Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Ronald Opito
ID: UNCST-2022-R011357
 PROFILING THE DISEASE BURDEN IN TESO THROUGH COMMUNITY BASED MEDICAL EDUCATION AND RESEARCH SERVICES AT SOROTI UNIVERSITY, A PROSPECTIVE STUDY. (PRODIB_COBMERS).
REFNo: HS6508ES

1. Assess the prevalence of common non-communicable disease (NCDs) in Teso subregion and the capacity of the health workers to diagnose them.
2. To determine the trends of common infectious diseases over a period of 10 years. (TB, Malaria, UTIs, hepatitis B, STIs, RTIs etc) within the Teso sub-region and assess the effectiveness in the preventive measures over the same period.
3. To establish the prevalence of common NTDs (Schistosomiasis, Onchocerciasis, trypanosomiasis etc) around wetland communities in eastern Uganda and the effectiveness of control measures.
Uganda 2025-09-12 16:20:07 2028-09-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Seju Kang
ID: UNCST-2024-R015536
 Developing Environmental Wastewater-Based Surveillance in Non-Sewered Areas in Low-Income Contexts
REFNo: HS5809ES

Research questions: To develop and validate a community-based environmental surveillance approach to detect infectious disease pathogens in urban areas with non-sewered sanitation. Objective 1: To design and implement a sampling plan that identifies high-risk locations for pathogens in non-sewered urban environments. Objective 2: To analyze pathogen levels and correlate findings with demographic and spatial data.
South Korea 2025-09-12 16:17:44 2028-09-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
alice namatovu
ID: UNCST-2025-R017415
 EVALUATION OF THE EFFECTIVENESS OF BACTERIOPHAGE COCKTAILS AGAINST MULTI-DRUG-RESISTANT BACTERIA ON PATIENTS WITH DIABETIC FOOT ULCERS ATTENDING SELECTED REFERRAL HOSPITALS IN UGANDA
REFNo: HS5652ES

Main objective:
To assess the efficacy of bacteriophages in the management of diabetic foot wounds/ulcers in animal models and among patients attending the selected referral hospitals in Uganda.

Specific Objectives
i) To determine the biological and genotypic characteristics of lytic bacteriophages against the MDR- bacteria isolated from diabetic wounds of patients.

ii) To determine the virulence genes of the bacteria isolated from DFU patients and those genes associated with antimicrobial resistance.
iii) Determine the phage receptor genes on the MDR bacteria isolated from DFU patients.

iv). To evaluate the effectiveness of the identified Bacteriophage preparation/cocktail in the healing of induced diabetic wounds in mice.
v). To evaluate the effectiveness of the identified bacteriophage preparation/cocktail in the healing of diabetic foot wounds on patients in selected referral hospitals in Uganda.

 Uganda 2025-09-12 16:14:57 2028-09-12 Medical and Health Sciences Clinical Trial Non-degree Award
Solomon Mbina Adomi
ID: UNCST-2024-R015658
 EFFECTS OF LYOPHILIZED LEAF EXTRACT OF KHAT (Catha edulis Forsk) ON HEPATORENAL SYSTEM AND LIPID METABOLISM IN HIGH FAT DIET INDUCED HYPERLIPIDEMIC MALE ALBINO WISTAR RATS
REFNo: HS5753ES

1. To characterize the bioactive compounds in lyophilized Catha edulis leaf extract using Gas chromatography-mass spectrometry (GC-MS) technique. 2. To determine the molecular interactions between bioactive compounds of Catha edulis leaf extract. and key proteins involved in lipid metabolism (leptin, adiponectin, and HMG-CoA reductase) using molecular docking analysis. 3. To determine the effect of lyophilized Catha edulis leaf extract on serum liver function parameters, (Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Alkaline Phosphatase (ALP), bilirubin, Albumin). in HFD-induced hyperlipidemic male albino Wistar rats. 4. To evaluate the effect of lyophilized Catha edulis leaf extract on kidney function indices (Urea, creatinine, serum electrolytes) in HFD-induced hyperlipidemic male albino Wistar rats. 5. To determine the effect of lyophilized Catha edulis leaf extract on serum leptin and adiponectin hormones levels in HFD-induced hyperlipidemic male albino Wistar rats. 6. To evaluate the effect of lyophilized Catha edulis leaf extract on serum lipid profile (Total cholesterol, High-density lipoprotein, low-density lipoproteins, and triglycerides) in HFD induced hyperlipidemic male albino Wistar rats. 7. To examine the effect of lyophilized Catha edulis leaf extract on the histology of the liver and kidney of HFD induced-hyperlipidemic male albino Wistar rats.
Nigeria 2025-09-12 16:13:25 2028-09-12 Medical and Health Sciences Non-Clinical Trial Degree Award
Magololo Mutesi Fiona
ID: UNCST-2024-R015533
 Changes in inpatient antibiotic use and antimicrobial resistance rates, through a collaborative quality improvement intervention: a study on adult surgical wards at Mulago National Referral Hospital.
REFNo: HS6321ES

4.1 Objectives. 4.1.1 General objective To reduce irrational inpatient antibiotic use by at least 10% in the adult surgical wards of Mulago National Referral Hospital using a collaborative quality improvement intervention approach. 4.1.2 Specific Objectives. 4.1.2.1 Specific Primary objectives. 1. To determine baseline and closeout rates of irrational inpatient antibiotic use in the adult surgical wards of Mulago National Referral Hospital at Month one and Month seven respectively. 2. To describe antimicrobial resistance rates and drug susceptibility patterns of commonly isolated bacterial pathogens obtained from patients admitted to the adult surgical wards of Mulago National Referral Hospital during the 24 months preceding this study (July 2023-June 2025). 3. To determine monthly rates of irrational antibiotic use on the adult surgical wards of Mulago National Referral Hospital from Month two to Month six, during the QI intervention implementation. 4. To explore health worker perceptions and lived experiences on antimicrobial resistance, antibiotic prescription and antimicrobial stewardship as well as the impact of AMR on the adult surgical wards of Mulago National Referral Hospital, at Month one and Month seven. 5. To reduce irrational antibiotic use by 10%, through developing and implementing a collaborative quality improvement intervention to on antimicrobial stewardship on the adult surgical wards of Mulago National Referral Hospital. 5.1.2.2 Specific Secondary objectives. 6. To describe the change in monthly rates of irrational inpatient antibiotic use following a quality improvement intervention in the adult surgical wards of Mulago National Referral Hospital. 7. To describe the relationship between irrational inpatient antibiotic use rates and antimicrobial resistance rates in adult gastrointestinal surgical wards of Mulago National Referral Hospital. 8. To describe the change in antimicrobial resistance rates and drug susceptibility profiles of isolates obtained from patients admitted to the adult surgical wards of Mulago National Referral Hospital during this study, compared to those of patients admitted in 24 months before this study (24 months preceding month 1).
Uganda 2025-09-12 12:24:29 2028-09-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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