Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Irumba Eleazar Paddy
ID:
The environmental stewardship by the church of Uganda in Albertine region- a case of Bunyoro-Kitara diocese.
REFNo: HS2675ES

4. To Explore the Theological Practices that the Church can use to enhance Environmental Stewardship in the Albertine Region.,3. To Establish the Relationship of Religious Teachings and Ethical Practices regarding Environmental Stewardship in the Albertine Region.,2. To Examine the role played by Church of Uganda in Environmental Stewardship in the Albertine Region,1. To investigate the current factors responsible for Environmental Degradation in the Albertine Region,
Uganda 2023-03-02 14:04:06 2026-03-02 Medical and Health Sciences Non-Clinical Trial Degree Award
John Bosco Ddamulira Mayanja
ID: UNCST-2022-R010819
ASSESSMENT OF THE MAGNITUDE AND CORRELATES OF HIV STIGMA AND DISCRIMINATION AND ITS EFFECTS ON THE COUNTRY’S HIV RESPONSE
REFNo: HS2690ES

To describe how different groups are affected by HIV related stigma and discrimination especially the key populations. ,To identify factors that perpetuate or mitigate stigma as well as the actions (resilience) taken by PLHIV to mitigate the impact of stigma and discrimination,To assess the effect of stigma and discrimination on the country’s HIV response.,To describe trends in experience of stigma and discrimination among PLHIV over time (comparing 2013, 2019 and 2022).,To determine the prevalence and distribution of the modes (internal and external) of HIV related stigma and discrimination manifestations among PLHIV ,To assess the magnitude and correlates of HIV stigma and discrimination and its effects on the country’s HIV response ,
Uganda 2023-03-02 14:02:36 2026-03-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Harriet Mpairwe
ID: UNCST-2025-R017439
Causes And MEchanisms foR non-atopic Asthma in children (CAMERA) Study
REFNo: HS2510ES

There is an urgent need for new and innovative research into the causes of non-atopic asthma (NAA), and the likely mechanisms involved. The objectives of this study are therefore to: I. investigate the causes of NAA in a variety of settings: high and low asthma prevalence, HICs and LMICs (Work Package 1 (WP1) II. investigate three possible mechanisms of NAA in these different settings, including the relative importance of neural mechanisms (Work Package 2 (WP2)) This intended scientific value of study is to provide key ground-breaking insights into the causes and mechanisms of the poorly-studied yet predominant non-atopic asthma phenotype because: (i) non-atopic asthma likely has different causes from atopic asthma, and these have been little studied to date in both high-income countries and low- and middle-income countries? (ii) non-atopic asthma likely involves different mechanisms, which require different treatments. This study is likely to show, in a variety of settings, that a substantial proportion of non-atopic asthma may involve different mechanisms, and will identify new directions and priorities for prevention, mechanistic research, and the development of new therapies
Uganda 2023-03-02 13:54:33 2026-03-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Iddi  Matovu
ID:
HIV RISKS AND INFECTION AMONG ADOLESCENT GIRLS AND YOUNG WOMEN AGED 15-24 YEARS IN UGANDA: DEVELOPMENT OF AN HIV-RISK REDUCTION MODEL FOR CENTRAL REGION
REFNo: HS2554ES

1) To determine the influence of behavioral and biological practices on the HIV Infection among AGYW in the Central region, Uganda.2) To assess the influence of socioeconomic factors on behavioral and biological practices associated with HIV Infection among AGYW in Central region, Uganda.3) To analyze the influence of structural factors on behavioral and biological practices associated with HIV Infection among AGYW in Central region, Uganda.4) To develop a multilevel HIV-Risk reduction model to facilitate the delivery of appropriate HIV prevention services responsive to the particular needs of the AGYW aged 15–24 years in the Central region, Uganda.
Uganda 2023-03-02 12:56:09 2026-03-02 Medical and Health Sciences Non-Clinical Trial Degree Award
Ritwika Sen
ID:
Supervision and Productivity Dynamics: Evidence from a Field (Work) Experiment
REFNo: SS1612ES

To examine the direct effects of the supervision of survey enumerators on their learning and individual performance., Examine the impact of supervision on the performance of employees through two distinct channels: monitoring and feedback.,
India 2023-03-02 12:53:15 2026-03-02 Social Science and Humanities Non-Clinical Trial Degree Award
Diana  Ntamu Nandagire
ID:
Baseline survey for diverse and resilient livelihoods for youth and women from refugee and host communities in Isingiro and Lamwo districts
REFNo: SS1547ES

Main objective
To establish baseline status of the selected indicators for the Uthabiti project impact, outcome and outputs.


a)To provide initial values for the impact and outcome indicators disaggregated by gendered households as appropriate in the Uthabiti intervention areas, establishing target levels for improvements in these indicators over the three-year implementation period.

b)To provide more evidence to describe the prevailing conditions of the target communities or populations in terms of their socio-economic wellbeing and self-reliance and refine intervention. This will provide the consortium team a deeper understanding of the context to tailor the interventions as well understanding how well or not, the proposed theory of change aligns with the demonstrated need of the target population survey.


c)To provide Uthabiti baseline indicator values that can be compared with the endline indicator values to measure the level of changes and inform future programing,, and


d)To integrate gender and social inclusion throughout the review.

Uganda 2023-03-02 12:52:03 2026-03-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Raymond Atwine
ID: UNCST-2022-R011223
A clinicopathologic digital image platform to aid the diagnosis of breast cancer amongst patients at Mbarara Regional Referral Hospital.
REFNo: HS2606ES

i. To develop a digital platform that will be used to process and store breast lesion images, symptoms, and risk factors among women presenting at Mbarara regional referral hospital with breast lesions.
ii. To digitize gross and histology annotated images of breast lesions from patients presenting at Mbarara regional referral hospital
iii. To develop a machine learning model for diagnosis of breast cancer in patients presenting with breast lesions at Mbarara Regional Referral Hospital

Uganda 2023-03-02 12:50:32 2026-03-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Fred Kayemba Jonah
ID:
CLIMATE CHANGE ADAPTATION AND SUSTAINABLE LIVELIHOOD OF WOMEN IN AGRICULTURE IN BUSOGA SUBREGION, EASTERN UGANDA: THE MODERATING EFFECT OF POLICY IMPLEMENTATION
REFNo: SS1620ES

1. To examine Structural Climate Change Adaptation factors associated with sustainable livelihood of women in agriculture in the Busoga sub region, Eastern Uganda. 2. To assess Social Climate Change Adaptation factors associated sustainable livelihood of women in agriculture in the Busoga sub region, Eastern Uganda. 3. To determine Institutional Climate Change Adaptation factors associated with sustainable livelihood of women in agriculture in the Busoga sub region, Eastern Uganda. 4. To assess climate change policy implementation factors moderating in the relationship between climate change adaptation and the sustainable livelihood of women in agriculture in the Busoga subregion, Eastern Uganda.
Uganda 2023-03-02 12:49:17 2026-03-02 Social Science and Humanities Non-Clinical Trial Degree Award
Henry Twinomujuni Kafunjo
ID:
INDIGENOUS KNOWLEDGE AND INTELLECTUAL PROPERTY OF TRADITIONAL MEDICINE IN UGANDA
REFNo: SS1539ES

1) To assess the perceptions of traditional healers in Uganda on the use of an intellectual property system in the protection of traditional medicine knowledge.
2) To examine the suitability of an intellectual property system in protecting traditional medicine knowledge and practice.
3) To evaluate the factors that facilitate proper functioning of the intellectual property system in protecting traditional medicine knowledge and practice.

Uganda 2023-02-27 10:10:15 2026-02-27 Social Science and Humanities Non-Clinical Trial Degree Award
Monil Khera
ID:
Investigate the effect of climate on the behaviour and demography of banded mongooses (Mungos mungo).
REFNo: NS443ES

Understand how body temperatures change in relation to the surrounding climate and what behaviours they are performing.
UK 2023-02-27 10:06:38 2026-02-27 Natural Sciences Non-Clinical Trial Degree Award
Josephine Bwogi
ID:
IDENTIFICATION OF PATHOGENS ASSOCIATED WITH MEASLES-LIKE ILLNESSES (MLI) IN UGANDA
REFNo: HS2678ES


To identify aetiological pathogens associated with measles-like rash illnesses in Uganda
Uganda 2023-02-24 17:00:31 2026-02-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Job Morukileng
ID:
Estimating the impact of COVID-19 on all-cause mortality in Uganda, during March 2021 to March 2022
REFNo: HS2687ES

To describe the distribution of excess mortality rate by key factors including cause, age, sex, ethnicity, location and socioeconomic status,To estimate excess mortality rate in Uganda during the COVID-19 pandemic (April 2020-March 2022),To estimate the impact of COVID-19 on all-cause mortality in Uganda, during April 2020 to March 2022 for planning, evaluating public health interventions and policy making.,
Uganda 2023-02-24 16:58:26 2026-02-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Susan  Nabadda Ndidde
ID: UNCST-2020-R014331
Establishing capacity for wastewater-based COVID-19 epidemiology and supporting implementation of pilot surveys in Uganda
REFNo: NS480ES

To strengthen laboratory capacity to implement wastewater-based COVID-19 Surveillance and support the use of data from the surveys to complement disease surveillance and monitor trends in Uganda.
Uganda 2023-02-24 16:51:42 2026-02-24 Natural Sciences Non-Clinical Trial Non-degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
Active Prevention and Treatment of Maternal Sepsis
REFNo: HS2613ES

To examine if the APT-Sepsis programme is effective at reducing infection related maternal mortality and severe morbidity.
To evaluate if the APT-Sepsis programme is effective at reducing secondary clinical outcomes of: Stillbirth, early neonatal death (infection related and total), maternal mortality (any cause), maternal near miss (any cause)
To explore differential or subgroup effects of the APT-Sepsis programme.
To understand the implementation of the APT-sepsis programme in Malawi and Uganda, to facilitate interpretation of trial outcomes and development of a longer-term implementation strategy.
To determine if the APT-Sepsis programme is cost effective.
Nigeria 2023-02-24 16:50:45 2026-02-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Moses Ocan
ID: UNCST-2020-R014731
COVID-19 Vaccine Effectiveness, Vaccine Uptake Determinants, and Impact of Pandemic on Health Programs in Uganda
REFNo: HS2664ES

Objective 1: To evaluate the real-world COVID-19 vaccine effectiveness in Uganda using a retrospective study design

Objective 2: To identify the barriers and enhancers to COVID-19 vaccination among healthcare workers in Uganda

Objective 3: To assess the impact of COVID-19 on healthcare programs in Uganda

Objective 4: To evaluate the real-world COVID-19 vaccine effectiveness and safety in Uganda using a prospective study design

Objective 5: To develop a national biorepository for COVID-19 samples at H3Africa Biorepository at Makerere University Biomedical Research Center (MaKBRC), College of Health Sciences, Uganda

Uganda 2023-02-23 8:26:55 2026-02-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Robert Ssekitoleko
ID: UNCST-2019-R001716
Promoting Universal Health Coverage for Amputees in Uganda through Social Enterprise and Engineering Innovation
REFNo: SIR192ES

The principles of patient autonomy, non-maleficence, beneficence, and justice will be employed. Institutional safeguards, such as human subjects review committees and policies governing organisational ethics, will be followed. To this end, we shall seek ethical approval from the Makerere University School of Biomedical Sciences Research Ethics Committee and the Uganda National Council for Science and Technology. We shall also seek permission from the Ministry of Health as well as the management of the health units from which the data will be collected. We will provide verbal and written explanations of the study, including the aim, the level of participation required, potential risks of involvement, and the approximate duration of participation. The consent will include full verbal (in case of illiteracy) and written/signed informed consent from all individuals and groups before accepting to be interviewed. We will seek written permission to record interviews, and access meeting minutes, reports, and other relevant documents from relevant persons prior to including them in the research. Participants will be asked to give verbal consent and confirm this by reading and signing the consent form (included in the appendix). The key informants, including service users, will be free to withdraw consent at any time without giving an explanation and without this negatively affecting the care they receive. Data collectors will translate information into the relevant local language where required. We will seek verbal consent from participants who struggle to read and write, and the next of kin will sign the consent form on behalf of the user. We will only include participants 18 years of age and older who can provide consent on their own. The participant information sheet will explicitly state that participation in this study is purely voluntary. Participants can withdraw at any time, up to 14 days after data collection, without giving the reason for their withdrawal from the study. Their decision to withdraw from the study will not affect the services they receive. Participants will have up to 48 hours after receiving full details about the study, to consider participating in the research and ask questions.
Uganda 2023-02-22 8:38:27 2026-02-22 Engineering and Technology Non-Clinical Trial Non-degree Award
Josephine Ayebare
ID:
An E-participation Model and Mobile Application Prototype for Inclusive Governance and Policy Development in Rural Uganda: Participatory Approach
REFNo: SS1621ES

To evaluate the usefulness of the model designed in objective 2 in achieving participation objectives through assessing the mobile application prototype designed in objective 3.,To co-design a mobile application prototype with the rural population stakeholders of Isingiro district in Uganda for based on the model developed in objective 2. ,To co-design a multi-dimensional model with the rural population e-participation stakeholders of Isingiro district in Uganda using the social-technical contextual factors and their SWOT analysis identified in objective 1. ,To identify and analyse the socio-technical contextual factors that influence political e-participation in rural Uganda. ,Aims to design and develop a multidimensional e-participation model and a mobile application prototype suitable for promoting e-participation among the rural population in Isingiro district in Uganda.,
Uganda 2023-02-21 13:17:02 2026-02-21 Social Science and Humanities Non-Clinical Trial Degree Award
Harriet Mayanja-Kizza
ID: UNCST-2021-R013074
PHASE 2C CLINICAL TRIAL OF NOVEL, SHORT-COURSE REGIMENS FOR THE TREATMENT OF PULMONARY TUBERCULOSIS: CRUSH-TB (Combination Regimens for Shortening TB Treatment)
REFNo: HS2650ES

Primary objective
(1) To compare the efficacy of each experimental regimen to the efficacy of standard treatment, using the intermediate endpoint of time to culture negative in liquid media.

Secondary objectives
(1) To compare the proportion of participants with a grade 3 or higher adverse event in each experimental arm with the control arm
(2) To describe the proportion of participants experiencing lack of sustained cure during treatment or follow-up to 52 weeks in each experimental arm as compared to control and make predictions as to how these regimens would perform in future phase III trials.
(3) To compare the efficacy of each experimental regimen to the efficacy of standard treatment, using the intermediate endpoint of time to culture negative in solid media
(4) To compare the proportion of participants in each arm who convert liquid and solid sputum cultures to negative by (a) 8 weeks of treatment and (b) 12 weeks of treatment
(5) To describe the rate of all-cause study drug discontinuation in each arm
(6) To compare time to sputum culture positivity curves through 17 weeks in the Mycobacterial Growth Indicator Tube (Bactec MGIT960) across arms
(7) To describe the proportion of participants experiencing lack of sustained cure during treatment or follow-up up to 78 weeks in each experimental arm as compared to control and make predictions as to how these regimens would perform in future phase III trials.
(8) To describe the population PK of bedaquiline and its M2 metabolite, with or without rifabutin co-administration (PK#1)
(9) To conduct pharmacokinetic/pharmacodynamics study of the test drugs to determine relationships between pharmacokinetic parameters (AUC, Cmax) and outcome measures (time to culture negativity or rate of change in TTP) using non-linear mixed effects models, adjusting for key covariates that may affect outcomes (e.g. companion drugs, HIV status, cavitary disease) (PK#2)

Uganda 2023-02-21 13:13:53 2026-02-21 Medical and Health Sciences Clinical Trial Non-degree Award
KIRABO NAKASIITA NKAMBWE
ID:
Mindset, Teaching and Learning Strategies in Sciences among Secondary School Students in Wakiso District: The mediating effect of Interest
REFNo: SS1591ES

6. To assess the moderating effect of teaching strategies on the relationship between mindset and learning strategies in sciences among O level students in Wakiso district,5. To assess the mediating effect of interest on the relationship between mindset and learning strategies in sciences among O level students in Wakiso district ,4. To determine the relationship between mindset and learning strategies in sciences among O level students in Wakiso district ,3. To assess the relationship between interest and learning strategies in sciences among O level students in Wakiso district ,2. To examine the relationship between mindset and interest in sciences among O level students in Wakiso district ,1. To establish the science interest levels among O level students in Wakiso district,To assess the effects of mindset, interest and teaching strategies on students’ use of learning strategies in sciences among O level students in Wakiso District,
Uganda 2023-02-21 13:08:23 2026-02-21 Social Science and Humanities Non-Clinical Trial Degree Award
Moses KIRYA Mateeke
ID:
Relationships among Core Competencies, Career Choices and Relevant influential factors based on final year Undergraduate Business Student’s Perceptions in Ugandan universities.
REFNo: SS1566ES

To empirically investigate the relationship among core competencies, career choices and relevant influential factors based on final undergraduate business student’s perception in Ugandan universities, Specifically, to explore:

1. The relationship among core competencies and career choices based on final year undergraduate business students’ perception in Uganda

2.The relevant influential factors on career choices and core competencies based on final year undergraduate business students’ perception in Uganda
Uganda 2023-02-21 13:01:29 2026-02-21 Social Science and Humanities Non-Clinical Trial Degree Award
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