Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Thereza Piloya Were
ID: UNCST-2019-R000491
Effects of Social Determinants of Health on Type 1 Diabetes (T1D) Care in Sub Saharan Africa; Perspectives from Uganda.
REFNo: HS5008ES

Primary
i. To describe the SDOH among the children and youths in Uganda.
ii. To determine the impact of SDoH on glycemic control of children and youths aged 6 months- 25 years in Uganda.
iii. To determine the effect of the SDoH on the physical growth of children and youths in Uganda.
Secondary
i. To set up a database of SDoH for children with T1D in Uganda.
ii. To determine the effect of the SDoH on the complications (DKA, severe hypoglycemia and hypertension) of children and youths in Uganda.

Uganda 2024-10-14 8:06:50 2027-10-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Cissy  Kityo
ID: UNCST-2021-R013663
Impact of Non-B HIV-1 Subtype on second-line Protease Inhibitor Regimens in Africa (INSPIRE)
REFNo: HS5035ES

To evaluate the effect of replicative fitness on susceptibility to PIs in patients with repeated failure in presence of known and novel Gag and Env PI-associated mutations.,To assess HIV-1 drug resistance in PI-resistant viruses using phenotypic drug susceptibility assay and recombinant viruses based on gag, pol, and env genes derived from patients failing 2L.,To determine the basis for second line (2L) treatment failures on ATV/r- and LPV/r-containing regimens in the absence and presence of protease-associated drug resistance.,To determine the effect of Non-B HIV-1 Subtype on second-line Protease Inhibitor Regimens in Africa.,
Uganda 2024-10-14 8:03:22 2027-10-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Benjamin Eyre
ID: UNCST-2024-R002750
Enumerating development: how interdisciplinary perspectives on the treatment of research officers can improve data for social transformation
REFNo: SS3327ES

To generate new knowledge on FOs perspectives in relation to their work practices and conditions with a particular focus on how they see this affecting the quality of the data they produce. ,To explore challenges FOs negotiate, including low salaries, precarious employment contracts, pressure to perform quickly, working in dangerous environments, and negotiating knowledge hierarchies.,To document the lived experience of FOs working in the behavioural economics research sector in Uganda. Their work involves conducting surveys, experiments, and RCTs in informal urban settlements, peri-urban, and rural areas. ,
UK 2024-10-14 8:02:17 2027-10-14 Social Science and Humanities Non-Clinical Trial Non-degree Award
Rosalind  Parkes-Ratanshi Parkes
ID: UNCST-2019-R000717
Providing Rapid HIV viral Diagnostics at Point of Care (The PROmPT) study.
REFNo: HS4881ES

Primary:
To evaluate quantitative performance of the HIV self-testing platform in a resource-limited setting (Uganda) compared to a laboratory-based, gold-standard FDA-approved HIV VL test (Roche Cobas Quantitative HIV-1 RNA, or Abbott Real Time HIV-1 assay, or similar) in PLHIV who have both viral suppression and non-suppression.

Secondary:
To evaluate patient acceptability of the HIV self-testing platform compared to gold standard VL assay
To compare the Turnaround Time (TaT) of the HIV VL self-testing assay and lab-based VL assay
To compare the assay performance of the HIV self-testing platform to lab-based testing by sex, age group, HIV viral load, HIV clade, and HIV risk group

UK 2024-10-08 18:13:17 2027-10-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Mohamed Abouaziza
ID:
Evaluating Impact of Financial Incentives on Agri-Businesses in Uganda
REFNo: A520ES

The specific objectives are to determine whether access to incentivized loans generates increased credit for SMEs, and whether this additional credit subsequently leads to higher revenues, profits, and downstream outcomes for these businesses,The main objective of this research is to examine the effects of financial incentives offered to lenders on agricultural Small and Medium Enterprises (SMEs) while identifying and understanding the challenges these enterprises encounter. Specifically, the study aims to assess whether exposure to these incentives influences the volume of agricultural loans at the bank level and to understand the effects of these incentives on SME growth and performance at the SME level.,
Egypt 2024-10-08 18:11:59 2027-10-08 Agricultural Sciences Non-Clinical Trial Non-degree Award
Josephine  Prynn Elsie Sunman
ID: UNCST-2024-R002840
Nested case control study of prevalence and aetiology of dementia in a rural Ugandan population, and a situational analysis of services available for affected families.
REFNo: HS4827ES

1) Evaluate the prevalence of dementia. 2) Establish the causes and associated factors of dementia to inform risk reduction strategies. 3) Understand the formal support available for people living with dementia and their families.
UK 2024-10-08 17:59:00 2027-10-08 Medical and Health Sciences Non-Clinical Trial Degree Award
OKELLO DAMOI JOSEPH
ID: UNCST-2022-R011560
Impact of the Global Laparoscopic Advancement Pro Training Program on the Fundamentals of Laparoscopic Surgery (FLS) Test Pass Rate among COSECSA Trainees and Members in Sub-Saharan African Countries
REFNo: HS4898ES

To evaluate the impact the GLAP Pro program on the FLS test pass rates among COSECSA trainees and members in Sub-Saharan African countries,To determine the factors associated with the FLS pass rate among intervention (GLAP Pro) group and the control (conventional training),To determine the FLS pass rate among COSECSA Trainees and members in sub-Saharan African countries, following GLAP pro training reception and conventional laparoscopic training,To evaluate the impact of global laparoscopic advancement pro training program on fundamentals of laparoscopic surgery (FLS) test passing rate among COSECSA Trainees and members in sub-Saharan African countries,
Uganda 2024-10-08 17:55:54 2027-10-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Madison Lindeman
ID: UNCST-2023-R006228
The Lived Menstrual Experiences of Women in Western Uganda
REFNo: SS3304ES

- To understand how menstruation impacts women in their daily lives to develop solutions and policy interventions rooted in women’s experiences to improve menstrual health in Uganda. - To explore the structural conditions, resources, and sociocultural discourses that surround menstruation and how these impact women’s embodied experiences. - To understand how women in Mbarara, Uganda experience and navigate menstruation in their everyday lives.
USA 2024-10-08 17:52:55 2027-10-08 Social Science and Humanities Non-Clinical Trial Degree Award
Gilbert Akampurira
ID: UNCST-2024-R003558
PREVALENCE AND FACTORS ASSOCIATED WITH EPISIOTOMY EXTENSION INTO THIRD- OR FOURTH-DEGREE PERINEAL TEARS AMONG WOMEN DELIVERING AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS5072ES

1. To determine the prevalence of episiotomy extension into third or fourth-degree perineal tears among women delivering at Mbarara Regional Referral Hospital.
2. To determine the factors associated with episiotomy extension into third or fourth-degree perineal tears among women delivering at Mbarara Regional Referral Hospital.

Uganda 2024-10-08 17:49:03 2027-10-08 Medical and Health Sciences Non-Clinical Trial Degree Award
John Rek
ID: UNCST-2024-R004373
Training of machine learning algorithms to detect bednet use in Busia Uganda
REFNo: HS4850ES

The objective of this study is to train a comprehensive platform for highly accurate remote monitoring of LLIN use and other behaviors related to malaria risk. We will:
1) gather real-life data about how LLINs are hung and used in the community,
2) train the machine learning algorithms based off pre-defined protocols informed by actual practice and
3) test the accuracy of the machine learning algorithms in real-life settings.

Uganda 2024-10-08 17:48:05 2027-10-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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