efficiencies and uptakes in upland rice productioniv. To ascertain the effect of biochar and different rates of NPK blended fertilizers integrated with diverse VCs on selected nutritional qualities of upland rice grains.
Uganda 2024-07-26 15:48:47 2027-07-26 Agricultural Sciences Non-Clinical Trial Degree Award
Sarah Kiguli
ID: UNCST-2021-R013020
In-Hospital Mortality Among Sickle-Cell Disease Patients with and without SARS-CoV-2 co-Infection at Mulago National referral Hospital.
REFNo: HS4253ES

Genral OBJECTIVE
The overall objective of this study is to determine the in-hospital annual mortality rate among SCD patients over the 2010 to 2022 13 years period, and the association with SARS-CoV-2 infection-related morbidity and mortality in Uganda.

SPECIFIC OBJECTIVES
1.To determine prevalent SCD events and time-trend (annual) of in-hospital mortality rate before the COVID-19 pandemic (2010 to 20190) at Mulago National referral & Teaching Hospital
2. To assess probable-cause of death by adjudicating the diagnosis made at the time of death
3. To investigate the individual and health system factors (e.g., pediatricians with SCD expertise, pediatric ICU, oxygen supply, blood bank, and access to Hydroxyurea) associated with in-hospital mortality
4. To assess the prevalence of SARS-CoV-2 infection and any bidirectional effect between SARS-CoV-2 and SCD on mortality among those with vs. without SARS-CoV-2 or SCD admitted in hospital between 2020 and 2022.


Uganda 2024-07-26 15:47:47 2027-07-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Edgar Mulogo Mugema
ID: UNCST-2023-R008170
Leveraging Molecular Technologies to Improve Diagnosis and Management of Pediatric Acute Respiratory Illness in Resource-Constrained Settings.
REFNo: HS4539ES

Refine existing host immune response classifiers for the differentiation of bacterial and viral causes of febrile ARI among children in Uganda. Determine the etiology of febrile ARI episodes using a diagnostic assessment that includes physician adjudication and is augmented by pathogen metagenomics. Develop and internally validate a host immune response signature that differentiates between causes of pediatric ARI in Uganda using previously identified gene transcripts. Develop novel clinical algorithms for pediatric ARI to inform antibiotic treatment decisions ,The objective of this proposal is to develop novel clinical algorithms for pediatric febrile ARI in sub-Saharan Africa to identify children with bacterial illness. To augment samples collected during a previous cohort study (MUST REC 14/03-19) to achieve sufficient sample size to develop a host gene expression signature that differentiates between viral and bacterial ARI, we will enroll 160 children presenting to St. Pauls Health Center IV with ARI and 20 healthy controls.,
Uganda 2024-07-26 15:44:44 2027-07-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Stephen Okoboi
ID: UNCST-2019-R001356
UNDERSTANDING DRIVERS OF TB AND MALARIA PREVALENCE AND INCIDENCE, AND BARRIERS TO UPTAKE OF HEALTH SERVICES AND RETENTION IN CARE – COMMUNITY VOICE PERSPECTIVE IN NAMAYINGO DISTRICT
REFNo: SS2915ES

To collaboratively develop recommendations for driving sustainable impact and improving health outcomes in the context of TB and malaria.,To identify community-specific needs and gaps in current TB and malaria interventions and healthcare delivery systems.,To explore the socio-economic, cultural, and behavioral factors influencing the spread and persistence of TB and malaria within communities.,To engage directly with community members to understand their perspectives on the barriers and drivers of TB and malaria prevalence and incidence.,To understand the drivers of TB and malaria prevalence and incidence, as well as barriers to the uptake of health services and retention in care from a community voice perspective in Namayingo district,
Uganda 2024-07-26 15:43:11 2027-07-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
William  Veness Andrew
ID:
Assessing Causal Processes of Multi-Hazard Risk in the Rwenzori Region
REFNo: NS842ES

Generation of an evidence base for solutions through a multi-hazard risk assessment inthe Rwenzori Mountains
Hydrological characterisation of the highlands
Evidencing the mechanisms of landslides and potential for vegetative stabilisation
Evidencing geomorphological changes in river valleys
Assessment of whether water quality is being impacted by soil erosion
UK 2024-07-26 15:42:01 2027-07-26 Natural Sciences Non-Clinical Trial Degree Award
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