Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Brenda Kakayi Catherine
ID: UNCST-2022-R008787
Insulin-like Growth Factor/Growth Hormone Levels and Stunting in HIV Exposed Uninfected Children from the 1077BF/P1084s study (CHASE: Changes in IGF/Hormone Axis and Stunting in HIV-Exposed uninfected children.
REFNo: HS2686ES

1. To investigate IGF-1, IGFBP-1, and IGFBP-3 as predictors of growth faltering/stunting in the first 2 years of life in HEU children

2. To describe the concentrations of hormonal growth factors in infants in relation to infant growth percentile at birth, 26 weeks, and 74 weeks of age.

Uganda 2023-04-03 20:41:44 2026-04-03 Medical and Health Sciences Clinical Trial Non-degree Award
Gerald Bareebe
ID:
Violence and Regime Trajectories in Post-Conflict Uganda and Rwanda
REFNo: SS1413ES

This study is driven by two important objectives: the first is the need to consider the influence of a “residue” social structure. What the cases of Uganda and Rwanda tell us is that, without understanding the underlying socio-political agency of the political regime and the armed elites that run it (and without knowing who their allies are or what the sources of constraints in that process are), it is difficult to resolve the socio-political problems that trouble most postwar states on the continent. The second is the need to show how post-war reconstruction in Africa is a function of elite interactions. The failure to understand this phenomenon has left post-conflict societies more vulnerable to conflict relapse. By investigating the interface of power elites in post-war state reconstruction, this research situates itself within a more empirical and contemporary African perspective and elevates the importance of social actors, specifically those whose actions reflect the intractability of power struggle. Specifically, the research seeks to achieve the following objectives:

? To understand the process of post-conflict state reconstruction in Uganda and Rwanda
? To understand factors that may hinder or enable the rebuilding of state institutions after a civil war.
? To compare the experience of Uganda and Rwanda with regards to how they both approached state reconstruction after a devastating civil war.
? To determine the nature and impact of policies taken by state-builders in both Uganda after the 1986 civil war and Rwanda after the 1991 genocide.

Uganda 2023-04-03 16:49:25 2026-04-03 Social Science and Humanities Non-Clinical Trial Non-degree Award
Timothy Allen Peter
ID: UNCST-2019-R001369
Public Authority and International Development Uganda Programme Phase 2
REFNo: SS1678ES

Inductive theory-building through comparative applications,New curriculum development for scholars and development professionals,Reciprocal capacity-building in the academy and knowledge production,Reflexive policy-making and governance impact,Generate impact, knowledge exchange and capacity building through a public authority lens,
UK 2023-04-03 16:41:36 2026-04-03 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jesse Rudy Lynn
ID: UNCST-2023-R008208
Prevalence of property Grabbing among widows in Uganda
REFNo: SS1677ES

To establish the total number of people protected in the different project areas districts as a result of Redeem’s program interventions., 1)To understand the indirect consequences of attempted and successful land/property grabbing for widows and orphans in the aftermath of the events, 2)To ascertain the criminal, violent or other means used by perpetrators to victimize widows and orphans through grabbing property or land in Uganda., 3)To determine the prevalence of property grabbing from widows in targeted areas of Uganda, 4)To measure the annual burden of property grabbing in the selected case work areas ,
USA 2023-04-03 15:40:08 2026-04-03 Social Science and Humanities Non-Clinical Trial Non-degree Award
GRACE MARY KENYONGA
ID:
Attitudes towards the use of pre-exposure prophylaxis for HIV among women in Uganda
REFNo: SS1473ES

General aim
Examine the attitudes towards the use of pre-exposure prophylaxis for HIV among women in Uganda.
Specific Objectives
1. Explore the attitudes women have towards PrEP
2. Identify the factors that influence the present attitudes towards PrEP
4. Identify other community variables that may encourage or constrain the uptake of PrEP.
6. Identify and recommend necessary interventions and measures to counteract any prevailing negative attitudes towards PrEP that may be prevailing in the community.

Uganda 2023-03-28 1:00:59 2026-03-28 Social Science and Humanities Non-Clinical Trial Degree Award
Alison Elliott
ID: UNCST-2023-R006524
Risk factors for severe schistosomal morbidity: an adult case-control study by the Uganda Schistosomiasis Multidisciplinary Research Centre (U-SMRC)
REFNo: HS2570ES

We hypothesise that factors at each step of the parasite life cycle interact to determine morbidity in schistosomiasis. The objective of this work is to investigate risk factors associated with advanced schistosomiasis morbidity among adults, using a case-control study.
UK 2023-03-24 2:35:04 2026-03-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Birungi Edwin Mutahunga Rwamatware
ID: UNCST-2021-R004880
Prevalence and predictors of antimicrobial resistance in clinical- and community-acquired upper respiratory bacterial samples in children under 5 in south-western Uganda
REFNo: HS2625ES

Upper respiratory infections are the second leading cause of death in children under 5 in Uganda, and account for 40% of all under-5 outpatient attendance at clinics and hospitals nationwide in Uganda. As bacterial cultures of lung aspirates are often not practical, the WHO recommends using a rapid breathing and chest wall in-drawing to diagnose pneumonia in children under 5, and recommends treatment with oral amoxicillin or co-trimoxazole, or intramuscular penicillin. The only study of anti-microbial resistance (AMR) in nasopharyngeal bacteria in Uganda comes from healthy children in the Iganga/Mayuge region (Eastern Uganda), where the authors found that one-third of children were given a self-prescribed antibiotic within the past two weeks for fever, running nose, or cough, that 60% carried Streptococcus pneumoniae, and that a high proportion (80% to 99%) of cultures were resistant to co-trimoxazole, penicillin, and oxacillin. At Bwindi Community Hospital, suspected acute respiratory infections accounted for 75% of all under-5 outpatient diagnoses in 2015/2016, and are the most common reason for under-5 admissions to the Pediatrics Ward (e.g., 34% of 830 admissions in 2015/2016). In addition, the majority of antibiotics prescribed for both children and adults were for suspected acute respiratory illness (5,273 of 17,910 prescriptions). Our proposed study seeks to build on previous work concerning Antimicrobial Resistance in the developing world with a specific focus, on clinical- and community-acquired upper respiratory bacterial infections in children under 5 in southwestern Uganda, and it will be the first to analyse spatio-temporal patterns of resistance and explicitly link those patterns to cultural and social characteristics and behaviours on the ground as well as healthcare infrastructure. We propose a multi-layered study to; 1) Analyze the prevalence and spatial associations of antibiotic resistance in nasopharyngeal bacterial isolates from children under 5 in the Bwindi Community Hospital (BCH) catchment area for a year in Kanungu District, Southwestern Uganda. 2) Assess the use of antibacterial drugs at home to treat acute respiratory illness in these children from children under 5 in the Bwindi Community Hospital (BCH) catchment area in Kanungu District 3) Assess practices of antibiotic distribution at drug shops in the BCH catchment region.
Uganda 2023-03-24 2:31:31 2026-03-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Alison Elliott
ID: UNCST-2023-R006524
Investigating determinants of varying schistosomal morbidity among preschool-age children in the Lake Albert and Lake Victoria regions: a cohort study by the Uganda Schistosomiasis Multidisciplinary Research Center
REFNo: HS2568ES

Our main objective is to understand the biological determinants of severe Schistosoma mansoni-associated morbidity and to identify better strategies for its prevention and control. Our specific objectives are to: 1. Compare, in pre-school age children, early-life Sm infection and Sm-specific immune responses between Lake Albert and Lake Victoria regions and identify co-exposures that modulate Schistosoma mansoni-specific immune responses and morbidity risk 2. Determine if there is a parasite genetic basis for differential Schistosoma mansoni morbidity 3. Determine how the population biological determinants of fresh-water snail Biomphalaria spp. act as local epidemiological drivers of Schistosoma mansoni
UK 2023-03-24 2:29:21 2026-03-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Olive Kobusingye Chifefe
ID:
Building the evidence-base for the integration of rehabilitative services into health systems – a case study of clubfoot treatment in Uganda
REFNo: HS2614ES

The study has two aims, each with subsequent research questions: Aim 1: To explore how policy makers, health providers, and caregivers define, understand and experience service integration and the potential implications for clubfoot treatment. (Qualitative) • How do health care providers define and experience service integration, and what are the impacts of integration on their day-to-day clinical operations, workflow, and roles? • How do district- and national-level bureaucrats and donors understand integration, and how does that shape integration of clubfoot treatment? • How do caregivers understand and experience integration, and how does it impact their child’s treatment? • How is the NCPU financed and what relationship does financial contribution have with integration? Aim 2: To improve understanding of how the CAST mobile health application (CAST) impacts health providers’ behavior, and what potential impacts the CAST could have on service quality. (Mixed) • What is the reach and adoption rate of CAST and its components among eligible Ugandan providers? • How might CAST modify provider behavior at the facility level, both for clubfoot treatment and other services? • How might the CAST facilitate quality of care and patient treatment? o How do supportive services from MiracleFeet/CoRSU contribute to this? (e.g. training, supportive supervision, help desk) o How does data from and usage of the Cast Community contribute to this? • What is the potential future of the CAST if external support is withdrawn from clubfoot treatment and all services are fully managed by the public sector?
Uganda 2023-03-24 2:25:26 2026-03-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JOSELYN RWEBEMBERA
ID: UNCST-2021-R013915
Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent Rheumatic Heart Disease: A non-inferiority randomized trial. (GOALIE)
REFNo: HS2659ES

Primary Objective:
To compare the proportion of children aged 5-17 years with latent RHD receiving oral penicillin prophylaxis who progress to worse valvular disease at 2-years compared to children who receive IM penicillin prophylaxis.

Uganda 2023-03-24 2:23:26 2026-03-24 Medical and Health Sciences Clinical Trial Non-degree Award
Samuel Ojelel
ID: UNCST-2019-R000996
Tropical Important Plant Areas of Uganda
REFNo: NS479ES

(i) To assess conservation status of priority plant species to guide Identification of Important Plant Areas

(ii) To promote sustainable use and protection of Important Plant Areas by developing partnership with key stakeholders

Uganda 2023-03-24 2:17:32 2026-03-24 Natural Sciences Non-Clinical Trial Non-degree Award
Denis Muhangi
ID: UNCST-2020-R014258
A STUDY ON CONDOM DEMAND, UTILIZATION, DISTRIBUTION AND DISPOSAL SURVEY 2022
REFNo: SS1605ES

1. To establish the condom demand for both the male and female condom users in the community programming in 61 districts of Uganda 2. To generate information on distribution and utilization of condoms among key, priority and general population in 61 districts of Uganda 3. To generate data to be used to fill gaps in comprehensive condom programming in relation to condom demand, distribution, management and disposal as well as modalities for strengthening condom logistics in Uganda 4. To explore new modalities for strengthening condom logistics among the non-traditional channels of condom distribution in the community. 5. To determine the extent of adherence to the condom waste management and disposal mechanisms developed by MoH, 6. To establish status and opportunities of using the Total Market Approach
Uganda 2023-03-24 2:13:39 2026-03-24 Social Science and Humanities Non-Clinical Trial Non-degree Award
Caroline  Nerima
ID:
FUNCTIONAL LIMITATIONS AMONG CHILD REFUGEES WITH DEVELOPMENTAL DISABILITIES AND BARRIERS TO EARLY CHILDHOOD INTERVENTION IN A UGANDAN REFUGEE SETTLEMENT.
REFNo: HS2666ES

1. To describe the functional limitations among children aged 1 month to 6 years with developmental disabilities.
2. To describe the early intervention services available for children with developmental disabilities living in refugee camps.
3. To describe the barriers to access to early intervention services for children with developmental disabilities.


Uganda 2023-03-24 2:10:43 2026-03-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Winnie  Muyindike R
ID: UNCST-2021-R013558
Tuberculosis, Alcohol, and Lung Comorbidities (TALC) Study
REFNo: HS2705ES

Qualitatively evaluate factors for tailoring pharmaco-behavioral alcohol and smoking interventions in PLWH being treated for TB. ,Explore how smoking alters the association of past-month heavy drinking and post-TB lung disease progression over time,• Aim 1b. Assess the association of past-month heavy drinking and post-TB lung disease progression over time. This aim uses recent alcohol use (30-day Timeline Followback, PEth) since direct mechanisms (e.g., alcohol toxicity) may drive the physiologic, anatomic, and immunologic outcomes of interest. We define past-month heavy drinking as ?7 drinks/week (women), ?14 drinks/week (men) or PEth>200 ng/mL.,• Aim 1a. Determine if past-year hazardous drinking is associated with post-TB lung disease. ,Aim 1. Determine the relationship between hazardous drinking and post-TB lung disease in PLWH.,
Uganda 2023-03-24 2:08:05 2026-03-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Denis Muhangi
ID: UNCST-2020-R014258
Sustainable Off-Grid Solutions for Pharmacies and Hospitals in Africa (SophiA). Sub-component 1: Needs Assessment of Hospitals/Health Centre IVs for the Sustainable Off-Grid Solutions Sub-component 2: Socio-Economic Acceptance and Participation Assessment for Stakeholders Sub-component 3: Life Cycle Assessment and Sustainability Assessment
REFNo: SS1627ES

Goal of the SophiA Project: To bring environmental, economic, social and health benefits, creating new business and job opportunities through new technological solutions; to support African countries to pursue sustainable pathways of development through a low-carbon, climate resilient and green growth trajectory, leapfrogging fossil fuels and high GWP refrigerant technologies; and to improve the quality of life of populations through better treatment and working conditions in rural and remote health facilities in Africa.

Specific Objectives of the Proposed Studies:
i) To assess the needs from several health stations in order to identify and match the most significant and suitable health station which can be served by one SophiA system, considering different uses, replicability, cost and constraints as pertains energy consumption and solar radiation.
ii) To assess the level of acceptance of the SophiA technological solutions by the relevant stakeholders including beneficiary communities, local leaders, health care providers and managers, district officials, and national level decision makers/policy makers.
iii) To conduct a Life Cycle Assessment (LCA) to evaluate the different environmental impacts and calculate the CO2 emissions for each of the SophiA technology: solar thermal, solar PV, thermal storage, electrical storage, ice storage, refrigerators).
Uganda 2023-03-24 2:04:40 2026-03-24 Social Science and Humanities Non-Clinical Trial Non-degree Award
Esther Nasuuna Michelle
ID:
The Epidemiology of Chronic Kidney Disease among young people living with HIV in Uganda
REFNo: HS2578ES

1. To describe the prevalence of CKD among YPLHIV in SSA. 2. To compare the prevalence and associated factors of CKD diagnosed with cystatin C or creatinine-based estimates among YPLHIV in Uganda.
3. To describe the comorbidities associated with CKD among YPLHIV in Uganda.
Uganda 2023-03-22 15:08:26 2026-03-22 Medical and Health Sciences Non-Clinical Trial Degree Award
Paul Bangirana
ID:
Blood-Biomarkers and Risk Factors of Acute Brain Injury associated with Neurodisability in Ugandan Children (BRAIN-Child)
REFNo: HS2628ES

Determine if elevated brain injury biomarkers in pediatric TBI correlate with post-discharge mortality or neurocognitive impairment (NCI) and health-related quality of life outcomes at 6-month follow-up,Determine if biomarkers and risk factors of brain injury elevated in pediatric CM are elevated in pediatric TBI,
Uganda 2023-03-21 3:29:20 2026-03-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Simon  Kasasa
ID: UNCST-2021-R012861
A National Survey to Determine the Prevalence of Latent and Active Tuberculosis, COVID-19 and HIV Among Prisoners and Prisons Staff in Uganda Prisons
REFNo: HS2373ES

Overall objective
To determine the burden and associated factors of TB, COVID-19, and HIV among inmates and staff in Uganda prisons in order to generate evidence that will inform future interventions.
Primary objectives
i. To estimate the prevalence and associated factors of LTBI among inmates and staff in the Uganda prisons.
ii. To determine the prevalence and associated factors of active TB disease among inmates and staff in Uganda prisons.
iii. To determine the current burden of COVID-19 among prisoners and staff using an integrated TB and COVID-19 screening and testing approach.
iv. To establish the burden of past COVID-19 infection among prisoners and staff in Uganda prisons.
v. To determine the prevalence of HIV among inmates and staff in Uganda prisons.
vi. To determine HIV program achievement and gaps in the Uganda Prisons in reference to the UNAIDS targets for HIV testing, positive individuals who are on treatment, and PLHIV with suppressed viral load (95-95-95).

Uganda 2023-03-21 3:23:05 2026-03-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Moreen Kabarungi
ID:
A FRAMEWORK TOWARDS THE IMPROVEMENT OF ADOPTION OF BLENDED LEARNING IN HIGHER EDUCATIONAL INSTITUTIONS CASE STUDY OF SOUTH WESTERN UGANDA.
REFNo: SS1665ES

The main objective of this study is to develop a framework to support the adoption of blended learning in higher educational institutions in south western Uganda.

The specific objectives are;
1. To establish the strengths, weaknesses and elicit the requirements of the existing blended learning frameworks and their level of usage and satisfaction in higher educational institutions.
2. To design a framework that supports the adoption of blended learning in higher educational institutions.
3. To evaluate the feasibility, acceptability and usage of the designed framework of blended learning in higher educational institutions.

Uganda 2023-03-21 3:19:16 2026-03-21 Social Science and Humanities Non-Clinical Trial Degree Award
Tonny Ssekamatte
ID: UNCST-2022-R010961
Understanding the barriers and facilitators to access and utilisation Sexual and Reproductive Health services among vulnerable/marginalized adolescents and young people in Uganda
REFNo: SS1673ES

To investigate the barriers and facilitators to access and utilisation Sexual and Reproductive Health services among vulnerable/marginalized adolescents and young people in Uganda ,Examine the role of social media/other sources in the spread of information and/or disinformation and how it potentially influences access to and use of SRH services.,Examine the role of social norms in influencing the use/non-use of SRH services among the populations of interest:,Explore the barriers and facilitators to accessing SRH services among vulnerable/marginalized 15–24-year-old adolescents and young people.,
Uganda 2023-03-21 3:16:17 2026-03-21 Social Science and Humanities Non-Clinical Trial Non-degree Award
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