Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Namulema Edith
ID:
Feasibility of using Continuous Positive Airway Pressure via the ‘LeVe CPAP System’ among Children with Acute Hypoxemic Respiratory Failure at Mengo Hospital Kampala Uganda: A mixed methods study
REFNo: HS2478ES

1) To assess the acceptability of the LeVe CPAP system to deliver continuous positive airway pressure among children with acute hypoxemic respiratory failure at Mengo Hospital Uganda.
2) To assess the safety of LeVe CPAP system among children with acute hypoxemic respiratory failure at Mengo Hospital Uganda.

Uganda 2022-11-09 13:49:10 2025-11-09 Medical and Health Sciences Clinical Trial Non-degree Award
Zula Namubiru
ID:
HARNESSING FISHERS' KNOWLEDGE FOR SUSTAINABLE FISHERY ON LAKE VICTORIA: A CASE OF KIGUNGU FISHING GROUND WAKISO DISTRICT
REFNo: SS1511ES

1.To assess fishers’ perceived attitude, knowledge and practice on illegal fishing on Lake Victoria
2. To engage fishers especially the youth on what they can do and how best they can be enabled to sustain the fishery resource
3. To discuss with fishers’ wives/ spouses and female fish smokers on what they can do and how best they can be enabled to sustain the fishery resource
4. To understand how different stakeholders can best support fishers for the sustainable conservation of the fishery resources
Uganda 2022-11-08 14:17:17 2025-11-08 Social Science and Humanities Non-Clinical Trial Degree Award
Francis Garuzooka John
ID:
Work and learning experiences of graduates from Technical and vocational Training Institutions in Uganda. A case Study
REFNo: SS1507ES

is to understand the work and learning experiences of graduates of TVET institutions in Uganda with a view of proposing strategies for recognizing and validating non-formal workplace learning and improving productivity,4. To Evaluate how TVET graduates balance work, training apprentices and learning at their workplaces.,3. To3. To analyse the progression of TVET graduates to higher level competences and qualifications as they work. ,2. To explain the relevance of the knowledge and skills acquired by graduates of TVET institutions to the current tasks they perform at their workplaces. ,1. To find out how TVET institutions prepare their learners for work and continuous learning,
 Uganda 2022-11-08 14:14:34 2025-11-08 Social Science and Humanities Non-Clinical Trial Degree Award
Enock Matovu
ID:
COntrolling and progressively Minimizing the Burden of Animal Trypanosomiasis in Uganda [COMBAT-U]
REFNo: A237ES

i. To determine the burden, socioeconomic importance, factors driving transmission network pathways of AAT and the knowledge gaps that exist in AAT vector identification
ii. To determine the differencesin the immune responses, metabolic and genetic profiles in trypanotolerant and susceptible cattle breeds
iii. To identify molecular determinants of trypanocidal drug resistance in Trypanosoma congolense field isolates in order to develop novel molecular test(s) to detect such drug resistant strains.

 Uganda 2022-11-08 14:11:16 2025-11-08 Agricultural Sciences Non-Clinical Trial Non-degree Award
Harriet Opondo
ID: UNCST-2022-R010927
 Mental Health needs Assessment of Children ages 0-5 years Living with HIV in an Urban setting in Uganda.
REFNo: SS1484ES

1. To describe and assess the spectrum of mental health needs (magnitude and prevalence) among children living with HIV ages 0-5 years. 2. To establish the awareness of health care workers regarding mental health needs among CLHIV (0-5) years and establish existing resources and capacities to respond to these needs. 3. To explore parent training needs of parents/primary caregivers of CLHIV (0-5) years who are presenting with mental health needs.
Uganda 2022-11-08 14:09:12 2025-11-08 Social Science and Humanities Non-Clinical Trial Degree Award
lydia Bunalema
ID: UNCST-2020-R014729
 Identification and validation of anti-plasmodial activity and artemisinin pharmacokinetic enhancement potential of medicinal plants used by Ugandan communities to treat malaria symptoms
REFNo: NS431ES

To formulate a herbal product for treatment of malaria To establish the protective effect of above herbal extracts against metabolic clearance of Dihydroartemisinin in a rabbit model To determine the susceptibility (RSA0-3h and IC50) of Plasmodium falciparum to the five most common herbal extracts used in treatment of malaria symptoms across Uganda To establish through a systematic review and ethnobotanical survey medicinal plants used in treatment of malaria symptoms in communities To investigate the anti-plasmodial activity and artemisinin pharmacokinetic enhancement potential of medicinal plants used by communities across Uganda in treatment of malaria symptoms,
 Uganda 2022-11-08 14:05:34 2025-11-08 Natural Sciences Non-Clinical Trial Non-degree Award
Wilson Mugizi
ID: UNCST-2022-R009877
 Resource Based View Approach in Implementation of E-Learning in Selected Ugandan Public Universities
REFNo: SS1454ES

i. To examine the relationship between universities tangible resources and e-learning implementation during and beyond Covid-19 pandemic era in Uganda
ii. To evaluate the relationship between the universities intangible resources and e-learning implementation during and beyond Covid-19 pandemic era in Uganda.
iii. To assess the relationship between universities capabilities and e-learning implementation during and beyond Covid-19 pandemic era in Uganda.
iv. To suggest the strategies for management of e-waste resulting from implementation e-learning implementation.

Uganda 2022-11-08 14:03:00 2025-11-08 Social Science and Humanities Non-Clinical Trial Non-degree Award
Kananura  Muhumuza Rornald
ID: UNCST-2019-R000239
 Improving Quality and Use of Newborn Indicators (IMPULSE): A two-phase project to describe and improve the quality and use of facility-level newborn indicators in African countries.
REFNo: HS2473ES

1. Map newborn indicator data availability in existing routine health information systems (RHIS) 2. Assess newborn key indicator data quality in existing RHIS. 3. Understand newborn indicator data use by different stakeholders in existing RHIS. 4. Analyse technical, organizational and behavioural enabling factors in RHIS to improve newborn indicator data quality and use 5. Measure the effect of the COVID-19 pandemic on newborn RHIS data
Uganda 2022-11-08 14:00:16 2025-11-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Francis Ekwan Uzu
ID: UNCST-2022-R009805
 Co-creating a Culturally Relevant Programme for Enabling Participation of Children with Brain Injury in Uganda (CEBU)
REFNo: HS2509ES

To explore the participants’ thoughts, feelings, and perceptions of the current intervention programme at the KWB-HTC.,To generate a culturally relevant programme (CRP) for enabling participation of children with brain injury in the KWB-HTC.,To describe the consequences and limitations of a CRP for children with brain injury in the KWB-HTC.,To describe how the participants co-create a Culturally Relevant Programme (CRP) enabling participation of children with brain injury in the KWB-HTC.,
 Uganda 2022-11-08 13:54:18 2025-11-08 Medical and Health Sciences Non-Clinical Trial Degree Award
Godfrey  Siu
ID: UNCST-2021-R005439
 STRENGTHENING THE HEALTH SECTOR SYSTEMS WORKFORCE IN THE PREVENTION AND RESPONSE TO VIOLENCE AGAINST CHILDREN: A PILOT PROJECT IN MAYUGE AND AMURU DISTRICTS
REFNo: SS1497ES

3. To measure impact and key outcomes of these interventions on health worker knowledge, attitudes, and competences in VAC service improvement and delivery.,2. To deliver a package of VAC interventions that is realistic, relevant and acceptable to health workers, including leadership development, training, dissemination of existing guidelines and the use of lay workers as case advocates to provide basic information and escort survivors to various referral points.,1. To explore, both qualitatively and quantitatively, the knowledge, practices and attitudes towards VAC prevention and response work, services offered, roles and current capacities, and barriers to involvement. ,Our aim is to collaboratively design and test the acceptability, feasibility, and scalability of a health worker capacity building and leadership strengthening VAC intervention in Mayuge and Amuru districts in eastern and northern Uganda.,
 Uganda 2022-11-08 13:49:21 2025-11-08 Social Science and Humanities Non-Clinical Trial Non-degree Award
Joseph Mugagga Isaac
ID:
Empowerment Beyond the Household: Measuring and Comparing the Collective Agency of Groups and Individuals
REFNo: A194ES

a) Measure the degree to which group members and the group as a whole verbally express and/or behaviorally indicate a sense of collective agency
b)Identify features of groups and external factors, including targeted interventions, that can successfully increase women’s collective agency
c)Understand how intersectionality affects the ability of women and men of different backgrounds to participate in, and benefit from, group processes
d)Understand the impacts of increased collective agency in terms of outcomes for individual women and their groups
e)Better understand linkages between empowerment within and outside the household


 Uganda 2022-11-08 13:36:34 2025-11-08 Agricultural Sciences Non-Clinical Trial Non-degree Award
Andreas Madestam
ID:
Closing the gender Gap in Agriculture: Experimental Evidence from Uganda
REFNo: SS1360ES

To evaluate if the gender gap in agriculture productivity is caused by lack of soft skills among female farmers in Uganda.
 Sweden 2022-11-08 13:32:20 2025-11-08 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jackson Orem
ID: UNCST-2021-R012016
 A Phase II Multicenter Study of Pomalidomide Monotherapy in HIV-Positive Individuals with Kaposi Sarcoma (KS) in Sub-Saharan Africa (SSA)
REFNo: HS2367ES

To evaluate if changes in serum cytokine levels correlate with clinical response.,To assess the effect of pomalidomide treatment on serum cytokine levels.,To evaluate the effects of pomalidomide monotherapy on standard measures of HIV control, i.e., CD4 counts and HIV viral loads, in this participant population.,To determine if pomalidomide monotherapy induces a minimal level of antitumor efficacy to justify its further development for HIV-associated KS in sub-Saharan Africa and is safe and tolerable.,
 Uganda 2022-11-08 13:27:55 2025-11-08 Medical and Health Sciences Clinical Trial Non-degree Award
Simons  Ezajobo
ID: UNCST-2021-R012010
 Uptake of HIV Testing Services through Assisted Partner Notification (APN) among Men in Wakiso District.
REFNo: HS2537ES

2.To understand the preferred partner notification approaches to help men feel more comfortable and confident in getting tested for HIV.,1.To assess the experience of males during the process of HIV testing services provision.,To identify barriers and facilitators to HIV testing among men in Uganda,
 Uganda 2022-11-08 13:23:56 2025-11-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Catriona  Waitt John
ID: UNCST-2019-R001068
 PHARMACOKINETICS OF DRUGS USED TO TREAT UNCOMPLICATED MALARIA IN BREASTFEEDING MOTHER-INFANT PAIRS
REFNo: HS2392ES

Primary Objectives;
1. To define transfer of lumefantrine and its active metabolite, desbutyl-lumefantrine from mother to breastfed infant.
2. To determine the clearance, AUC, and volume of distribution of lumefantrine and desbutyl-lumefantrine
Secondary Objectives
1. To describe covariates influencing drug exposure in maternal plasma, breast milk and infant plasma
2. To develop a population pharmacokinetic model including the breast and the infant as compartments, which will both enable optimal use of sparse data from future studies and enable simulations of different doses or combinations.
3. To assess depression and anxiety levels among breastfeeding mothers on first line antimalarial drugs.
4. Beliefs about medicines in breastfeeding mothers receiving antimalarial treatment



 UK 2022-11-04 16:05:41 2025-11-04 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Dinah Amongin
ID: UNCST-2020-R014663
 Innovations for continuity of HIV, TB and malaria services during the COVID-19 pandemic in Uganda
REFNo: HS2477ES

The goal of this research is to collate and assess the impact of innovative people-centred and community-based approaches adopted during the covid-19 pandemic to ensure continued HIV, TB and malaria services in Uganda. This will inform the ongoing and future pandemic/epidemic response actions.
Specific objectives are:
1. To identify innovations used to mitigate the impact of the covid-19 pandemic on the provision, access, and utilization of HIV, TB and Malaria services in Uganda.
2. To assess the impact of innovations to mitigate the impact of the COVID-19 pandemic on HIV, TB, and Malaria services provision, access, and utilization.
3. To document the lessons learnt in innovating to mitigate the impact of COVID-19 on HIV, TB and malaria services in Uganda during the pandemic.

 Uganda 2022-11-03 12:21:51 2025-11-03 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Albert Munyeshyaka
ID:
Cosmological studies in modified Gauss-Bonnet gravity
REFNo: NS434ES

To determine evolution of overdensities and velocity perturbations in f (G) grav- ity,To analyse perturbations of a Chaplygin gas model in f (G) gravity,To analyse covariant velocity and overdensities of quasi-Newtonian cosmological model in f (G) gravity,To derive evolution of 1 + 3 covariant linear perturbation equations in f (G) gravity.,The aim of this study is to explore cosmological studies in modified Gauss-Bonnet gravity.,
 Rwanda 2022-11-03 12:09:30 2025-11-03 Natural Sciences Non-Clinical Trial Degree Award
MICHAEL JACKSON WAKWABUBI
ID:
Financial distress in local governments in Uganda
REFNo: SS1429ES

To establish the relationship between local government delivery system and financial distress in local governments in Uganda To assess the relationship between revenue concentration and financial distress in local governments in Uganda To examine the relationship between revenue concentration, local governance, corruption and LG delivery system in local governments in Uganda To assess the mediating effect of LG delivery system in the relationship between revenue concentration, local governance, corruption and financial distress in local governments in Uganda To establish the relationship between local governance and financial distress in local governments in Uganda To establish the relationship between corruption and financial distress in local governments in Uganda
Uganda 2022-11-03 11:38:10 2025-11-03 Social Science and Humanities Non-Clinical Trial Degree Award
Hannah Kibuuka
ID: UNCST-2020-R014355
 ‘Remdesivir: Monitored Emergency Use for Filoviral Disease’
REFNo: HS2531ES

To offer patients with laboratory-confirmed filovirus disease (e.g. Ebola virus [EBOV], Bundibugyo virus [BDBV], Marburg virus [MARV] disease, and Sudan virus [SUDV]) under the clinical supervision of the protocol Principal Investigator or their designated physicians, access to treatment with Remdesivir under monitored conditions.
Uganda 2022-11-02 17:30:52 2025-11-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eugene Ruzagira
ID: UNCST-2023-R008282
 Efficacy, Safety and Effectiveness of Injectable Cabotegravir/Rilpivirine in Improving HIV Control in Sub-Saharan Africa: A pragmatic Phase 3 Open-label Randomized Controlled Trial.
REFNo: HS2475ES

Primary objective:
To demonstrate the non-inferior efficacy of switching to every 2 months (Q2M) intramuscular (IM) injection of cabotegravir (CAB) long acting (LA) plus rilpivirine (RPV) LA compared with continuation of first-line oral ART over 12 months in people living with HIV (PLHIV) with a history of, or at risk of, sub-optimal HIV control.

Secondary objectives:
1) To demonstrate the antiviral activity and the impact on retention in HIV care of switching to Q2M CAB LA + RPV LA compared with continuation of oral ART over 12 and 24 months in PLHIV with a history of, or at risk of, sub-optimal ART adherence or engagement in care.

2) To demonstrate the immunological activity of switching to Q2M CAB LA + RPV LA compared with continuation of oral ART over 12 and 24 months in PLHIV with a history of, or at risk of, sub-optimal ART adherence or engagement in care. This will be measured through change in CD4+ T cell count and incidence of HIV disease progression.

3) To evaluate the safety and tolerability of switching to Q2M CAB LA + RPV LA compared to continuation of oral ART.

4) To assess genotypic viral resistance in participants experiencing protocol-defined confirmed virological failure (plasma HIV-1 RNA >200 c/ml) and its impact on future treatment options including proportion who resuppress on dolutegravir.

5) To evaluate the effect of Q2M CAB LA + RPV LA on health-related quality of live, treatment satisfaction and treatment adherence. To describe cost-effectiveness and acceptability of the regimen.

Uganda 2022-11-02 17:27:11 2025-11-02 Medical and Health Sciences Clinical Trial Non-degree Award
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