Birungi Edwin Mutahunga Rwamatware
ID: UNCST-2021-R004880
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Prevalence and predictors of antimicrobial resistance in clinical- and community-acquired upper respiratory bacterial samples in children under 5 in south-western Uganda
REFNo: HS2625ES
Upper respiratory infections are the second leading cause of death in children under 5 in Uganda, and account for 40% of all under-5 outpatient attendance at clinics and hospitals nationwide in Uganda.
As bacterial cultures of lung aspirates are often not practical, the WHO recommends using a rapid breathing and chest wall in-drawing to diagnose pneumonia in children under 5, and recommends treatment with oral amoxicillin or co-trimoxazole, or intramuscular penicillin. The only study of anti-microbial resistance (AMR) in nasopharyngeal bacteria in Uganda comes from healthy children in the Iganga/Mayuge region (Eastern Uganda), where the authors found that one-third of children were given a self-prescribed antibiotic within the past two weeks for fever, running nose, or cough, that 60% carried Streptococcus pneumoniae, and that a high proportion (80% to 99%) of cultures were resistant to co-trimoxazole, penicillin, and oxacillin.
At Bwindi Community Hospital, suspected acute respiratory infections accounted for 75% of all under-5 outpatient diagnoses in 2015/2016, and are the most common reason for under-5 admissions to the Pediatrics Ward (e.g., 34% of 830 admissions in 2015/2016). In addition, the majority of antibiotics prescribed for both children and adults were for suspected acute respiratory illness (5,273 of 17,910 prescriptions). Our proposed study seeks to build on previous work concerning Antimicrobial Resistance in the developing world with a specific focus, on clinical- and community-acquired upper respiratory bacterial infections in children under 5 in southwestern Uganda, and it will be the first to analyse spatio-temporal patterns of resistance and explicitly link those patterns to cultural and social characteristics and behaviours on the ground as well as healthcare infrastructure.
We propose a multi-layered study to;
1) Analyze the prevalence and spatial associations of antibiotic resistance in nasopharyngeal bacterial isolates from children under 5 in the Bwindi Community Hospital (BCH) catchment area for a year in Kanungu District, Southwestern Uganda.
2) Assess the use of antibacterial drugs at home to treat acute respiratory illness in these children from children under 5 in the Bwindi Community Hospital (BCH) catchment area in Kanungu District
3) Assess practices of antibiotic distribution at drug shops in the BCH catchment region.
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Uganda |
2023-03-24 2:31:31 |
2026-03-24 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Alison Elliott
ID: UNCST-2023-R006524
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Investigating determinants of varying schistosomal morbidity among
preschool-age children in the Lake Albert and Lake Victoria regions: a cohort study by the
Uganda Schistosomiasis Multidisciplinary Research Center
REFNo: HS2568ES
Our main objective is to understand the biological determinants of severe Schistosoma
mansoni-associated morbidity and to identify better strategies for its prevention and
control.
Our specific objectives are to:
1. Compare, in pre-school age children, early-life Sm infection and Sm-specific
immune responses between Lake Albert and Lake Victoria regions and identify
co-exposures that modulate Schistosoma mansoni-specific immune responses
and morbidity risk
2. Determine if there is a parasite genetic basis for differential Schistosoma
mansoni morbidity
3. Determine how the population biological determinants of fresh-water snail
Biomphalaria spp. act as local epidemiological drivers of Schistosoma mansoni
|
UK |
2023-03-24 2:29:21 |
2026-03-24 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Olive Kobusingye Chifefe
ID:
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Building the evidence-base for the integration of rehabilitative services into health systems – a case study of clubfoot treatment in Uganda
REFNo: HS2614ES
The study has two aims, each with subsequent research questions:
Aim 1: To explore how policy makers, health providers, and caregivers define, understand and experience service integration and the potential implications for clubfoot treatment. (Qualitative)
• How do health care providers define and experience service integration, and what are the impacts of integration on their day-to-day clinical operations, workflow, and roles?
• How do district- and national-level bureaucrats and donors understand integration, and how does that shape integration of clubfoot treatment?
• How do caregivers understand and experience integration, and how does it impact their child’s treatment?
• How is the NCPU financed and what relationship does financial contribution have with integration?
Aim 2: To improve understanding of how the CAST mobile health application (CAST) impacts health providers’ behavior, and what potential impacts the CAST could have on service quality. (Mixed)
• What is the reach and adoption rate of CAST and its components among eligible Ugandan providers?
• How might CAST modify provider behavior at the facility level, both for clubfoot treatment and other services?
• How might the CAST facilitate quality of care and patient treatment?
o How do supportive services from MiracleFeet/CoRSU contribute to this? (e.g. training, supportive supervision, help desk)
o How does data from and usage of the Cast Community contribute to this?
• What is the potential future of the CAST if external support is withdrawn from clubfoot treatment and all services are fully managed by the public sector?
|
Uganda |
2023-03-24 2:25:26 |
2026-03-24 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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JOSELYN RWEBEMBERA
ID: UNCST-2021-R013915
|
Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent Rheumatic Heart Disease: A non-inferiority randomized trial. (GOALIE)
REFNo: HS2659ES
Primary Objective:
To compare the proportion of children aged 5-17 years with latent RHD receiving oral penicillin prophylaxis who progress to worse valvular disease at 2-years compared to children who receive IM penicillin prophylaxis.
|
Uganda |
2023-03-24 2:23:26 |
2026-03-24 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Samuel Ojelel
ID: UNCST-2019-R000996
|
Tropical Important Plant Areas of Uganda
REFNo: NS479ES
(i) To assess conservation status of priority plant species to guide Identification of Important Plant Areas
(ii) To promote sustainable use and protection of Important Plant Areas by developing partnership with key stakeholders
|
Uganda |
2023-03-24 2:17:32 |
2026-03-24 |
Natural Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Denis Muhangi
ID: UNCST-2020-R014258
|
A STUDY ON CONDOM DEMAND, UTILIZATION, DISTRIBUTION AND DISPOSAL SURVEY 2022
REFNo: SS1605ES
1. To establish the condom demand for both the male and female condom users in the community programming in 61 districts of Uganda
2. To generate information on distribution and utilization of condoms among key, priority and general population in 61 districts of Uganda
3. To generate data to be used to fill gaps in comprehensive condom programming in relation to condom demand, distribution, management and disposal as well as modalities for strengthening condom logistics in Uganda
4. To explore new modalities for strengthening condom logistics among the non-traditional channels of condom distribution in the community.
5. To determine the extent of adherence to the condom waste management and disposal mechanisms developed by MoH,
6. To establish status and opportunities of using the Total Market Approach
|
Uganda |
2023-03-24 2:13:39 |
2026-03-24 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
|
Caroline Nerima
ID:
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FUNCTIONAL LIMITATIONS AMONG CHILD REFUGEES WITH DEVELOPMENTAL DISABILITIES AND BARRIERS TO EARLY CHILDHOOD INTERVENTION IN A UGANDAN REFUGEE SETTLEMENT.
REFNo: HS2666ES
1. To describe the functional limitations among children aged 1 month to 6 years with developmental disabilities.
2. To describe the early intervention services available for children with developmental disabilities living in refugee camps.
3. To describe the barriers to access to early intervention services for children with developmental disabilities.
|
Uganda |
2023-03-24 2:10:43 |
2026-03-24 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Winnie Muyindike R
ID: UNCST-2021-R013558
|
Tuberculosis, Alcohol, and Lung Comorbidities (TALC) Study
REFNo: HS2705ES
Qualitatively evaluate factors for tailoring pharmaco-behavioral alcohol and smoking interventions in PLWH being treated for TB. ,Explore how smoking alters the association of past-month heavy drinking and post-TB lung disease progression over time,• Aim 1b. Assess the association of past-month heavy drinking and post-TB lung disease progression over time. This aim uses recent alcohol use (30-day Timeline Followback, PEth) since direct mechanisms (e.g., alcohol toxicity) may drive the physiologic, anatomic, and immunologic outcomes of interest. We define past-month heavy drinking as ≥7 drinks/week (women), ≥14 drinks/week (men) or PEth>200 ng/mL.,• Aim 1a. Determine if past-year hazardous drinking is associated with post-TB lung disease. ,Aim 1. Determine the relationship between hazardous drinking and post-TB lung disease in PLWH.,
|
Uganda |
2023-03-24 2:08:05 |
2026-03-24 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Denis Muhangi
ID: UNCST-2020-R014258
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Sustainable Off-Grid Solutions for Pharmacies and Hospitals in Africa (SophiA).
Sub-component 1: Needs Assessment of Hospitals/Health Centre IVs for the Sustainable Off-Grid Solutions
Sub-component 2: Socio-Economic Acceptance and Participation Assessment for Stakeholders
Sub-component 3: Life Cycle Assessment and Sustainability Assessment
REFNo: SS1627ES
Goal of the SophiA Project: To bring environmental, economic, social and health benefits, creating new business and job opportunities through new technological solutions; to support African countries to pursue sustainable pathways of development through a low-carbon, climate resilient and green growth trajectory, leapfrogging fossil fuels and high GWP refrigerant technologies; and to improve the quality of life of populations through better treatment and working conditions in rural and remote health facilities in Africa.
Specific Objectives of the Proposed Studies:
i) To assess the needs from several health stations in order to identify and match the most significant and suitable health station which can be served by one SophiA system, considering different uses, replicability, cost and constraints as pertains energy consumption and solar radiation.
ii) To assess the level of acceptance of the SophiA technological solutions by the relevant stakeholders including beneficiary communities, local leaders, health care providers and managers, district officials, and national level decision makers/policy makers.
iii) To conduct a Life Cycle Assessment (LCA) to evaluate the different environmental impacts and calculate the CO2 emissions for each of the SophiA technology: solar thermal, solar PV, thermal storage, electrical storage, ice storage, refrigerators).
|
Uganda |
2023-03-24 2:04:40 |
2026-03-24 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
|
Esther Nasuuna Michelle
ID:
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The Epidemiology of Chronic Kidney Disease among young people living with HIV in Uganda
REFNo: HS2578ES
1. To describe the prevalence of CKD among YPLHIV in SSA.
2. To compare the prevalence and associated factors of CKD diagnosed with cystatin C or creatinine-based estimates among YPLHIV in Uganda.
3. To describe the comorbidities associated with CKD among YPLHIV in Uganda.
|
Uganda |
2023-03-22 15:08:26 |
2026-03-22 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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Paul Bangirana
ID:
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Blood-Biomarkers and Risk Factors of Acute Brain Injury associated with Neurodisability in Ugandan Children (BRAIN-Child)
REFNo: HS2628ES
Determine if elevated brain injury biomarkers in pediatric TBI correlate with post-discharge mortality or neurocognitive impairment (NCI) and health-related quality of life outcomes at 6-month follow-up,Determine if biomarkers and risk factors of brain injury elevated in pediatric CM are elevated in pediatric TBI,
|
Uganda |
2023-03-21 3:29:20 |
2026-03-21 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Simon Kasasa
ID: UNCST-2021-R012861
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A National Survey to Determine the Prevalence of Latent and Active Tuberculosis, COVID-19 and HIV Among Prisoners and Prisons Staff in Uganda Prisons
REFNo: HS2373ES
Overall objective
To determine the burden and associated factors of TB, COVID-19, and HIV among inmates and staff in Uganda prisons in order to generate evidence that will inform future interventions.
Primary objectives
i. To estimate the prevalence and associated factors of LTBI among inmates and staff in the Uganda prisons.
ii. To determine the prevalence and associated factors of active TB disease among inmates and staff in Uganda prisons.
iii. To determine the current burden of COVID-19 among prisoners and staff using an integrated TB and COVID-19 screening and testing approach.
iv. To establish the burden of past COVID-19 infection among prisoners and staff in Uganda prisons.
v. To determine the prevalence of HIV among inmates and staff in Uganda prisons.
vi. To determine HIV program achievement and gaps in the Uganda Prisons in reference to the UNAIDS targets for HIV testing, positive individuals who are on treatment, and PLHIV with suppressed viral load (95-95-95).
|
Uganda |
2023-03-21 3:23:05 |
2026-03-21 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Moreen Kabarungi
ID:
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A FRAMEWORK TOWARDS THE IMPROVEMENT OF ADOPTION OF BLENDED LEARNING IN HIGHER EDUCATIONAL INSTITUTIONS
CASE STUDY OF SOUTH WESTERN UGANDA.
REFNo: SS1665ES
The main objective of this study is to develop a framework to support the adoption of blended learning in higher educational institutions in south western Uganda.
The specific objectives are;
1. To establish the strengths, weaknesses and elicit the requirements of the existing blended learning frameworks and their level of usage and satisfaction in higher educational institutions.
2. To design a framework that supports the adoption of blended learning in higher educational institutions.
3. To evaluate the feasibility, acceptability and usage of the designed framework of blended learning in higher educational institutions.
|
Uganda |
2023-03-21 3:19:16 |
2026-03-21 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
|
Tonny Ssekamatte
ID: UNCST-2022-R010961
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Understanding the barriers and facilitators to access and utilisation Sexual and Reproductive Health services among vulnerable/marginalized adolescents and young people in Uganda
REFNo: SS1673ES
To investigate the barriers and facilitators to access and utilisation Sexual and Reproductive Health services among vulnerable/marginalized adolescents and young people in Uganda ,Examine the role of social media/other sources in the spread of information and/or disinformation and how it potentially influences access to and use of SRH services.,Examine the role of social norms in influencing the use/non-use of SRH services among the populations of interest:,Explore the barriers and facilitators to accessing SRH services among vulnerable/marginalized 15–24-year-old adolescents and young people.,
|
Uganda |
2023-03-21 3:16:17 |
2026-03-21 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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Annet Nanungi Kabuye
ID:
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An mhealth framework for cancer surveillance in Uganda
REFNo: HS2695ES
To develop an mhealth data framework for cancer surveillance in Uganda.,
|
Uganda |
2023-03-21 3:06:26 |
2026-03-21 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
|
Elizabeth (Betsy) Ness-Edelstein Ann
ID:
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Cooperative Development Program Evaluation
REFNo: SS1664ES
Assess how the specific work of Health Partners in Uganda is contributing to the overall program objectives,● Contribute to the evidence base on effective cooperative development approaches.,● Identify the assumptions or gaps in the project’s design or management approach to help inform a new project design,● Illuminate ways in which the entire project is making progress toward the stated Project Purpose or not,
|
USA |
2023-03-21 3:04:41 |
2026-03-21 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
|
Edward Mokooza Kibikyo
ID: UNCST-2020-R014923
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Understanding Barriers and Facilitators to Establishing Palliative Care Units at Hospitals in Uganda.
REFNo: SS1510ES
4. To identify the facilitators of establishing palliative care units in hospitals in Uganda. ,3. To describe barriers to the establishment of palliative care units in hospitals in Uganda.,2. To document the functionality of existing PC units in hospitals in Uganda. ,1. To determine the proportion of public and private hospitals with PC units.,
|
Uganda |
2023-03-16 13:06:27 |
2026-03-16 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
|
Zhubin Chen
ID:
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The Impact of Social Health Insurance on the Incentives of Health Care Providers in East Africa: A Mixed-methods Approach
REFNo: SS1574ES
1.1 Describe how social health insurance functions and how health care providers respond to the economic incentives of social health insurance in Rwanda, Kenya, and Uganda
1.2 Pose hypotheses based on 1.1 and test them empirically using nationally representative data
2. Follow different institutional actors (ministry of health, health facilities, NGOs, and community organizations) and describe how they perceive the function of social health insurance in Rwanda, Kenya, and Uganda
3. Compare the impact mechanism of social health insurance in Rwanda, Kenya, and Uganda and document how the impact evolves on different paths and at different stages towards UHC
|
China |
2023-03-16 13:04:14 |
2026-03-16 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
|
Peace Tumuheki Buhwamatsiko
ID:
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Experiences of students combining work and study at Ugandan universities
REFNo: SS1646ES
To explore experiences of students who combine work and study at both private and public universities in Uganda with a view of making recommendations that will contribute to improving their university education experience and promote inclusive lifelong learning agenda in higher education,To explore and examine the suitable academic and administrative supports for students combining work and study,To explore the classroom learning experiences of students who combine work and study,To uncover the motivations underlying the decision to combine work and study at university and the associated benefits and challenges,
|
Uganda |
2023-03-16 13:02:52 |
2026-03-16 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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Victoria Nankabirwa
ID: UNCST-2021-R011871
|
Implementation of an eRegistry Enabled Transition from Four to Eight Antenatal Care Contacts - a Cluster-Randomized Controlled Trial in Mukono and Buikwe, Uganda (eReg4ANC8)
REFNo: HS2662ES
III. Undertake a cRCT of the new ANC8 vs. the current ANC4 schedule for low-risk pregnancies, to estimate its impact on quality of care, health, and satisfaction.,II. To assess and respond to factors across the i-PARIHS and COM-B domains to guide the facilitation of feasibility, acceptability, fidelity, and effectiveness of implementation of digitally enabled ANC8 at scale. ,I. To assess and respond to factors across the PARIHS and COM-B domains to guide the facilitation of feasibility, acceptability, fidelity, and effectiveness of the implementation of DHIS2 eRegistries for ANC at scale. ,
|
Uganda |
2023-03-16 13:01:11 |
2026-03-16 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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