Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Raymond Tweheyo
ID: UNCST-2020-R014507
Evaluating the pilot of the Community Health Extension Worker (CHEW) strategy in Uganda: assessing feasibility, and effectiveness for improving Village Health Team (VHT) supervision and reporting
REFNo: HS2545ES

General Objective
To explore the acceptability, document the implementation process and evaluate the effectiveness of the Community Health Extension Worker strategy in two districts of Uganda to guide improving the community health system

Specific Objectives
1) To assess the acceptability of introducing a Community Health Extension Worker (CHEW) strategy in a district health system.

2)To document the process of setting up and implementing a Community Health Extension
Worker (CHEW) strategy within a district health system.

3) To estimate the program costs and duration for setting up a government-led Community Health Extension Worker (CHEW) strategy within a district health system.

4) To determine the effectiveness of the CHEW strategy for improving the quality of Village Health Team (VHT) member’s supervision and reporting in a district health system.

5) To assess the effect of the CHEW strategy on community-level indicators: completion of four antenatal care visits, skilled delivery attendance, fully immunized under-fives, and U5 sick children seen by VHTs and treated within 24 hours.

UK 2023-01-03 13:08:01 2026-01-03 Medical and Health Sciences Clinical Trial Non-degree Award
BRIDGET SHARON ANGUCIA
ID:
COMMON CANCERS AND ASSOCIATED RISK FACTORS IN ARUA DISTRICT UGANDA 2017 TO 2021
REFNo: HS2539ES

1.To determine the commonest cancers in Arua District from 2017 to 2021
2.To determine the risk factors associated with the commonest lifestyle associated cancers amongst men from Arua district 2017 to 2021
3.To find out the risk factors associated with the commonest lifestyle associated cancers amongst women from Arua district 2017 to 2021

Uganda 2023-01-03 12:34:21 2026-01-03 Medical and Health Sciences Non-Clinical Trial Degree Award
Fatumo  Segun Adeyemi
ID:
Assessing the genetic architecture of circulating protein biomarkers of cardiometabolic diseases in African and European populations.
REFNo: HS2527ES

1. To assess the genetic architecture of 3000 circulating blood protein biomarkers implicated in Cardiometabolic Diseases in African populations.
2. Assess rare regulatory variants affecting protein levels via gene-based burden analysis across coding and non-coding sequence variation
3. To perform colocalization testing for variant prioritization
4. To assess the predictive power of protein quantitative trait loci (pQTL) in cardiometabolic disease.
5. Assess causal associations between proteins and Cardiometabolic diseases using Mendelian randomization approaches.
6. To compare the genomic characteristics and architecture of African and European proteomes.
7. To build capacity in proteomic data analysis in Africa.


UK 2023-01-03 12:31:49 2026-01-03 Medical and Health Sciences Non-Clinical Trial Degree Award
Anthony Mpairwe
ID:
Child Maltreatment and Child Protection Strategies in South Western Uganda
REFNo: SS1483ES

To explore the lived experiences of maltreated children in Mbarara City and Sheema District ,To assess community members' knowledge about child protection strategies and services available in Uganda,To determine the factors influencing utilization of child protection strategies available in Mbarara City and Sheema District, Southwestern Uganda.,
Uganda 2023-01-03 12:29:06 2026-01-03 Social Science and Humanities Non-Clinical Trial Degree Award
Paul Okello Edward
ID:
One Health approach to identify local drivers of antimicrobial drug resistance in peri-urban Kampala, Uganda
REFNo: HS2377ES

1: Identify local drivers of antimicrobial resistance in poultry farms in Uganda through a case-control study
2a: Assess the level of antibiotic use and antibiotic resistance on a selected poultry farm by sampling litter, soil, and chicken ceca or cloaca for microbiological, analytical chemistry, and microbiome analysis.
2b: Assess the level of antibiotic use and antibiotic resistance in human populations directly exposed to poultry or poultry products from the farm.
3. Assess the level of antibiotic use and antibiotic resistance in environmental samples collected from soil, water bodies and vegetable gardens close to the poultry farm and in exposed human populations.
Uganda 2023-01-03 12:19:31 2026-01-03 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Moses Joloba Lutaakome
ID: UNCST-2022-R011558
An investigation of Ebola virus transmission and host immune responses among humans in Uganda
REFNo: HS2618ES

Objective 1: Characterize host immune responses to Ebola infection, therapy, and vaccination to define responses associated with protection, reduced disease, clearance of virus, and long-term post-EVD sequelae.

Objective 2: Investigate the cellular and molecular determinants of Ebola disease severity and outcome using advanced genomic studies (nascent transcriptomics)

Objective 3: Conduct seroprevalence studies to determine the burden of Ebola infection among asymptomatic contacts of EVD patients in the affected areas

Objective 4: Model periodic occurrence and transmissibility of Ebola virus within the community

Uganda 2022-12-23 18:12:56 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Clovice Kankya
ID: UNCST-2020-R010154
Understanding and Improving Antimicrobial Stewardship Among Small and Medium Sized Dairy Farmers in Uganda
REFNo: HS2607ES

1. To assess the current level of knowledge, attitudes, as well as practices among target
dairy farmers and animal health service professionals
2. To understand the barriers and enablers to implement best practices in dairy production,
with a focus on behavioural barriers.
3. To develop the Food Safety AMR training curriculum by farmers and other relevant
stakeholders.
4. To ascertain the determinants of AMR among the different dairy farms.
5. To identify behaviourally informed interventions to mitigate the barriers using enabler
analysis.
Uganda 2022-12-23 18:11:07 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Monica Swahn H
ID: UNCST-2021-R012004
The Onward Project On Well-being and Adversity (“TOPOWA”): Pilot Study of Wearables
REFNo: SS1560ES

The objective of this study is to assess the feasibility and acceptability of using consumer-grade wearable wrist devices to assess sleep and activity space of adolescent girls and young women in slum communities in Kampala, Uganda. This objective will be answered through wearables wrist devices, daily diaries, focus groups discussions and a survey to collect the experiences of AGYW who are 18-24 years of age.
USA 2022-12-23 18:08:19 2025-12-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
Pontiano  Kaleebu
ID: UNCST-2020-R019901
Performance evaluation of the Determine™ HIV Early Detect 4th Generation HIV Rapid Diagnostic test
REFNo: HS2603ES

Primary Objectives:
1. To evaluate the Laboratory performance (Sensitivity and specificity) of the Determine™ HIV Early Detect
2. To assess the field performance of the Determine™ HIV Early Detect in parallel with the Determine™ HIV-1/2 test
Secondary Objective:
1. To assess the effectiveness of the Determine Early Detect to identify acute HIV infection among newly infected individuals

Uganda 2022-12-23 18:06:59 2025-12-23 Medical and Health Sciences Clinical Trial Non-degree Award
Fahad Muwanda
ID:
Childhood responses to Hepatitis B vaccine in Uganda: the role of Human Leukocyte Antigen (HLA) and T-Cell Receptor (TCR) diversity
REFNo: HS2604ES

To determine the long-term persistence of protective hepatitis B vaccine antibody titers among 15-17 years old childhood recipients who were enrolled on the UNEPI. ,Characterize the T-cell immunophenotypes and function, and compare hepatitis B vaccine responders with non-responders. ,Characterize host TCR and HLA genotypes and their association with hepatitis B vaccine responses among under 5 year-old childhood recipients in the UNEPI.,To determine the prevalence of immunological non-responsiveness to hepatitis B vaccine among under 5 year-old childhood recipients in the UNEPI recruited in Kawempe Division, Kampala.,To determine the immunogenetic factors associated with non-responsiveness in hepatitis B vaccine childhood recipients, and persistence of immuno-protection accorded by the vaccine in Uganda.,
Uganda 2022-12-23 18:04:07 2025-12-23 Medical and Health Sciences Non-Clinical Trial Degree Award
Jonathan Kayondo
ID: UNCST-2021-R008325
Contained laboratory studies of the genetically-modified, non-gene drive, self-limiting male bias Anopheles gambiae strain Ag(PMB)1.
REFNo: HS2601ES

• Establishing and maintaining wild-type Anopheles strains Ag(WT) for use in the study.
• Importing and maintaining of the Ag(PMB)1 strain from Target Malaria partner laboratories into the insectary in accordance with ACL2 standard operating procedures for this strain.
• Further Introgression and maintaining the Ag(PMB)1 strain in a local genetic background.
• Confirmation of the genotype of the Ag(PMB)1 strain by molecular methods, including storage of samples.
• Conducting experiments on specific insect life history parameters under containment including:
o Effect of the transgenes on lifecycle parameters
o Female feeding avidity
o Fecundity
o Egg hatch
o Confirming the male bias phenotype by observing the distortion of sex ratio and proportions of transgenic vs. non transgenic individuals
o Accuracy of mosquito sorting methods
o Larval development rate and adult hatching (eclosion)
o Adult eclosion (emergence of an adult insect from a pupa) and adult longevity
• Conducting a colony augmentation exercise, to temporarily increase colony numbers.
• Assessment of mating competitiveness between Ag(WT) and strain Ag(PMB)1 males.
• Assessment of insecticide susceptibility status of the Ag(PMB)1 strain compared with the non-transgenic wild-type An. gambiae, using standard World Health Organization protocols.
• Conducting experiments to optimize mosquito rearing methods.
All studies will be performed using the imported Ag(PMB)1 strain and local wild-type Ag(WT), no genetic transformation of either of these two strains will be done in country.

Uganda 2022-12-23 18:02:42 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Robert Downing George
ID: UNCST-2020-R014615
Sample collection for the development of a new Abbott Rapid Diagnostics COVID- 19/ Flu A&B Rapid Panel
REFNo: HS2592ES

Influenza (Flu) and COVID-19 are both contagious respiratory illnesses - they share some similar symptoms but are caused by different viruses. Because some of the symptoms of flu and COVID-19 are similar, distinguishing infection between these viruses cannot be made based on symptoms alone. Diagnostic testing is needed to determine which of the two viruses is the cause of the illness.
Abbott Rapid Diagnostics is developing a new COVID-19 / Flu A&B rapid test device that can detect both flu and COVID-19 viruses in a patient sample and distinguish between them. The test is being developed on an improved lateral flow platform, to be conducted at the point-of-care. This study is intended to collect samples to aid in the research and development process for this new test. The study will provide standard-of-care PCR testing and potentially molecular sequencing for patient management at clinical sites in Uganda.

UK 2022-12-23 18:01:38 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
DARIUS OWACHI
ID: UNCST-2022-R009373
KNOWLEDGE, ATTITUDE AND PRACTICES OF HEALTH WORKERS TOWARDS ANTIMICROBIAL RESISTANCE AND ANTIMICROBIAL STEWARDSHIP – A CROSS-SECTIONAL SURVEY IN KAMPALA, UGANDA
REFNo: HS2598ES

To determine the knowledge, attitude and practices of antimicrobial prescribers at Kiruddu Hospital towards antimicrobial resistance ,
Uganda 2022-12-23 18:00:14 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
EUNICE Ndyareeba
ID:
Achievement Goal Orientation, Self-efficacy and Academic Engagement among Compassion and Non-compassion supported Adolescent students in Secondary Schools in Southwestern Uganda
REFNo: SS1562ES

1.Assess the relationship between achievement goal orientation and academic engagement 2.Determine the relationship between self-efficacy and academic engagement 3.Examine the mediation role of self-efficacy on the relationship between achievement goal orientations and academic engagement 4. Examine whether there is a significant difference between achievement goal orientation and academic engagement among compassion-supported and non-compassion supported adolescents
Uganda 2022-12-23 17:58:52 2025-12-23 Social Science and Humanities Non-Clinical Trial Degree Award
Joyce  Nankumbi
ID:
Effect of the healthy baby tool kit on the maternal-infant and young child feeding practices among HIV-positive/exposed mother-baby dyads
REFNo: HS2491ES

Assess the maternal, infant, and young child feeding practices among HIV-positive/exposed mother-baby dyads
Evaluate the effectiveness of the healthy baby tool kit on the maternal-infant and young child feeding practices
assess the barriers and facilitators to implementation of the Healthy baby tool kit
Uganda 2022-12-23 17:54:26 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joseph Mugisha Okello
ID: UNCST-2022-R009461
Functional Needs Assessment Survey in Kalungu District, Uganda
REFNo: HS2495ES

1. To pilot test the Functional Needs Assessment Tool (FNAT) survey methodology and bespoke data collection app. 2. Across the domains of vision, hearing, mobility, cognition, communication, self-care and mental health to estimate the: a. prevalence of functional difficulties b. unmet and total need for rehabilitation services c. unmet and total need for AP
Uganda 2022-12-23 17:50:49 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Cecilia  Nantume
ID:
An evaluation of DMPA-SC Self Injection Interactive Voice Response (IVR) Training for Family planning Providers in 5 Districts in Uganda
REFNo: HS2593ES

To determine how the IVR approach compares traditional in-person training in terms of costs and effectiveness. ,To determine whether the IVR approach is an acceptable method of training health workers on new contraceptive method ,To determine feasibility and effectiveness of using IVR approach to train health providers on administering a new contraceptive method,
Uganda 2022-12-23 17:46:55 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Julius Ssendiwala
ID:
Strengthening of Infection Prevention and Control in PEPFAR-supported Facilities during COVID-19 Pandemic in Uganda
REFNo: HS2564ES

1) Develop IPC indicators to support routine IPC reporting and performance monitoring.
2) Develop a centralized IPC reporting mechanism for streamlining IPC data collation, analysis, and reporting.
3) Validate data reported to the centralized database, perform data quality assessments, and implement quality improvements (QI) activities.
4) Monitor adherence to IPC policies, guidelines, and standards across all levels of the healthcare system.
5) Support the implementation of IPC capacity building interventions (trainings, mentorships, support supervision, IEC materials and Job aides, WASH supplies/PPEs) at all levels of the healthcare system.
6) Enhance surveillance systems for COVID-19 infections among HCW

Uganda 2022-12-23 17:43:55 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Micheal Mwebaza
ID:
Leadership Styles and Organisational Commitment of Academic Staff in Selected Universities in Uganda
REFNo: SS1543ES

To establish the extent to which laissez faire leadership styles influence organisational commitment of academic staff in Kyambogo and Uganda Christian Universities, To establish the extent to which autocratic leadership style influence organisational commitment of academic staffs in Kyambogo and Uganda Christian Universities,To establish the extent to which democratic leadership style influence organisational commitment of academic staffs in Kyambogo and Uganda Christian University,
Uganda 2022-12-23 17:42:41 2025-12-23 Social Science and Humanities Non-Clinical Trial Degree Award
John Bosco Isunju
ID: UNCST-2019-R001803
Impact of a community-level advocacy intervention on HIV, TB, and malaria-related knowledge, attitude, and practices (KAP) among most at-risk populations in Uganda
REFNo: HS2577ES

Broad objectives
To assess the impact of a community-level advocacy intervention on the uptake of HIV, TB and Malaria prevention services among the most-at-risk populations in Uganda

Specific objectives
1. To determine the impact of a community-level advocacy intervention on uptake of HIV prevention services among most-at-risk populations in Uganda
2. To establish the impact of a community level advocacy intervention on knowledge on TB among most-at-risk populations in Uganda
3. To determine the impact of a community level advocacy intervention on uptake of malaria prevention services most-at-risk populations in Uganda
4. To explore the facilitators and barriers for uptake of HIV, TB and malaria prevention services among most-at-risk populations in Uganda

Uganda 2022-12-23 17:33:21 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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