Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Harriet Mayanja-Kizza
ID: UNCST-2021-R013074
A phase 2, partially-blinded, randomised trial assessing the safety and efficacy of TBAJ876 or bedaquiline, in combination with pretomanid and linezolid in adult participants with newly diagnosed, drug-sensitive, smear-positive pulmonary tuberculosis
REFNo: HS2928ES

The objectives of the trial are to evaluate the efficacy, safety, and tolerability of TBAJ876 (3 doses) or bedaquiline in combination with pretomanid and linezolid in adult participants with newly diagnosed, smear-positive pulmonary DS-TB in comparison to the SOC
Uganda 2023-08-07 15:20:08 2026-08-07 Medical and Health Sciences Clinical Trial Non-degree Award
Kamada Lwere
ID: UNCST-2022-R009359
GUT MICROBIOME COMPOSITION, IMMUNE RESPONSE, AND GENETIC PREDISPOSITION TO ALZHEIMER’S DISEASE AND RELATED DEMENTIA IN A UGANDAN POPULATION.
REFNo: HS2930ES

1. To conduct a systematic review of the gut microbiome composition of individuals with Alzheimer’s disease and related dementia. 2. To determine the composition of the gut microbiome and compare individuals with ADRD and their controls. 3. To determine the levels of proinflammatory cytokines and compare individuals with ADRD and their controls. 4. To determine the distribution of ApoE (ApoE2, ApoE3 and ApoE4 variants) and ABCA7(Premature termination codon (PTC) mutations) and Presenilin (PSEN 1, 2 mutations) and compare individuals with ADRD and their controls.
Uganda 2023-08-07 15:12:16 2026-08-07 Medical and Health Sciences Non-Clinical Trial Degree Award
Ephraim Kisangala
ID:
Preferences, value and impact of informal caregivers in the management of chronic diseases in sub-Saharan Africa (SSA)
REFNo: SS1846ES

• To examine the health and economic impact of caregiving on informal caregivers (ICGS) of patients with chronic diseases in sub-Saharan Africa • To understand the factors ICGs consider when making a decision to provide care to a person with a chronic disease in SSA. • To explore how providing informal care affects the lives of informal caregivers. • To determine the most important factors in the decision to provide informal care. • To estimate the monetary value of providing informal care to patients with chronic diseases.
Uganda 2023-08-07 15:04:16 2026-08-07 Social Science and Humanities Non-Clinical Trial Degree Award
Shubaya Naggayi Kasule
ID:
Infections, Academic Achievement and Cognitive Functioning among Children with Sickle Cell Anaemia in Uganda.
REFNo: SS1883ES

To synthesize data on academic achievement among children with SCA in LMICs and assess academic achievement, cognitive functioning and infections among Ugandan children with SCA.
Uganda 2023-08-07 14:59:23 2026-08-07 Social Science and Humanities Non-Clinical Trial Degree Award
Alfred Wonyaka
ID:
Eco theology: A strategy for Ecological protection in Mountain Elgon Region Church of Uganda
REFNo: SS1713ES

a). To analyze the current ecological trends in Mountain Elgon region
b.) To access the effects of current ecological trends on ecological health in Mountain Elgon region.
c.) To examine how eco theology could be utilized as a strategy for ecological protection in Mountain Elgon region.

Uganda 2023-08-07 14:56:55 2026-08-07 Social Science and Humanities Non-Clinical Trial Degree Award
Hellen Ndagire
ID:
CHARACTERISATION OF BACTERIAL COMMUNITIES IN BLOODSTREAM AND RECTAL SWABS AMONG GOATS AND CATTLE FROM SELECTED DISTRICTS IN UGANDA
REFNo: A336ES

1. To screen for bacterial communities in the blood stream and rectal swab among cattle and goats free of overt disease from Wakiso, Kampala and Kassanda Districts of Uganda
2. To characterize the bloodstream and rectal swab bacteria from cattle free of overt disease using 16S rRNA typing
3. To characterize the bloodstream and rectal faecal bacteria from goats free of overt disease using 16S rRNA typing

Uganda 2023-08-07 14:55:24 2026-08-07 Agricultural Sciences Non-Clinical Trial Degree Award
Grace Kiiria
ID:
MANAGEMENT OF REFUGEE CATCH-UP EDUCATION PROGRAMMES FOR TRANSITIION TO SECONDARY SCHOOL
REFNo: SS986ES

i. To explore perceptions of stakeholders on the planning processes for implementing Refugee Catch-up Education programmes.

ii. To explore how Refugee Catch-up Education programmes are coordinated to enhance transition of learners to secondary level.

iii. To examine socio-emotional, economic and political factors influencing the planning and coordination of Refugee Catch-up Education programmes.
Uganda 2023-08-04 17:19:58 2026-08-04 Social Science and Humanities Non-Clinical Trial Degree Award
Nicole  Eggers
ID:
Refuge in the Spirit: Religion in the Lives of Congolese Refugees
REFNo: SS1915ES

The project will investigate the significance of religion at different junctures of the Congolese refugee experience. We will conduct interviews among those still living in refugee camps in Kenya and Burundi, as well as among those who have left the camps — either to be repatriated to Congo, or to be resettled in the United States. We will look at the role of mainstream, transnational, internationally connected religious communities as well as smaller, non-denominational, and independent churches. This multi-sited, multi-confessional (i.e., concerning multiple religious identities) approach will allow us to feature a diversity of refugee perspectives and offer a more comprehensive understanding of refugee experiences than can be found in existing studies. At the same time, our qualitative, oral history/ethnographic approach to the research will allow us to highlight the many contingencies of individual experience and consider how other aspects of refugee identity — such as gender, age, or ethnicity — intersect with religion. Thus, this research seeks to attain the following specific objectives:
1. To establish and document from lived experiences of Congolese refugees the ways in which they navigate their flight experiences.
2. To understand the role religion and/or spirituality play in the lives of Congolese refugees (or repatriated refugees) in different geographic locations (USA, Kenya, Burundi, and Congo)
3. To analyze different refugees’ resilience mechanisms in coping with their flight experiences.
USA 2023-08-03 16:05:45 2026-08-03 Social Science and Humanities Non-Clinical Trial Non-degree Award
Peter Kisaakye
ID:
An Empowered and Self-Sustaining Community of Bulambuli District by 2025
REFNo: SS1890ES

1. To collect data for the project impact and outcome indicators that will allow for a before and after comparisons in subsequent assessments of the project’s performance
2. To assess the level of citizen engagement in local government processes
3. To identify factors that contribute to or hinder citizen participation in local decision-making
4. To measure the prevailing norms around accountability, transparency, and monitoring behavior
5. To understand the causality between the knowledge, awareness, and behavior of local government officials and the resulting effects on citizen participation

Uganda 2023-08-03 16:04:38 2026-08-03 Social Science and Humanities Non-Clinical Trial Non-degree Award
Wilson Birungi
ID:
urogenital bacterial colonization: Prevalence, antibiotic susceptibility and associated factors among women with preterm labour at Mbarara Regional Referral Hospital
REFNo: HS3075ES

4. To determine the factors associated with urogenital bacterial colonization among women with preterm labour at Mbarara Regional Referral Hospital,3. To describe the antibiotic susceptibility patterns of the bacterial isolates in the urogenital tract of women with preterm labour admitted at Mbarara Regional Referral Hospital,2. To identify bacterial isolates from the urogenital tract of women with preterm labour admitted at Mbarara Regional Referral Hospital.,1. To determine the prevalence of urogenital bacterial colonization among pregnant women with preterm labour admitted at Mbarara Regional Referral Hospital.,To determine the prevalence of urogenital bacterial colonization, antibiotic susceptibility patterns and factors associated among women with preterm labour admitted at Mbarara Regional Referral Hospital.,
Uganda 2023-08-03 16:03:06 2026-08-03 Medical and Health Sciences Non-Clinical Trial Degree Award
Alex Saturday
ID: UNCST-2023-R007459
Analysis of Land Use Change Implications on Limnological Characteristics of Ishasha River, Western Uganda
REFNo: A323ES

Build capacities by providing training on “Participatory River Catchment Monitoring (PRCM)”. ,Investigate the spatiotemporal variations in phytoplankton composition and biomass in the river.,Investigate the spatio-temporal distribution of zooplankton composition and abundance,Determine the spatio-temporal distribution of physico-chemical water quality variables and discharge,Evaluate LULC changes in the sub-catchment for a period of 30 years (1991-2020) using satellite imagery and Geographical Information Systems (GIS).,To assess the limnological characteristics of Ishasha River in relation to land use patterns in Southwestern Uganda,
Uganda 2023-08-03 16:02:12 2026-08-03 Agricultural Sciences Non-Clinical Trial Non-degree Award
Heeji Bae
ID:
Towards a Decolonial Understanding of Peace Education in Uganda: Unpacking Ugandan Teachers’ Perspectives in Central and Northern Regions
REFNo: SS1889ES

[General objectives] This study is dedicated to developing a nuanced understanding of how local teachers in central and northern Uganda conceptualise peace education differently, given the complexities of the dissimilar history of conflicts in these regions. Through the research, the following two themes will be examined in a critical postcolonial and decolonising manner. First, the research will delve into how the experiences of violent conflicts differ between the central and northern regions of Uganda, which will be conducted through a thorough literature review. Second, it will identify the mechanisms through which current peace education has been introduced, either as thematic areas of the national curriculum or initiatives supported and implemented by Western organisations. This theme will be further supported by conducting interviews. Thus, the primary focus of this research is to gain a fruitful insight into the existing practice of peace education and initiatives in Uganda, and how it can be designed if introduced as a separate subject of the national curriculum from primary levels. [Specific objectives] 1. To investigate how teachers in central and northern Uganda conceptualise peace education and to what extent and in what ways any differences between their conceptualisations manifest. 2. To explore the perspectives of Ugandan teachers on Western interventionism in peace education and how such interventions influence their approach to teaching peace education.
South Korea 2023-08-03 16:01:21 2026-08-03 Social Science and Humanities Non-Clinical Trial Degree Award
Emily Brownell
ID:
Stories from the Substrate: East African History from the Soil
REFNo: SS1870ES

“Stories from the Substrate” takes shape around several research questions but most fundamentally it asks: What might the history of East Africa look like if we start from the soil? Starting from the soil suggests a point of view, and a trajectory as well as a subject. Together, this offers an opportunity to rework some of the well-trod territory of East African historiography, highlighting new themes and subjects. In African history, scholars have overwhelmingly trained their attention on people and events rather than thinking from and with nonhuman things. What then, comes into focus when we work from the soil, bringing together unlikely stories from which to consider the region’s history? Divided into three parts, this project gathers twentieth century histories of how East Africans have been engaged with animals, plants, and minerals through the substrate.[2] Together, these histories reveal narratives of labor, health, science, and environments by focusing on everyday negotiations of life in the region. Working from government archives, scientific studies, travelers accounts, and oral history interviews to write a series of thematic chapters, this project looks to the relationship between people and soil to build a non-elite history of the region. In starting from the soil, this project is important not just for the stories and actors it highlights, but also what it decenters. In the case of East Africa, this means eliding the ethnic and racial logics of the colonial archive, decentering political events and figures that have dominated the region’s historiography, and reworking narratives of environmental change that centre on colonial development schemes.
USA 2023-08-03 16:00:15 2026-08-03 Social Science and Humanities Non-Clinical Trial Non-degree Award
Adolf Mbalangu
ID:
Buganda Clan Systems Pedagogy and wildlife Conservation in Uganda: A Case of the indigenous Counties of Buganda Kingdom
REFNo: SS1863ES


i. In which ways do totems as part of Buganda clan systems pedagogy used to conserve wildlife?

ii. To what extent are taboos as part of Buganda clan systems pedagogy used to conserve wildlife?

iii. Which prospects do traditional spirituality/beliefs as part of Buganda clan systems pedagogy use to conserve wildlife?

iv. How does foreign religion/culture influence Buganda’s clan systems pedagogy on wildlife conservation?

Uganda 2023-08-03 15:47:47 2026-08-03 Social Science and Humanities Non-Clinical Trial Degree Award
Nambusi Kyegombe Davina Ndibalekera
ID: UNCST-2022-R009559
Sexual Harassment and abuse of women and girls In low-wage work in Uganda (SHARI)
REFNo: SS1705ES

1. To explore the lived experience of sexual harassment in the context of low-wage work in Uganda
2. To explore the socially normative perceptions of sexual harassment amongst women and men in men and women in Uganda
3. To identify the different dimensions of sexual harassment in workplace settings.
4. To Compare and refine current constructs of sexual harassment towards a definition that is relevant to women and contextually adaptable, including exploring behaviours that may fall into so-called ‘grey areas’; and
5. To cognitively test the measures that are developed.
Uganda 2023-08-03 15:45:34 2026-08-03 Social Science and Humanities Non-Clinical Trial Non-degree Award
ALLAN BUZIBYE
ID:
LABORATORY PREDICTORS OF DOLUTEGRAVIR-ASSOCIATED HYPERGLYCEMIA IN A COHORT OF UGANDANS LIVING WITH HIV
REFNo: HS2962ES

4 To compare mean baseline plasma levels of pro-inflammatory biomarkers/cytokines between PLHIV with and without incident hyperglycemia who are initiated on DTG.,3 To compare mean intracellular magnesium concentration between PLHIV on DTG with and without hyperglycemia.,2 To compare the mean baseline plasma levels of mitochondria dysfunction biomarkers between HIV positive patients with and without incident hyperglycemia at the time of DTG switch. ,1 To compare DTG pharmacokinetic (PK) parameters between HIV positive patients with and without incident hyperglycemia.,To investigate the mechanisms for dolutegravir-associated hyperglycaemia in a Ugandan HIV positive population.,
Uganda 2023-08-03 15:42:11 2026-08-03 Medical and Health Sciences Non-Clinical Trial Degree Award
SIMON ARUNGA
ID: UNCST-2021-R013498
PILOTING TESTING OF POINT OF CARE DIAGNOSTICS TO IMPROVE DIAGNOSIS OF MICROBIAL KERATITIS IN UGANDA.
REFNo: HS2719ES

1. Our overall aim is to improve the diagnosis of the type of MK (bacterial or fungal) at secondary-level facilities in Uganda. We will do this by comparing several novel alternative point of care diagnostic tests in a phased tertiary level and secondary level approach. 2. Assess the diagnostic performance (relative diagnostic yield, time to diagnosis, uptake, and ease of use) of the alternative point-of-care tests in three secondary units in Uganda.,1. Measure the performance (sensitivity and specificity) of these tests carried out by general ophthalmic clinic personnel, compared to a composite reference standard and the ocular microbiologist at the tertiary unit in Uganda. 3. Determine the sensitivity and specificity of several novel alternative diagnostic tests compared to a composite reference standard. Novel tests to be compared include calcofluor White + KOH, smartphone-based fluorescence microscopy, and the isothermal amplification test. The tests will be conducted by an ocular microbiologist at the tertiary unit in Uganda.
Uganda 2023-08-03 15:40:49 2026-08-03 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joseph Baluku B
ID: UNCST-2019-R000612
Incidence of mortality and associated factors among TB survivors in rural Uganda.
REFNo: HS2947ES

1. To determine the incidence rate of mortality among TB survivors at Masaka Regional Referral Hospital 2. To compare the incidence of mortality among TB survivors with and without HIV coinfection at Masaka Regional Referral Hospital 3. To determine the factors associated with mortality among TB survivors at Masaka Regional Referral Hospital
Uganda 2023-08-02 18:18:03 2026-08-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Gloria Abura-Meerdink Akello
ID: UNCST-2023-R007309
Project Title: A Community Engaged and Mixed Methods Approach to Exploring and Assessing Adolescent Mental Health and Psychosocial Needs for School Based Settings in Uganda
REFNo: SS1922ES

To assess the acceptability and feasibility of mental health assessment for adolescents in school-based settings in Uganda,To pilot a screening process for assessing the social determinants of health, depression and anxiety among adolescents within a school-based setting in Uganda. ,To explore adolescent mental health and psychosocial needs within low resource school-based settings in Uganda. At this stage in the research, the adolescent mental health and psychosocial needs will be generally defined as physical, social, emotional, behavioral and academic needs critical for promoting adolescent health, wellbeing and quality of life.,
Uganda 2023-08-02 18:15:57 2026-08-02 Social Science and Humanities Non-Clinical Trial Degree Award
Alain Favina
ID:
AFFILIATE STIGMA AMONG CAREGIVERS AND TREATMENT OUTCOMES AMONG PEOPLE WITH MENTAL ILLNESS IN SOUTHWESTERN UGANDA
REFNo: HS2779ES

To establish the relationship between affiliate stigma and treatment adherence and quality of life among people with mental illness in southwestern Uganda.,To determine factors associated with affiliate stigma among caregivers of people with mental illness in southwestern Uganda.,To determine the prevalence of the affiliate stigma among caregivers of people living with mental illness in Southwestern Uganda.,
Burundi 2023-07-27 21:05:27 2026-07-27 Medical and Health Sciences Non-Clinical Trial Degree Award
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