Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Alexandra Tomkins Elizabeth
ID:
Deaf Ways of Knowing
REFNo: SS1733ES

To use and teach co-creative and audiovisual methods, such as film, photography, art, drawing and drama, to better understand the lifeworlds, social needs and future aspirations of deaf Ugandan children,To research the social and educational needs of deaf children in low income countries by developing new deaf centred pedagogical approaches and deaf inclusive learning contexts.
UK 2023-06-05 16:52:00 2026-06-05 Social Science and Humanities Non-Clinical Trial Degree Award
Aubryn Sidle Allyn
ID:
Validating a Measure of Girls’ Agency: A Five-Country Validation & Adaptation of the AMPLIFY Agency Survey
REFNo: SS1726ES

Determine measurement invariance of the AMPLIFY Agency measure across study countries to assess the comparability of derived scores across different countries.,Assess the validity of use of the AMPLIFY Agency survey as a pre-post program outcome evaluation measure overall and in each study country.,Assess the content and construct validity of the AMPLIFY Agency survey as a four-dimension measure of adolescent girls’ agency in each of the 5 study countries (Kenya, Tanzania, Rwanda, Uganda and Malawi).,Assess the reliability of the AMPLIFY Agency survey as a measure of adolescent girls’ agency in each of the 5 study countries (Kenya, Tanzania, Rwanda, Uganda and Malawi).,
USA 2023-05-31 15:26:05 2026-05-31 Social Science and Humanities Non-Clinical Trial Non-degree Award
Patience  OPUTAN
ID: UNCST-2022-R008760
Impact of climate change related events on the health and wellbeing of forcibly displaced people in Uganda
REFNo: HS2824ES

1) To explore the effects of climate change-related events on the health and well-being of forcibly displaced people in Uganda
2) To describe the effects of climate change-related events on access to WASH services among forcibly displaced people in Uganda
3) To explore the adaptation mechanisms on the health and access to WASH services employed by forcibly displaced people in response to climate change -related events in Uganda

Uganda 2023-05-29 20:39:17 2026-05-29 Medical and Health Sciences Non-Clinical Trial Degree Award
RICHARD MPANGO STEPHEN
ID:
Adaptation and Evaluation of the New Forest Parenting Program (NFPP) in the management of ADHD among Children and Adolescents infected with HIV (CA-HIV) in Uganda (Formative phase)
REFNo: SS1721ES

i) To adapt and evaluate the effectiveness of the NFPP in the management of ADHD among Children and adolescents infected with HIV (CA-HIV).
ii) To evaluate the acceptability and feasibility of NFPP in the management of ADHD among CA-HIV.
Uganda 2023-05-29 20:36:58 2026-05-29 Social Science and Humanities Clinical Trial Degree Award
FREDDIE SSENGOOBA Peter
ID: UNCST-2021-R011834
Balancing safety and good care in the context of infectious disease outbreak: learning systems for Infection Prevention and Control (IPC) in Uganda
REFNo: HS2821ES

4. To explore viable channels and methods for strengthening learning health systems in the context of IPC for ID outbreaks. ,3. To examine how caregivers provide care and mitigate risk in the context of infectious disease outbreaks.,2. To examine how geographic and social hierarchies impact on IPC and care practices in clinics and communities,1. To document the recent history of ID epidemic outbreaks and health systems preparedness, including IPC measures and their influence on institutional memory and practice. ,to strengthen epidemic preparedness in Uganda through a learning health systems approach that takes into account lived experience and institutional memory of the health workforce, lay care-givers and recipients of care during and beyond the COVID-19 crisis. ,
Uganda 2023-05-29 20:33:11 2026-05-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
Performance Evaluation of the Alinity m HIV-1 Assay using DBS for HIV Viral load Determination
REFNo: HS2878ES

• To assess Alinity m HIV-1 DBS viral load agreement with Abbott RealTime HIV-1 DBS viral load results by evaluating: o Quantitative assessment of bias, limits of agreement and correlation, o Misclassification above or below the clinical threshold o Comaparison of non-suppression rates in participants tested with the Alinity m HIV-1 DBS assayvs. the Abbott RealTime HIV-1 assay.,• To assess Alinity m HIV-1 DBS viral load agreement with Alinity m HIV-1 plasma viral load results by evaluating: o Quantitative assessment of bias, limits of agreement and correlation o Misclassification above or below the clinical threshold o Comparison of non-suppression rates in participants when using plasma vs. DBS as sample types on the Alinity m HIV-1 assay ,
Uganda 2023-05-29 20:29:43 2026-05-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Grace Ahimbisibwe Miriam
ID: UNCST-2021-R012129
Pediatric HIV Cure Collaborative Study Version 2.0 dated 16 Sep 2021
REFNo: HS2671ES

1. Identify correlates of susceptibility to proviral reactivation through immune profiling, which will be analyzed by multiparameter by flow cytometry methods, antibody profiling and transcriptomic analyses by bulk RNA-seq of PBMCs and CD4+ T cells in perinatal and adult infections.
2. To quantitatively and qualitatively characterize viral reservoirs, in children, adolescents and youth living with HIV compared with adults through determining and comparing the size, composition, and inducibility of the latent HIV reservoir in different geographic locations and subtypes, and characterizing their differences. The size will be determined by HIV DNA quantitative assays and inducibility by TILDA. The composition will be determined by near full-length sequencing for intact and defective genomes.
Uganda 2023-05-26 8:39:02 2026-05-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eugene Kinyanda
ID: UNCST-2023-R008028
Proposal to address the medium- to long-term EBOLA associated psychological Distress and psychosocial problems in Mubende District in central Uganda (Ebola+D Project)
REFNo: HS2870ES

To undertake a project to address the medium- to long-term EBOLA associated psychological Distress and psychosocial problems in Mubende District in central Uganda. Aims i) To develop, implement and evaluate the Ebola+D mental health intervention in Mubende district ii) To investigate the nature of mental health problems of community members accessing the Ebola+D mental health intervention and factors associated with treatment outcomes including immunological biomarkers iii) To explore the EVD associated negative beliefs and lived out experiences of affected members of the community (including health care workers)
Uganda 2023-05-26 8:34:43 2026-05-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kamwine Monicah
ID:
MICROBIAL AND METAGENOMIC ANALYSIS OF BACTERIAL COMMUNITIES IN MILK PRODUCTS PRODUCED IN MBARARA CITY, UGANDA
REFNo: HS2673ES

General objective
To characterize bacterial communities in milk products produced in Mbarara City, Uganda using culture techniques and metagenomic analysis
Specific Objectives
1. To determine the presence, levels of overall bacterial contamination load and bacterial profile in different milk products produced in Mbarara city, Uganda
2. To characterize the predominant microbiota in each milk product, determine the percentage of relative abundance of main identified bacterial genera, in each of the milk products produced in Mbarara city, Uganda.
3. To determine Virulence factors of the isolated bacteria
4. To determine the antimicrobial susceptibility patterns of pathogenic bacteria isolated from milk products produced in Mbarara city, Uganda

Uganda 2023-05-25 12:11:40 2026-05-25 Medical and Health Sciences Non-Clinical Trial Degree Award
Deborah Ekusai-Sebatta
ID: UNCST-2021-R003878
REGULATION OF DATA SHARING IN INTERNATIONAL GENOMIC RESEARCH: ETHICAL, SOCIAL AND LEGAL IMPLICATIONS
REFNo: SS1730ES

3. To evaluate the ethico-regulatory frameworks governing data sharing practices of genomic research in Uganda,2. To determine stakeholder knowledge, attitudes and practices (KAP) on sharing of data in collaborative genomic research in Uganda.,1. To establish the genomic data sharing practices and perceptions in collaborative human genomic research in Low and Middle Income Countries .,To comprehend the ELSI of the data sharing in international collaborative genomic research from a regulatory stand point. This will involve an evaluation the data sharing policies and explore the knowledge, perceptions and experiences of stakeholders involved in the conduct of international genomic research,
Uganda 2023-05-25 12:10:10 2026-05-25 Social Science and Humanities Non-Clinical Trial Degree Award
juliet cheptoris
ID:
Experiences and perceptions of Intimate Partner Violence (IPV) among Adolescent Girls and Young Women (AGYW) enrolled in the DREAMS Project in Mukono District, Uganda, 2023
REFNo: SS1718ES

General study objective To explore experiences and perceptions of Intimate Partner Violence (IPV) among Adolescent Girls and Young Women (AGYW) 15-24 enrolled in the DREAMS Program in Mukono District Specific Objectives 1. To explore the knowledge and perceptions on IPV among Adolescent Girls and Young Women (AGYW) who are enrolled in the DREAMS program 2. To examine the experiences of IPV among AGYW before and after enrolling in the DREAMS program. 3. To determine the factors associated with Intimate Partner Violence among AGYW who enrolled in the DREAMS program.
Uganda 2023-05-25 12:08:46 2026-05-25 Social Science and Humanities Non-Clinical Trial Degree Award
Rosalind  Parkes-Ratanshi Parkes
ID: UNCST-2019-R000717
HIV and sexually transmitted infection international biorepository and diagnostic test performance
REFNo: HS2724ES

• To create a biorepository to test retrospectively the performance of investigational, emerging diagnostic technologies in the intended population or setting compared to a reference comparator for diagnosing HIV/STIs using frozen samples.
• To test prospectively the accuracy of investigational, emerging diagnostic technologies in the intended population or setting compared to a standard comparator for diagnosing HIV/STI infection
• To determine agreement between self-collected swabs, saliva and clinician-collected swab samples for the diagnosis of STI using a reference test in Uganda.
• To determine agreement between self-collected blood, saliva and clinician-collected blood samples for the diagnosis of HIV using a reference test in Uganda.
• Determine the proportion of non-reportable results (unresolved, indeterminate and incomplete) and turn-around time compared to reference test.
• To assess acceptability of self-collected blood samples, swab tests, and saliva for testing HIV/STI in both participants and healthcare workers in Uganda.
• To explore socio-demographic, behavioural and clinical factors associated with positive HIV and other STI diagnosis

UK 2023-05-25 12:07:08 2026-05-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Richard Idro
ID: UNCST-2021-R013599
Dihydroartemisinin-piperaquine and azithromycin for the post-discharge management of children with severe anaemia in Malawi, Kenya and Uganda; A, multicentre, parallel-group, two-arm, randomised, double-blind superiority trial.
REFNo: HS2815ES

To determine if PDMC with four courses of monthly AZ treatment in combination with four months of weekly DP is superior to PDMC with weekly DP-alone in reducing non-malaria SCCV by six months post-discharge in children aged <5 years admitted with severe anaemia (Hb<5g/dl) who are ready to be discharged and are clinically stable and able to switch to oral medication,
Uganda 2023-05-25 12:04:54 2026-05-25 Medical and Health Sciences Clinical Trial Non-degree Award
David Meya Bisagaya
ID: UNCST-2019-R000837
Platform Trial For Cryptococcal Meningitis - PLATFORM-CM
REFNo: HS2649ES

The purpose of this study is to know whether this oral form of amphotericin (MAT2203) is safe and effective in the treatment of people sick with cryptococcal meningitis.
Uganda 2023-05-25 12:01:51 2026-05-25 Medical and Health Sciences Clinical Trial Non-degree Award
CHRISTINE MBABAZI -MPYANGU
ID:
Freedom of Religion or Beliefs Leadership Network (FoRBLN): A case study of Tororo district in Uganda.
REFNo: SS1308ES

Overall goal To explore a new synthesis of theoretical models derived from a combination of work in cognitive anthropology with modes theory, social psychology with identity fusion, leadership psychology with barrier crossing leadership. The research aims to address the following research questions 1. What role do imagistic group experiences play in fostering identity fusion Vs group identification bonds directed at the ingroup vs outgroup. 2. How far attitudes towards and experiences of barrier crossing leadership lead to improved intergroup attitudes and behaviours. 3. Whether individual empathetic abilities moderate the effects of imagistic experiences and/ or barrier crossing leadership. 4. How far the evidence from the cross cultural sample supports the theoretical model outline by modes theory.
Uganda 2023-05-25 11:59:07 2026-05-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
JULIET MWANGA-AMUMPAIRE
ID: UNCST-2022-R009420
Omuyambi: Traditional healer support to improve HIV viral suppression in rural Uganda
REFNo: HS2780ES

Aim 2: Evaluate implementation of the Omuyambi intervention using a convergent, mixed methods study design guided by the Consolidated Framework for Implementation Research (CFIR). Participants for this Aim will include TH and PLWH from Aim 1, in addition to staff from affiliated HIV clinics, and Ministry of Health (MoH) AIDS Control Division Officers who will be invited to participate in in- depth interviews and structured surveys. Following the convergent mixed methods approach38, quantitative and qualitative data – including validated survey instruments, in-depth interviews, and structured observations – will be collected to evaluate context pertinent to Omuyambi implementation over a 24-month period.,Aim 1: We will compare the Omuyambi intervention versus HIV clinic-based care (control) in a cluster randomized trial to assess the effectiveness of a community-based traditional healer (TH)-facilitated support program for people living with HIV (PLWH) in Mbarara District. We will conduct a CRT of Omuyambi versus TH’s referrals for clinic-based HIV care at 40 TH cluster sites over 33 months in Aim 1. The unit of randomization is the TH; each cluster includes TH and adult PLWH who are ART naďve or defaulted from HIV care. TH who are randomized to Omuyambi will facilitate HIV support for ART naďve or nonadherent PWLH receiving care at their practice.,We propose a parallel arm cluster randomized trial to compare the intervention (Omuyambi) to the control in Aim 1 to assess the effectiveness of the intervention and use a mixed methods approach to evaluate the implementation in Aim 2.,
Uganda 2023-05-18 16:44:40 2026-05-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Gideon Nsubuga
ID:
Inflammageing and anti-inflammageing cytokines in the HIV-seropositive and HIV-seronegative geriatric populations in Uganda.
REFNo: HS2889ES

1) To determine the mean inflammageing and anti-inflammageing cytokine levels in HIV-seropositive compared to HIV-seronegative geriatric populations in Uganda. 2) To determine the risk factors for inflammageing and anti-inflammageing cytokines in the HIV-seropositive compared to the HIV-seronegative geriatric population in Uganda.
Uganda 2023-05-18 16:05:34 2026-05-18 Medical and Health Sciences Non-Clinical Trial Degree Award
Margaret Lubwama
ID: UNCST-2019-R000636
Antimicrobial resistance training course for preclinical undergraduate health sciences students in Makerere University
REFNo: HS2831ES

Increase knowledge of AMR among preclinical undergraduate health sciences students at MakCHS,To develop and execute a blended AMR training course curriculum for preclinical undergraduate health sciences students at MakCHS,To determine the knowledge gap about AMR among clinical undergraduate health sciences students at MakCHS ,To improve knowledge about AMR among preclinical undergraduate health sciences students at MakCHS
Uganda 2023-05-18 16:03:18 2026-05-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Justine Bukenya Nnakate
ID: UNCST-2021-R012503
Multi-City Menstruation-Friendly Public Toilet (MFPT) Study
REFNo: HS2796ES

General objective
To describe public toilets in Kampala city and identify approaches to improve their menstrual health and hygiene (MHH) compatibility (or “friendliness”)

Specific objectives
• To describe public toilets and their menstrual health and hygiene (MHH) compatibility (or “friendliness”) in Kampala city.
• To identify approaches to improve their menstrual health and hygiene (MHH) compatibility (or “friendliness”) in Kampala city.

Uganda 2023-05-18 16:02:21 2026-05-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Richard Wamimbi Wotti
ID:
DEMOCRACY HUMAN RIGHTS AND GOVERNNANCE LEARNING, EVALUATION, AND RESEARCH (DRG-LER) II ACTIVITY GENDER-BASED VIOLENCE PORTFOLIO PERFORMANCE EVALUATION
REFNo: SS1709ES

To understand what is working, challenges faced, knowledge gaps, and what can be improved in USAID/GenDev’s GBV portfolio - RISE Activity Cluster,
Uganda 2023-05-18 16:01:29 2026-05-18 Social Science and Humanities Non-Clinical Trial Non-degree Award
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