Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Jacob  Mutazindwa Kasabunga
ID: UNCST-2024-R015547
Agriculture and Livelihoods in Uganda
REFNo: SS3430ES

Main objective/ purpose
The purpose of the baseline study is to determine baseline values related to the current state of agricultural production, productivity, and the levels of access to commercialization facilities and to affordable and sustainable rural microfinance for value chain development in Uganda.

Specific Objectives
Specifically the baseline study aims: -
i. To assess the feasibility of investments in the coffee, rice, oil seed (sunflower and soybean), simsim (sesame), dairy (milk and milk products), and goats and sheep value chains to improve farmer incomes, and the feasibility of investments in cassava, maize and beans to improve food security as well as the cross-cutting themes of climate change as well as gender.

ii. To obtain qualitative data through conducting stakeholder interviews, facilitating focus group discussions, and obtaining quantitative data through a survey in targeted regions in Uganda.
iii. To assist in other research activities, including assisting the project team in identifying survey subjects that meet project inclusion criteria and respondents that can inform the feasibility study.
iv. To assist in piloting and refinement of data collection instruments and contribute to analysis to inform the Baseline Report and Feasibility Study

Uganda 2024-11-27 15:38:15 2027-11-27 Social Science and Humanities Non-Clinical Trial Non-degree Award
Stella Neema
ID: UNCST-2019-R000814
Understanding the processes and acceptability of a child-friendly paediatric formulation of Praziquantel for the treatment of schistosomiasis among preschool-aged children in endemic districts in Uganda
REFNo: SS3420ES

The overall aim of this study is to analyse the factors surrounding the pilot introduction of arPZQ among PSAC in communities in Uganda at the macro, meso and micro levels.

Objectives

1. To evaluate the acceptance, appropriateness and perception of paediatric schistosomiasis treatment and distribution (delivery) among caregivers and other community members

2. To analyse the acceptance and perception of the paediatric praziquantel distribution methods among implementation personnel

3. To evaluate advocacy, social mobilisation and communication strategies and toolkits supporting the delivery of paediatric schistosomiasis treatment

4. To evaluate the pilot implementation of the weight-based dosing protocol


Uganda 2024-11-26 19:48:25 2027-11-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
JOSEPHINE  BAYIGGA
ID: UNCST-2024-R003757
Understanding preferred Tuberculosis Treatment adherence interventions among persons identified with Alcohol use Disorder in Kampala, Uganda: A mixed methods study
REFNo: SS3228ES

The study aims to elicit the preferred tuberculosis treatment adherence interventions among persons with alcohol use disorder in Kampala, Uganda,
Uganda 2024-11-26 19:46:58 2027-11-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Eve  Namisango
ID: UNCST-2021-R014038
Improving end-of-life care for dying patients and their families in Ugandan ICUs
REFNo: HS4832ES

5. Synthesise the findings to produce recommendations for future end-of-life care in ICU practice, research and policy.,To explore clinicians’ experiences of end-of-life care provision in Ugandan ICUs and the use of person-centred outcome measures.,3. To utilise the Integrated Palliative care Outcome Scale (IPOS) staff version as a tool in identifying symptoms and important concerns at the end of life in ICU,2. To assess symptoms and important concerns at end=of-life in ICU using the integrated palliative care outcome scale ,1. To explore ICU clinician’s perspectives of factors influencing the provision of quality end-of-life care through a survey,To explore factors influencing the provision of end-of-life care in Ugandan ICUs test and evaluate the use of person-centred outcome measures in improving end-of-life care in dying patients and their families,
Uganda 2024-11-26 19:41:46 2027-11-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Fred Nalugoda
ID: UNCST-2021-R013343
Improving understanding of Capacity to consent to sensitive biomedical Research among adolescents in Rakai Uganda (ICARE)
REFNo: SS3447ES

Aim 1: Sampling from RCCS-experienced and RCCS-naïve households, and using the MacCAT-CR, examine adolescent capacity to consent to biomedical research and correlates of that capacity.
1.a: Compare capacity to consent among early, middle, and late adolescents and their guardians.
1.b: Assess correlates of capacity, including actionable factors such as health literacy and education and biomedical-related factors such as PrEP eligibility, use, awareness, beliefs, peer norms, and stigma.
Aim 2: Using a systematic qualitative analysis – guided by our conceptual framework for mapping age differences – examine processes of decision-making around biomedical prevention and biomedical research (e.g., stigma, understanding of biomedical prevention and research risks and benefits and constructs like randomization, privacy, safety and autonomy) among guardians and early, middle and late adolescents.
Aim 3: In partnership with US and Uganda researchers, and IRB members, construct a digital toolkit to support decision making regarding key aspects of minor consent in low-resource settings.

Uganda 2024-11-26 19:40:05 2027-11-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jacklyn Arinaitwe Makaaru
ID: UNCST-2024-R015354
Examining the combined effects of a two-generation model involving childcare and financial support interventions to vulnerable businesswomen in urban refugee and host communities in Kampala
REFNo: SS3367ES

i) To understand the status of childcare burden and its attendant constraints on livelihoods for urban refugee women.
ii) To design interventions that alleviate the childcare burden for urban refugee women while at the same time improving their social and economic welfare.
iii) To evaluate the effects of these interventions on reducing the burden of childcare as well as business growth, productivity, profitability, livelihoods, and the wellbeing of urban refugee women/caregivers.

Uganda 2024-11-25 17:30:05 2027-11-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Edgar Mulogo Mugema
ID: UNCST-2023-R008170
Viral causes of acute respiratory illness among hospitalized children in Kasese District, Uganda:an observational cohort study.
REFNo: HS5218ES

Primary Objectives

The primary objective of this study is to test the feasibility of implementing rapid molecular diagnostic test and assess the burden and epidemiology of influenza subtypes A and B, SARS- CoV-2, and RSV among pediatric patients hospitalized for ARI in Kasese District, Uganda.

Specific Aims

Determine the feasibility of implementing a rapid molecular diagnostic testing program at peripheral health centers in rural western Uganda. We will measure the number of eligible children consenting to testing, the number of tests performed, the median time from sample collection to result, and the number of invalid test results due to either operator error or equipment issues.

Measure the proportion of pediatric hospitalizations for ARI attributable to SARS-CoV-2, influenza subtype A and B, and RSV in communities with different population densities in Kasese district. We will enroll children admitted with ARI, test a nasopharyngeal swab for influenza, SARS-CoV-
2 and RSV using the Cepheid GeneXpert platform, and document participant demographic information.

Describe the clinical presentation and management for patients admitted with respiratory illness to health facilities in Kasese District. We will record the vaccination history, presenting symptoms, diagnoses, and treatments administered, including antibiotics. We will also follow-up all enrolled participants two weeks after admission to determine illness outcomes. We will compare these variables between those who test positive and those who test negative for SARS-CoV-2, influenza, and RSV.

Uganda 2024-11-25 17:28:46 2027-11-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JULIET BABIRYE ALLEN
ID: UNCST-2023-R005641
PREVALENCE AND ASSOCIATED FACTORS OF DYSLIPIDEMIAS AMONG PLHIV AT GOMBE HOSPITAL, IN RURAL UGANDA
REFNo: HS5050ES

ii. To determine the factors associated with dyslipidemia among PLHIV in rural Uganda.,i. To determine the prevalence of dyslipidemia among PLHIV in rural Uganda,To determine the prevalence of dyslipidemia and the associated factors among PLHIV attending the HIV clinic at Gombe hospital.,
Uganda 2024-11-25 17:25:45 2027-11-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Dorit Stein Talia
ID: UNCST-2022-R010349
Modeling Health and Welfare Impacts of National Health Insurance in Uganda
REFNo: SS2522ES

To advance the use of routinely collected administrative data and simulation modeling for health policy decision-making in Uganda. ,To support evidence-based policy debates around what outcomes a national health insurance program should achieve, for whom, how, and at what cost. ,To quantify the distributional health and financial risk protection benefits that may occur from scaling-up a benefits package of health interventions for the most common chronic diseases in Uganda (i.e., cardiovascular diseases, cancers, diabetes).,This study aims to generate empirical evidence on the potential population health, poverty alleviation, and equity impacts of increasing public expenditure on health in the form of a national health insurance scheme in Uganda.,
USA 2024-11-25 17:24:28 2027-11-25 Social Science and Humanities Non-Clinical Trial Degree Award
ERIC WOBUDEYA
ID: UNCST-2019-R001047
Rapid Research for Diagnostics Development TB Network in children and Assessing Diagnostics at POC for TB in children (R2D2_ADAPT Kids)
REFNo: HS5144ES

1. To validate the diagnostic accuracy of design-locked novel TB tests in children with presumptive intrathoracic TB overall and in key sub-groups to inform policy development.
2. To assess the usability and acceptability of design-locked novel TB tests for children.

Uganda 2024-11-25 17:23:03 2027-11-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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