David Meya Bisagaya
ID: UNCST-2019-R000837
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A Phase 2 Novel Antimicrobial Combination Therapy to Treat Tuberculous Meningitis
REFNo: HS5711ES
1. Assess the safety and efficacy of a novel anti-TB combination regimen with greater bactericidal activity than current standard of care (SOC) therapy
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Uganda |
2025-07-18 14:05:06 |
2028-07-18 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Kiconco KerenHappuchBita
ID: UNCST-2024-R016072
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“TRAINER-TRAINEE MANAGEMENT PROCESSES IN INFORMAL VOCATION EDUCATION TRAINING ARRANGEMENTS IN UGANDA”
REFNo: SS3744ES
1.4 Objectives of the study
i) To find out the management processes engaged in the practice of IVET.
ii) To discover how the informal nature shapes the management processes.
iii) To establish potential factors influencing the trainer –trainee management process of IVET.
iv) To find out coping approaches and strategies utilized in IVET management.
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Uganda |
2025-07-18 13:58:51 |
2028-07-18 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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Elias Kumbakumba
ID: UNCST-2022-R011183
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Consortium to Reduce Infant Mortality in Uganda (CONRIM-U)
REFNo: HS6270ES
OBJECTIVES
The overall CONRIM objective is to contribute to the elimination of preventable Neural tube defects (NTDs), Neonatal Sepsis (NS) and the resultant Infectious Hydrocephalus in Uganda.
SURVEILLANCE OBJECTIVES
The study aims to investigate the burden of NS and NTDs within the Busoga subregion, their associated risk factors, the role of genomics in their causation, and the extent to which effective public health interventions and prevention policies can contribute to their reduction.
Specific objectives for the SURVEILLANCE ARM of the CONRIM Unified Protocol include:
1. To estimate the true burden of NTD and NS in Busoga region
In order to achieve this, we will
1.1 Establish comprehensive village level surveillance and build the community network and capacity for accurate routine surveillance on NS and NTDs.
1.2 Employ advanced methods of adaptive surveillance to optimize cost effective observation for NS and NTD at the community level. These can then be extrapolated to other important infant conditions like Malnutrition, and scaled up nationally
2. To determine genetic and environmental contribution to NTD and NS risk and prevention
In order to achieve this, we hope to
2.1 Identify populations or geographical areas that are at increased risk of NS and NTDs in Uganda, for targeted follow-on prevention measures, and policy formation
2.2 Determine whether ancestral genomics might separate different risk groups with similar folate levels. This will lead to optimization of folate for diverse African ancestries.
SAMPLING OBJECTIVES
The general objective of the Sampling Arm is to prospectively diagnose, treat and prevent infant paenibacillus infections.
Specific objectives for the SAMPLING ARM of the CONRIM Unified Protocol include:
3. To evaluate the ability to diagnose Paenibacillus infections at the hospitals.
In order to achieve this objective, we will
3.1 Set up real time qPCR sampling on site at specific sites treating these infants. This will enable the treating clinicians be able to diagnose this infection and plan treatment
3.2 Plan for Nanopore Same Day Sequencing for both Microbe Detection and Antibiotic Resistance determination
4. To determine the optimal treatment for infant paenibacillus infections and evaluate for outcomes.
In order to achieve this objective, we hope to
4.1 Start a prospective registry of infants diagnosed with this infection, focusing on observing treatments and outcomes.
4.2 Lay the foundational work for optimization of brain growth following treatment for infant infections and malnutrition.
5. To identify Sources and Routes of infection leading to infant Paenibacilliosis so as to Prevent these infections
In order to achieve this objective, we will
5.2 Identify potential environmental reservoirs of infant paenibacilliosis.
5.3 Assess for potential transmission routes of infection related to infant care and feeding practices. The consenting mothers whose infants underwent testing for Paenibacillus will be requested to complete a detailed structured interview designed to elucidate the possible pathways of infection stemming from infant care practices.
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Uganda |
2025-07-18 13:55:00 |
2028-07-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Caroline Birungi
ID: UNCST-2021-R012954
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EVALUATING THE EFFECTIVENESS OF INSTRUCTION IN RESPONSIBLE CONDUCT OF RESEARCH ON TRAINEES’ KNOWLEDGE, SKILLS, AND ATTITUDES FOR DECISION-MAKING IN RESEARCH AND PRACTICE IN SOUTHWESTERN UGANDA
REFNo: HS5771ES
1.3.1 General Objective
To evaluate the effectiveness of instruction in responsible conduct of research on trainees’ knowledge, skills, attitudes and behaviors towards decision making in research and practice among those who attended RCR training under the Mbarara University Research Ethics Education Program (MUREEP) from March 2019 to December 2023.
1.3.2 Specific objectives
1. To assess the effectiveness of instruction in RCR offered by MUREEP from March 2019 to December 2023 on trainees' knowledge of the core norms, principles, regulations, and rules governing the practice of research.
2. To evaluate the effectiveness of instruction in RCR offered by MUREEP from March 2019 to December 2023 on trainees’ problem-solving skills for ethical conduct of research.
3. To examine the effectiveness of instruction in RCR offered by MUREEP from March 2019 to December 2023 on trainees’ attitudes and behaviors towards ethical decision-making in research
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Uganda |
2025-07-18 13:52:09 |
2028-07-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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Betty OKOT
ID: UNCST-2021-R013938
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Assessing the Feasibility of Introducing Playful Parenting Intervention for Enhancing School Readiness, Foundational Literacy and Numeracy in a Crisis Context in Uganda
REFNo: SS3839ES
Overall, the study aims to respond to the challenges of providing education in refugee and displacement contexts by assessing the feasibility of implementing a playful parenting intervention to promote school readiness, foundational literacy, and numeracy skills among refugee children.
Study objectives
The following objectives will guide the study:
1) To examine the level of caregivers’ and education stakeholders’ knowledge of playful parenting practices, policies and how they contribute to school readiness and early years education/learning
2) To determine the levels of foundational numeracy and literacy proficiency among children at baseline.
3) To assess the improvement in mean foundational numeracy and literacy levels over 24 months by comparing baseline and post-intervention proficiency scores using standardized assessments.
4) To examine whether interactive play and parental guidance could improve school readiness, foundational literacy and numeracy competencies, parent-child relationships, and socio-emotional skills and resilience in children.
5) To identify facilitators and barriers to playful parenting, school readiness, and foundational literacy and numeracy among refugee learners and recommend alleviating strategies.
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Uganda |
2025-07-18 13:48:28 |
2028-07-18 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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