Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
MICHAEL JACKSON WAKWABUBI
ID:
Financial distress in local governments in Uganda
REFNo: SS1429ES

To establish the relationship between local government delivery system and financial distress in local governments in Uganda To assess the relationship between revenue concentration and financial distress in local governments in Uganda To examine the relationship between revenue concentration, local governance, corruption and LG delivery system in local governments in Uganda To assess the mediating effect of LG delivery system in the relationship between revenue concentration, local governance, corruption and financial distress in local governments in Uganda To establish the relationship between local governance and financial distress in local governments in Uganda To establish the relationship between corruption and financial distress in local governments in Uganda
Uganda 2022-11-03 11:38:10 2025-11-03 Social Science and Humanities Non-Clinical Trial Degree Award
Hannah Kibuuka
ID: UNCST-2020-R014355
‘Remdesivir: Monitored Emergency Use for Filoviral Disease’
REFNo: HS2531ES

To offer patients with laboratory-confirmed filovirus disease (e.g. Ebola virus [EBOV], Bundibugyo virus [BDBV], Marburg virus [MARV] disease, and Sudan virus [SUDV]) under the clinical supervision of the protocol Principal Investigator or their designated physicians, access to treatment with Remdesivir under monitored conditions.
Uganda 2022-11-02 17:30:52 2025-11-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eugene Ruzagira
ID: UNCST-2023-R008282
Efficacy, Safety and Effectiveness of Injectable Cabotegravir/Rilpivirine in Improving HIV Control in Sub-Saharan Africa: A pragmatic Phase 3 Open-label Randomized Controlled Trial.
REFNo: HS2475ES

Primary objective:
To demonstrate the non-inferior efficacy of switching to every 2 months (Q2M) intramuscular (IM) injection of cabotegravir (CAB) long acting (LA) plus rilpivirine (RPV) LA compared with continuation of first-line oral ART over 12 months in people living with HIV (PLHIV) with a history of, or at risk of, sub-optimal HIV control.

Secondary objectives:
1) To demonstrate the antiviral activity and the impact on retention in HIV care of switching to Q2M CAB LA + RPV LA compared with continuation of oral ART over 12 and 24 months in PLHIV with a history of, or at risk of, sub-optimal ART adherence or engagement in care.

2) To demonstrate the immunological activity of switching to Q2M CAB LA + RPV LA compared with continuation of oral ART over 12 and 24 months in PLHIV with a history of, or at risk of, sub-optimal ART adherence or engagement in care. This will be measured through change in CD4+ T cell count and incidence of HIV disease progression.

3) To evaluate the safety and tolerability of switching to Q2M CAB LA + RPV LA compared to continuation of oral ART.

4) To assess genotypic viral resistance in participants experiencing protocol-defined confirmed virological failure (plasma HIV-1 RNA >200 c/ml) and its impact on future treatment options including proportion who resuppress on dolutegravir.

5) To evaluate the effect of Q2M CAB LA + RPV LA on health-related quality of live, treatment satisfaction and treatment adherence. To describe cost-effectiveness and acceptability of the regimen.

Uganda 2022-11-02 17:27:11 2025-11-02 Medical and Health Sciences Clinical Trial Non-degree Award
Clare Bangirana Ahabwe
ID: UNCST-2021-R012842
Violence Against Children and Youth Surveys (VACS) Cognitive Testing of Gender Attitude and Norm Measures Among Youths in Humanitarian Settings in Uganda
REFNo: SS1486ES

• To evaluate participants’ interpretation of the gender measures, consider and weigh relevant aspects of their lives and formulate a response based on those considerations.
• To test and refine gender measures that are understandable to 13-24-year-old study participants for inclusion in the core VACS questionnaire and future VACS administration.
• To identify context specific relevance of proposed gender measures in the administration of VACS in a humanitarian setting within Uganda.

Uganda 2022-11-02 10:14:05 2025-11-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Achilles Kiwanuka
ID:
Comparative Analysis of Health Information Systems Approaches in Use in Uganda
REFNo: HS2521ES

1. Describe the achievements, challenges, lessons learned and prospects for using the paper based HMIS, Smart Paper Technology and fully digitalized approaches for managing health information in Uganda.
2. Assess performance, usability and functionality of the fully digitalised and paper based HMIS approaches at the community level and Smart Paper Technology at the health facility level using the Performance of Routine Information System Management (PRISM) framework.
3. Analyze the cost benefit of using Smart Paper Technology and fully digitalised approaches of health information systems in Uganda.
4. Analyze the cost effectiveness of using Smart Paper Technology and fully digitalised approaches over the paper based HMIS for managing health information in Uganda.
5. Assess the impact on the budget after adopting Smart Paper Technology or fully digitalised approaches for managing health information with a focus to community health information systems in Uganda.
6. Evaluate the scalability of the Smart Paper Technology and fully digitalised approaches considering geographic scale and integration with other HMIS components

Uganda 2022-11-01 18:27:02 2025-11-01 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Okee Margaret Jill
ID:
USING INFORMATION AND COMMUNICATION TECHNOLOGY FOR LEARNING ENHANCEMENT IN HIGHER EDUCATION INSTITUTIONS: CASE OF KAMPALA METROPOLITAN AREA
REFNo: SIR144ES

1.To determine the relationship between e-learning pedagogy and learning enhancement.
2.To determine the relationship between motivation of students and learning enhancement.
3.To determine the relationship between ICT systems characteristics and learning enhancement.
4.To determine the combined effects of the relations of e-learning pedagogy and ICT systems characteristics on motivation of students.
5.To determine the combined effects of the relationships of e-learning pedagogy, motivation of students and ICT characteristics on learning enhancement.
6.To establish the intermediating role of the e-learning policy between institutional support and learning enhancement.
Uganda 2022-10-31 15:34:11 2025-10-31 Engineering and Technology Non-Clinical Trial Degree Award
Charles Drago Kato Drago
ID: UNCST-2021-R012897
Development and evaluation of a community-based bat-human interface monitoring program for zoonotic spillover early warning and response in Uganda
REFNo: HS2428ES

1) To build a community-created map of bat-human interfaces in Bundibugyo.
2) Establish an ecological baseline on the bats and human- bat interactions in Bundibugyo district
3) Establishing a sustainable bat-human interface monitoring program
Uganda 2022-10-31 15:31:18 2025-10-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Dr. Betty Kwagala
ID: UNCST-2022-R009048
Economic and Health impact and the resilience of last mile populations in artisanal and small- scale mining unplanned settlements in Sub-Saharan Africa before, during and after COVID-19: The case of Ghana and Uganda
REFNo: SS1496ES

4) To identify, co-develop and pilot test one context specific priority intervention to strengthen last mile adolescent girls’ resilience during future crises,3) To describe the interventions proposed by these populations and literature for strengthening adolescent girls’ coping skills and fostering resilience during the COVID-19 pandemic recovery and their applicability to future crises,2) To identify the coping mechanisms adolescent girls used to support their health and economic wellbeing during the pandemic.,1) To assess the economic and health impacts of the COVID-19 pandemic on the last-mile adolescent girls living in unplanned mining communities in Uganda and Ghana. To describe and assess the economic, health impacts and the resilience of adolescent girls in unplanned mining communities and coping mechanisms during the COVID-19 pandemic to support their future resilience and ability to cope during recovery and in similar future crises.
Uganda 2022-10-28 15:09:30 2025-10-28 Social Science and Humanities Non-Clinical Trial Non-degree Award
Hannah Kibuuka
ID: UNCST-2020-R014355
A randomized, double-blind, positive-controlled Phase III clinical trial to evaluate the efficacy and safety of SCTV01E (A COVID-19 Alpha/Beta/Delta/Omicron Variants S-Trimer Vaccine) in population previously unvaccinated with COVID-19 vaccine and aged ≥18 years
REFNo: HS2508ES

To evaluate the protective efficacy of SCTV01E against symptomatic COVID-19 occurring from 14 days after the 2nd dose in population
previously unvaccinated with COVID-19 vaccine.


To evaluate the protective efficacy of SCTV01E against symptomatic COVID-19 occurring from 7 days after the 3rd dose in population previously unvaccinated with COVID-19 vaccine
Uganda 2022-10-28 15:05:42 2025-10-28 Medical and Health Sciences Clinical Trial Non-degree Award
DAVID KITYA
ID: UNCST-2022-R009620
ASSESSMENT OF NEURAL TUBE DEFECTS AMONG NEWBORNS IN UGANDA: A STUDY OF PREVALENCE, RISK FACTORS, AND THE ROLE OF GENE-ENVIRONMENTAL INTERACTIONS (NTDS IN UGANDA)
REFNo: HS2479ES

Determine the proportion of newborns with neural tube defects.
2. Assess the correlation of common NTD risk factors in the development of NTDs.
3. Evaluate the environmental-gene interactions in the development of NTDs.

Uganda 2022-10-28 13:30:38 2025-10-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jackson Orem
ID: UNCST-2021-R012016
AMC-104, Feasibility study of ocular surface squamous neoplasia (OSSN) surgical excision in people living with HIV in sub-Saharan Africa (SSA)
REFNo: HS2366ES

To assess the feasibility of conducting multi-center prospective studies on surgical excision of suspected OSSN lesions in SSA in people living with HIV/AIDS (PLWHA).,
Uganda 2022-10-28 13:28:27 2025-10-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Clovice Kankya
ID: UNCST-2020-R010154
Capacitating One Health in Eastern and Southern Africa (COHESA)
REFNo: SS1482ES

To understand One Health performance, capacity, and bottlenecks within Uganda,To understand Current One Health Research and Innovation within Uganda,To understand One Health challenges, gaps and capacities within Uganda,
Uganda 2022-10-27 9:26:54 2025-10-27 Social Science and Humanities Clinical Trial Non-degree Award
EDITH  NAKKU-JOLOBA NAKKU
ID: UNCST-2021-R013931
MULT-COUNTRY AETIOLOGY OF GENITAL ULCER STUDY
REFNo: HS2498ES

To determine the prevalence of other sexually transmitted infections in individuals with GUD,To assess the Aetiology of genital ulcer diseases in Low and Middle Income Countries.,
Uganda 2022-10-27 7:52:03 2025-10-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
STANDARD i-Q COVID-19 Ag Home Test - Laymen study including Usability.
REFNo: HS2511ES

The objective of this laymen study is to establish the usability of the STANDARD i-Q COVID-19 Ag Home Test in a self-testing environment. More specifically, the study will assess whether the instructions for use and labels are clear and understandable and whether the test can be performed correctly by laypersons.,
Uganda 2022-10-27 7:48:55 2025-10-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Daniel Kibuuka Musoke
ID: UNCST-2021-R011749
Survey Protocol Zone of Influence Survey Uganda 2022 Feed the Future Phase Two Zone of Influence and Resilience Focus Zone Midline Indicator Assessment
REFNo: A232ES

The Midline Survey will collect primary data to generate estimates for a total of 25 indicators—14 Feed the Future P2-ZOI indicators, plus a new indicator on water security, and 10 RFZ indicators, which will only be collected in the RFZ. ,
Uganda 2022-10-27 7:38:03 2025-10-27 Agricultural Sciences Non-Clinical Trial Non-degree Award
David Musoke
ID:
Experiences of Village Taskforce members and Community Health Workers in COVID-19 prevention and control in Uganda
REFNo: HS2502ES

To assess the experiences of village task force members and community health workers (CHWs) in response to COVID-19 so as to provide information to strengthen community response to the pandemic in Uganda.
Uganda 2022-10-27 7:35:53 2025-10-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Clara HOZER
ID: UNCST-2022-R010004
Inter-individual variation in sleep strategies and consequences for fitness and cognition in wild chimpanzees (Pan troglodytes)
REFNo: NS433ES

- To assess whether chimpanzees display inter-individual variation in sleep strategies
- To determine if these strategies are driven by endogenous and social factors
- To explore if these sleep strategies have specific fitness consequences
- To investigate if these sleep strategies are in a trade-off relation with cognitive performance

France 2022-10-27 7:33:37 2025-10-27 Natural Sciences Non-Clinical Trial Degree Award
Willy Ssengooba
ID: UNCST-2022-R001801
Feasibility, Usability and Acceptability of stool-based qPCR to diagnose TB in children aged up to 8-years and HIV- positive adults in Mozambique, Eswatini and Uganda: a qualitative study
REFNo: SS1492ES

To identify cultural, socioeconomic and health system barriers and facilitators to the diagnostic tool’s implementation and uptake,To assess healthcare professionals’ perception of usefulness and applicability and related factors,To assess patients’ compliance and satisfaction with the intervention,To assess the participants’ (caretakers and PLWHA)/health professionals’ interpretation of a procedure involving stool collection for TB diagnosis in the light of current information, education communication messages regarding TB transmission,To describe participants’ views on, experiences with, and reactions towards the intervention,To explore participant’s perceptions and attitudes regarding TB in general and diagnosis in particular,To assess the feasibility of stool-based TB diagnostics from the healthcare professionals, patients and caregiver’s perspective in Uganda, Eswatini and Mozambique,
Uganda 2022-10-27 7:29:40 2025-10-27 Social Science and Humanities Non-Clinical Trial Non-degree Award
Paul Kiptis Kipyator
ID:
PITYRIASIS ROSEA: PREVALENCE, CLINICAL VARIANTS, AND DERMOSCOPIC FEATURES AMONG PATIENTS ATTENDING THE SKIN CLINIC AT MBARARA REGIONAL REFERRAL HOSPITAL, UGANDA
REFNo: NS435ES

To describe the dermoscopic features of Pityriasis rosea at MRRH Skin clinic.,To describe the clinical variants of Pityriasis rosea at MRRH Skin clinic.,To determine the prevalence of Pityriasis rosea at MRRH Skin clinic.,To determine the prevalence, clinical variants, and dermoscopic features of Pityriasis rosea among patients attending the Skin clinic at MRRH.,
Kenya 2022-10-27 7:26:09 2025-10-27 Natural Sciences Non-Clinical Trial Degree Award
Allison Ross
ID:
Behavioral Nudges to Encourage Appropriate Antibiotic Use Among Health Professionals in Uganda
REFNo: HS2429ES

Collect immediate post-intervention and follow up data to analyze and assess the short- and medium-term impact of the behavioral intervention. Implement the behavioral intervention developed in Phase II to impact prescribing behaviors. Develop a culturally appropriate behavioral intervention based on findings from Phase I. Gain an improved understanding of the cultural context around prescriptions in Ugandan hospitals to inform intervention development. Additionally, collect baseline data on prescribing behaviors among staff. Increase adherence to national antibiotic prescribing guidelines among hospital-based health care providers in Uganda by implementing a behavioral “nudge” intervention, contributing to the containment of AMR in the country.
USA 2022-10-27 7:21:19 2025-10-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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