Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
Search By Approval Date:
Clear Filter Total: 6,261
Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Adoke Yeka
ID: UNCST-2021-R004300
An adaptive, randomized, active-controlled, open-label, sequential cohort, multicenter study to evaluate the efficacy, safety, tolerability and pharmacokinetics of intravenous cipargamin (KAE609) in adult and pediatric participants with severe Plasmodium falciparum malaria (KARISMA – KAE609’s Role In Severe Malaria)
REFNo: HS1980ES

Primary objective
To assess the efficacy of different doses of
intravenous cipargamin vs artesunate by evaluating the proportion of
participants with ? 90% reduction of parasitemia at 12 hours post
administration of the first dose.

Secondary Objectives
1. To assess the presence/absence of severe malaria related individual
signs over time
2. To evaluate parasite clearance dynamics and proportion of participants
with recrudescence and reinfection
3. To assess recovery of participants as measured by time (days and hours)
to discharge from hospital or recovery from prostration
4. To evaluate the safety and tolerability of IV cipargamin
5. To assess the risk of long term neurological sequelae for participants at
Day 29
6. The assess the risk of hemolysis (early and delayed) during the study
duration
7. To characterize the plasma pharmacokinetics of IV cipargamin

Uganda 2023-08-18 9:05:14 2026-08-18 Medical and Health Sciences Clinical Trial Non-degree Award
Juliane Etima
ID: UNCST-2022-R008983
Young Generation Alive Survey: Determining Knowledge, Aspirations, and Behaviors of Ugandan Adolescents and Young People Living with HIV.
REFNo: SS1910ES

To understand the HIV knowledge and behaviors among HIV+ and perinatally exposed adolescents and young people in Uganda with respect to achieving career aspirations, financial security, and safe intimate relationships.,
Uganda 2023-08-15 15:43:39 2026-08-15 Social Science and Humanities Non-Clinical Trial Non-degree Award
Fiona Ssozi Catherine
ID:
PATHWAYS TO CHANGE: TOWARDS GENDER JUSTICE IN SCIENCE, ENGINEERING, TECHNOLOGY AND MATHEMATICS (STEM) RESEARCH IN AFRICA (GEJUSTA)
REFNo: SIR240ES

Primary objective: Examine causes of under-representation and reframe Gender Analysis in STEM in Africa
Secondary objectives: Map under-representation, barriers and support mechanisms; explore STEA+M approaches; Develop Gender-aware design methodologies; Develop a support network for mentoring early-career female researchers

Uganda 2023-08-15 15:42:06 2026-08-15 Engineering and Technology Non-Clinical Trial Non-degree Award
Jesca Nantume
ID: UNCST-2021-R013984
EVALUATING EQUITABLE ACCESS TO HEALTH SERVICES FOR SCHISTOSOMIASIS IN COMMUNITY-BASED HEALTH CENTERS; A MIXED METHODS CROSSECTIONAL STUDY IN MAYUGE AND KALUNGU DISTRICT IN UGANDA
REFNo: SS1887ES

3. To identify and understand the barriers that hinder equitable access to health services for schistosomiasis, including socio-economic factors such as income, education level, and employment status, as well as cultural beliefs, attitudes, and practices that affect healthcare-seeking behaviors.,2. To evaluate the accessibility of health services for schistosomiasis in terms of geographical proximity, transportation, cost, and waiting times for individuals seeking diagnosis, treatment, and follow-up care.,1. To assess the availability of health services for schistosomiasis in community-based health centers in Mayuge and Kalungu Districts, Uganda, including the availability of diagnostic tools, treatment options, and healthcare professionals trained in schistosomiasis management.,The main aim of the study is to assess and evaluate the level of equitable access to health services for schistosomiasis in community-based health centers in Mayuge and Kalungu Districts, Uganda, by considering various factors such as availability, accessibility, utilization, and quality of services. The objective is to gain a comprehensive understanding of the barriers and facilitators that impact equitable access to schistosomiasis healthcare services, including the influence of socio-economic factors, cultural beliefs, knowledge and awareness levels, and gender dynamics.,
Uganda 2023-08-15 15:40:28 2026-08-15 Social Science and Humanities Non-Clinical Trial Non-degree Award
Alison Elliott
ID: UNCST-2023-R006524
Understanding the role of, and relationship between, structural, social and biological determinants of vaccine response to improve vaccine impact in Kenya and Uganda: a formative study.
REFNo: HS2901ES

1. To conduct a scoping review exploring how social, structural and biological drivers interact to influence vaccine response. 2. To undertake formative ethnographic case studies to investigate these interactions in two communities where biological factors are known to influence vaccine response. 3. To map stakeholders and influencers critical to vaccine impact in Uganda and Kenya. 4. To work with stakeholders and communities to co-design the VAnguard community surveys to be conducted in year 2 of the programme
UK 2023-08-10 15:46:52 2026-08-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sylivia Namwano
ID: UNCST-2023-R008071
A pragmatic early detection and warning model for reduction of landslide effects for communities at risk
REFNo: SIR243ES

To evaluate the efficiency, reliability, effectiveness and usability of the designed pragmatic early detection and warning model for reduction of landslide effects for communities at risk,To establish ideal characteristic of an effective and efficient landslide early detection and warning systems for communities at risk,To design a pragmatic early detection and warning model for reduction of landslide effects for communities at risk,
Uganda 2023-08-10 15:22:18 2026-08-10 Engineering and Technology Non-Clinical Trial Degree Award
Brian Mikka
ID:
Prevalence and factors associated with low-level viremia in HIV patients on NNRTIs substituted to dolutegravir-based regimen at Kitebi health center
REFNo: NS627ES

To determine the factors associated with LLV among PLHIV who were substituted to DTG-based regimens at Kitebi health centre.,To determine the prevalence of LLV among PLHIV substituted to DTG-based regimen at Kitebi health centre.,To determine the prevalence and factors associated with low-level viremia among patients substituted from NNRTIs to dolutegravir- based first-line regimen at Kitebi health centre.,
Uganda 2023-08-10 15:19:55 2026-08-10 Natural Sciences Non-Clinical Trial Degree Award
Ruth Namazzi
ID: UNCST-2020-R014305
Full Assessment of Clinical Transfusion Support (FACTS): An assessment of hematologic diseases among blood transfusion recipients and donated units at a pediatric regional referral hospital in Uganda
REFNo: HS2908ES

To determine the prevalence of SCA among children requiring blood transfusions at the children’s ward of the Jinja Regional Referral Hospital (JRRH) • To determine the prevalence of malaria parasitemia among children requiring blood transfusions at the children’s ward of the Jinja Regional Referral Hospital • To determine the prevalence of malaria parasitemia among donated, transfused blood units • To determine the incidence of iron deficiency among transfusion recipients donated, transfused blood units • To determine the RBC RhCE and Kell antigen profile on donated units and transfusion recipients
Uganda 2023-08-10 13:53:54 2026-08-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Henry Mugerwa
ID: UNCST-2019-R000420
PLATINUM: A multi-part, multi-center PLATform study to assess the efficacy, safety, tolerability and pharmacokinetics of anti-malarial agents administered as monotherapy at multiple dose levels and/or combination therapy IN patients with Uncomplicated Plasmodium falciparum Malaria
REFNo: HS2748ES

Main Objectives:
1. Part A: To assess the parasite clearance time (PCT) of oral doses of an anti- malarial agent administered as monotherapy in patients with uncomplicated P. falciparum malaria
2. Part B: To assess the effect on adjusted 28-day cure rate of an anti-malarial agent administered orally as combination therapy versus the standard of care (SoC) in patients with uncomplicated P. falciparum malaria

Secondary Objectives
1. Part A: To assess the effect on adjusted 28-day cure rate of an anti-malarial agent administered orally as monotherapy in patients with uncomplicated P. falciparum malaria
2. Part B: To assess the parasite clearance time (PCT) of oral combinations of anti-malarial agents versus SoC in patients with uncomplicated P. falciparum malaria
3. To characterize PK of each anti-malarial agent administered orally as monotherapy [Part A] and/or as combination therapy [Part B] in patients with uncomplicated P. falciparum malaria
4. To assess the safety and tolerability of each anti-malarial agent administered orally as monotherapy [Part A] and/or as combination therapy versus SoC [Part B] in patients with uncomplicated P. falciparum malaria
Uganda 2023-08-10 13:49:44 2026-08-10 Medical and Health Sciences Clinical Trial Non-degree Award
ANITA MUHAIRWE
ID:
CORPORATE GOVERNANCE ROLES AND EMPLOYEE SATISFACTION IN HIGHER EDUCATION INSTITUTIONS: A CASE OF SELECTED PRIVATE UNIVERSITIES IN UGANDA
REFNo: NS618ES

iii. To assess the effect of corporate governance roles on employee satisfaction in selected private universities in Uganda ,ii. To analyze the contribution of work environment to employee satisfaction in selected private universities in Uganda.,i. To assess the relationship of corporate governance roles and work environment in selected private universities in Uganda. ,
Uganda 2023-08-08 15:05:06 2026-08-08 Natural Sciences Non-Clinical Trial Degree Award
Ezekiel Mupere
ID: UNCST-2021-R012739
Assessing the effect of mealworm consumption and production on nutrition and health status of children in refugee and host communities in Western Uganda, a Refugee Insect Production For Food and Feed ( RefIPro) Project
REFNo: HS3071ES

D. To assess child anthropometrics/growth and dietary intake over 6 months in preparation for a mealworm-based school meal intervention study,C. To develop a nutritious school meal enhanced with mealworm and with high acceptability among the target group of school children,B. To assess the progress of building the capacity for scaling up mealworm production including identifying local feed substrate and assess the implementation processes in the local context ,A. To assess barriers and drivers among key stakeholders (farmers, farmers associations, school heads/teachers/parents/children) of mealworm consumption and production for sale ,Improving nutrition and health of refugee and host community children through the production of mealworm,
Uganda 2023-08-08 12:45:34 2026-08-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bernard Kikaire
ID:
Effect of an interactive SMS system in improving the reporting of adverse drug reactions among people living with HIV in Tanzania and Uganda: a randomized controlled trial: The REMIND ADR TRIAL
REFNo: HS2922ES


To investigate the effectiveness of SMS reminders on improving ADR reporting compared to no SMS among people living with HIV in Tanzania and Kampala Uganda.
To describe the most commonly reported ADR profiles among people living with HIV in Tanzania and Uganda.
To determine the most common routes/ methods of reporting ADR used by PLHIV.
To explore the causal relationship between the commonly reported ADRs and ART.
To improve treatment options for participants who reported ADR.
To explore the technical feasibility and acceptability of the intervention in reporting ADR among PLHIV.

Uganda 2023-08-08 12:42:32 2026-08-08 Medical and Health Sciences Clinical Trial Non-degree Award
Joseph Lutaakome
ID: UNCST-2020-R008323
Strategies and Treatments for Respiratory Infections & Viral Emergencies (STRIVE)
REFNo: HS2703ES

Strategies and Treatments for Respiratory Infections & Viral Emergencies (STRIVE) is a master protocol being conducted in many countries around the world, and funded by the National Institutes of Health, USA. STRIVE will evaluate the safety and effectiveness of unlicensed and licensed treatments and different combinations of treatments, to improve the health outcomes of adults
hospitalised with acute respiratory infections, like COVID-19 or influenza.
Uganda 2023-08-08 12:39:21 2026-08-08 Medical and Health Sciences Clinical Trial Non-degree Award
Mathias Gerecht
ID:
Colonialism and racism in Uganda : a study of racial speeches and policies in the Western province (1890-1962)
REFNo: SS1854ES

1. Showing which racial theories and stereotypes were developed by which colonial actors and when.
2. Understanding how these racial theories and stereotypes were developed (how was this knowledge constructed ?)
3. Analysing the various ways the Ugandan people reacted to this racism.

France 2023-08-08 12:33:56 2026-08-08 Social Science and Humanities Non-Clinical Trial Degree Award
BARBARA NAGGAYI RITA
ID: UNCST-2019-R000062
Digital Storytelling for Global Health Research and Action
REFNo: SS1603ES

Preparing an evidence-based, practice-informed, GH focused DST package consisting of guidelines, recommendations, and innovation, which can be adapted in Phase 2 into tools and training materials for sharing with others in Canada and beyond.,
Uganda 2023-08-07 16:22:34 2026-08-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
Ronald Nkangi
ID: UNCST-2021-R012153
Role and clinical significance of unconventional gamma delta T cell in cervical cancer and HIV- 1 co-infection
REFNo: HS2832ES

To assess the association of frequency and functions of ?? T cell with clinicopathological characteristics of Cervical cancer among women living with HIV infection ,To assess the cytotoxic effects of ?? T cell among women living with cervical cancer and HIV co-morbidity,To assess the immune phenotypes of the ?? T cells among women living with cervical cancer and HIV co-morbidity.,To assess the frequencies of different subsets of ?? T cells in peripheral blood among women living with cervical cancer and HIV co-infection.,To investigate the role and clinical significance of gamma delta (??) T cells among the women with cervical cancer and HIV co-morbidity.,
Uganda 2023-08-07 16:18:49 2026-08-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rapheal Wangalwa
ID: UNCST-2022-R008718
Ecological niche modelling of at-risk medicinal plants in a changing climate in Uganda: A case of Warburgia ugandensis
REFNo: NS466ES

To model the potential distribution area of Warburgia ugandensis under the current environmental conditions and predict its distribution under various future climate change scenarios
Uganda 2023-08-07 16:17:48 2026-08-07 Natural Sciences Non-Clinical Trial Non-degree Award
Yang Jae Lee
ID: UNCST-2021-R012449
Mental Health Stigma in Rural Uganda
REFNo: SS1860ES

D. Radio Drama's Effects on Stigma: Develop a radio drama designed to communicate de-stigmatizing information about mental health and measure differences in stigma and likelihood of seeking treatment among those exposed to radio theater and those not exposed. ,C. Attitudes and Stigma towards Mental Illness in Healthcare Seeking Population: To evaluate both the prevalence of and attitudes and stigma towards mental illness in healthcare seeking population to assess their subjective reasons for seeking healthcare and currently accesible treatment modalities for mental distress. Through illuminating the current definitions and practices for mental illness, future interventions can be targeted to build upon current community definitions and structures for mental illness. ,B. Stigma and Suicidality: Evaluate experience of individuals with history of suicidality and their families to understand current practices and attitudes, as well as stigma experienced from disclosure of suicidality. Stigma of suicidality could impact treatment seeking as well as recurrence of suicidality, and it is critical to understand it.,A. Pathways to Care: To assess mental health attitudes, practice, stigma and the feasibility of collaboration among key individuals on potential pathways to care including traditional healers, families of individuals with mental illness, individuals with mental illness, health workers, and religious leaders through qualitative and quantitative, or mixed, methods. Elucidating pathways to care is critical for finding bottlenecks in obtaining treatment for future interventions. A particular focus will be developing ageement on potential forms of collaboration acceptable to the different parties. ,
USA 2023-08-07 15:23:20 2026-08-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
Simon  Okongo
ID:
PREVALENCE, ASSOCIATED FACTORS, AND CUTANEOUS EFFECTS OF SKIN LIGHTENING AMONG PATIENTS AT MBARARA REGIONAL REFERRAL HOSPITAL SKIN CLINIC. RefNO: SS1867ES
REFNo: SS1867ES

To determine the cutaneous effects of skin lightening among MRRH skin clinic patients. ,To identify the factors associated with skin lightening among MRRH skin clinic patients.,To establish the prevalence of skin lightening among MRRH skin clinic patients.,To establish the prevalence, the associated factors, and cutaneous effects of skin lightening among MRRH skin clinic patients.,
Uganda 2023-08-07 15:22:35 2026-08-07 Social Science and Humanities Non-Clinical Trial Degree Award
Juliet Namukasa
ID:
Low-carbon Mobility in Kampala: User perspectives and practices on walking, cycling and public transport.
REFNo: SS1921ES

The following research questions will be addressed: i. What factors have influenced the adoption and non-adoption of low-carbon mobility transport modes by Kampala’s every day travelers? Who is adopting what (choice of modes), how frequently and why? ii. Is there an enabling environment that supports adoption and implementation of low-carbon mobility modes of transport? How are new infrastructures connected to these mobility modes and domesticated? iii. What strategies should be in place to support more widespread usage of low-carbon mobility modes of transport (including shared solutions) and how can the middle class be encouraged to use mass transportation modes? iv. What is the potential of e-mobility being introduced in Uganda to replace the fossil fuelled vehicles?
Uganda 2023-08-07 15:21:03 2026-08-07 Social Science and Humanities Non-Clinical Trial Degree Award
View Sort By:

"A prosperous Science and Technology Led Ugandan Society."