Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Emmy Okello
ID: UNCST-2020-R009792
“Active Case Detection and Decentralized Dynamic Registry to Improve the Uptake of Rheumatic Heart Disease Secondary Prevention” ADD-RHD "Part 2B"
REFNo: HS2351ES

Primary Objectives
Objective 1 (Aim 1): To determine the diagnostic performance (sensitivity and specificity) of primary MOH nurses who have completed certification in focused echocardiography acquisition and interpretation by expert trainers to accurately identify patients who are screen positive and screen negative for rheumatic heart disease.
Objective 2 (Aim 2): To determine the diagnostic performance (sensitivity and specificity) of secondary MOH nurses who have completed certification in focused echocardiography acquisition and interpretation by MOH nurse trainers to accurately identify patients who are screen positive and screen negative for rheumatic heart disease.

Secondary Objectives:
• RHD and echocardiography knowledge
• Provider satisfaction with training curriculum
• Time to certification
• Screening volumes
• Longitudinal image quality
• Provider confidence
• Diagnostic performance for other common categories of cardiac diseases: moderate/severe left ventricular dysfunction, moderate/severe pericardial effusion.

Uganda 2022-09-27 16:22:25 2025-09-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jafesi Pulle
ID: UNCST-2020-R014213
A User-Centered Automated Two-way Messaging System to Support Prophylaxis Adherence in Rheumatic Heart Disease
REFNo: HS2411ES

1: Employ a user-centered design to develop a message bank and a two-way messaging intervention to support RHD secondary antibiotic prophylaxis in Uganda.

2: Compare patient-reported outcomes between RHD patients who receive standard prophylaxis support (current ACT platform) and those who receive enhanced prophylaxis support (current ACT platform + SMS intervention).

Uganda 2022-09-27 16:15:50 2025-09-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rita Makabayi-Mugabe
ID:
Evaluation of barriers and facilitators to access to tuberculosis (TB) care in Uganda.
REFNo: HS2441ES

To find out barriers to access to TB care among patients and health workers in Uganda To find out facilitators to access to TB care among patients and health workers in Uganda To document intervention functions to alleviate barriers to and enhance facilitators for access to TB care in Uganda
Uganda 2022-09-23 12:52:32 2025-09-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
2019-nCoV Antigen Test (Later Flow Method) Diagnostic sensitivity and diagnostic specificity. "Clinical Performance Study Plan - CPSP nr. WON-CPH 22-038"
REFNo: HS2419ES

• Establish the diagnostic sensitivity and diagnostic specificity of the Wondfo 2019-nCoV Antigen Test (Lateral Flow Method) in a self-testing environment when performed by laymen and to provide data to demonstrate the product is safe and effective for its intended use. • To assess the usability of the self-test for its intended use by laymen, the laymen will be observed by healthcare professionals. These observations will be captured using a questionnaire-based survey.
Uganda 2022-09-23 12:49:47 2025-09-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Catriona  Waitt John
ID: UNCST-2019-R001068
An Evaluation of the HIV Self-Testing 10X investment in Uganda
REFNo: HS2397ES

1. To determine (i) impact of HIVST within priority populations and (ii) demonstrate the demographics of those taking up testing and (iii) identify target populations not being reached
2. Identify the gaps in the HIV prevention and care cascades from distribution of HIVST kits to confirmatory testing, linkage to care and provision of ART or preventative services
3. Determine the health provider costs of different HIVST distribution models, and which models or combination of models are cost-effective for policy makers in Nigeria and Uganda to implement.

UK 2022-09-23 12:46:13 2025-09-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
George Mudanga Mukone
ID: UNCST-2022-R003997
Mapping the Geographical Distribution and Risk factors of Podoconiosis in Uganda
REFNo: HS2442ES

I. To investigate the spatial distribution of podoconiosis and Tungiasis in Uganda,
II. To quantify the population at risk of podoconiosis Uganda
III. To establish the association between Podoconiosis and tungiasis as co-morbidities in Uganda

Uganda 2022-09-23 12:44:23 2025-09-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Susan Babirye
ID: UNCST-2021-R013201
Analysis of the impact of COVID-19 on employment, economic status, and HIV risk and vulnerability among women living in urban informal settlements in two cities in Uganda: a participatory action research
REFNo: HS2458ES

1. To evaluate the impact of COVID-19 on employment (paid and unpaid work) and socio-economic status of women living in urban informal settlements in Kampala and Mbale city.

2. To determine how the changes in employment and economic status have influenced risk and vulnerability to HIV among women living in urban informal settlements in Kampala and Mbale city.

3. To explore the strategies implemented by women living in urban informal settlements in Kampala and Mbale city to cope with COVID-19-related work stress that expose them to HIV risk and vulnerability.

4. To examine the difference between existing COVID-19 recovery interventions in Uganda and the current socioeconomic and health needs of women living in urban informal settlements in Kampala and Mbale city as regards to safeguarding from HIV risk and vulnerability.

5. To convene key stakeholders to deliberate on the findings of study questions 1, 2, 3 and 4 in order to collectively identify and co-design gender transformative solutions to improve the socioeconomic well-being and reduce HIV risk and vulnerability among women living in urban informal settlements and living with HIV.

Uganda 2022-09-23 12:39:21 2025-09-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eddy Walakira Joshua
ID: UNCST-2022-R009077
Costs and benefits of ethical recruitment to Overseas Private Recruitment Agencies in Uganda
REFNo: SS1410ES

The objective of this case study is to use a market-based lens to assess the business case for the IRIS CBP in the Ugandan context.
Uganda 2022-09-23 12:32:59 2025-09-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
Joseph  OPUL
ID:
Contribution of Education to Resilience of Refugee Learners, A Case Study of Primary Schools in Nakivale Settlement, Isingiro District, Western Uganda
REFNo: SS1448ES

i.To assess the contribution of the curriculum to resilience of refugee learners; A case study of primary schools in Nakivale refugee’s settlement, Isingiro District, Western Uganda.
ii.To examine the role of teachers in resilience of refugee learners; A case study of primary schools in Nakivale refugee’s settlement, Isingiro District, Western Uganda.
iii.To examine the role of school leadership in resilience of refugee learners; A Case study of Primary schools in Nakivale refugee’s settlement, Isingiro District, Western Uganda.
Uganda 2022-09-23 12:15:46 2025-09-23 Social Science and Humanities Non-Clinical Trial Degree Award
Rose Nakasi
ID: UNCST-2022-R010805
Building AI Based Models for Diagnosis of Malaria
REFNo: SIR131ES

General Objective
To develop machine learning diagnostic systems from thick and thin blood smear image datasets for automated diagnosis of malaria in Uganda.
Specific Objectives
To achieve this, the project will have the following specific objectives;
1. To collect, curate and generate an open and labeled standardized malaria image dataset of thick and thin blood smear images from Uganda.
2. Develop machine learning models for automated detection of malaria in thick and thin blood smear images.
3. To build mobile and web-based applications for automated diagnosis of malaria.
4. To validate the developed ML models with expert ground truth annotations for malaria diagnosis.
Uganda 2022-09-23 12:14:44 2025-09-23 Engineering and Technology Non-Clinical Trial Non-degree Award
Shamilah Namusisi
ID:
Improving Household and Community Practices to reduce human contact with bats in Bundibugyo District
REFNo: SS1406ES

To determine the effectiveness of the “Living Safely with Bats” model developed by the USAID-PREDICT project at a community level. ,Improve community knowledge of, and increase uptake of safety practices through a multi-pronged social and behavior change (SBC) strategy.,Engage local women, women groups and school clubs in testing out plants that repel bats due to their scent, including as mint and rosemary.,Identify locally available and affordable materials to keep bats out of homes and community buildings. ,The overall goal of this intervention is to reduce the risk of exposure from pathogens arising as a result of human contact with bats by deterring bats from entering houses and buildings, as well as improving household and community safety practices once the bats have already entered or roosted.,
Uganda 2022-09-23 11:53:17 2025-09-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
BRENDA KHARONO
ID:
Stage of Maternal and Perinatal Death Surveillance and Response (MPDSR) implemented in Regional Referral Hospitals in Uganda-A mixed Methods Study
REFNo: HS2425ES

2. Enablers and Factors to MPDSR Implementation across the above RRHs,1. To describe the level of implementation of MPDSR in regional referral hospitals in Uganda,The purpose of this study is to describe the level of implementation of MPDSR in regional referral hospitals in Uganda. ,
Uganda 2022-09-21 21:36:30 2025-09-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nikita Bedov
ID:
Evolution and Behavioural Ecology of Natural Predator Interactions Between Mongooses and Snakes
REFNo: NS398ES

The overall objective is to analyse interactions between mongooses and snakes using model presentations. I want to understand how anti-snake behaviour varies across mongoose species and between groups with different compositions (by age, dominance, experience and sociality). Furthermore, I will examine ecological effects on mongoose-snake interactions by a comparison across geographic areas in Africa with different ecosystems and different guilds and combinations of snake and mongoose species.
By carrying out model presentations to the banded mongooses in Uganda, I aim to achieve the following:
1. To characterise banded mongoose foraging and hunting behaviour on snakes by observing how individuals interact with models of different snake species and models of other prey items, recording their physical behaviour and vocalisations.
2. To investigate whether different stimuli of the snake models, specifically movement of the model or the addition of natural snake scent, cause differences in behaviour mongooses exhibit towards them.
3. To investigate whether response to snakes varies under different group and environmental factors, such as in different group sizes and compositions, at varying distance from den or cover, or when pups are present.
4. To examine if mongooses have individual-level patterns or ‘defensive personalities’ by relating behavioural observations with life-history data from the long-term records about the same mongoose individuals collected by the Banded Mongoose Project.
Spain 2022-09-21 21:34:08 2025-09-21 Natural Sciences Non-Clinical Trial Degree Award
Byamah Mutamba Brian
ID: UNCST-2022-R011124
Strengthening Care in collaborAtion with People with lived Experience of psychosis in Uganda (SCAPE-U
REFNo: HS2327ES

General objective
To assess the impact of SCAPE-U on individual, family members’ and health system outcomes, and evaluate trial procedures to determine the optimal design for a future fully-powered cluster randomised controlled trial (RCT).
Specific objectives
1. To assess the feasibility and acceptability of SCAPE-U from the perspective of people with lived experience of psychosis, their family members and primary and community care providers.
2. To demonstrate proof-of-concept for the benefit of SCAPE-U for service users (i.e., patients with psychosis receiving primary care services) and their families, including changes in psychosis symptoms, quality of life, frequency of hospitalization and the potential impacts on family members.
3. To determine changes in health systems outcomes in terms of primary care provider knowledge, attitudes, competency in psychosis diagnosis and management, as well as accuracy of diagnosis and fidelity to treatment guidelines in actual care settings.
4. To evaluate trial procedures, including costing, recruitment and retention, and data collection protocols, to determine the optimal design for a future fully-powered cluster RCT

Uganda 2022-09-21 21:32:50 2025-09-21 Medical and Health Sciences Clinical Trial Non-degree Award
Jagoda Byszko Magdalena
ID:
"Understanding origins of social brain and communication in wild primates"
REFNo: NS335ES

Determining the complexity and diversity of chimpanzee gestural and voice communication repertoire. Identifying communication differences depending on social and environmental factors. Identifying patterns of social structures and the factors that influence them. Determining whether and to what extent gestural communication contributes to the creation and maintenance of complex social systems.
Poland 2022-09-21 21:27:15 2025-09-21 Natural Sciences Non-Clinical Trial Non-degree Award
Henry Ssenyondo
ID:
Maternal Antibody in Milk After Group B Streptococcus Vaccination in Uganda: MAMA study
REFNo: HS1986ES

General Objective • To determine the concentration of antibody transferred in breastmilk following vaccination with Group B Streptococcal vaccine Specific Objectives • To determine the anti-GBS (anti-Alp1N, Alp2N, AlpCN and RibN) Immunoglobulin A (IgA) concentrations in the colostrum of women following vaccination with a GBS-containing vaccine or placebo in pregnancy.
• To determine the total IgA and Immunoglobulin G (IgG) concentrations in the colostrum and breastmilk of women at less than 48 hours, 28 (+/-4 days) and 56 (+/- 6 days) days after delivery following vaccination with a GBS-containing vaccine or placebo in pregnancy.
• To determine the anti-GBS (antiAlp1N, Alp2N, AlpCN and RibN) IgA concentrations in the breastmilk of women at 28 (+/-4 days) and 56 (+/- 6 days) days after delivery following vaccination with a GBS-containing vaccine in pregnancy.
• To determine the anti-GBS (antiAlp1N, Alp2N, AlpCN and RibN) IgG concentrations in the colostrum and breastmilk of women at less than 48 hours, 28 (+/-4 days) and 56 (+/- 6 days) days after delivery following vaccination with a GBS-containing vaccine in pregnancy.
Uganda 2022-09-21 21:13:49 2025-09-21 Medical and Health Sciences Clinical Trial Degree Award
Brian Kule
ID:
Long-term Follow-up Surveys of the MasterCard Foundation Scholars Program
REFNo: SS1434ES

a) To investigate whether the program puts
beneficiary students on a sustained human capital accumulation path and what are the
returns to secondary education generated by the program.

b) To investigate whether the program promotes gains in consumption, health,
assets, livestock holdings, and savings

c)Identify areas where the program successfully spurred systems change within partner schools, TVET institutions, employers, and/or the government; and

d)Evaluate the resilience of both Scholars and the educational system within the context of COVID- 19 shocks and identify potential areas where resilience could be further developed or strengthened.
Uganda 2022-09-20 13:10:43 2025-09-20 Social Science and Humanities Non-Clinical Trial Non-degree Award
TWINOMUJUNI ROSEBELL
ID:
CITIZENS’ PARTICIPATION IN DECENTRALIZED EDUCATION SERVICE DELIVERY IN LOCAL GOVERNMENTS IN UGANDA. THE CASE OF BUSHENYI, MUKONO, GULU AND MBALE DISTRICTS
REFNo: SS1409ES

i. To analyse the fit between citizen participation and decentralised education services in selected Local Governments in Uganda.
ii. To assess the fit between decentralised education as a service and Quality of service in selected Local Governments in Uganda.
iii. To examine the effect of Quality of services on service delivery in selected Local Governments in Uganda.
iv. To measure the contribution of Citizen Participation on service delivery in selected Local Governments in Uganda.

Uganda 2022-09-20 13:07:57 2025-09-20 Social Science and Humanities Non-Clinical Trial Degree Award
Patrick Mawadri
ID:
EFFECT OF ESTRUS SYNCHRONIZATION PROTOCOLS ON REPRODUCTIVE PERFORMANCE OF INDIGENOUS CATTLE ON EXTENSIVE MANAGEMENT SYSTEM IN UGANDA
REFNo: A219ES

i. To evaluate the conception rate of estrus synchronization protocols used in cattle on extensive management system in Uganda using retrospective data
ii. To compare the effects of modified ovsynch protocols on ovulation of cows of short horn zebu and Ankole long-horned cattle on extensive management system in Aswa Ranch in Northern Uganda
iii. To compare the effects of modified ovsynch protocols on conception of cows of short horn zebu and Ankole long-horned cattle on extensive management system in Aswa Ranch in Northern Uganda

Uganda 2022-09-20 12:54:54 2025-09-20 Agricultural Sciences Non-Clinical Trial Degree Award
Moses Dombo
ID: UNCST-2021-R013076
PERFORMANCE OF THE DECENTRALIZATION POLICY IN AGRICULTURAL SERVICE DELIVERY IN LOCAL GOVERNMENTS IN UGANDA Cases of Butaleja, Mpigi and Bushenyi districts
REFNo: A206ES

a) To assess whether administrative decentralization has resulted in improved human resource management (HRM) functions in the three local governments, in the context of agricultural service delivery.
b) To explore whether political decentralization has enhanced citizen participation, voice, and representation in agricultural service delivery.
c) To determine whether fiscal decentralization has been responsive to the revenue collection and management needs of the three local governments, in the context of delivering public agricultural services.
d) To investigate whether, through decentralization, the three local governments have been able to provide enhanced agricultural extension services.

USA 2022-09-20 12:52:13 2025-09-20 Agricultural Sciences Non-Clinical Trial Degree Award
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