Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Henry Mugerwa
ID: UNCST-2019-R000420
 A Phase 1b, Age De-Escalation/Dose Escalation Trial to Evaluate Safety, Tolerability, and Pharmacokinetics of MAM01 in an African Population of Adults and Children in a Setting of Perennial Malaria Transmission
REFNo: HS5298ES

Primary Objective. To assess the safety and tolerability of MAM01. Secondary Objectives. To assess the safety of MAM01. To characterize the PK of MAM01 following SC, IV, and IM administration of MAM01. To assess the formation of anti-drug antibodies (ADAs) to MAM01. Exploratory Objectives. To assess the protective efficacy of a single dose of MAM01 over 182 days against Pf infection, as detected by blood smear microscopy compared to a placebo. To assess the protective efficacy of a single dose of MAM01 over 182 days against Pf infection, as detected by blood smear microscopy compared to placebo. To assess the protection of MAM01 against events of malaria illness (first/only and all episodes). To correlate MAM01 concentration with Pf infection risk. To assess the complexity of Pf infection following administration of MAM01 or placebo.
Uganda 2024-12-23 12:23:27 2027-12-23 Medical and Health Sciences Clinical Trial Non-degree Award
Eleanor Namusoke Magongo
ID: UNCST-2021-R013199
 Outcome Evaluation of the Young People and Adolescent Peer Support (YAPS) program Implementation in Uganda
REFNo: HS4809ES

1. To assess fidelity of the YAPS program implementation by different stakeholders (MoH, Implementing Partners, Districts, Facilities, and YAPS personnel)
2. To establish the effect of the YAPS program on the clinical cascade for Adolescents and Young People Living with HIV.
3. To explore perspectives of YAPS and other stakeholders on the effectiveness of the YAPS program.
4. To estimate the incremental costs of implementing the YAPS model at the different levels of implementation (National, District and health facility)

 Uganda 2024-12-23 12:17:40 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
DANLADI MAKERI
ID: UNCST-2024-R005300
 Characterization of Staphylococcus aureus Isolated from Foot Ulcers of Diabetic Patients Attending Kampala International University Teaching Hospital, Bushenyi District, Uganda
REFNo: HS4836ES

v. To determine the molecular phylogeny of Staphylococcus aureus isolated from foot ulcers of Diabetic patients attending Kampala International University Teaching Hospital Bushenyi district, Uganda,iv. To determine the antibiogram profile of Staphylococcus aureus isolated from foot ulcers of Diabetic patients attending Kampala International University Teaching Hospital Bushenyi district, Uganda,iii. To assess the phenotypic distribution of Staphylococcus aureus in foot ulcers of Diabetic patients attending Kampala International University Teaching Hospital Bushenyi district, Uganda.,ii. To determine factors associated with diabetic foot infections among Diabetic patients with foot ulcers attending Kampala International University Teaching Hospital Bushenyi district, Uganda ,i. To determine the prevalence of diabetic foot infection among Diabetic patients with foot ulcers attending Kampala International University Teaching Hospital Bushenyi district, Uganda,To characterize Staphylococcus aureus isolated from foot ulcers of Diabetic patients attending Kampala International University Teaching Hospital Bushenyi district, Uganda ,
 Nigeria 2024-12-23 12:15:59 2027-12-23 Medical and Health Sciences Non-Clinical Trial Degree Award
Francis Omujal
ID: UNCST-2019-R000428
 DOCUMENTATION OF BATWA INDIGENOUS PEOPLE AND LOCAL COMMUNITIES’ KNOWLEDGE FOR BIO-PROSPECTING FOR THERAPEUTICS PRODUCTS
REFNo: NS658ES

c) To identify priority natural medicinal resources that can be used by BIP for development of therapeutic products for specific diseases ,b) To assess the availability status of medicinal resources used for TMK by the BIP,a) To document the traditional medicine practices of the BIP,To document TMK of the Batwa indigenous people for the development of therapeutic products.,
 Uganda 2024-12-23 12:14:59 2027-12-23 Natural Sciences Non-Clinical Trial Non-degree Award
Edgar Mulogo Mugema
ID: UNCST-2023-R008170
 Epidemiology of pediatric severe malaria in the Kasese District of western Uganda
REFNo: HS5367ES

Study Objectives The overarching goal of this proposed project is to describe the epidemiology of severe malaria among children in the Kasese District of western Uganda. Our scientific objective is to determine if the demographic, clinical, and laboratory characteristics of children admitted to a more urban level IV health center are different from our previous findings at a rural level III health center. To test this hypothesis, we propose to: AIM 1: Describe the demographic characteristics of children admitted to SPHC with a diagnosis of malaria. We will conduct a prospective, observational study, enrolling children admitted to the IPD. Participating caregivers will complete a questionnaire documenting basic demographic factors as well as information about the household (e.g., location, LLIN access and use). We hypothesize that most children will be (i) <12 years of age, (ii) from areas within 20km of SPHC, and (iii) have previously sought care at lower-level facilities. AIM 2: Document the clinical and laboratory characteristics of children admitted to SPHC with a diagnosis of malaria: We will elicit a history of illness from the caregiver and record relevant information including vital signs, results of laboratory testing (e.g., malaria RDT, hemoglobin, etc.), along with treatments administered during the hospitalization. We hypothesize that nearly all children will receive ≥24 hours of intravenous artesunate, but there may be substantial variation in dosing. AIM 3: Estimate measures of severe malaria incidence and associated morbidity and mortality among children presenting to SPHC with malaria. We will record the results of laboratory testing for malaria in the OPD to determine the malaria positivity rate and incidence of SM (i.e., proportion with a positive RDT who are admitted). Among those who are admitted, we will document disposition (e.g., discharge, transfer, death) and complete follow up at 14, 30, 45, and 60 days post-discharge. We hypothesize that mortality will be greatest among children referred from lower-level facilities and those with delayed presentations
Uganda 2024-12-23 12:12:56 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Justus Asasira
ID: UNCST-2021-R012092
 Socioeconomic and Environmental Impacts of Biomass Briquettes and Solar Cooking Technologies Acceptance by Households in Southwestern Uganda
REFNo: SS2319ES

1. To explore the stakeholders’ perceptions about adopting biomass briquettes for cooking in Southwestern Uganda.
2. To assess the influence of business models on the acceptance and economic feasibility of biomass briquettes and solar technologies for cooking in Southwestern Uganda.
3. To compare the environmental impacts and benefits of producing and using solar technologies with non-renewable sources of energy for cooking in Southwestern Uganda.
4. To identify the design attributes that make biomass briquettes and solar cooking technologies socially acceptable by households in Southwestern Uganda.

 Uganda 2024-12-23 12:11:58 2027-12-23 Social Science and Humanities Non-Clinical Trial Degree Award
OSCAR AYUYA INGASIA
ID: UNCST-2024-R002553
 Gender Analysis; Address gendered aspects of awareness of lower-risk plant protection products/technologies in Uganda
REFNo: A534ES

To explore the roles men and women play in pest management and the products used for pest management in potato farming,To assess the differences between men, women, and young people\'s, values, power dynamics and behaviors which shape their access to and use of digital tools.,To examine the traditional pest prevention technologies, and the gendered obstacles faced by men women and young people,To respond to the needs of farmers and the systems that support them, by helping countries predict, prevent, and prepare for plant health threats, thereby reducing crop losses. ,
 Kenya 2024-12-23 12:09:26 2027-12-23 Agricultural Sciences Non-Clinical Trial Non-degree Award
Isaac Kitone
ID: UNCST-2024-R002847
 Kabale University (KAB) Sustainable Energy Generation System (KSEG) Project
REFNo: SIR421ES

To test the automated non-fossil fuel driven power generator,To construct an automated non-fossil fuel driven power generator ,To design an automated non-fossil fuel driven power generator ,To collect data on existing generator power needs in three western Ugandan districts, Kabale, Mbarara and Ntungamo,To design and construct an automated non-fossil fuel driven power generator ,
 Uganda 2024-12-23 12:07:01 2027-12-23 Engineering and Technology Non-Clinical Trial Non-degree Award
Andrew Mujugira
ID: UNCST-2019-R000871
 UNMET ORAL HEALTH NEEDS AND BARRIERS TO ORAL HEALTH AND SEXUAL HEALTH SERVICE UTILISATION AMONG MEN WHO HAVE SEX WITH MEN AND TRANSGENDER PEOPLE IN UGANDA: A MIXED METHODS PILOT STUDY
REFNo: HS5226ES

Objective 1: Estimate the prevalence of oral diseases, HIV, OHPV,
and self-reported STIs and their impact on oral health conditions in
MSM/TGP.
Objective 2: Identify the key barriers to health service utilization
experienced by MSM/TGP.
 Uganda 2024-12-23 12:05:34 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JOYCE NAMWASE
ID: UNCST-2024-R005002
 FEASIBILITY AND EFFECTIVENESS OF A TRAINING INTERVENTION FOR INFORMAL CAREGIVERS OF PEOPLE LIVING WITH DEMENTIA IN RURAL UGANDA (FETIC-DU)
REFNo: HS5165ES

3. To evaluate the feasibility and effectiveness of the training program in improving knowledge and skills of informal care givers for persons with dementia in rural Uganda. 1.4 Research questions
Uganda 2024-12-23 12:04:08 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Daniel Murokora Murokora
ID: UNCST-2024-R002689
 Outcomes Evaluation of Reproductive, Maternal and Newborn Care Interventions Implemented by BAMA in Uganda
REFNo: HS5155ES

General Objective
To evaluate the outcomes of Reproductive, Maternal and Newborn Care interventions at BAMA Supported Sites in Uganda.

Specific Objectives
1. To evaluate the impact of NMH interventions on IMMR and IPMR since 2015
2. To explore factors influencing mortality trends since 2015
3. To document the optimum package of MNH interventions that impacted MMR and PMR
4. To assess the impact of BAMA interventions on HPV vaccination uptake for out-of-school girls as well general population (women aged 25-49) cervical cancer screening and linkage to appropriate services
5. To assess the effect of BAMA project interventions on infant development outcomes and adolescent mother’s physical, social, and mental wellbeing outcomes
6. To determine the feasibility and sustainability of MRP
7. To assess the impact of the implementation of MPS transport solution on MNH outcomes
8. To assess the design and impact of the mentor midwives model on MNH outcomes
9. To determine optimum mentorship package and its impact on quality of care and clinical outcomes

 Uganda 2024-12-23 12:03:10 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Winnifred Kansiime Kimara
ID: UNCST-2021-R012131
 Faecal exposure behaviours, risk profiles, and predicted efficacy of Water Sanitation and Hygiene interventions in Imvepi, Uganda and Cox’s Bazar, Bangladesh refugee settings
REFNo: HS5190ES

4. To predict the efficacy of suggested interventions on reducing faecal exposure in the private domain in Imvepi and Cox’s Bazar refugee settings (Study IV),3. To determine the factors associated with faecal exposure among children and adults in Imvepi and Cox’s Bazar refugee settings (Study III),2. To determine the faecal exposure risk profile of children and adults in the private and public domain of Imvepi and Cox’s Bazar refugee settings (Study II),1. To explore faecal exposure behaviours and pathways of children and adults in the private and public domain of Imvepi and Cox’s Bazar refugee settings (Study I),To establish the faecal exposure profiles and associated factors in the private and public domain and predict the efficacy of suggested interventions in Imvepi, Uganda and Cox’s Bazar, Bangladesh refugee settings so as to guide exposure reduction interventions.,
 Uganda 2024-12-23 12:01:21 2027-12-23 Medical and Health Sciences Non-Clinical Trial Degree Award
DANIEL BUGEMBE LULE
ID: UNCST-2024-R015332
 DEVELOPMENT OF NOVEL APPROACHES FOR HIV DRUG RESISTANCE DETECTION USING NANOPORE SEQUENCING TECHNOLOGY
REFNo: HS5352ES

Objectives and Hypothesis
Primary Objective
To develop an end-to-end nanopore NGS workflow for the routine clinical detection of HIV drug
resistance (HIVDR).
Secondary Objective
To compare the HIVDR scoring between Sanger and Nanopore sequencing method of matched samples
to evaluate their concordance for detecting drug resistance mutations.
Exploratory Objectives
1. To develop a method for PCR amplification of low plasma viral load samples, genotype these
with the nanopore method and derive HIVDR mutations.
2. To identify improvements to the nanopore base-calling algorithms that may obviate high error
rates.
3. Provide an expeditious end-to-end analysis pipeline for analysis of HIVDR of Nanopore generated
sequences.
4. To establish if the various base-calling errors of the Nanopore sequencing are occurring in a
stochastic or non-stochastic manner.
 Uganda 2024-12-23 11:59:00 2027-12-23 Medical and Health Sciences Non-Clinical Trial Degree Award
Edgar Mulogo Mugema
ID: UNCST-2023-R008170
 Identifying Barriers to Infection Prevention & Control Guideline Adherence in Western Uganda.
REFNo: HS5360ES

Primary Objectives The primary objective of the proposed project is to demonstrate the effects of limited physical facility infrastructure, diminished supplies, and gaps in IPC knowledge amongst HCP and how they may relate to IPC practice implementation at the health facility level to inform efficient and effective future improvement efforts. Specific Aims AIM 1: Evaluate adherence to national IPC guidelines across a variety of healthcare facility levels in Western Uganda via a standardized observation protocol through facility-level evaluations. 1A. Guided by Uganda’s national IPC best practices for healthcare facilities and a standardized facility-level checklist adopted from the World Health Organization, we will perform observations of the facility’s physical characteristics, healthcare supplies, and healthcare personnel workflow, including observations of hand hygiene adherence with a standardized checklist. AIM 2: Assess IPC knowledge, attitudes, and practices of healthcare personnel at multiple levels of Uganda’s national healthcare system, identifying primary barriers to National IPC Guideline adherence. 2A. Healthcare Personnel Surveys: Surveys will consist of both qualitative and quantitative elements to ascertain information on their awareness of foundational IPC concepts within national guidelines, circumscribe a working understanding of the implementation of IPC measures across different healthcare facility settings before and after the COVID-19 pandemic, and determine health facility-level attributes that may prevent rigorous adherence to IPC guidelines. 2B. Healthcare Personnel Focus Group Discussions: Focus group discussions will be oriented in such a manner as to ascertain common themes and information on awareness of foundational IPC concepts, gain a perspective on the experience of IPC practices across a variety of facility levels and HCP roles, and understand what limitations are experienced by HCP during their daily patient care-oriented activities. Through these discussions, we hope to gain a working understanding of the implementation of IPC measures across different healthcare facility settings before and after the COVID-19 pandemic, and determine health facility-level attributes, gaps in IPC education and/or training, and HCP workflow concerns that may prevent rigorous adherence to IPC guidelines.
Uganda 2024-12-23 11:57:43 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joyce Kambugu Balagadde
ID: UNCST-2020-R014996
 Stakeholder perspectives for the approach to treatment recommendations for kids presenting with advanced or incurable cancer
REFNo: HS5203ES

Using the instrument described in 1.1, identify personal, professional, and contextual factors influencing the perspectives and decision-making approaches of key non-physician stakeholders in Uganda in the upfront care of children diagnosed with advanced or incurable cancer through qualitative data collection and analysis.,To adapt an existing instrument for use in Uganda that helps explore the personal, professional, and contextual factors that influence the perspectives and decision-making approaches of key non-physician stakeholders (patients, families, multidisciplinary clinicians), specifically with respect to recommending upfront curative treatment versus non curative treatment (for example, with palliative-intent) in children diagnosed with advanced or incurable cancer in LMICs.,
 Uganda 2024-12-23 11:55:35 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Julius Duula Waiswa
ID: UNCST-2024-R015879
 BURDEN AND SPATIAL DYNAMICS OF TICK SPECIES AMONG CATTLE GRAZING ALONG THE BUFFER ZONE OF LAKE NAKUWA IN KALIRO DISTRICT
REFNo: A529ES

1. Determine the burden of tick species infesting cattle grazing along the buffer zone of Lake Nakuwa.
2. Determine spatial dynamics of the different tick species infesting cattle grazing along the buffer zone of Lake Nakuwa
3. Identify factors promoting and maintaining high tick infestation burdens along the buffer zone of Lake Nakuwa.

Uganda 2024-12-23 11:54:12 2027-12-23 Agricultural Sciences Non-Clinical Trial Degree Award
Edith Namakula
ID: UNCST-2022-R006923
 Pethidine versus Morphine use for management of postoperative pain in Mulago National Referral Hospital, Uganda
REFNo: HS5240ES

1. To determine the prevalence of pethidine versus morphine prescription for the management of postoperative pain in MNRH, Uganda.
2. To explore the side effects experienced during the use of pethidine versus morphine for the management of postoperative pain in MNRH, Uganda.
3. To determine the factors associated with pethidine prescription for the management of postoperative pain in MNRH, Uganda.
4. To explore barriers and facilitators of pethidine versus morphine prescription in the management of postoperative pain in MNRH, Uganda.

 Uganda 2024-12-23 11:53:21 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Brenda Birungi
ID: UNCST-2024-R015642
 Receiving cash amidst competing norms: the case of breastfeeding South Sudanese refugees in bidi-bidi settlement, uganda.
REFNo: SS3525ES

To explore how breastfeeding South Sudanese refugees navigate their cultural norms and cope with cash transfer project norms.

Specific objectives.
1. To establish the cultural norms that guide breastfeeding among South Sudanese refugees in bidi-bidi settlement.
2. To examine how beneficiaries relate with the official norms (project and state norms) in bidi-bidi settlement.
3.To assess the impact of cultural norms on the participation of south sudenese refugees in cash transfer interventions in bidi-bidi settlement.
Uganda 2024-12-23 11:52:27 2027-12-23 Social Science and Humanities Non-Clinical Trial Degree Award
JAMMY OMARA
ID: UNCST-2022-R009800
 ASSESSING DIFFERENTIAL DIAGNOSES, ASSOCIATED FACTORS AND GEOSPATIAL DISTRIBUTION OF CHRONIC LOWER LIMB ULCERS AMONG ADULTS IN ZOMBO DISTRICT, UGANDA
REFNo: HS5272ES

General objective
To determine differential diagnoses and associated factors for chronic lower limb ulcers among adults in Zombo district.

specific objectives
1. To determine the differential diagnoses for chronic lower limb ulcers among adults in Zombo district
2. To describe the associated factors with chronic lower limb ulcers among adults in Zombo district
3. To describe the geospatial distribution of individuals with chronic lower limb ulcers in Zombo district
 Uganda 2024-12-23 11:51:16 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Filippo Ferraro
ID: UNCST-2024-R016002
 Key Performance Indicator Framework for refugees integration in Uganda
REFNo: SS3441ES

The main objectives of the study are to:
1. ldentify the specifics support needs of refugees in Uganda.
2. Explore the perception and understanding of refugee’s local people and stakeholders
on the concept of integration.
3. Explore the existing welfare and integration programme available in Uganda.
4. Determine the facilitators and the barriers to the integration of refugees in Uganda.
5. Develop a Key Performance Indicator framework for the integration of refugees in
Uganda.

 Italy 2024-12-23 11:50:16 2027-12-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
Chinatsu  Hattori
ID: UNCST-2024-R002354
 Determinants of Family Planning use among women of reproductive age in refugees and host communities in Lamwo District, Uganda: a cross-sectional study
REFNo: HS5291ES

Main Objective To identify the factors influencing the utilization of family planning methods among women of reproductive age in the refugee settlement and host communities in Lamwo District, Uganda. Specific Objectives (i)To estimate the contraceptive prevalence among women of reproductive age in both refugee settlements and host communities. (ii)To analyze contraceptive use in terms of readiness, willingness, abilities, and other associated factors among women of reproductive age in refugee settlements and host communities.
 Japan 2024-12-23 11:49:09 2027-12-23 Medical and Health Sciences Non-Clinical Trial Degree Award
GRACE KANSIIME
ID: UNCST-2019-R000380
 OUTCOMES AND HEALTHCARE NEEDS OF PATIENTS WITH HIV AND KIDNEY DISEASE IN UGANDA.
REFNo: HS5305ES

1. To determine the contribution of CKD to 5-year mortality among PWH in Uganda.
2. To determine barriers and facilitators to nephrology care among PWH and CKD comorbidity in Uganda.

 Uganda 2024-12-23 11:46:08 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
NAKAYISO  ESEZA
ID: UNCST-2024-R002957
 INFLUENCE OF SAVINGS AND CREDIT COOPERATIVE STRATEGIES ON FINANCIAL EMPOWERMENT OF WOMEN IN MASAKA DISTRICT, UGANDA.
REFNo: SS3454ES

The study aims to: i. Evaluate the impact of financial training and advisory services on women\'s financial literacy and decision-making in Masaka District. ii. Investigate the effectiveness of loan and credit strategies in promoting women\'s financial empowerment. iii. Assess the role of savings strategies in fostering women\'s financial empowerment. iv. Evaluate the influence of government policies on women\'s access to financial services and economic opportunities. v. Examine how cultural factors moderate the relationship between SACCO strategies and women\'s financial empowerment.
 Uganda 2024-12-23 11:44:21 2027-12-23 Social Science and Humanities Non-Clinical Trial Degree Award
Stephen Tukwasibwe
ID: UNCST-2022-R011535
 Surveillance of malaria drug and diagnostic resistance in newly arrived refugees in Uganda
REFNo: HS5317ES

1. To characterize drug resistance profiles of P. falciparum parasites collected from newly arrived refugees in Uganda
2. To evaluate the prevalence of P. falciparum HRP-2 gene deletions that mediate diagnostic resistance in newly arrived refugees in Uganda

 Uganda 2024-12-23 11:42:43 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Paul  Kutyabami
ID: UNCST-2020-R015029
 An Evaluation of Perceptions and Effectiveness of the Ethical Review Process at Makerere University: A pilot Evaluation at the School of Health Sciences Research and Ethics Committee
REFNo: HS5322ES

1. Assess the perceptions of researchers (from the departments of pharmacy, nursing, dentistry, staff at Makerere University and researchers outside the institution) regarding MaKSHSREC’s ethical review process.
2. To assess the level of satisfaction among researchers on the existing MaKSHSREC ethical review processes.
3. Assess the efficiency and effectiveness of MaKSHSREC ethical review processes.
4. Explore the challenges and areas for improvement in the current MaKSHSREC ethical review processes.

Uganda 2024-12-23 11:38:43 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
PAULA KWOREKWA
ID: UNCST-2024-R005035
 Assessing the Impact of COVID-19 on the Knowledge, Attitude, and Practice of Medical Waste Management among Waste Handlers at Luweero General Hospital
REFNo: HS5350ES

Main Objective:
To investigate the impact of COVID-19 on the Knowledge, attitude, and practice of medical waste management among waste handlers at Luweero General Hospital.
Specific Objectives:
1. To determine the knowledge of medical waste handlers in recommended waste management practices following the COVID-19 pandemic.
2. To investigate the attitude of medical waste handlers towards practicing the recommendations for proper Medical Waste Management in the post COVID-19 pandemic era.
3. To compare the practices for medical waste management before and after the COVID-19 pandemic.


Uganda 2024-12-23 11:37:27 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
David Aziku
ID: UNCST-2023-R007595
 Baseline Study for Safe and Inclusive Cities Project -Uganda.
REFNo: SS3476ES

To evaluate the achievement of the programme’s intended outcomes, integrating qualitative insights and quantitative data on change in outcome indicators over time (from endline to end-line).

Identify and validate good practices, learnings, and examples of innovation on gender transformative programming.

To generate practical recommendations related to the programme outcomes and the approaches to inform future programming.
 Uganda 2024-12-23 11:36:17 2027-12-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
Rebecca Nansubuga Kaaya
ID: UNCST-2024-R002104
 Piloting a frugally innovated surgical fracture table in Uganda: Assessing its functionality, usability, and acceptability.
REFNo: SIR454ES

To pilot a frugally innovated surgical fracture table in Uganda and assess its functionality, usability, and acceptability in resource-limited healthcare settings through:
1. To evaluate the functionality of the frugally innovated surgical fracture table selected healthcare professionals by assessing its ability to: securely position patients, allow for stable positioning and smooth adjustment of the tentative limb position.
2. To assess the usability of the surgical fracture table selected healthcare professionals by measuring: the time required for set-up, the perceived ease of use of the table, the perceived comfort levels during manipulation.
3. To determine the acceptability of the surgical fracture table among selected healthcare professionals by assessing: their overall satisfaction with the table's design, functionality, and usability, willingness to recommend or use the table in their clinical practice and their perceptions of the table's potential impact on patient outcomes and safety

 Uganda 2024-12-23 11:35:30 2027-12-23 Engineering and Technology Non-Clinical Trial Non-degree Award
Afiz Kibuuka Kibuuka
ID: UNCST-2021-R012755
 A phase III, Multicenter, Randomized, Placebo Controlled, Double blind Study to Assess Efficacy and Safety of Crizanlizumab (5 mg/kg) versus placebo, with or without Hydroxyurea/Hydroxycarbamide Therapy, in Adolescent and Adult Sickle Cell Disease Patients with Frequent Vaso-Occlusive Crises
REFNo: HS5365ES

To compare the efficacy of 5 mg/kg of crizanlizumab versus placebo, with or without hydroxyurea/hydroxycarbamide, on the annualized rate of VOCs* that are healthcare professional (HCP)-managed (including VOCs leading to management at a health care facility or those managed via remote consultation) over the planned 52-week treatment period in SCD patients aged 12 years and older with a history of frequent VOCs (4-12 events in 12 months prior to the screening visit).
To compare the efficacy of 5 mg/kg of crizanlizumab versus placebo, with or without hydroxyurea/hydroxycarbamide, on the annualized rate of all VOCs including VOCs that are HCP-managed (including VOCs leading to management at a health care facility or those managed via remote consultation) and VOCs that are self-managed without recommendations from HCP during the event over the planned 52 week treatment period in SCD patients aged 12 years and older with a history of frequent VOCs (4-12 events in the 12 months prior to the Screeening visit
To evaluate the annualized rate of VOCs by type of management between treatment arms over the planned 52-week treatment period: • VOCs that are HCP-managed at a health care facility • VOCs that are HCP-managed via remote consultation • VOCs that are self-managed without recommendations from HCP during the event • VOCs that are HCP-managed via remote consultation or self-managed without recommendations from HCP during the event
To evaluate the time to first VOC that is HCP managed (including VOCs leading to management at a health care facility or those managed via remote consultation) between treatment arms over the planned 52-week treatment period.
To evaluate the proportion of participants free from VOCs that are HCP-managed (including VOCs leading to management at a health care facility or those managed via remote consultation) between treatment arms over the planned 52-week treatment period.
 Uganda 2024-12-23 11:34:49 2027-12-23 Medical and Health Sciences Clinical Trial Non-degree Award
Wakib Bunnya
ID: UNCST-2024-R016233
 An analysis of youth participation in elections
REFNo: SS3488ES

Three key objectives guide the research: first, to examine the role of voter education in shaping youth participation; second, to analyze the inclusion of young women and youth with disabilities in elections; and third, to explore the role of youth in peacebuilding and election-related violence.
Uganda 2024-12-23 11:32:13 2027-12-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
Spencer  Birungi
ID: UNCST-2024-R003017
 TRANSBOUNDARY MIGRATION SURVEILLANCE CONTROLS AND THE INFECTIOUS DISEASES MONITORING MECHANISMS: THE CASE OF WEST NILE UGANDA-DEMOCRATIC REPUBLIC OF THE CONGO
REFNo: SS3504ES

1. To describe the transboundary migration patterns along the West Nile Uganda – DRC borderline
2. To explore the transboundary migration infectious disease monitoring in practice along the West Nile Uganda –DRC borderline
3. To establish the association between the transboundary migration surveillance controls and the practices in monitoring of infectious diseases at border points; of entry
4. To describe the adherence to protocols for infectious disease monitoring before, during and after the outbreaks at border points of entry


 Uganda 2024-12-23 11:29:01 2027-12-23 Social Science and Humanities Non-Clinical Trial Degree Award
MARGARET NAKATO
ID: UNCST-2024-R002167
 LIBRARY SERVICE QUALITY AND USER SATISFACTION AMONG GRADUATE STUDENTS IN THE FACULTIES OF SCIENCE AND ENGINEERING AT KYAMBOGO UNIVERSITY, UGANDA
REFNo: SS3545ES

The objectives of the study are to:
1. Establish the effect of tangibility on graduate students' satisfaction with library services at Kyambogo University.
2. Determine the effect of reliability on graduate students' satisfaction with library services at Kyambogo University.
3. Examine the effect of empathy on graduate students' user satisfaction with library services at Kyambogo University.
4. Establish the effect of responsiveness on graduate students' user satisfaction with library services at Kyambogo University.
5. Determine the effect of assurance on graduate students' user satisfaction with library services at Kyambogo University.
6. Develop a framework for measuring library service quality at Kyambogo university
 Uganda 2024-12-23 11:27:18 2027-12-23 Social Science and Humanities Non-Clinical Trial Degree Award
Lily Bastian R
ID: UNCST-2024-R002139
 A Mixed Methods Study on Psychosocial and Health Practices Among Young People Living with HIV (YPLHIV) in Kampala, Uganda
REFNo: HS5354ES

The objective of this study is to assess the impact of resilience on sexual practices, behaviors, and health-related outcomes among young people living with HIV (YPLHIV) in Kampala, Uganda.
 USA 2024-12-23 11:24:59 2027-12-23 Medical and Health Sciences Non-Clinical Trial Degree Award
Andrew Seguya Ggunga
ID: UNCST-2024-R002054
 Assessing the World Economic Forum’s Travel and Tourism Development Index as A Framework for Uganda's Tourism Growth
REFNo: SS3501ES

To create a prioritised ranking of factors that accurately predict tourism and travel growth in Uganda, using data-driven methods and expert analysis to measure the impact of each factor on key growth indicators such as tourist arrivals, revenue, and employment.,To investigate, over the same period, whether there are factors not included in the WEF Travel and Tourism Development Index framework that effectively predict T&T growth in Uganda.,This study will investigate, using data from the Tourism Master Plan 2014-2024, whether the factors included in the WEF Travel and Tourism Development Index framework (such as infrastructure, environmental sustainability, and government policies) effectively predict T&T growth in Uganda, measured through indicators of tourist arrivals, revenue, and employment.,
 Uganda 2024-12-23 11:23:37 2027-12-23 Social Science and Humanities Non-Clinical Trial Degree Award
John Francis Mafuko Francis
ID: UNCST-2024-R002186
 Management of medicinal indigenous knowledge on snakebites in selected districts of Eastern Uganda.
REFNo: SS3517ES

i.To examine the sharing of the medicinal indigenous knowledge by the snakebites herbalists’ in Pallisa and Kamuli districts of Eastern Uganda.
ii. To establish the essential kind of information to be documented by the medicinal indigenous herbalists on snakebites management in Pallisa and Kamuli districts of Eastern Uganda for future use.
iii. To establish whether there is incorporation of the explicit medicinal indigenous herbalists’ knowledge on snakebites by the medical practitioners in Pallisa and Kamuli districts of Eastern Uganda.
iv. To evaluate the likelihood of the community in using the two-eyed seeing framework to integrate western knowledge and indigenous knowledge to deal with the snakebites in Pallisa and Kamuli districts of Eastern Uganda.
v. To propose a medicinal indigenous snakebites herbalists’ knowledge management framework in Pallisa and Kamuli districts of Eastern Uganda.

Uganda 2024-12-23 11:21:49 2027-12-23 Social Science and Humanities Non-Clinical Trial Degree Award
Ernest Mwebaze
ID: UNCST-2024-R015880
 EmpowerHerAI: Advancing Gender Equality and Responsible AI in Sub-Saharan Africa through Gender and Responsible AI Network (GRAIN)
REFNo: SIR456ES

General Objective
The general objective of the research study is to develop and evaluate low-resource multilingual AI language models by addressing issues of gender fairness, bias, and trustworthiness, and promoting inclusive and culturally contextualized AI tools for African languages.

Specific Objectives
1. Conduct a comprehensive review of existing datasets and training processes to identify potential gender gaps in relation to fairness, bias, and trustworthiness issues in low-resource multilingual language models.
2. Curate and collect parallel datasets for selected African languages to improve the development of low-resource multilingual language technologies.
3. Develop a robust and generalizable framework for creating AI language tools that address gender fairness, safety, and trustworthiness in non-English, low-resource multilingual models.
4. Develop a framework for incorporating human feedback and preferences into evaluating multilingual machine translation, speech recognition, and synthesis models, addressing the unique gender challenges presented by low-resource settings.

 Uganda 2024-12-23 11:15:21 2027-12-23 Engineering and Technology Non-Clinical Trial Non-degree Award
KADAI LAWAN ALHAJI
ID: UNCST-2024-R015583
 Analysis of Antimicrobial Metabolites of Aspergillus fumigatus, Isolated from Kitagata Hot Spring Utilizing Metabolomic and Molecular Docking Techniques
REFNo: NS891ES

Objectives
1 To ascertain physicochemical characteristics of Kitagata hot springs.
2 To isolate and identify thermophilic Aspergillus fumigatus from water sample of Kitagata hot spring.
3 To produce, extract and fractionate metabolites of thermophilic Aspergillus fumigatus to be isolated.
4 To determine the efficacy of antimicrobial value of extracted metabolites from the study organisms.
5 To simulate and predict the interaction between two structures of the metabolites

 Nigeria 2024-12-23 11:14:18 2027-12-23 Natural Sciences Non-Clinical Trial Degree Award
Edgar Mulogo Mugema
ID: UNCST-2023-R008170
 Improving business continuity for health services following extreme weather events (RESilience in HeAlth Post-Extreme weather events-RESHAPE Study)
REFNo: HS5370ES

Overall Objective

The primary objective of the proposed study is to develop and deploy the tools that will help healthcare services to better prepare for EWEs, cope better when affected by such events, and recover more effectively afterwards.


Specific Aims
Aim 1: Describe the healthcare systems in the Kasese District, and its served communities and how both have been affected by and responded to EWEs to provide a foundation for locally relevant insights into processes and adaptations, and their influence on health outcomes

Aim 2: Develop, with local partners, through business continuity planning, resilience engineering and participatory research methods, protocols for EWE preparedness, response and recovery, and guidance on good practices, knowledge exchange, and interventions development as a process for enhancing resilient healthcare delivery

Uganda 2024-12-23 11:10:15 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bamidele Olaiya Charles
ID: UNCST-2024-R003262
 OPTIMIZATION OF MECHANICAL AND THERMAL PROPERTIES OF SANDCRETE-BRICKS INCORPORATING SAWDUST AND BANANA-LEAF ASH USING GENETIC ALGORITHM AND ARTIFICIAL-NEURAL-NETWORK
REFNo: SIR366ES

i. To characterize the Sawdust Ash (SDA) and Banana Leaf Ash (BLA)
ii. To examine the effects of varying percentages of sawdust and banana-leaf ashes on the mechanical (compressive strength, flexural strength) and thermal properties of sandcrete bricks.
iii. To develop an optimization approach using a combination of Genetic Algorithm (GA) and Artificial Neural Network (ANN) to determine the optimal mix proportions for sandcrete bricks with improved mechanical and thermal properties.
iv. To evaluate the mineralogical and microstructural properties of the sandcrete bricks made with the SDA and BLA.
v. To provide insights into the sustainable and energy-efficient production of sandcrete bricks incorporating sawdust and banana-leaf ash

 Nigeria 2024-12-23 11:08:48 2027-12-23 Engineering and Technology Non-Clinical Trial Degree Award
Gertrude Nakigozi
ID: UNCST-2023-R007979
 CLIMATE SHOCK PILOT STUDY
REFNo: NS890ES

Validate the climate shock survey for Lake Victoria basin/ South western Uganda and examine determinants of climate variability impact, and conduct a comparison on the effects of Climate variability by community and occupation Climate variability
 Uganda 2024-12-23 11:07:21 2027-12-23 Natural Sciences Non-Clinical Trial Non-degree Award
Julia Harrison
ID: UNCST-2024-R004345
 Neonatal and Pediatric HIV and Sepsis on a Pediatric Surgery Ward in Uganda: A Prospective Study Standardizing HIV Testing and Sepsis Resuscitation and Treatment Algorithm to Guide Clinical Care
REFNo: HS5416ES

Main Objective 1. The general objective of this project is to determine the prevalence of sepsis, the underlying etiologies leading to sepsis, and the prevalence of HIV among patients with sepsis on the pediatric surgery ward at Mulago hospital. Additionally, our objective is to implement the 2020 surviving sepsis campaign guidelines on the pediatric surgery ward at Mulago Hospital. Specific Objectives 1. We will identify the etiologies leading to sepsis on the pediatric surgery ward at Mulago Hospital by examining the underlying pathologies in patients diagnosed with sepsis over a period of 7 months 2. We will determine the prevalence of HIV among patients with sepsis on the pediatric surgery ward at Mulago Hospital by testing patients with sepsis for HIV over a period of 7 months 3. We will implement the 2020 Surviving Sepsis Campaign Guidelines on the pediatric surgery ward at Mulago Hospital over a period of 1 month 4. We will determine the prevalence of sepsis on the pediatric surgery ward at Mulago Hospital by tracking patients diagnosed with sepsis over a period of 7 months
 USA 2024-12-23 11:05:56 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
SIYA AGGREY
ID: UNCST-2019-R001737
 WATER HYACINTH’S EXTENT ON FRESHWATER SITES WITHIN QUEEN ELIZABETH NATIONAL PARK, UGANDA; IMPLICATIONS ON WATER QUALITY AND WILDLIFE HEALTH
REFNo: NS894ES

i) To assess the spatial extent and distribution of Water hyacinth (Pontederia crassipes) in Lake Edward, Lake George and the Kazinga Channel
ii) To examine the determinants of Water hyacinth (Pontederia crassipes) distribution within Lake Edward, Lake George and the Kazinga Channel
iii) To assess impact of Water hyacinth (Pontederia crassipes) on water quality within Lake Edward, Lake George and the Kazinga Channel
iv) To analyze policies that would support management of Water hyacinth (Pontederia crassipes) invasion within Lake Edward, Lake George and the Kazinga Channel.

 Uganda 2024-12-23 11:03:12 2027-12-23 Natural Sciences Non-Clinical Trial Non-degree Award
Solomon Kibudde
ID: UNCST-2021-R013747
 PHASE II RANDOMIZED NON-INFERIORITY TRIAL OF HYPOFRACTIONATED RADIOTHERAPY FOR LOCALLY ADVANCED CERVICAL CANCER IN UGANDA.
REFNo: HS5348ES

1) To compare the incidence of grade 3+ gastrointestinal and genitourinary toxicity at 1 year post-treatment with hypofractionated radiotherapy (40 Gy in 16 fractions) and conventional fractionated radiotherapy (45 Gy in 25 fractions) in women with cervical cancer in Uganda.
2) To evaluate and compare local control and cervical cancer-specific survival rates at 1 year after hypofractionated radiotherapy (40 Gy in 16 fractions) versus conventional radiotherapy (45 Gy in 25 fractions).
3) To determine the association between stage-adjusted mean squamous cell carcinoma antigen (SCC-Ag) at 1-month post-treatment with the Progression-free survival at 1- year post-treatment with hypofractionated radiotherapy (40 Gy in 16 fractions) or conventionally fractionated radiotherapy (45 Gy in 25 fractions).
4) To compare the costs of healthcare to patients with cervical cancer treated with hypofractionated radiotherapy (40 Gy in 16 fractions) versus conventional fractionated radiotherapy (45 Gy in 25 fractions).
5) To evaluate patient-reported outcomes and quality of life in patients with cervical cancer treated with hypofractionated radiotherapy (40 Gy in 16 fractions) versus conventional fractionated radiotherapy (45 Gy in 25 fractions).

 Uganda 2024-12-23 11:01:22 2027-12-23 Medical and Health Sciences Clinical Trial Degree Award
Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
 Investigation of mpox transmission, disease sequel, and molecular epidemiology in Uganda (Mpoxep)
REFNo: HS5387ES

Primary Objectives
1. To characterize the socio-demographic, clinical, immunological, and virologic epidemiology of Mpox cases in Uganda.
2. To describe the natural history and asymptomatic transmission dynamics of Mpox among contacts.
3. To assess risk factors for clinical hospitalization, ICU admission, and fatal Mpox outcomes.
4. To investigate long-term sequelae among Mpox survivors.

Secondary Objectives
1. To determine the incidence and prevalence of Mpox among high-risk populations (long-distance truck drivers, commercial sex workers, refugees, and PLHA).
2. To assess infection risk and asymptomatic transmission using serology among contacts.
3. To identify risk factors for infection among ‘de novo’ cases with no documented epidemiological link.
4. To explore socio-anthropological factors influencing Mpox transmission, prevention, and care-seeking behavior.
5. To identify potential animal reservoirs of MPXV in Uganda.
6. To describe histopathologic features of Mpox skin lesions and localization of MPXV in different body organs and tissues.

 Uganda 2024-12-23 10:56:56 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Wycliff Odude
ID: UNCST-2024-R002431
 Small-scale field evaluation of the efficacy, residual activity and acceptability of Sovrenta® 15WP against Malaria Vectors in Adjumani district, West Nile, Uganda.
REFNo: HS5300ES

1. To determine the susceptibility levels of both wild-type and Kisumu strain malaria vectors to Sovrenta® 15WP insecticide in Adjumani District, West Nile, Uganda.
2. To determine the comparative residual activity of Sovrenta® 15WP and Actellic 300CS insecticides on common wall-type surfaces in Adjumani, West Nile, Uganda over 10 months.
3. To generate specific information related to the acceptability of Sovrenta® 15WP insecticide as a new product by the community in Adjumani, West Nile, Uganda.
4. To assess the ease of use of the Sovrenta by the spray operators under field conditions in Adjumani District, West Nile, Uganda.

Uganda 2024-12-10 16:05:33 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Roy Mayega William
ID: UNCST-2022-R010983
 Africa Regional Education System Resilience Observatory (ARESRO) Study - A Case Study of Uganda
REFNo: SS3453ES

General objective
To contribute to the improvement of the education system resilience in Uganda through evidence-informed programming.
Specific objectives
1) To explore the meanings and practices of education system resilience in Uganda
2) To explore the potential impact of future shocks and stressors, risk, vulnerability, and capacities (absorptive, adaptive, and transformative) on the future education ecosystems and outcomes in Uganda
3) To identify effective approaches and planning to address the future shocks and stressors, risks, vulnerabilities, and capacity for better education system resilience in Uganda

 Uganda 2024-12-10 16:04:12 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
ALEX ARIO RIOLEXUS
ID: UNCST-2024-R002455
 DEATHS AND INFECTIONS AVERTED, A COST - EFFECTIVENESS ANALYSIS AND FACTORS THAT INFLUENCE ADOPTION AND IMPLEMENTATION OF THE 7-1-7 TARGETS IN UGANDA: A case study of three Priority diseases
REFNo: HS5278ES

1.To estimate the number of deaths and cases from prioritized diseases (EVD, anthrax, Measles and Rift Valley fever disease) averted if 7-1-7 targets are met in Uganda
2.To conduct a cost-effectiveness analysis for Uganda’s Ministry of Health implementing the 7-1-7 framework in responding to prioritized diseases (EVD, anthrax, Measles and Rift Valley fever disease) using societal perspective.
3.To explore and profile the factors that influence the adoption and implementation of 7-1-7 targets among different stakeholders in Uganda
 Uganda 2024-12-10 16:02:45 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Violet Nkwanzi
ID: UNCST-2024-R002493
 Examining the Impact of Adverse Childhood Experiences on Human Trafficking Vulnerability and the Long-term Mental Health Outcomes of Women Survivors of Trafficking (18-35 years) in Uganda.
REFNo: SS3451ES

Aim 1: To quantitatively examine the association between ACEs, human trafficking vulnerability, and long-term mental health outcomes (anxiety, depression, PTSD). Aim 2: To determine the factors that moderate the effects of ACEs on human trafficking vulnerability and the long-term mental health outcomes of women survivors of trafficking. Aim 3: To qualitatively explore sources of resilience and gaps in existing policies and services for women affected by human trafficking in Uganda To inform comprehensive survivor centered interventions, this study will collect additional data on quality of life, gender-based violence, substance use and financial capability of survivors of trafficking.
Uganda 2024-12-10 16:01:57 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Akusa Patrice Mawa
ID: UNCST-2024-R015660
 Service availability and readiness assessment for establishing biobanks of patient left-over samples from routine healthcare provision in Uganda and Kenya
REFNo: HS5328ES

1. To assess the current practices with left-over samples in hospitals and the attitude, willingness, and acceptability of stakeholders towards biobanking.
2. To audit human resources, laboratory infrastructure, governance, and data systems to understand available resources to support the establishment of left-over sample biobanks in health facilities
3. Undertake a detailed analysis of costs that will be needed to sustain operational activities on a yearly basis for either a federated or centralised approach of biobanking left-over samples in Uganda and Kenya
4. Assess the regulatory environment and engage relevant national regulatory bodies to adapt guidelines for left-over sample biobanking in Uganda and Kenya.


 Uganda 2024-12-10 16:00:04 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Stephen Tukwasibwe
ID: UNCST-2022-R011535
 Surveillance of P. falciparum Drug and Diagnostic Resistance in Refugee Populations
REFNo: HS5230ES

To conduct comprehensive malaria molecular surveillance in refugee populations to generate high quality molecular, epidemiological and entomologic data for monitoring geographic and temporal trends and thereby inform interventions to best protect refugee and local host populations.
Uganda 2024-12-10 15:59:04 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jude  Nicholars Iyke
ID: UNCST-2023-R007962
 THE EFFECTS OF PERSONALITY TRAITS ON THE ACCEPTANCE OF BIOMETRIC CONTROLLED HEALTH INFORMATICS IN PUBLIC HOSPITALS IN UGANDA
REFNo: SIR430ES

The purpose of this sequential mixed-method design study is to assess the relationship between the personality traits and acceptance of Biometric Controlled Health Informatics in Gulu and Soroti Regional Referal public Hospitals in Uganda that will help health strategists and policy makers evaluate how the personality traits of health workers affect their acceptance of biometric controlled health informatics (BCHI) for secure access for clinical and non-clinical health workers to patient records in public hospitals in Uganda . ,To examine how personality traits affect the acceptance of Biometric Controlled Health Informatics in these public hospitals using the acceptance model that was developed for that purpose,To determine the connection between acceptances of Biometric Controlled Health Informatics and personality traits in these public hospitals.,To establish health workers’ awareness of Biometric Controlled Health Informatics in these public hospitals,
 Nigeria 2024-12-10 15:54:44 2027-12-10 Engineering and Technology Non-Clinical Trial Degree Award
Susan Nayiga
ID: UNCST-2020-R014642
 Managing AMR: Everyday experience with antibacterial drug resistant infections in central Uganda
REFNo: SS3469ES

1. To track the trajectories of illness, care, recovery or decline of patients diagnosed with antibacterial drug resistant infections.
2. To link the social, economic and illness histories and opportunities of patients with their onward trajectories with antibacterial drug resistant infections
3. To identify equity dimensions of the how systems manage antibacterial drug resistant infections and points for intervention to support recovery

 Uganda 2024-12-10 15:53:27 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Francis Kakooza
ID: UNCST-2024-R002803
 Evaluation of capture enrichment for viral sequencing in a remote setting in Uganda.
REFNo: HS5270ES

Objective 2: Evaluate Analytical Performance in Uganda. NGS testing of blood samples from confirmed clinical cases and suspected clinical samples will be conducted. This includes de-identified archived blood samples collected from a sepsis cohort among participants who consented for their samples to be used for future research related to sepsis in Fort Portal, Uganda, at Fort Portal Regional Referral Hospital, which has enhanced biosafety capabilities. ,Objective 1: Develop and Optimize NGS Platform To pilot the use of a field-deployed portable next-generation sequencing for testing of archived sepsis blood samples in Uganda to search for hantavirus or bunyavirus infections. The project plans to field test the Oxford Nanopore Technologies (ONT) platform with archived blood samples. Phylogenetic trees will be developed, and virus clades and variants or new viruses will be described. The performance of enriched-NGS to detect the virus will be compared to index testing with RT-PCR when there are 5 or more positive results.,
 Uganda 2024-12-10 15:52:01 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Anke Weisheit
ID: UNCST-2024-R004890
 ETHNO BOTANICAL SURVEY OF MEDICINAL PLANTS USED IN THE TREATMENT OF WOUNDS IN GULU DISTRICT
REFNo: SS2928ES

To investigate the preparation and application methods of these medicinal plants for wound healing purposes.,To identify and document medicinal plants used by the local communities in Gulu district for treating various types of wounds.,The aim of this study is to conduct an ethnobotanical survey to document the traditional knowledge and use of medicinal plants for treating wounds among the communities in Gulu district, Uganda.,
 Germany 2024-12-10 15:50:43 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Irene Nakayenga Mutesi
ID: UNCST-2024-R004951
 Global Corridor, Urbanisation, Everydaylife and Techno-social Differentiation
REFNo: SS2860ES

2. To explore the everyday assembling of Corridor Urbanization to assess how investment in infrastructure is generating intra-urban and inter-urban relations/material connections between urban regions., To explain the global, urban geography of infrastructural corridors in reshaping the urbanization process in order to set a new agenda for global research,3. To investigate the everyday experiences of Corridor Urbanization within urban regions in order to understand the differentiated ways in which infrastructure is operated and accessed,1. To assess the global, urban geography and selected history of new corridors and the ways these projects are assembled in order to understand the role of urban regions,The aim of GlobalCORRIDOR is to address the challenge of how we understand Corridor Urbanization and to assess how these infrastructure led transformations are shaping urban inequality, as an everyday experience of techno-social differentiation,
 Uganda 2024-12-10 15:50:00 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Joseph Ngonzi
ID: UNCST-2019-R001579
 OPTIMIZATION, VALIDATION AND ASSESSMENT OF FEASIBILITY AND ACCEPTABILITY OF HPV TESTING USING CODA
REFNo: HS4734ES

To develop and establish a novel rapid multi-modal algorithm (CANOPY) for screening and treatment of cervical cancer integrating multiple (CODA, VIA, ML) screening modalities to improve diagnostic yield. ,To gather design feedback to improve CODA workflow and device design, and refine CODA device, assay, and workflow using this critical feedback provided by Ugandan stakeholders,To evaluate the feasibility and acceptability of CODA in a clinical setting in Uganda based on feedback from clinical, public health, and patient stakeholders,To evaluate HPV testing using CODA in comparison to other (VIA, ML, ATILA System) devices for clinicians and patients engaged in community-based cervical cancer screening. ,To determine the diagnostic accuracy of CODA a clinical setting, using FP rate and comparison with gold-standard HPV tests and cytology,We will optimize, validate and assess the feasibility and acceptability of HPV testing using CODA and develop and validate a multimodal cervical cancer screening algorithm to optimize diagnostic yield (CANOPY).,
 Uganda 2024-12-10 15:49:00 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Anxious   Niwaha Jackson.
ID: UNCST-2023-R008010
 Investigating the pancreas pathology underlying Lean Sub Saharan African Diabetes in Uganda
REFNo: HS5340ES

a. To compare the beta cell mass in pancreata obtained at autopsy in lean diabetes cases
versus lean controls
b. To evaluate the degree of pancreatic immune infiltration (Insulitis) in lean diabetes cases
and lean controls
c. To quantify the degree of misfolded protein stress in pancreata obtained at autopsy in lean
diabetes cases and lean controls
d. To evaluate beta cell dedifferentiation in lean SSA diabetes
e. To examine the exocrine pancreas for chronic pancreatitis and pancreatic duct calcification
in pancreata obtained at autopsy in lean diabetes cases versus lean controls
f. To determine the concentration of POPs in pancreata obtained at autopsy in lean diabetes
cases and lean controls.
g. To establish a pancreata and related tissue (blood and mesenteric fat) platform to enable
further studies related to diabetes and other metabolic diseases.

 Uganda 2024-12-10 15:47:20 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
 Implementation and evaluation of peer support and navigation supported by Project ECHO for patients with cancer in Uganda
REFNo: HS5297ES

6. To evaluated perceived program feasibility, acceptability, and appropriateness through surveys and exit in-depth interviews with peer navigators, patients, and UCI oncologists,5. To adapt the Cancer Behavior Inventory (CBI-B) self-efficacy scale, Edmondton Symptom Assessment Scale (ESAS), and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ C30) quality of life for cancer patients questionnaire to the Uganda context by soliciting feedback from UWOCASO members and UCI oncology and palliative care specialists,4. To evaluate program impact by measuring patient self-efficacy, symptom burden, and quality of life using the above adapted scales at enrollment, 1, 3, 4 and 6 months after the program start ,3. To evaluate program impact by comparing the proportion of patients who completed treatment for early stage disease and or had treatment adherence of > 6 months in case of metastatic disease among patients matched with peer support and navigation right away versus six months later. ,2. To pair 100 cancer survivors with 200 matched patients with cancer in the Kampala, Wakiso, and Gulu districts of Uganda for peer support and navigation. Half of the selected patients will be randomized to be matched to peer support immediately, and half six months later . ,1. To provide refresher training in peer support and navigation to 100 cancer survivors. We will focus on the five most common cancers in Uganda (breast, cervical, prostate, Kaposi sarcoma, Non-Hodgkin lymphoma).,
 Uganda 2024-12-10 15:46:22 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
ELIZABETH KYAZIKE
ID: UNCST-2023-R005557
 The Lasting Scars of War: Understanding the Socio-environmental Impact of Changing Global Commodity Chains in East Africa During the Second World War, 1937-1962
REFNo: SS3146ES

General Objective
The project's general objective is to document the impact of World War II on the Lake Victoria-area environment in the immediate (wartime) and midterm (into the post-war period) periods.
Specific Objective
Specifically, the project seeks to:
1) Evaluate the changes in environmental patterns of use (agricultural use, resource extraction, etc.) during the Second World War and its socio-environmental impacts.
2) Examine how the linkages between Africa (affected population), Great Britain (colonial power and prosecutor of war) and Switzerland (experts and trading companies) drove environmental change.
3) Analyze how global patterns were evident in the Lake Victoria region, in particular in relation to sustainable practices and cultures.

 Uganda 2024-12-10 15:43:59 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
DANIEL KIIZA
ID: UNCST-2024-R004044
 Development and Validation of a Machine Learning Prediction Model for Early Mortality among patients with HIV-Associated Cryptococcal Meningitis in Uganda
REFNo: HS5103ES

Primary Objectives: 1. To develop a machine learning model for the prediction of early mortality among patients with HIV-CM co-infection. 2. To validate a machine learning model for the prediction of early mortality among patients with HIV-CM co-infection. Exploratory Objective: 3. To develop and validate a machine learning model for the prediction of mortality (as a continuous outcome) among patients with HIV-CM co-infection.
 Uganda 2024-12-10 15:42:48 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Silvia Awor
ID: UNCST-2019-R000591
 PREDICTORS OF USE, PHYTOCHEMICAL PROFILES AND ANTISICKLING ACTIVITIES OF HERBAL MEDICINES FOR TREATING SICKLE CELL DISEASE IN ACHOLI SUB-REGION
REFNo: HS5030ES

2. To document the herbal medicines used for treating sickle cell disease in AchTo determine the anti-sickling activity of aqueous crude extracts of herbal medicines for sickle cell treatment in the Acholi sub-region. ,To assess the phytochemical profiles of selected herbal medicines used for the treatment of sickle cell disease in Acholi sub-region,To document the herbal medicines used for treating sickle cell disease in Acholi sub-region,To determine the predictors of the use of herbal medicines for the treatment of sickle cell disease in Acholi sub-region,To assess the predictors of use and antisickling activities of herbal medicines used for treating sickle cell disease in the Acholi sub-region of northern Uganda,
 Uganda 2024-12-10 15:41:38 2027-12-10 Medical and Health Sciences Non-Clinical Trial Degree Award
Abbas Mugisha
ID: UNCST-2023-R007013
 Internally displaced persons and psychosocial challenges of females at Muhokya IDP, Kasese district, Ugands
REFNo: SS3392ES

i)To identify the psychosocial challenges experienced by internally displaced females at Muhokya IDP camp
ii)To explore the coping mechanisms employed by internally displaced females to manage the psychosocial challenges at Muhokya IDP camp
iii)To explore the redress mechanisms available for the psychosocial challenges faced by internally displaced females at Muhokya IDP camp
iv)To propose recommendations on how to best assist internally displaced females overcome their challenges at Muhokya IDP camp
 Uganda 2024-12-10 15:26:35 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
ARTHUR EMORU
ID: UNCST-2024-R003421
 PREVALENCE AND FACTORS ASSOCIATED WITH CHRONIC POST-SURGICAL PAIN AMONG PATIENTS THAT RECEIVED AMBULATORY INGUINAL HERNIA SURGERY AT KYABIRWA SURGICAL CENTER
REFNo: HS5068ES

To determine factors associated with chronic pain after inguinal hernia repair among adult patients at Kyabirwa Surgical Center,To assess the prevalence of chronic pain after inguinal hernia repair among adult patients at Kyabirwa Surgical Center,To determine the prevalence of and factors associated with chronic pain after inguinal hernia repair in Kyabirwa Surgical Center’s adult patient population,
 Uganda 2024-12-10 15:25:15 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Orace David Tom
ID: UNCST-2024-R003113
 Students’ Loan Financing Scheme and Completion of STEM based Programmes in Public Universities in Uganda
REFNo: SS3353ES

i). To explore the nature of students’ loan financing scheme in public universities in Uganda
ii). To assess the completion of STEM based programmes by students on loans scheme in public universities in Uganda
iii). To evaluate the perceptions and experiences of STEM students regarding the impact of students’ loan scheme on their completion in public universities in Uganda
iv). To establish the relationship between students’ loan financing scheme and completion of STEM based programmes in public universities in Uganda

Uganda 2024-12-10 15:23:45 2027-12-10 Social Science and Humanities Non-Clinical Trial Degree Award
Stevens Bechange
ID: UNCST-2022-R009190
 Understanding Access to Business Financing for Young Entrepreneurs with and without Disabilities in Urban Uganda
REFNo: SS3471ES

The specific objectives will be:
1. To identify the different types of business financing options accessible by and preferred by young enterpreneurs with and without disabilities including what drives them to use these options.
2. To understand existing barriers for young enterpreneurs with and without disabilities in accessing and using the different business financing products, what can be done to address these and recommendations for more widespread access.
3. To describe how financial products from the RISE/E Programme affect young enterpreneurs with and without disabilities and their businesses and how they can be further improved.
4. Develop a database that includes demographic, socio-economic; and business financing information to facilitate the evaluation of success or failure with access to finance.

Uganda 2024-12-10 15:17:09 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
DORAH NAMPIJJA
ID: UNCST-2022-R009694
 Improving heart failure self-care with short, structured telephone calls in Uganda (HEART-CALLS)
REFNo: HS5307ES

To improve heart failure self-care through feasible and acceptable short, structured telephone calls in Uganda
Uganda 2024-12-10 15:16:13 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kamya Moses
ID: UNCST-2020-R014203
 Transformative approaches to rapidly and efficiently test demand creation interventions to promote HIV retesting in adults at increased risk of HIV The Innovative Behavioral Intervention Strategies Megatrial (IBIS-Megatrial) Study
REFNo: HS5319ES

Aim 1. Adapt behavioral economics interventions to promote HIV retesting using a participatory prototyping approach in rural Kenya and Uganda.
Aim 2. Determine the effectiveness of many behavioral economics interventions to promote HIV retesting among high-risk adults in a multi-arm randomized trial.
Aim 3. Estimate heterogeneous treatment effects and identify optimal demand creation interventions.

 Uganda 2024-12-10 15:15:04 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Hannah Kibuuka
ID: UNCST-2020-R014355
 Sub-Study C – “Evaluation of Host-Response and/or Pathogens from Biospecimens Collected with a Capillary Blood Collection TASSO that Minimizes Pain Among a Subset of Patients Enrolled in an Observational Study of Sepsis in Uganda
REFNo: HS5332ES

1) Identify pathogens collected via the minimal pain Tasso collection device and those
collected via venipuncture (0 Hour and Day 28 of the main study)
2) Identify host-response biomarkers collected via the minimal pain Tasso collection device
and those collected via venipuncture (0 Hour and Day 28 of the main study)
3) Evaluate the correlation between host biomarkers and pathogens collected via the
minimal pain Tasso collection device to those collected via venipuncture at two study
visits (0 Hour and Day 28 of the main study)
4) Evaluate collection failure rates with the Tasso device

Uganda 2024-12-10 15:13:26 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Naheem Tijani Adekilekun
ID: UNCST-2022-R010325
 Biogenic synthesis of silver nanoparticles from Termitomyces sp. and their antimicrobial activity against clinical samples of resistant pathogenic Candida species
REFNo: HS5244ES

i. To synthesize silver nanoparticles (AgNPs) by employing the metabolites of Termitomyces species;

ii. To characterize the AgNPs biosynthesized and establish the phylogeny of Candida species using molecular techniques;

iii. To determine the antimicrobial activity of the fabricated AgNPs in contrast to common antifungal agents against resistant pathogenic Candida species.

 Nigeria 2024-12-10 15:11:28 2027-12-10 Medical and Health Sciences Non-Clinical Trial Degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
 STANDARD Q Syphilis Ab Test – Validation of Specimens
REFNo: HS5333ES

The objective of this study is to demonstrate the equivalence of serum, venous whole blood (EDTA-K2, EDTA-K3, sodium citrate, sodium heparin), plasma (EDTA-K2, EDTA-K3, sodium citrate, sodium heparin) and fingerprick whole blood on the STANDARD Q Syphilis Ab Test according to WHO TSS-6 Part 1: 1.2.1.
 Uganda 2024-12-10 15:09:47 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rose Nakasi
ID: UNCST-2022-R010805
 Automated Mobile Microscopy for Tuberculosis Diagnosis in Uganda
REFNo: SIR450ES

1. Create an open, labelled, inclusive dataset for digital sputum microscopy images collected from the Ugandan population,
2. Develop a machine learning aided point-of-care learning platform for digital sputum microscopy image acquisition and interpretation.
3. Develop machine learning models for automatic recognition of TB bacilli features in digital sputum microscopy images,
4. Integrate the developed models in a decision support web application,
5. Validate the developed system in a clinical study.

 Uganda 2024-12-10 15:02:13 2027-12-10 Engineering and Technology Non-Clinical Trial Non-degree Award
Yasushi Miyauchi
ID: UNCST-2023-R005483
 Analysis of excitatory amino acids in Ustilago maydis of maize and sorghum in northern Uganda.
REFNo: A475ES

To measure the amount of each excitatory amino acid contained in Ustilago maydis of maize and sorghum by using Gas Chromatography,
 Japan 2024-12-10 15:01:21 2027-12-10 Agricultural Sciences Non-Clinical Trial Degree Award
Saidah  Menya
ID: UNCST-2024-R003540
 Improving quality maternal and new-born care: An investigation into the relevance and effectiveness of quality care processes in three health facilities with in Nakaseke and Luwero districts in Uganda
REFNo: HS5038ES

4. To evaluate whether the quality improvement process improves maternal and newborn outcomes. ,3. To establish a baseline data and evaluate whether the quality improvement process increases quality of care scores in three health facilities and compare with the baseline,2. To implement and monitor the quality improvement tool and relevant processes and gather feedback on their relevance and utility in the AdaraNewborn facilities.,1. To develop a quality improvement process within all AdaraNewborn facilities, including a quality improvement tool that prioritise the WHO maternal and newborn health standards,To monitor and assess the implementation of quality improvement processes to evaluate whether they contribute to improved quality of care within a health facility and overall maternal and newborn outcomes.,
 Uganda 2024-12-10 14:58:15 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Muriel Mac-Seing
ID: UNCST-2024-R005208
 Invisibility of disability in Global South and North: Equitable access to health services in the context of climate change
REFNo: SS3507ES

To strengthen research collaboration and solidarity through co-creation, trust-building, and inclusive co-learning between partners and researchers from Uganda and Canada.,Considering the results of the above objective, to further explore the perspectives of relevant intersectoral actors on the relationships between access to health services for women and men with disabilities, including access to veterinary services for their animals, and climate change in Québec, Canada, and Gulu District, Northern Uganda.,To identify key priority research areas through a scoping review that will synthesise the existing literature and identify research gaps in the relationships between access to health services for PWD, including access to veterinary services for their animals, and climate change.,To explore the perspectives on the relationships between access to health services among women and men with disabilities and climate change in the Global South and North.,
 Canada 2024-12-10 14:56:23 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Deo Nsamba
ID: UNCST-2024-R004495
 INNOVATIVE ALTERNATIVE INTERIOR DECORATES AND EXECUTION OF SEMI ABSTRACT LANDSCAPE MONUMENTS AT KABALE UNIVERSITY
REFNo: SIR319ES

i. To assess areas with quality clay around Kabale using a pilot study in developing innovative interior decorates and semi abstract landscape monuments
ii. To identify and analyze the characteristics and properties of selected clays in the laboratory of civil engineering Kabale University. for use in developing innovative interior decorates and semi-abstract landscape monuments.
iii. To explore and develop creative techniques for transforming the selected local clays into innovative interior decorates and semi abstract landscape monuments.
iv. To execute and evaluate the effectiveness of the developed interior decorates and semi abstract landscape monuments in enhancing aesthetic appeal, functionality and sustainability.
Research questions


i. How will quality clay around Kabale be assessed in developing an innovative interior decorates and semi abstract landscape monuments.
ii. What type of selected local clays will be identified and analyzed through their characteristics and properties in Kabale for use in developing innovative interior decorates and semi abstract landscape monuments?
iii. What suitable techniques will be explored and developed to have creative techniques that will transform the selected local clays into innovative interior decorates and semi abstract landscape monuments?
iv. How will creative innovative approaches of innovative interior decorates and semi abstract landscape monuments be executed and evaluated?

Uganda 2024-12-10 14:54:46 2027-12-10 Engineering and Technology Non-Clinical Trial Non-degree Award
Sarah Lewinger Julianne
ID: UNCST-2024-R004045
 Prayer, Poetry, and Protest: Pentecostalism and Political imagination among Ugandan Youth
REFNo: SS2594ES

The primary objective of this research project is to investigate how young people in Kampala, Uganda, aged eighteen to thirty-five, mobilize charismatic Christian discourses, practices, and communities to imagine their futures, engage with politics, and navigate conditions of political repression, economic precarity, and social disintegration. Specifically, the project aims to:
1. Explore the diverse ways in which young people draw upon charismatic Christianity as a resource for making sense of their lives, asserting their dignity, and envisioning alternative social and political possibilities.
2. Examine how young people's "god-talk" – a critical and creative method of biblical reinterpretation and intimate conversation with the divine – challenges conventional understandings of the political and expands notions of political agency and engagement.
3. Investigate the role of social memory in shaping contemporary youth political imaginations, by considering how young people's religious-political expressions both draw upon and depart from earlier movements, such as the Holy Spirit Movement.
4. Identify and analyze the spaces, practices, and cultural forms through which young people develop and express their political subjectivities, with a focus on artistic and creative practices, such as spoken word poetry and music.
5. Contribute to anthropological debates on the complex and often contradictory role of religion in social movements, as well as the ways in which marginalized youth navigate and challenge the constraints of their political contexts.
This project aims to generate new insights into the religious and political imaginations of urban Ugandan youth, and to shed light on the diverse and unexpected ways in which young people are actively engaging with politics outside of the formal political sphere. By taking seriously the political significance of religious and artistic imaginaries, this research has the potential to expand our understanding of what constitutes the political and to contribute to broader debates about youth agency, social movements, and the role of religion in public life.
USA 2024-12-10 14:52:31 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
PREETI KUMARI
ID: UNCST-2024-R001852
 Science Laboratory Operationalization, Secondary School Students’ Academic Attitude, Motivation, and Performance in Mbarara City, Uganda
REFNo: SS3434ES

1. To assess the conditions of science laboratories in secondary schools in Mbarara City, Uganda, to get a ground-level reality check.
2. To examine the relation between science laboratory operationalization and student’s attitude towards science.
3. To investigate the effect of science laboratory operationalization on motivation in choosing science as a career.
4. To relate the science laboratory operational conditions to students' performance in science education.
5. To study the mediation effect of student’s attitude and motivation in science subjects on performance.

 India 2024-12-10 14:47:47 2027-12-10 Social Science and Humanities Non-Clinical Trial Degree Award
sandra etumah omon
ID: UNCST-2024-R003992
 Assessment of the Nutritional Profile and Biochemical Adaptation of Zea mays L. Grown around Kilembe Mining Area, Kasese, Uganda
REFNo: NS809ES

1. To assess the Physicochemical characteristics of the soil and heavy metal content such as copper, lead, cobalt, Nickel, Cadmium, Mercury, chromium, and arsenic at the research site.
2. To analyze the heavy metals content (copper, lead, cobalt, Nickel, Cadmium, Mercury, chromium, and arsenic) of the maize plant grown at the mining site and their translocation.
3. To analyze the nutritional profile: proximate analysis (carbohydrates, protein, fats/oil, crude fiber, moisture, and ash), mineral element (iron, magnesium, manganese, calcium, sodium, phosphorus, sulfur, and potassium), and Vitamins (thiamine, niacin, riboflavin, retinol, cobalamin, pyridoxine, tocopherol, ascorbic acid, and cholecalciferol) of the maize grown around the mining site.
4. To assess the oxidative stress markers (malondialdehyde, tocopherol, and proline) and the enzymatic antioxidant capacity (glutathione peroxidase, superoxide dismutase, and catalase) in the leaves during the vegetative stage of the maize plant.
5. To quantitatively determine the hormonal levels (ABA, auxins, and brassinosteroids) in the leaves during the vegetative stage of the maize
6. To determine bioremediation options from the culturable rhizospheric soil bacteria isolated from around the mining site.

 Nigeria 2024-12-10 14:44:20 2027-12-10 Natural Sciences Non-Clinical Trial Degree Award
Maria Magdalene Namaganda
ID: UNCST-2021-R004319
 Development of a machine learning model for prediction of virological failure in a resource-limited setting
REFNo: HS3982ES

Sub-study 1 To identify the risk factors associated with virological failure among PLWH in east Africa from 2014 to 2024. Sub-study 2 To analyse the trends of ART use and incidence of virological failure rates among PLWH in TASO-Uganda health centres from 2014 to 2024. Sub-study 3 To develop and validate machine learning models for prediction of virological failure. Sub-study 4 To evaluate the practical utility of the HIV virological failure predictive models developed in a clinical setting.
Uganda 2024-12-10 14:40:45 2027-12-10 Medical and Health Sciences Non-Clinical Trial Degree Award
Jackson Orem
ID: UNCST-2021-R012016
 A Phase III, Randomized, Open-Label, Non-Inferiority Study of Paclitaxel and Pegylated Liposomal Doxorubicin for Treatment of HIV-related Kaposi Sarcoma in Resource-Limited Settings
REFNo: HS4073ES

To describe the incremental cost-effectiveness ratio per QALY gained (as assessed by PROPr) between PLD and PTX,To assess quality of life across PROMIS domains (i.e., cognitive function, physical function, fatigue, pain interference, depressive symptoms, anxiety, ability to participate in social roles and activities, and sleep disturbance) with the PROPr tool at start of therapy, mid-treatment, and after treatment with PLD and PTX ,To describe the cost of therapy across AMC sites in sub-Saharan Africa to deliver both PLD and PTX by micro-costing analysis for goods and time-in-motion analysis for services. ,To estimate the objective response rate (defined as the sum of complete and partial responses) for AIDS-KS, response duration and overall survival in each treatment arm. ,To evaluate whether there is sufficient evidence to conclude that PLD is non-inferior to PTX in people with severe AIDS-associated KS receiving concomitant ART in resource-limited settings. ,
 Uganda 2024-12-10 14:39:24 2027-12-10 Medical and Health Sciences Clinical Trial Non-degree Award
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