Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
David Mukunya
ID: UNCST-2022-R010707
Effect of neonatal sepsis on neurodevelopment of infants at two years in Mbale (ENON): a cohort study nested in the BabyGel Trial.
REFNo: HS2950ES

Main Objective 1. To compare development and growth at two years between 200 infants who were hospitalized for neonatal sepsis and 200 infants who did not suffer from neonatal sepsis. Specific Objectives 1.To compare participant characteristics between infants who were hospitalized for neonatal sepsis and those who did not suffer from neonatal sepsis 2.To compare growth (defined as weight for height z scores and height for age z scores) between infants who were hospitalized for neonatal sepsis and those who did not suffer from neonatal sepsis. 3.To compare neurodevelopment (measured as development for age z scores DAZ) at two years between 200 infants who were hospitalized for neonatal sepsis and 200 infants who did not suffer from neonatal sepsis
Uganda 2023-07-14 10:03:27 2026-07-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Elliot Avila Vicente
ID:
Study on the Adoption of Electric Pressure Cookers
REFNo: SS1842ES

1. To quantify the contribution of EPCs to overall household electricity consumption
2. To assess the effects of reducing the price of electricity on the usage of EPCs
3. To assess the effects of increasing households’ access to data about electric cooking costs on
their usage of EPCs
USA 2023-07-14 10:01:09 2026-07-14 Social Science and Humanities Non-Clinical Trial Non-degree Award
Rhoda Wanyenze
ID: UNCST-2021-R013352
A Hybrid Implementation-Effectiveness Trial of Game Changers for Cervical Cancer Prevention (GC-CCP) in Uganda
REFNo: SS1873ES

1. Conduct a multisite RCT of the GC-CCP network-based advocacy strategy to evaluate effects on CC screening uptake, access to early-stage treatment and prevention of advanced disease among unscreened alters across urban/rural and public/private clinics,4. Evaluate the cost-effectiveness of Implementing GC-CCP to increase CC screening and low cost, early-stage treatment, and prevent advanced disease, compared to enhanced usual care.,3. Examine mediators and moderators (among index, alter and network characteristics) of intervention effects on (a) alter CC screening; and (b) engagement in CC prevention advocacy of index and alter (1st and 2nd degree) to better understand its multiplier effect on diffusion of advocacy throughout a network.,2. Use a mixed methods approach (semi-structured interviews and administrative clinic data) to examine clinic-, provider-, and client-level barriers and facilitators of GC-CCP Implementation and Sustainment.,
Uganda 2023-07-13 11:13:19 2026-07-13 Social Science and Humanities Clinical Trial Non-degree Award
Chloé OULD AKLOUCHE Malika
ID:
Punitive innovation and penal control: A comparison of community service orders in Kenya and Uganda
REFNo: SS1852ES

1- By analysing a punitive innovation, to reveal that public policies are always constructed by a multitude of actors and that models are always translated locally.

2- To identify the conditions of possibility and development of rehabilitative sentences that allow the reintegration of offenders and reduce recidivism.

3- To bring an empirical contribution to the functioning of community service orders in Kenya and Uganda by observing the way it is applied to understand its effects.
France 2023-07-13 11:11:18 2026-07-13 Social Science and Humanities Non-Clinical Trial Degree Award
Flavia Matovu Kiweewa
ID: UNCST-2021-R013337
Persistent HPV Infection among African Women: An Observational Cohort Ancillary Study from the ASPIRE Parent Trial
REFNo: HS2916ES

Correlation between persistent HR HPV infection and abnormal cytology, Incidence of persistent HR HPV infections, defined as HR HPV detected at two visits 4.5 months apart
Uganda 2023-07-13 11:09:36 2026-07-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Regina Ndagire Nabikindu
ID: UNCST-2021-R012657
KNOWLEDGE, ATTITUDE, AND PRACTICES REGARDING ANTIBIOTIC USE AND ANTIMICROBIAL RESISTANCE: A MIXED METHODS STUDY AMONG URBAN SLUM DWELLERS IN UGANDA
REFNo: HS2941ES

To assess the knowledge of antibiotic use and AMR in households in Bwaise slum, Kawempe division,To explore the barriers and facilitators of antibiotic use in households in Bwaise slum, Kawempe division,To establish the factors associated with knowledge of antibiotic use and AMR in households in Bwaise slum, Kawempe division,To determine the attitude and practices regarding antibiotic use in households in Bwaise slum, Kawempe division,To investigate the knowledge, attitude and practices regarding antibiotic use and AMR among urban slum dwellers in Kampala, Uganda,
Uganda 2023-07-13 11:07:04 2026-07-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Justine  Komunyena Tumusiime
ID: UNCST-2023-R008465
Engaging Young Women in Human-Centered Design for the Integration of HIV Prevention with Family Planning Services in Uganda
REFNo: HS2956ES

1. Understand YW’s perspectives on the pain points and opportunities related to uptake, effective use, and continuation of HIV prevention and contraceptive services.
2. Generate concepts for innovative service models for delivering voluntary contraception and HIV prevention services to YW.
3. Assess feasibility, scalability as perceived as perceived by different stakeholders, and acceptability of these models through use of prototypes and
dialogues with YW, public and private health care providers, and policymakers.

Uganda 2023-07-13 10:22:52 2026-07-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Raymond Atwebembere
ID:
Prevalence and Factors Associated with Suicide Behavior Amongst Adolescents Living with HIV in ALow Socio-Economic Setting; Masaka District, Central Uganda
REFNo: SS1874ES

1. To assess the prevalence of Suicide Behavior Amongst Adolescents Living with HIV

2. To assess the factors associated with Suicide Behavior Amongst Adolescents Living with HIV
Uganda 2023-07-13 10:15:57 2026-07-13 Social Science and Humanities Non-Clinical Trial Degree Award
Mayanja Kajumba
ID: UNCST-2022-R009050
The Perspectives of Adolescents with Epilepsy: Development of a Patient-driven Intervention to Impact Health Literacy in Uganda
REFNo: HS2955ES

Aim 3: To understand key methods that the target groups use to learn, and to gather specific ideas that AWE have about effective ways to communicate information about epilepsy. That is: 3A) Identify the commonly used media and/or other epilepsy literacy delivery channels; 3B) Determine the effective ways to deliver information about epilepsy; 3C) Determine the level of accessibility to smartphones or computers, and the feasibility of using an APP or Computer Program to track seizures, and medication usage, and to deliver information about epilepsy.,Aim 2: To determine specific social groupings (e.g., school, family, community) that AWE believe most need education to impact epilepsy literacy. That is: 2A) Identify the patient’s perceived priority areas for epilepsy literacy; and 2B) Determine the patient-prioritized target social groupings for epilepsy health literacy.,Aim 1: To understand the experiences of adolescents with epilepsy (AWE) in relation to community stigma and discrimination and its impact. That is; 1A) Determine the patient history of epilepsy: the onset of seizures, and perceptions; 1B) Determine the immediate and long-term reactions/responses to epilepsy among patients, families, and community members; and 1C) Determine the nature and extent of familial, school, and community-based beliefs and misconceptions about epilepsy,The main objective of this study is to explore the relationship between epilepsy and stigma through the experiences of adolescents, who represent a pertinent target audience and are often agents of change in their communities.,
Uganda 2023-07-13 10:13:23 2026-07-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
A Phase III, Randomized, Open-Label, Multicenter Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared with Physician’s Choice of Adjuvant Endocrine Monotherapy in Patients with Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (Lidera)
REFNo: HS2193ES

Main Objective

1. To demonstrate superiority of giredestrant over the control treatment.
Specific Objectives

1. To evaluate the efficacy of giredestrant compared with Therapy of Physician's Choice
2. To evaluate the safety of giredestrant compared with Therapy of Physician's Choice
3. To characterize giredestrant Pharmacokinetics
4. To evaluate health status utility scores of participants treated with giredestrant compared with Therapy of Physician's Choice
5. To evaluate the tolerability of giredestrant compared with Therapy of Physician's Choice
6. To identify and/or evaluate biomarkers that are predictive of response to giredestrant (i.e., predictive biomarkers), are early surrogates of efficacy, are associated with progression to a more severe disease state (i.e., prognostic biomarkers), are associated with acquired resistance to giredestrant, are associated with susceptibility to developing adverse events or can lead to improved adverse event monitoring or investigation (i.e., safety biomarkers), can provide evidence of giredestrant activity (i.e., pharmacodynamic biomarkers), or can increase the knowledge and understanding of disease biology and drug safety
Uganda 2023-07-13 10:07:44 2026-07-13 Medical and Health Sciences Clinical Trial Non-degree Award
JOAN KABAYAMBI PROSE
ID:
Exploring Implementation Experiences to Adapt Digitized Payment of Community Health Workers: A Case Study of Benin and Uganda
REFNo: HS2926ES

The general objective of the study is to document the experiences of using DFS, identify good practices for the planning and implementation of gender-sensitive, national and sustainable digital health payment (DHP) of CHWs. ,iii) Design, using the identified good practices, a prototype for effective, gender-sensitive, and sustainable digital payment systems for CHWs in resource-constrained settings such as Benin and Uganda,ii) Assess the level of readiness and requirements for DHP of CHWs based on the experiences of using digital payment systems of community health workers during vaccination campaigns in Benin and Uganda,i) Understand the experiences, challenges, and opportunities of digital health payment systems for community health workers in Sub-Saharan Africa in immunization campaigns taking into account gender aspects ii) Assess the level of readiness and requirements for DHP of CHWs based on the experiences of using digital payment systems of community health workers during vaccination campaigns in Benin and Uganda iii) Design, using the identified good practices, a prototype for effective, gender-sensitive, and sustainable digital payment systems for CHWs in resource-constrained settings such as Benin and Uganda,
Uganda 2023-07-11 11:25:02 2026-07-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eddy Walakira Joshua
ID: UNCST-2022-R009077
Forced Labor Measurement Study: Ugandan Labor Migrants in the Middle East
REFNo: SS1872ES

Overall objective
To provide representative estimates of experiences of forced labor indicators among Ugandan migrant workers in the Middle East based on The International Conference of Labour Statisticians’ (ICLS) Guidelines concerning the measurement of forced labour, 2018.

Specific objectives

I. Explore the best way to interpret and operationalize the definitions presented in the guidelines
II. Explore how the ways in which questions are asked affects responses
III.Provide recommendations to improve questionnaire design and ultimately data quality

Uganda 2023-07-11 11:22:59 2026-07-11 Social Science and Humanities Non-Clinical Trial Non-degree Award
joseph  mwizerwa
ID:
Promoting Cultural Humility Through a Collaborative Online Transcultural Education and Leadership Development for Nurses in the Global Community
REFNo: HS2856ES

3. Conduct a posttest (endline) survey to evaluate the success of the training intervention in improving the participants’ leadership and collaborative competencies.,2. Design and implement appropriate/customized learning activities/course content informed by the baseline survey results.,1. Carry out a pretest to understand the participants’ baseline collaborative and leadership competencies prior to the intervention.,Develop an assessment process to determine whether students (graduates and/or undergraduates) are achieving the planned global learning and leadership development outcomes.,Design learning activities and course content that will allow students to demonstrate global learning and leadership development outcomes,Initiate a course syllabus or co-curriculum revision process to define global learning and leadership development outcomes for a course or academic program for graduates and undergraduate nursing students.,
Uganda 2023-07-10 17:48:52 2026-07-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Clovice Kankya
ID: UNCST-2020-R010154
Taxonomic Assessment of Selected Angiosperm Families in East Africa
REFNo: A318ES

Broad Objective
To provide a comprehensive study on the taxonomic and phylogenetic analysis of the Hydnoraceae, Poaceae, Viburnaceae, Velloziaceae, and Rutaceae species in East Africa.

Specific Objectives
a. To explore the inter-species diversity in Hydnoraceae from East Africa.
b. To produce the first revision of tribe Cynodonteae in the Flora of Central Africa.
c. To assess the taxonomic status of Sambucus L., (Viburnaceae) in East Africa.
d. To understand the taxonomic update and revision of the family Velloziaceae.
e. To provide a taxonomic revision of the genus Zanthoxylum and Vepris in East Africa.

Uganda 2023-07-10 17:24:14 2026-07-10 Agricultural Sciences Non-Clinical Trial Non-degree Award
Arthur  Mpimbaza
ID: UNCST-2022-R008866
Risk of contracting malaria among hospitalized patients at Jinja regional referral hospital, Uganda: a prospective cohort study.
REFNo: HS2918ES

The objective of this study is to determine the risk of hospitalized patients with non-malarial illnesses contracting malaria during their stay in hospital.
Uganda 2023-07-07 11:07:23 2026-07-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Flavia Matovu Kiweewa
ID: UNCST-2021-R013337
A Phase 2/3, Open-Label Study of the Pharmacokinetics, Safety, and Antiviral Activity of the GS-9883/Emtricitabine/Tenofovir Alafenamide (GS9883/F/TAF) Fixed Dose Combination (FDC) in HIV-1 Infected Adolescents and Children.
REFNo: HS2931ES

The primary objective of this study is to confirm the dose of B/F/TAF FDC in HIV-1 infected pediatric participants, to confirm the dose of B/F/TAF TOS in HIV-1 infected pediatric participants and to evaluate the safety and tolerability these medications.
Uganda 2023-07-06 17:23:47 2026-07-06 Medical and Health Sciences Clinical Trial Non-degree Award
Mildred Nakanwagi Julian
ID: UNCST-2021-R013459
Relationship of Robusta coffee native diversity with the abiotic and biotic environment
REFNo: A290ES

i. To determine the level of diversity and patterns on the population structure of diverse coffee germplasm in Uganda
ii. To assess the degree of coherence between genetic and morphological variation across and within C. canephora populations in Uganda.
iii. To determine the influence of abiotic factors on adaptive genetic variation in wild C. canephora accessions across ecogeographic zones of Uganda.
iv. To determine the abundance of biotic resilience associated unique alleles among and within C. canephora populations from different natural forests in Uganda.

Uganda 2023-07-06 17:18:28 2026-07-06 Agricultural Sciences Non-Clinical Trial Degree Award
Christopher Daly
ID:
An Assessment of Maternal Recognition of Neonatal Sepsis following Implementation of Standardized Newborn Discharge Education in Western Uganda
REFNo: HS2902ES

The primary objective of this study is to identify whether implementing a newborn discharge education checklist and providing an educational module in the maternity ward setting will lead to improvement in mothers’ ability to identify the danger signs of neonatal illness. Secondary objectives will include identifying maternal barriers to education, identifying maternal opinions on educational needs, and identifying how mothers will seek care in case of neonatal sepsis concerns.
USA 2023-07-06 17:17:42 2026-07-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Elizabeth Ayebare Ombeva
ID: UNCST-2020-R003666
EVALUATING THE EFFECT OF A LOW-COST FOETAL HEART RATE MONITOR AND EDUCATIONAL PACKAGE ON MONITORING INTERVALS AND NEWBORN OUTCOMES IN GULU DISTRICT.
REFNo: HS2868ES

1. To assess the effect of a low-cost Foetal Heart Rate Monitoring device (Moyo) on the Foetal Heart Rate monitoring intervals.
2. To assess the effect of a low-cost FHRM device (Moyo) on detection of fetal heart rate abnormalities
3. To evaluate the effect of the intervention package on immediate newborn outcomes
4. To explore health care providers experiences of Foetal Heart Rate Monitoring before and after the intervention.
Uganda 2023-07-06 17:16:36 2026-07-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nicholas Kilimani
ID: UNCST-2022-R010981
Supported childcare and women labor market participation in East Africa: Evidence from Uganda
REFNo: SS1689ES

Determine the impact of supported childcare programs on women labor market participation in Uganda.

Specific Objectives

a) Identify which childcare programs are better suited for workers across the different labour market segments.
b) Determine the extent to which supported childcare influences women labour market outcomes.
c) Identify whether supported childcare provides significant spillovers to other community members besides mothers’ participation in paid work.
d) Identify the sociocultural factors that influence women labour market participation.

Uganda 2023-07-06 17:15:03 2026-07-06 Social Science and Humanities Non-Clinical Trial Non-degree Award
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