Bruce Kirenga J
ID: UNCST-2019-R001460
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A multiple arm, multiple stage (MAMS), phase 2B/C, open label, randomized, controlled platform trial to evaluate experimental arms including an increased dose of rifampicin, an optimized dose of pyrazinamide, moxifloxacin and sutezolid, in adult subjects with newly diagnosed, smear-positive pulmonary tuberculosis
REFNo: HS2644ES
Primary Efficacy Objective:
Rifampicin- containing experimental arms (arms 1,2)
To evaluate whether one or more of two experimental regimens based on
optimized dose rifampicin, optimized dose of pyrazinamide, and moxifloxacin
given for 12, respectively 17 weeks, are superior to standard treatment given for
26 weeks, as assessed by time to sputum culture conversion to negative in liquid
media.
Sutezolid-containing experimental arm (arm 4)
To evaluate whether the efficacy of an experimental regimen composed of
sutezolid, delamanid, bedaquiline, and moxifloxacin given for 17 weeks is
superior to standard treatment given for 26 weeks, as assessed by time to
sputum culture conversion to negative in liquid media.
Secondary Objectives This study’s secondary objectives are:
Efficacy
To assess treatment efficacy based on proportion of patients with relapse
free outcome at 12 months after randomization.
To assess treatment efficacy based on the rate of decline of bacterial load
measured by the Molecular Bacterial Load Assay
To rank the relative efficacy of the experimental four-drug combinations
for the treatment of pulmonary tuberculosis within the first twelve weeks
of treatment, and select the most efficient experimental treatment
regimen or regimens for further development.
Safety and Tolerability
To assess the frequency, severity, and type of adverse events (AEs), and AErelated
treatment discontinuations.
Pharmacokinetics
To describe the pharmacokinetics of the drugs and doses used, and to assess
possible relationships between pharmacokinetic parameters of the various drugs and between pharmacokinetic parameters and participant characteristics.
Pharmacodynamics To describe relationships between pharmacokinetic parameters on the one hand and efficacy and safety endpoints on the other hand.
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Uganda |
2023-04-11 15:27:11 |
2026-04-11 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Andrew Muhumuza
ID: UNCST-2022-R009010
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Incidence and predictors of castration resistance among patients with prostate cancer on androgen deprivation therapy at two referral hospitals in Uganda
REFNo: HS2759ES
To identify the predictors of castration resistance among prostate cancer patients on ADT at Mbarara Referral Hospital oncology unit and Uganda cancer Institute, Mulago National Referral Hospital. ,To determine the incidence of castration resistance among patients with prostate cancer on ADT at Mbarara Referral Hospital oncology unit and Uganda cancer Institute, Mulago National Referral Hospital.,To determine the incidence and predictors of castration resistance among prostate cancer patients on ADT at Mbarara Referral Hospital oncology unit and Uganda cancer Institute, Mulago National Referral Hospital.,
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Uganda |
2023-04-11 14:20:29 |
2026-04-11 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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SAM ALI
ID: UNCST-2020-R014824
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Stillbirth in High Burden Settings: Ample Room for Improvement using Biomarkers and Ultrasound Technologies (iTECH)
REFNo: HS2762ES
1. To evaluate the relation between placental histopathological lesions and biomarkers, placenta ultrasound and hemodynamic changes after stillbirth and near miss stillbirth in order to understand the underlying mechanisms and specify the prediction model.
2. To engage with important stakeholders on the value of these diagnostic technologies in the community, co-creating the project design, implementation and eventual uptake into practice guidelines.
3. To establish the predictive performance of maternal characteristics and markers emerging from this project for stillbirth and other related endpoints in non-anomalous fetuses and assess the feasibility of integrating relevant markers into clinical decision support tools.
4. To prospectively evaluate patterns of (bio)markers, maternal cardiovascular function and contemporary ultrasound markers in pregnancy, to understand their role in the chain of events and pathophysiology of stillbirth in a resource poor setting.
5. To develop and validate a prediction model for use at the point of care in low-and middle-incomes countries (LMICs) to quantify a woman’s individual risk of antepartum stillbirth based on a set of easily measurable, accessible, highly predictive and cost-effective markers, and make it freely available for healthcare providers in low-resource settings.
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Uganda |
2023-04-06 8:06:27 |
2026-04-06 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Juliana Namutundu
ID:
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IMPROVING CERVICAL CANCER SCREENING LITERACY AMONG HIV-INFECTED WOMEN IN CARE AT RURAL PUBLIC HEALTH FACILITIES IN EAST CENTRAL UGANDA
REFNo: HS2753ES
3) To assess the feasibility, acceptability and preliminary effectiveness of a cervical cancer screening literacy improvement implementation strategy for Women living with HIV in care at rural public health facilities in East Central Uganda.,2) To design a cervical cancer screening literacy improvement implementation strategy for Women living with HIV in care at rural public health facilities in East Central Uganda.,1) To conduct a multi-level assessment of barriers and facilitators of cervical cancer screening literacy among HIV-infected women in care at rural public health facilities in East Central Uganda.,
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Uganda |
2023-04-05 17:05:10 |
2026-04-05 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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Margaret Nafuna Sarah
ID:
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EXAMINING MOTIVATIONAL STRATEGIES INFLUENCING PERFORMANCE OF TUTORS IN CORE PRIMARY TEACHERS’ COLLEGES IN EASTERN UGANDA
REFNo: SS1647ES
3. To analyse the challenges that may influence the effective motivation of tutors in Core PTCs in Eastern Uganda.,2. To examine the views of tutors on how motivational strategies affect their performance in Core PTCs in Eastern Uganda.,1. To investigate motivational strategies employed in Core PTCS in Eastern Uganda. ,
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Uganda |
2023-04-04 9:36:11 |
2026-04-04 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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Milcah Abasabyona
ID:
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Intimacies of Identification and Lived Citizenship among the Ghetto Youths in Kampala, Uganda
REFNo: SS1654ES
Main Objective:
To investigate how citizen certification and identification influences levels of belonging to a place and space, impacts on citizen-state relationship and individual personhood.
Specific Objectives:
1. To capture the individual practical experiences of legal certification and identification processes among the Ghetto youths.
2. To examine the regulatory effects of identification documents on citizenship rights, a sense of belonging, and personhood among the Ghetto youths in Kampala.
3. To explore the different key Identification documents and their role in the day to day lives of the Ghetto Youths.
4. To trace the ways in which the undocumented Ghetto youths create alternative routes to lived citizenship and self-certification.
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Uganda |
2023-04-04 9:32:41 |
2026-04-04 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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ANYASE AMAZA RONALD
ID: UNCST-2022-R009325
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Development of a Natural Anti-Aflatoxin Product
REFNo: HS2692ES
To develop a prototype natural based anti-aflatoxin product made from Ugandan plants.,To establish a database of plants in Uganda with anti-aflatoxin potential,To determine the indigenous approaches of aflatoxin control in Uganda.,To develop a natural based anti-aflatoxin product ,
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Uganda |
2023-04-03 21:04:19 |
2026-04-03 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Scovia Mbalinda Nalugo
ID: UNCST-2020-R014259
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Professional Identity of Ugandan Nurses and Midwives: Exploring the understanding, Perceptions and Experiences among student Nurses and Midwives, Recent Graduates and Nurse Educators
REFNo: HS2712ES
Explore nurse and midwife top management in the ministry of health and nurses and midwives council perception and experiences fostering professional identity in nursing in the country.,3. Explore nurse and Midwife educators’ perceptions and experiences fostering professional identity in nursing and midwife at Mbarara University of Science and Technology and Makerere university,2. Explore challenges and barriers to professional identity formation at Mbarara University of Science and Technology and Makerere University,1. Describe the understanding of the professional identity of final year undergraduate nurses and midwives and recent graduates at Mbarara University of Science and Technology and Makerere University.,
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Uganda |
2023-04-03 21:00:42 |
2026-04-03 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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zaina Nakabuye
ID:
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Technology orientation and the export performance of SME exporting firms in Uganda.
REFNo: SS1472ES
2. To establish the relationship between knowledge absorptive capacity and export performance.
3. To examine the relationship between supply chain agility and export performance.
4. To investigate the moderation of knowledge absorptive capacity between technology orientation and export performance.
5. To investigate the moderation of supply chain agility between technology orientation and export performance.
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Uganda |
2023-04-03 20:58:43 |
2026-04-03 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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Pooja Chitneni
ID: UNCST-2021-R012955
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Development and assessment of an HIV disclosure intervention for men in Uganda - Aim 1
REFNo: HS2682ES
Aim 1. Identify the unique HIV disclosure needs and preferences among MWH to support HIV disclosure. ,
|
USA |
2023-04-03 20:55:31 |
2026-04-03 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Joseph Kirabira
ID: UNCST-2019-R001427
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Prevalence of and factors associated with mental disorders and coping mechanisms among students at Busitema University.
REFNo: HS2700ES
To explore factors influencing mental disorders among students at Busitema UniversityTo explore the coping mechanisms used by students at Busitema University
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Uganda |
2023-04-03 20:53:26 |
2026-04-03 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Andrew Mujugira
ID: UNCST-2019-R000871
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Qualitative research to prepare for novel HIV prevention products
REFNo: HS1749ES
Define a preliminary strategy for the integration of novel PrEP products (e.g., injectable Cabotegravir, Dapivirine intravaginal ring, TFV/LNG intravaginal ring) into existing oral PrEP programs by conducting qualitative interviews with experts in novel PrEP products, oral PrEP programs, and end users.
To achieve this aim, we will conduct approximately 60 key informant interviews (KII) with: 1) clinical trialists leading studies of novel PrEP products, 2) oral PrEP program leaders in sub-Saharan Africa and 3) young women in Uganda who have decided not to use oral PrEP during recent PrEP studies.
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Uganda |
2023-04-03 20:51:28 |
2026-04-03 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Waiswa Peter
ID: UNCST-2020-R014921
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Prevalence of intestinal colonization by ESBL-producing Enterobacterales in neonates at Jinja Regional Referral Hospital
REFNo: HS2737ES
• To highlight the area of antibiotic resistance in neonates in this setting ,• To conduct a point-prevalence surveillance of ESBL-producing Enterobacterales in the neonatal unit at two specific time-points with two weeks apart.,The overall aim of this project is to create base-line data for future infection prevention control strategies in the area of newborn care at Jinja Referral Hospital.,
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Uganda |
2023-04-03 20:49:30 |
2026-04-03 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Stella Maris Nanyonga
ID:
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Optimizing antimicrobial use in the management of Upper Respiratory Tract Infections through antimicrobial stewardship in Community Pharmacy practice in Uganda; A patient centered approach
REFNo: HS2617ES
Primary Objectives
1. To assess the knowledge, attitude, and practice (KAP) towards self-medication among patients who visit community pharmacies for the management of Upper respiratory tract infections.
2. To explore the barriers and facilitators of self-medication in the community.
3. To explore prescriber views and understanding on the use of delayed prescribing in primary care.
Secondary Objectives
4.To evaluate the effectiveness of training and delayed prescribing intervention on antibiotic consumption among patients with URTI who visit community pharmacies.
5. To describe dispensing and prescribing patterns of pharmacy staff when managing patients with upper respiratory tract infections at the community pharmacy
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Uganda |
2023-04-03 20:46:30 |
2026-04-03 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Brenda Kakayi Catherine
ID: UNCST-2022-R008787
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Insulin-like Growth Factor/Growth Hormone Levels and Stunting in HIV Exposed Uninfected Children from the 1077BF/P1084s study (CHASE: Changes in IGF/Hormone Axis and Stunting in HIV-Exposed uninfected children.
REFNo: HS2686ES
1. To investigate IGF-1, IGFBP-1, and IGFBP-3 as predictors of growth faltering/stunting in the first 2 years of life in HEU children
2. To describe the concentrations of hormonal growth factors in infants in relation to infant growth percentile at birth, 26 weeks, and 74 weeks of age.
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Uganda |
2023-04-03 20:41:44 |
2026-04-03 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Gerald Bareebe
ID:
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Violence and Regime Trajectories in Post-Conflict Uganda and Rwanda
REFNo: SS1413ES
This study is driven by two important objectives: the first is the need to consider the influence of a “residue” social structure. What the cases of Uganda and Rwanda tell us is that, without understanding the underlying socio-political agency of the political regime and the armed elites that run it (and without knowing who their allies are or what the sources of constraints in that process are), it is difficult to resolve the socio-political problems that trouble most postwar states on the continent. The second is the need to show how post-war reconstruction in Africa is a function of elite interactions. The failure to understand this phenomenon has left post-conflict societies more vulnerable to conflict relapse. By investigating the interface of power elites in post-war state reconstruction, this research situates itself within a more empirical and contemporary African perspective and elevates the importance of social actors, specifically those whose actions reflect the intractability of power struggle. Specifically, the research seeks to achieve the following objectives:
To understand the process of post-conflict state reconstruction in Uganda and Rwanda
To understand factors that may hinder or enable the rebuilding of state institutions after a civil war.
To compare the experience of Uganda and Rwanda with regards to how they both approached state reconstruction after a devastating civil war.
To determine the nature and impact of policies taken by state-builders in both Uganda after the 1986 civil war and Rwanda after the 1991 genocide.
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Uganda |
2023-04-03 16:49:25 |
2026-04-03 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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Timothy Allen Peter
ID: UNCST-2019-R001369
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Public Authority and International Development Uganda Programme Phase 2
REFNo: SS1678ES
Inductive theory-building through comparative applications,New curriculum development for scholars and development professionals,Reciprocal capacity-building in the academy and knowledge production,Reflexive policy-making and governance impact,Generate impact, knowledge exchange and capacity building through a public authority lens,
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UK |
2023-04-03 16:41:36 |
2026-04-03 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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Jesse Rudy Lynn
ID: UNCST-2023-R008208
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Prevalence of property Grabbing among widows in Uganda
REFNo: SS1677ES
To establish the total number of people protected in the different project areas districts as a result of Redeem’s program interventions.,
1)To understand the indirect consequences of attempted and successful land/property grabbing for widows and orphans in the aftermath of the events,
2)To ascertain the criminal, violent or other means used by perpetrators to victimize widows and orphans through grabbing property or land in Uganda.,
3)To determine the prevalence of property grabbing from widows in targeted areas of Uganda,
4)To measure the annual burden of property grabbing in the selected case work areas ,
|
USA |
2023-04-03 15:40:08 |
2026-04-03 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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GRACE MARY KENYONGA
ID:
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Attitudes towards the use of pre-exposure prophylaxis for HIV among women in Uganda
REFNo: SS1473ES
General aim
Examine the attitudes towards the use of pre-exposure prophylaxis for HIV among women in Uganda.
Specific Objectives
1. Explore the attitudes women have towards PrEP
2. Identify the factors that influence the present attitudes towards PrEP
4. Identify other community variables that may encourage or constrain the uptake of PrEP.
6. Identify and recommend necessary interventions and measures to counteract any prevailing negative attitudes towards PrEP that may be prevailing in the community.
|
Uganda |
2023-03-28 1:00:59 |
2026-03-28 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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Alison Elliott
ID: UNCST-2023-R006524
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Risk factors for severe schistosomal morbidity: an adult case-control study
by the Uganda Schistosomiasis Multidisciplinary Research Centre (U-SMRC)
REFNo: HS2570ES
We hypothesise that factors at each step of the parasite life cycle interact to determine
morbidity in schistosomiasis.
The objective of this work is to investigate risk factors associated with advanced schistosomiasis morbidity among adults, using a case-control study.
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UK |
2023-03-24 2:35:04 |
2026-03-24 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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