Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Rhoda Wanyenze
ID: UNCST-2021-R013352
GENDER EQUALITY AND WOMEN LEADERSHIP IN HIGHER EDUCATION IN EAST AFRICA.
REFNo: SS1672ES

General objective: To establish the prevailing landscape of gender equality in universities in East Africa. Specific objectives: (1) To assess entry and completion rates of women in selected academic programs in universities in East Africa for the period 2012-2022. (2) To establish the status of female academic staff engagement in academia and research (e.g., publishing rates) and leadership in universities in East Africa for the period 2012-2022. (3) To examine existing mechanisms for promoting gender equity and women leadership (e.g., university-wide policies, practices, services) as well as success factors, challenges and barriers to gender equality in universities in East Africa.
Uganda 2023-04-26 11:12:07 2026-04-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Abel  Kakuru
ID: UNCST-2022-R009193
The immune response to malaria within the germinal center
REFNo: HS2717ES

Comprehensively map the germinal center immune landscape during malaria infection.

Identify key cells and processes required for and/or disrupting the induction of malaria germinal center and antibody responses.

Identify key cells and processes required for germinal center and antibody induction to vaccines that are disrupted by malaria.

Identify and test drugs that can boost germinal center responses appropriate for use in malaria exposed children.

Uganda 2023-04-26 11:08:15 2026-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Michael Galvin
ID:
Improving HIV Outcomes through Collaborative Mental Health Interventions
REFNo: SS1642ES

To assess the perspectives of traditional and faith healers and biomedical mental health professionals on mental health treatment for people living with HIV/AIDS who have mental illness using a qualitative approach. We will interview 5-10 traditional healers and 5-10 faith healers over 2-4 months in early 2023. They will be recruited from the local area based on their experience working with people with HIV/AIDS and mental illness. These interviews will aid in characterizing the different conceptions of mental illness etiology and treatment strategies among both traditional healers in the African tradition and faith healers/pastors in the Christian tradition, and examine if collaboration between traditional and faith healers, and biomedical service providers can be developed to best serve people living with HIV/AIDS and improve health outcomes.,Objective 1b - To determine the characteristics of people living with HIV/AIDS and mental illness using a quantitative approach. We will collect cross sectional data on this population regarding of mental illness and HIV disease severity and duration, sociodemographics, and traditional and biomedical care history.,Objective 1a – To examine the experiences of people living with HIV/AIDS with mental illness in the Psychiatric Unit at Mbarara Hospital and traditional healer clinics using a qualitative approach. We will interview 15-25 patients living with HIV/AIDS and mental illness over 2-4 months in early 2023. They will be recruited from the psychiatric unit at Mbarara hospital. By interviewing mental health patients living with HIV, we can better understand how they view their illness, how local beliefs inform mental health care utilization, as well as their pathway to care and ultimately treatment outcomes.,To develop an intervention in which biomedical professionals collaborate with local traditional and faith healers to provide mental health services which will ultimately improve viral suppression, increase longevity, and reduce preventable morbidity and mortality.
USA 2023-04-26 11:03:04 2026-04-26 Social Science and Humanities Non-Clinical Trial Degree Award
Julian Adong
ID: UNCST-2021-R013487
An mHealth intervention to address the burden of depression and anxiety among perinatally-infected adolescents and young adults with HIV in Uganda.
REFNo: HS2691ES

Pilot U-SMART Voices among PAYWH with symptoms of anxiety and/or depression ,Adapt the group-based psychosocial mental health intervention, Sauti Ya Vijana (SYV; voice of the youth), to create the Uganda Social Media intervention to improve ART and Treatment outcomes (U-SMART)-Voices,Characterize the symptoms of depression and anxiety among PAYWH and correlation with quality of life.
Uganda 2023-04-26 10:51:31 2026-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Phiona Bukirwa
ID: UNCST-2022-R009880
Self-reported knowledge about palliative care offers and access to morphine by patients with cancer in Kyadondo County, Uganda
REFNo: HS2738ES

1. To assess patient knowledge of palliative care services. 2. To assess patient access to morphine and investigate the reasons for poor access 3. To describe the barriers to the intake of morphine,
Uganda 2023-04-26 10:44:36 2026-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eriab Kapuru Asinja
ID: UNCST-2022-R011430
Title: Uptake of modern contraceptive methods and birth outcomes among women with caesarian sections in Kasese district, Uganda: leveraging innovative digital technology for empowering community health workers in delivering family planning services
REFNo: HS2639ES

4- To investigate the feasibility of using mobile phone health text messaging to women through CHWs and estimate the effect on contraception uptake among women in Kagando (sub-study IV),3- To explore women’s knowledge, attitudes and practices with various methods of contraception and evaluate the perceived benefits and satisfaction with contraception services, comparing those who had CS births and those who never had CS births (sub-study III),2- To estimate the frequency of repeat caesarian sections and factors associated with birth outcomes (sub-study –II).,1- To determine if CHWs can accurately document and follow households in defined geographical areas assigned to them (demographic surveillance area) using mobile phones and the feasibility of linking these data with hospital records (sub-study I).,The main objective of this study is to build the capacity of community health workers to accurately register households, including pregnant mothers and follow them with targeted health messages to improve birth outcomes,
Uganda 2023-04-26 10:40:21 2026-04-26 Medical and Health Sciences Non-Clinical Trial Degree Award
Simon Walusimbi
ID:
Impact of Tuberculosis Preventive Treatment (TPT) on Tuberculosis incidence and all-cause mortality among People Living with HIV (PLHIV) Receiving Anti-Retroviral Treatment (ART) in Uganda
REFNo: HS2772ES

To determine how long after TPT completion does TB incidence begin to rise again in patients who have completed TPT,To compare TB incidence and all-cause mortality among PLHIV who received TPT as 6-month INH versus 3HP regimen,To establish the risk factors for developing TB among PLHIV who have completed TPT,To compare TB incidence and mortality among PLHIV in Uganda who have completed TPT with PLHIV who have not completed TPT,To determine the incidence of all-cause mortality among PLHIV in Uganda who have completed TPT, at 12, 24, and 36 months of TPT completion.,To determine the incidence of newly diagnosed TB disease among PLHIV in Uganda who have completed TPT, at 12, 24, and 36 months after TPT completion,To evaluate the impact of TPT on TB incidence and all-cause mortality among PLHIV in Uganda,
Uganda 2023-04-26 10:39:06 2026-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Charles  Kajubi
ID: UNCST-2022-R008989
Baseline Study for Safe and Inclusive Cities Project -Uganda.MAKSHSREC-2022-420
REFNo: SS1582ES

To measure the long-term impact of the intervetions on the project participants and formulate recommendations for Plan International Uganda to further strengthen research.,To determine the baseline values for outcome indicators from the onset of the project.,
Uganda 2023-04-26 10:37:49 2026-04-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Patrick Muinda Emmanuel
ID:
An Information Technology Governance Framework for Improved Success of Digital Transformation Projects for Technical, Vocational Education and Training (TVET)
REFNo: SIR180ES

To test and evaluate the designed ITG Framework for Improved Success of Digital Transformation Projects in TVET institutions,To design and develop an ITG Framework for Improved Success of Digital Transformation Projects in TVET institutions,To determine the factors for improved success of Digital Transformation Projects in TVET institutions,To establish the effectiveness of Information Technology Governance applied in TVET institutions,The General Objective of this study is to develop an Information Technology Governance (ITG) framework for improved success of Digital Transformation Projects in the TVET subsector,
Uganda 2023-04-26 10:31:45 2026-04-26 Engineering and Technology Non-Clinical Trial Degree Award
ELIZABETH ASIGE
ID:
THE IMPACT AND COST-EFFECTIVENESS OF A COMMUNITY-BASED PROGRAM FOR CHILDREN WITH CEREBRAL PALSY AND THEIR CAREGIVERS AND THE STAKEHOLDERS IN UGANDA.
REFNo: HS1979ES

1. To examine the impact of a community-based program on children with CP reported frequency of participation in the home, school, and community activities. 2. To assess the impact of a community-based training program on improving caregiver knowledge regarding CP and reducing caregiver stress. 3. To determine the impact of a communication and advocacy program in broadening stakeholders’ knowledge, attitude and practices regarding childhood disability and inclusion. 4. To determine the cost-effectiveness of a community-based program on children with CP, their caregivers, and the stakeholders in relation to costs and benefits.
Uganda 2023-04-20 21:15:22 2026-04-20 Medical and Health Sciences Clinical Trial Degree Award
Jedediah Silver
ID: UNCST-2023-R007939
The Effects of Cassava Drying Technology on Commercialization and Consumption Smoothing
REFNo: SS1700ES

The main goals of the pilot RCT are to ascertain the technical efficiency of the machines, the viability of the model where agents operate the machines and charge a fee for drying, and to observe how harvest and sales timing, consumption and cropping decisions change when farmers gain access to drying technology. In addition, we will explore additional mechanisms including varying the contract structure, and getting a sense of which channels are most salient to focus on (e.g. how likely we would be to detect effects on intertemporal smoothing beyond addressing the barriers to adoption to a seemingly profitable technology).
USA 2023-04-20 21:05:53 2026-04-20 Social Science and Humanities Non-Clinical Trial Non-degree Award
Beatrice  Onyango Ekesa
ID:
Bio-efficacy of Pro-Vitamin A-rich banana to improve vitamin A status among children in Uganda living in an area with a high burden of inflammation
REFNo: HS2721ES

3. Establish the stability of retinol isotopes on DSS at room temperature in the determination of TBS of vitamin A.,2. Assess the effect of inflammation and nutritional status on vitamin A absorption and TBS assessment among school-aged Ugandan children.,1. Determine the bio-efficacy of carotenoids in Pro-Vitamin A rich bananas in improving TBS in children aged 6-14years.,This study will determine the bio-efficacy of carotenoids in Pro-Vitamin A-rich banana-based diets and their potential in improving the vitamin A body stores by the RID technique among school-going children aged 6-14years living in Tororo district, an area with a high burden of inflammation.,
Kenya 2023-04-19 12:44:24 2026-04-19 Medical and Health Sciences Clinical Trial Non-degree Award
Bernard Muhangi Wakabi
ID:
Managerial competences and performance of Microfinance Institutions in Uganda
REFNo: SS1693ES

iii. To establish the moderating effect of stakeholder management on the relationship between managerial competencies and financial performance of MFIs in Uganda.,ii. To examine the mediating effect of competitive advantage in the relationship between managerial competencies and financial performance of MFIs in Uganda.,i. To examine the relationship between managerial competencies and financial performance of MFIs in Uganda.,The study will examine the relationship between managerial competencies and financial performance while examining the mediating effect of competitive advantage and stakeholder management's moderating effect in the relationship between managerial competencies and financial performance of MFIs in Uganda.,
Uganda 2023-04-19 12:41:29 2026-04-19 Social Science and Humanities Non-Clinical Trial Degree Award
Violet  Gwokyalya
ID: UNCST-2022-R010490
An Evaluation Study of Oral PrEP Delivery Models in Uganda
REFNo: HS2734ES

Primary Objectives 1. To document Oral PrEP delivery models currently in use in Uganda. 2. To establish the contribution of the various Oral PrEP delivery models to uptake of PrEP. 3. To establish the contribution of the various Oral PrEP delivery models to continuity of PrEP. 4. To establish the costs involved in implementing different PrEP delivery models in Uganda. 5. To document the best practices from the different PrEP Delivery models and the recommendations for promoting efficient and sustainable PrEP services. Secondary objective. To establish the feasibility of injectable PrEP delivery in Uganda
Uganda 2023-04-19 12:27:39 2026-04-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rosalind  Parkes-Ratanshi Parkes
ID: UNCST-2019-R000717
A pilot etiological study of genital ulcer disease in Uganda, including the burden of macrolide resistant T pallidum
REFNo: HS2728ES

-To determine the proportion of genital ulcers caused by syphilis compared with other causes of genital ulcer disease in a contemporary Ugandan setting.
-To determine the proportion of T pal isolates with evidence of macrolide resistance markers.
-To determine agreement between clinical diagnosis and treatment compared with laboratory diagnosis of GUD.
-To determine agreement between GUD PCR result and serological markers of infection including POCT and lab-based assays.
-To develop a library of GUD pictures stratified by microbiological diagnosis.


UK 2023-04-19 12:17:44 2026-04-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
GODFREY TUMUHAISE
ID:
Rapid Assessment of Avoidable blindness /Disability in the Northern, Eastern and Western Regions of Uganda in people aged 50 Years and above
REFNo: SS1695ES

• To determine the causes of blindness and VI.,• To explore the relationship between disability and socio-economic status and eye health,To determine the prevalence of disability among the study population. ,• To assess factors affecting access to cataract surgical services by determining cataract surgical coverage.,• To determine the prevalence and distribution of blindness and VI in the study population.,To estimate the prevalence and causes of blindness and visual impairment among people aged ?50 years in Uganda.,
Uganda 2023-04-19 12:14:06 2026-04-19 Social Science and Humanities Non-degree Award
Carolyne Akello Agwau
ID: UNCST-2021-R013375
The CATALYST Study: Catalyzing access to new prevention products to stop HIV
REFNo: HS2801ES

The overall goal of the study is to characterize and assess the implementation of an enhanced service delivery package providing choice of PrEP products among women at PEPFAR/USAID delivery sites in Kenya, Lesotho, South Africa, Uganda, and Zimbabwe. The study has three primary objectives: Objective 1: Characterize the implementation of the enhanced service delivery package for informed PrEP choice for women in PEPFAR/USAID public health service delivery sites and assess individual-, provider-, facility-, community-, and health system-level facilitators of and barriers to the implementation process. (Achieved through process evaluation, and nested costing and community acceptance studies) Objective 2: Describe patterns of PrEP use and use effectiveness in the context of informed PrEP choice and assess sociodemographic and contraceptive use correlates of PrEP use patterns. (Achieved through cohort and nested PEU study) Objective 3: Describe clinically relevant indicators among PrEP users, including rates of HIV infection and drug resistance among PrEP users who acquire HIV following PrEP initiation or had undetected HIV prior to PrEP initiation. (Achieved through cohort, including CAB HIV testing algorithm nested study)
Uganda 2023-04-13 16:51:59 2026-04-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Pontiano  Kaleebu
ID: UNCST-2020-R019901
Field Evaluation of National HIV Testing Services Algorithm
REFNo: HS2701ES

Main Objective
To determine the appropriate HIV rapid test algorithm to be used in Uganda considering the new kits on the market.

Specific objectives
1. To assess specificity, sensitivity, negative predictive value (NPV), positive predictive value (PPV) of the rapid HIV tests on the market in Uganda and come up with best RDT algorithm.
2. To identify an algorithm that will best identify acute HIV infections
3. To determine the inter-observer and inter-lab agreement in HIV diagnosis using evaluated RDTs.

Uganda 2023-04-12 15:44:58 2026-04-12 Medical and Health Sciences Clinical Trial Non-degree Award
STUART TURANZOMWE
ID:
PREVALENCE, SEVERITY AND FACTORS ASSOCIATED WITH ANAEMIA AMONG WOMEN WITH CERVICAL CANCER AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS2749ES

To determine the factors associated with anaemia among women with cervical cancer at Mbarara Regional Referral Hospital,To describe the severity of anaemia among women with cervical cancer at Mbarara Regional Referral Hospital,To determine the prevalence of anaemia among women with cervical cancer at Mbarara Regional Referral Hospital,To determine the prevalence, severity and factors associated with anaemia among women with cervical cancer at Mbarara Regional Referral Hospital,
Uganda 2023-04-12 14:46:12 2026-04-12 Medical and Health Sciences Non-Clinical Trial Degree Award
Samuel Kawuma
ID:
Facilitators and barriers to retention on Pre-exposure prophylaxis (PrEP) among Female Sex Workers attending Kiruddu National Referral Hospital.
REFNo: HS2771ES

1. To identify the implementation gaps along the Pre-Exposure Prophylaxis continuum of care and assess the factors associated factors with retention on PrEP among FSWs at Kiruddu National referral Hospital.,To design a stakeholder informed evidence-based intervention to improve retention on PrEP among FSWs at Kiruddu National Referral Hospital ,2. To determine the facilitators and barriers of retention on PrEP among FSWs in care at Kiruddu National referral Hospital.,
Uganda 2023-04-12 14:43:04 2026-04-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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