Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Adeodata Rukyalekere Kekitiinwa
ID: UNCST-2019-R000799
 An evaluation protocol by Baylor-Uganda titled: Leveraging on the Orphan and Vulnerable Children (OVC) platform to Improve TB case finding, TB Preventive therapy and TB treatment outcomes under ACE-FORT Project
REFNo: HS2534ES

1) Conduct a baseline TB/HIV performance indicator assessment among OVC supported under the ACE-Fort project.
2) Compare TB case finding, prevention and treatment outcomes before and after implementing accelerated TB-OVC integrated services,
3) Describe geographical hotspots with high number of OVC with TB under the ACE-Fort Project.,
4) Evaluate adoption and contextual factors influencing implementation of the accelerated TB-OVC integration services by CSO staff,
5) Estimate the cost of implementing accelerated TB-OVC integration services under the ACE-Fort Project.

Uganda 2022-11-28 11:40:05 2025-11-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Moses  Mulumba
ID: UNCST-2021-R013832
 REGULATING THE MIGRATION OF HEALTH APPS IN UGANDA
REFNo: SS1500ES

The goal of this research is to contribute to the development of a conceptual framework of digital health coloniality as a way of understanding and contesting the digital inequalities that the migration of mHealth data out of Africa cause.

Research Objectives:
- To document future risks of data migration as a form of digital health colonialism while benchmarking on stories of data misuse.

- To establish whether or not contract law reinforces digital health colonialism through the migration of data.
 Uganda 2022-11-28 11:18:32 2025-11-28 Social Science and Humanities Non-Clinical Trial Non-degree Award
Waiswa Peter
ID: UNCST-2020-R014921
 Improving vaccine knowledge and misinformation resistance through the mobile-based game Cranky Uncle: Vaccine Edition
REFNo: HS2519ES

To explore the game's effectiveness across different segments of the population, age groups and education levels.,To evaluate the impact of the mobile game on vaccine knowledge, acceptance and intent and ability to detect misinformation,To explore the resistance/ability to detect different types of misinformation after playing the CU game.,To assess vaccine knowledge, acceptance, and intent after playing the CU game.,To test the effect of the Cranky Uncle mobile game on vaccine knowledge, acceptance, and intent and resistance/ability to detect different types of misinformation through playing the game ,To establish whether the Cranky Uncle game significantly increases vaccine knowledge, acceptance and intent, and resistance to misinformation. If there are areas where the game is ineffective, these findings will inform attempts to improve the game’s performance in these areas.,
 Uganda 2022-11-28 11:15:54 2025-11-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bonny Aloka
ID: UNCST-2022-R010624
 Development and Evaluation of Nutrient-Dense Composite from Local Food Materials to Manage Moderate Acute Malnutrition (MAM) and Nodding Syndrome in northern Uganda
REFNo: A234ES

3. To investigate the stakeholder perception regarding the nutrient dense composites developed to manage MAM and NS in Acholi and Lango sub-regions,To evaluate the efficacy of the recipes in improving the conditions of clients with MAM and nodding syndrome in Acholi and Lango sub-regions,To test the level of acceptability of the developed composites by the selected mothers/care takers and their children in Acholi and Lango sub-regions,To develop a nutrient dense composites from local food materials to manage MAM and nodding syndrome in Lango and Acholi sub-regions,To develop a nutrient dense composite from local food materials to manage moderate acute malnutrition (MAM) and nodding syndrome in Lango and Acholi sub-regions in northern Uganda.,
 Uganda 2022-11-28 11:12:34 2025-11-28 Agricultural Sciences Clinical Trial Non-degree Award
Annet Onzia Aketoko Aketoko
ID: UNCST-2021-R012391
 Reducing maternal and congenital syphilis in Uganda. A mixed methods observational study
REFNo: HS2436ES

Qualitative objectives:
1. To understand experiences of women who test positive for syphilis during pregnancy and learn how to better support them.
2. Explore participants’ views on syphilis related birth outcome and treatment of new babies with syphilis.
3. To explore attitudes towards syphilis testing and treatment in male partners of syphilis positive women.
4. To assess barriers and enablers to elimination of maternal and congenital syphilis among stakeholders (health care workers in ANC units, policy makers-MoH).

Quantitative objectives: Through use of routinely collected data
1. To evaluate the birth outcomes in mothers who received syphilis treatment during ANC period.
2. To document number of babies who test RPR/TPHA positive at birth.
3. To document the number of partners that were notified, tested and received treatment for Syphilis
4. To assess the proportion of mothers who tested syphilis positive and those that utilized mhealth

 Uganda 2022-11-28 10:36:50 2025-11-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 Ring vaccination trial to evaluate the efficacy and safety of Sudan ebolavirus vaccines in Uganda
REFNo: HS2574ES

Probable SUVD and death from confirmed SUVD ,main secondary objective is to assess the safety of the vaccine by monitoring weekly for 21 days any adverse reactions to vaccination and any other serious adverse events,The primary analysis will be of laboratory-confirmed SUVD (from samples taken either while living, or within 48 hours of death),
 Uganda 2022-11-23 15:04:05 2025-11-23 Medical and Health Sciences Clinical Trial Non-degree Award
David Mukunya
ID: UNCST-2022-R010707
 Cerebral Oximetry, Metabolism and Perfusion for Prognosis And Management of Asphyxiated Neonates (COMPPAMAN) in eastern Uganda: a pilot study
REFNo: HS2551ES

1. To demonstrate the feasibility of monitoring cerebral tissue oxygenation (SO2), cerebral blow flow (CBF) and cerebral oxygen metabolism (CMRO2) among asphyxiated neonates and preterm infants in Jinja Regional Referral Hospital (Jinja RRH).
2. To determine evolution of post-natal cerebral hemodynamics and oxygen metabolism in asphyxiated and preterm infants in the first week of life. Specifically, we will
a. Perform several (daily) NIRS measurements over days on asphyxiated and preterm infants and up to two measurements on term newborns without evidence brain injury.
b. Compare these results in the first week of life with different etiologies of brain injury (hypoxia vs IVH) and controls.
c. Correlate NIRS results with the severity of brain insults determined by ultrasound.
H2.1 Asphyxiated neonates and preterm infants have lower Day 1 CBF and CMRO2 than controls.
H2.2 The decrease in CBF and CMRO2 is in proportion to the severity of brain injury.
3. To determine the predictive values of SO2, CBF and CMRO2 in neonatal mortality in the first week of life.
Gather data as in Aim 2.
H3.1 Cerebral hemodynamics and metabolism in the first week of life are sensitive biomarkers for mortality prediction.
H3.2 Changes in CBF and CMRO2 with age will add to the predictive value of mortality model at one week of life.

 Uganda 2022-11-23 12:51:56 2025-11-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Christopher Muteesasira
ID:
Predicting Research Productivity of Academic Staff with PhDs in Universities in Uganda Using Bean's Model
REFNo: SS1521ES

To examine whether the individual variables in Bean’s model mediate the relationship between organisational variables and individual research productivity.,To examine whether organisational variables in Bean’s model predict individual variables.,To examine whether individual variables in Bean’s model predict individual research productivity.,To examine whether organisational variables in Bean’s model predict individual research productivity.,To examine whether Bean’s (1982) model can be used to predict research productivity of a member of academic staff with a PhD in a university in Uganda. ,
 Uganda 2022-11-23 12:50:38 2025-11-23 Social Science and Humanities Non-Clinical Trial Degree Award
PROSSY NANTALE NABATTE
ID:
CHARACTERIZATION OF HUMAN PAPILLOMAVIRUS GENOTYPES AND THEIR CORRELATES AMONG WOMEN LIVING WITH HIV ATTENDING ANTIRETROVIRAL THERAPY CLINIC IN MUKONO, UGANDA
REFNo: HS2550ES

To assess how medical history predisposes women living with HIV to Human papillomavirus genotypes in Mukono.,To establish how sexual practices predisposes women living with HIV to Human papillomavirus genotypes in Mukono.,To identify how socio-demographic factors predispose women living with HIV to Human papillomavirus genotypes in Mukono.,To describe the characteristics of Human papillomavirus genotypes among a cohort of WLHIV attending antiretroviral therapy clinic in Mukono, Uganda.,To explore the types and occurrence of HPV infection by genotyping Human papillomavirus among a cohort of WLHIV attending antiretroviral therapy clinic in Mukono, Uganda. ,
 Uganda 2022-11-23 12:47:55 2025-11-23 Medical and Health Sciences Non-Clinical Trial Degree Award
Christine Nalwadda Kayemba
ID: UNCST-2020-R014220
 Final evaluation of Our Rights, Our Lives, Our Future (O3) Programme
REFNo: SS1515ES

2. Assess progress against targets set at baseline, validate, and populate the results framework.,4. Provide conclusions and actionable recommendations that can shape future programming and implementation by UNESCO of initiatives to advance education, health and wellbeing of AYP.,3. Identify opportunities, challenges, good practices, and lessons that will be useful for strengthening and enhancing the design and implementation of the next phase of the programme.,1. Ascertain the effectiveness (results/impact), efficiency, and sustainability of the O3Programme,The overall goal of this final evaluation is to provide UNESCO with a systematic assessment of the full implementation period of the O3 Programme (2018-2022) across all 33 countries. This assessment will analyse both expected and unexpected results and how these were achieved; capture challenges faced and measures taken to adapt and respond to these challenges; and extract good practices and lessons learned.,
 Uganda 2022-11-23 12:46:32 2025-11-23 Social Science and Humanities Non-degree Award
Emma Ndagire Tina
ID: UNCST-2022-R010041
 Assessing the Feasibility of adopting an Acute Rheumatic Fever Diagnosis and Management Algorithm in Uganda
REFNo: HS2542ES

1. Determine how accurately frontline health care providers at selected health facilities in Wakiso district implement the ARF algorithm in Uganda.

2. To determine the factors that will influence the adoption of a novel ARF diagnostic and management algorithm by health care providers at selected community health facilities in Wakiso district.

 Uganda 2022-11-23 12:42:36 2025-11-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jonathan Izudi
ID: UNCST-2019-R000469
 Effectiveness of Intensive Adherence Counselling on Viral Load Suppression among Adolescents and Adults Living with HIV in Uganda
REFNo: HS2553ES

o explore the facilitators of and barriers to repeat VL suppression after IAC completion among adolescents and adults on ART with an initial VL ≥1,000 copies/ml after ≥6 months of ART in Kampala, Uganda using a qualitative case study design (Aim 3),To examine the risk factors for repeat VL persisting at ≥1,000 copies/ml after completing IAC among adolescents and adults on ART with an initial VL ≥1,000 copies/ml after ≥6 months of ART in Kampala, Uganda using a nested case-control study design.,To evaluate the impact of IAC on VL suppression and all-cause mortality among adolescents and adults on ART with VL ≥1,000 copies/ml after ≥6 months of ART in Kampala, Uganda using a regression discontinuity design,
 Uganda 2022-11-23 12:41:12 2025-11-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Muniirah Mbabazi
ID:
Gender dynamics in accessing and utilizing Nutrition and WASH services-An exploratory study.RefNO:2022-392
REFNo: HS2544ES

Document key recommendations for advocacy on gender, nutrition and WASH and local and national levels.,Examine how gender dynamics influence access and utilisation of nutrition and WASH services at household and community levels in Maracha and Bugweri districts,Undertake a document review to identify policy gaps in key policy documents on nutrition, WASH and gender in Uganda,To examine how gender dynamics shape access and utilisation of WASH and nutrition services in promoting women’s leadership, decision making, promoting equal and positive gender norms, improving access to resources as well as building contextual research evidence on local resilience, sustainability in Maracha and Bugweri districts in Uganda,
 Uganda 2022-11-23 12:39:59 2025-11-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Andrew Hope
ID:
Strengthening national capacity for tsetse control in Uganda
REFNo: SS1490ES

The primary aim of this study is to monitor and assess the implementation of the action plan to strengthen the capacity for implementing tsetse control at COCTU and in the Districts where tiny targets are deployed. This study will follow-up on the capacity strengthening action plan developed in 2017 with the aim to enable COCTU to implement tsetse control for gHAT independently of LSTM.
The aims will be achieved by the following objectives:
1. Conduct semi-structured interviews with key personnel at COCTU and the District level to fully understand the current level of execution of the action plan for strengthening the capacity to for implementing tsetse control in Uganda.

2. Conduct participatory meeting at the District level with COCTU and District staff to collaboratively assess the progress towards the establishment of a stronger and independent tsetse control system in Uganda (based on findings from objective 1).

UK 2022-11-23 12:38:07 2025-11-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
Yunia Mayanja
ID:
Improving HIV Prevention among Adolescent Girls and Young Women in Uganda.
REFNo: HS2490ES

The purpose of the PhD project is to determine preferences for biomedical HIV prevention methods among 14-24-year-old adolescent girls and young women (AGYW) at risk of HIV infection and to evaluate a peer support intervention aimed at improving uptake of and adherence to oral pre-exposure prophylaxis (PrEP). Main Study Aims: i) To determine preferences for five biomedical HIV prevention methods among 14-24-year-old AGYW at risk of HIV infection in Kampala, Uganda including oral PrEP, injectable PrEP, vaginal ring, PrEP implant and HIV vaccine. ii) To evaluate a peer support intervention aimed at improving uptake of and adherence to oral pre-exposure prophylaxis (PrEP), the only currently available biomedical HIV prevention method in Uganda. Study Objectives: i. To determine preferences for five biomedical HIV prevention methods among 14-24-year-old AGYW in Kampala, Uganda, and determine factors associated with preference for oral PrEP. ii. To evaluate the effect of a peer support intervention on uptake of and adherence to oral PrEP among 14-24-year-old AGYW at risk of HIV infection in Kampala, Uganda. iii. To evaluate the effect of a peer support intervention aimed at improving oral PrEP uptake and adherence, on sexual behavior and reproductive health outcomes among AGYW in Kampala, Uganda. iv. To explore AGYW perceptions and experiences of the peer support intervention aimed at improving oral PrEP uptake and adherence.
Uganda 2022-11-23 12:36:50 2025-11-23 Medical and Health Sciences Non-Clinical Trial Degree Award
Grace  Kentaro Maria
ID:
FEMININE IDENTITY IN ANTI-COLONIAL STRUGGLES: THE LEGACY OF MUHUMUZA OF NYABINGI MOVEMENT IN KIGEZI, UGANDA
REFNo: SS1144ES

1. To trace the origins of the Nyabingi Movement to 1900 and its goals in the history of Kigezi
2. To assess the contribution of Nyabingi movement in the anti-colonial struggles
3. To examine the contribution of Muhumuza in anti-colonial struggle as a role model in demonstrating women leadership to other women in other struggles
4. To examine the role of oral history in portraying women’s and men’s roles in anti-colonial struggles

 Uganda 2022-11-23 12:32:43 2025-11-23 Social Science and Humanities Non-Clinical Trial Degree Award
JOSEPH MWESIGWA SAMUEL
ID:
THE SELECTION OF TECHNICAL AND VOCATIONAL EDUCATION AND TRAINING OPTION BY SECONDARY SCHOOL CANDIDATES IN UGANDA
REFNo: SIR99ES

To establish the awareness of parents of students in secondary schools in Uganda about the TVET option as a career choice for their children.,To investigate the method of course selection by TVET college students in Uganda.,To determine the perception of secondary school teachers in Uganda on TVET as a career choice by the candidates.,To investigate the availability of career guidance information to secondary school candidates on TVET courses in Uganda.,The main objective of the study will be to establish the factors influencing the selection of TVET option by secondary school candidates in Uganda. ,
 Uganda 2022-11-23 12:29:54 2025-11-23 Engineering and Technology Non-Clinical Trial Degree Award
Viola  Nyakato Nilah
ID: UNCST-2021-R013698
 Community-based Alternative Learning Environments for Parenting and Pregnant Teens: A Response to Uganda’s Increased Prevalence Due to the Impact of the COVID-19 Global Pandemic
REFNo: SS1487ES

This research aims to conduct a participatory assessment of factors that enhance adoption of alternative education environments for parenting and pregnant teens by involving communities in reflecting on and defining special needs for school re-entry and providing for second-chance education after pregnancy in Uganda.,To comprehensively disseminate the recommendations and guidelines for policy uptake,To co-create policy recommendations for community-based alternative education environments for parenting and pregnant teens,To conduct participatory multi-level needs assessment and policy pecommendations ,
 Uganda 2022-11-23 12:28:32 2025-11-23 Social Science and Humanities Non-Clinical Trial Degree Award
Emmy Okello
ID: UNCST-2020-R009792
 Accelerating Delivery of rheUmatic heart disease preventive iNterventions in Uganda (ADUNU)
REFNo: HS2470ES

Objective 1: Demonstrate the impact of ADUNU, using the RE-AIM framework to assess program Reach,
Effectiveness, Adoption, Implementation, and Maintenance. Objective 1 has five sub-objectives:
a) Reach – Use echocardiography to increase the proportion of individuals with RHD who are detected, including identification of sub-groups not reached (target: 50% Kitgum district] or 25% [Amuru district] detected).


b) Effectiveness – Achieve goals in (1) registry enrollment (target: 90% of those diagnosed by RHD testing), (2) retention (target: 90% of those enrolled), and (3) adherence (target: 90% of those retained).

c) Adoption – Assess the proportion of healthcare facilities and providers that adopt ADUNU and understand barriers and facilitators to adoption success.

d) Implementation – Assess the proportion of healthcare providers and facilities demonstrating high fidelity to the relevant ADUNU components and protocols in which they have been trained and reasons for suboptimal performance.

e) Maintenance – Understand the (1) proportion of facilities and providers continuing to implement ADUNU as designed, and (2) sustainment of retention and adherence levels among individuals enrolled in the registry at 24 months post-introduction

Objective 2: Estimate the cost-effectiveness and budget impact of ADUNU. This objective will build on the first objective and will use standard methods for economic evaluation of health programmes.

 Uganda 2022-11-23 12:26:29 2025-11-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Filippo Grisolia
ID:
One for all and all for cash? An inquiry into social network and collective action effects of cash transfers in rural Uganda
REFNo: SS1467ES

Focus on social capital, agency and collective action measures,Focus on climate change adaptation and mitigation patterns,Investigate CT effects,
 Italy 2022-11-17 3:55:31 2025-11-17 Social Science and Humanities Non-Clinical Trial Degree Award
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